Download Curriculum Vitae Ebo Derk de Muinck

Curriculum Vitae
Ebo Derk de Muinck
ADDRESS:
Office:
Department of Medical and Health Sciences,
Division of Cardiovascular Medicine
Linköping University
SE-581 85 LINKÖPING
Sweden
Home:
Säby Roxvik
SE-58599 LINKÖPING
Sweden
Tel. office: --46-13-222112
Tel. hospital: --46-13-220000, pager no: 2112
Fax: --46-13-145929
[email protected]
Tel. home: --46-13-58210
Tel. mobile: --46-730759843
DATE AND PLACE OF BIRTH: February 15, 1957, Rotterdam, The Netherlands
VISA STATUS: E.U. Resident
EDUCATION:
DATE
INSTITUTION
DEGREE
July 14, 1983
Rijksuniversiteit Groningen, Faculteit der Medische
Wetenschappen (University of Groningen, Faculty of
Medical Sciences)
M.D.
POSTDOCTORAL TRAINING:
DATE
SPECIALTY
INSTITUTION
May 25, 1994
Ph.D.
Rijksuniversiteit Groningen, Faculteit der
Medische Wetenschappen (University of
Groningen, Faculty of Medical Sciences)
Thesis Title:
Distal Coronary Hemoperfusion during
Percutaneous Transluminal Coronary
Angioplasty
June 1, 1989
Cardiology
Rijksuniversiteit Groningen, Faculteit der
Medische Wetenschappen (University of
Groningen, Faculty of Medical Sciences)
June 1988 –
June 1989
Fellowship in Interventional Cardiology Universitair Medisch Centrum Groningen
(Groningen University Hospital)
Sept. 1985 –
June 1988
Residencies in: Clinical Cardiology,
Universitair Medisch Centrum Groningen
Coronary Care, Cardiothoracic Surgery, (Groningen University Hospital)
Echocardiography, Cardiac Exercise
Testing, Nuclear Cardiology,
Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D.
Page 2
Consultations to General Surgery,
Vascular Surgery and Internal Medicine,
Diagnostic Coronary Angiography,
Heart Transplantation
Sept. 1984 –
Sept. 1985
Research Rotation
Universitair Medisch Centrum Groningen
(Groningen University Hospital) and
Martini Ziekenhuis Groningen (Martini
Hospital Groningen, affiliated with
Groningen University Hospital)
Sept. 1983 –
Sept. 1984
Residencies in: Internal Medicine
(Endocrinology and Heamtology),
Clinical Cardiology
Medisch Spectrum Twente (‘Medical
Spectrum Twente’, affiliated with
Groningen University Hospital)
LICENSURE AND CERTIFICATION:
DATE
LICENSURE/CERTIFICATION
July 14, 1983
M.D., The Netherlands’ Ministry of Health
June 19, 1989
Cardiologist, The Netherlands’ Royal Society of Medicine
April 1, 2009
Educational Commission for Foreign Medical Graduates (ECFMG)
ACADEMIC APPOINTMENTS:
DATE
ACADEMIC TITLE
INSTITUTION
Mar. 15-2010
Professor of Vascular Biology
Linköping University
Mar. 15-2010
Associate Professor of Vascular Biology
Center for Medical Imaging science and
Visualization, Linköping University
Nov. 1, 2009
Associate Professor of Cardiovascular
Medicine
Center for Medical Imaging science and
Visualization, Linköping University
Sept. 1, 2009
onward
Associate Professor of Cardiovascular
Medicine
Linköping University
July 1, 2007 –
Sept. 1, 2009
Associate Professor of Medicine/Physiology Dartmouth Medical School
May 4 – May 29, Visiting Professor, Department of Cardiology St. Paul’s Hospital, Vancouver, B.C,
2009
Canada
Sept. 2002-2007 Assistant Professor of Medicine/Physiology Dartmouth Medical School
July 2001 –
Sept. 2002
Visiting Scientist, Department of Medicine, Dartmouth Medical School
Section of Cardiology
Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D.
Page 3
April 1995 –
Sept. 2002
Assistant Professor, Cardiovascular Research University of Maastricht, Faculty of
Institute (CARIM), Maastricht, The
Medical Sciences
Netherlands.
HOSPITAL APPOINTMENTS:
DATE
HOSPITAL TITLE
INSTITUTION
Sept. 1, 2009
onward
Staff Cardiologist, ‘Överläkara’
Linköping’s University Hospital,
Sweden
April 1995 –
Sept. 2002
Staff Interventional Cardiologist
Academisch Ziekenhuis Maastricht
(Maastricht University Hospital)
June 1989 –
April 1995
Staff Interventional Cardiologist
Universitair Medisch Centrum
Groningen (Groningen University
Hospital)
OTHER PROFESSIONAL POSITIONS:
DATE
POSITION TITLE
INSTITUTION/ORGANIZATION
March, 2010
Member Scientific Advisory Board
Center for Medical Imaging science
and Visualization, Linköping
University
February, 2010
Clinical Co-Director
Integrative Regenerative Medicine
Institute (IGEN), Linköping
University, Sweden
April, 2009
Scientific Founder
Celdara Medical, LLC
2007-2008
Scientific Director Pre-Clinical Research at the Dartmouth Medical School
Angiogenesis Research Center
Sept. 2002-2007 Director Pre-Clinical Research at the
Angiogenesis Research Center
Dartmouth Medical School
1999 –
July 2001
Consultant regarding coronary intervention
Medtronic Vascular
April 1995 –
July 2001
Program Director Cardiovascular Research
Institute Maastricht (CARIM) Research Line
III ‘Vascular Biology’
Rijksuniversiteit Maastricht, Faculteit
der Medische Wetenschappen
(University of Maastricht, Faculty of
Medical Sciences)
June 1989 –
April 1995
Consultant to the Department of Biomedical
Engineering
Rijksuniversiteit Groningen, Faculteit
der Medische Wetenschappen
(University of Groningen, Faculty of
Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D.
Page 4
Medical Sciences)
June 1989 1991
Coordinator of the joint Heart Transplant
Program of the University Hospitals of
Groningen and Utrecht
Universitair Medisch Centrum
Groningen (Groningen University
Hospital)
Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D.
Page 5
COMMITTEE ASSIGNMENTS: Assignments since Dartmouth College appointment in August
2002:
National/International:
YEAR
COMMITTEE
ROLE
INSTITUTION
2007
2007
Study Section
Study Section
ad hoc project reviewer
ad hoc project reviewer
2005 onward
Israel Science Foundation
Research Foundation
Flanders-Belgium
American Heart Association
Committee on
abstract reviewer
Scientific Sessions
Program
Study Section
ad hoc project reviewer
NIH/NHLBI
Atherosclerosis and Inflammation
of the Cardiovascular System
Study Section
ad hoc program project reviewer
NIH/NHLBI
‘Inflammation and Repair in
Cardiac Ischemia-Reperfusion’
Study Section
ad hoc program project reviewer
NIH/NHLBI
‘Specialized Centers for Cell
Based Therapy’
Study Section
ad hoc grant application reviewer Charles H. Hood Foundation
Study Section
ad hoc grant application reviewer Research Foundation –
Flanders
2005
2005
2005
2005
2005
2005 onward
Study Section
grant application reviewer
The Netherlands’
Organization for Health
Research and Development
Netherlands’ Heart
Foundation
2002 onward
Study Section
grant application reviewer
YEAR
COMMITTEE
ROLE
INSTITUTION
2003 - 2006
Study Section
grant application reviewer
Northeast Affiliate of the
American Heart Association
Regional:
Institutional:
YEAR
COMMITTEE
ROLE
INSTITUTION
2010 onward
Core Facility Board
member
Faculty of Health Sciences,
Linköping University
2006 onward
Department of Physiology
Seminar Committee
member
Dartmouth Medical School
Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D.
Page 6
Everett Koop Research
Building Imaging Planning
Committee
member
Dartmouth Medical School
2005 onward
American Cancer Society
Institutional Research Grant
Review Committee
grant application
reviewer
American Cancer Society
2004 - 2006
IACUC
member
Dartmouth Medical School
2003 onward
Department of Physiology
Graduate Student Committee
member
Dartmouth Medical School
2003 onward
Thesis Committee Justin
Gaudet (Biochemistry)
member
Dartmouth Medical School
2003 - 2006
Thesis Committee Laura
Emond (Physiology)
member
Dartmouth Medical School
MEMBERSHIP, OFFICE & COMMITTEE ASSIGNMENTS IN PROFESSIONAL SOCIETIES:
YEAR
SOCIETY
ROLE
1996 onward
American Heart Association Council on Clinical
Cardiology
member
American Heart Association Council on Atherosclerosis, member
Thrombosis and Vascular Biology
1997 onward
American Association for the Advancement of Science
member
2000 onward
North American Vascular Biology Organization
member
2003 - 2006
American Heart Association, Interdisciplinary Working member
Group on Functional Genomics and Translational Biology
2006 - 2008
International Society for Molecular Imaging
member
EDITORIAL BOARD:
DATE
ROLE
BOARD NAME
January 1, 2010,
onward
Board Member
Atherosclerosis, Editorial Board
July 1, 2007 –
July 1, 2009
Board Member
European Heart Journal, International Editorial
Board
Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D.
Page 7
AWARDS AND HONORS:
DATE
AWARD NAME
2005
U.S. Permanent Residency, Outstanding Investigator Track
2002
Pfizer/ACCF Visiting Professorship Program in Cardiovascular Medicine 2002
2001
Interuniversity Cardiology Institute of the Netherlands (I.C.I.N.), fellowship in
support of a year as visiting scientist at the Angiogenesis Research Center,
Dartmouth Medical School, Hanover NH.
2000
Gordon Research Conference Vascular Biology, Plymouth NH, U.S.A., July 2000:
Poster prize: Conserved flow-mediated arterial remodeling despite impaired nitricoxide dependent vasodilation in atherosclerotic mice.
1994
First Conference on Technology and Health Care, Stuttgart, Germany, June 1994:
Poster prize: Active coronary hemoperfusion provides protection against ischemia
during percutaneous transluminal coronary angioplasty.
JOURNAL REFEREE ACTIVITIES:
Reviews since Dartmouth College appointment in August 2002:
American Journal of Physiology: Heart and Circulation Physiology
American Journal of Cardiology
Antioxidants and Redox Signaling
Arteriosclerosis Thrombosis and Vascular Biology
Atherosclerosis
Cardiovascular Research
Catheterization and Cardiovascular Interventions
Circulation
Circulation Research
European Heart J
Eur J Clin Investigation
Haemostasis
J Mol Cell Cardiol
J Vasc Research
Netherlands’s Journal of Medicine
OTHER ACTIVITIES
Invited visiting
professors
Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D.
Page 8
Name
Home Institution (outside institutions only)
Date of visit
Prof. J.C. Leiter
Department of Physiology, Dartmouth Medical School,
Hanover, NH, USA
6 months total
between 2010 2012
Name
Home Institution (outside institutions only)
Date of visit
Prof. D. J. Stewart
Ottawa Hospital Research Institute, Ottawa, Ontario,
Canada
05-26-2010 –
05-28-2010
Prof. M. Amiji
Nanomedicine Education and Research Consortium,
Northeastern University, Boston, MA, USA
12-18-2007
Prof. J.R. Lindner
Department of Cardiology, Oregon Health and Science
University, Portland, OR, USA
11-28-2007
Dr. W. Liu
Laboratory of Diagnostic Radiology Research/Philips
Medical Systems, National Institutes of Health, Bethesda,
MD, USA
09-17-2007 –
09-18-2007
Prof. P. Doevendans
Department of Cardiology, Utrecht University Hospital,
the Netherlands
11-17-2005
Prof. J. Tijssen
Department of Cardiology, Academic Medical Center,
Amsterdam, the Netherlands
03-03-2005 –
03-05-2005
Dr. R. de Winter
Department of Cardiology, Academic Medical Center,
Amsterdam, the Netherlands
03-03-2005 –
03-05-2005
Prof. P. Carmeliet
Center for Transgene Technology & Gene Therapy,
Flanders Interuniversity Institute for Biotechnology,
Leuven, Belgium
10-06-2004
Prof. M. Krieger
Department of Biology, Massachusetts Institute of
Technology, Cambridge, MA, USA
11-13-2003
Hosted speakers
Student grant applications mentored and edited (only awarded grants are mentioned)
Recipient
Grant
Award date
Dmitri Baklanov
Vascular Biology Working Group Cardiovascular
Medicine Fellow Research Award
10-22-2002
Extension of Vascular Biology Working Group
Cardiovascular Medicine Fellow Research Award
10-09-2003
S.M. Tenney Medical Student Fellowship Grant,
American Heart Association, Northeast Affiliate Predoctoral Fellowship Grant
03-29-2006
05-24-2006
Theodore You
Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D.
Page 9
Robert McGarr
Albert J. Ryan fellowship
05-15-2008
Meagan Tibbo
Howard Hughes Medical Institute, undergraduate
research fellowship
05-19-2008
Kareem Halim
Howard Hughes Medical Institute, undergraduate
research fellowship
05-19-2008
Ming H. Lee
Howard Hughes Medical Institute, undergraduate
research fellowship
05-19-2008
Workshop organizer: leader/director
University of New Hampshire/Dartmouth Nanotechnology
Initiative, the Inn at Marshland Farm, Quechee, VT
04-03-2006
Workshop organizer: co-organizer
Workshop on Atherosclerosis and Molecular Imaging
CMIV (Center for Medical Imaging Science and
Vislualization), Linköping’s University, Linköping,
Sweden
12-16- 2009
MAJOR RESEARCH INTERESTS:
My laboratory is a translational lab. with a focus on understanding and measuring the impact of
CD13/APN as announced by molecular imaging on neo-vascularization, ischemic wound healing,
perfusion, oxygenation and function of the heart.
PATENT
‘Modification of ischemic wound healing and other inflammatory responses through temporary
depletion and/or functional modification of dendritic cells’
U.S. provisional application no: 61/112375
RESEARCH FUNDING: Previous
NHLBI (R01 HL078622). (P.I.: de Muinck)
Structure/Function of Neovessels Imaged with NGR Peptide
Annual Direct Costs: $ 250,000
9/22/04 – 8/31/08
Philips Electronics North America Corp. (P.I.: de Muinck)
Multimodal Imaging of Neo-Vessels
Annual Direct Costs: $150,650
9/1/05-2/1/08
35%
NHLBI (1 RO1 HL 69442-01) (Shapiro)
Subcontract PI: de Muinck
6/1/02-6/1/06
25%
35%
Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D.
Page 10
CD154-CD13 Pathway in Inflammation Driven Angiogenesis
Subcontract Annual Direct Costs $100,000
Percardia, Inc. (P.I.: de Muinck)
4/1/02-3/31/06
20%
Percutaneous ventricle-to-coronary bypass (VPASS) A novel nonsurgical method for myocardial
perfusion of ischemic heart disease
Annual Direct Costs: $195,821
Boston Scientific (P.I.: de Muinck)
3/18/06-3/17/06
3%
Accuracy of Transendocardial Catheter Targeting and Description of Injectate Distribution Patterns in
Porcine Model of Acute Myocardial Infarction: The Insights from 3D Echocardiography
Annual Direct costs: $55,880
Ension, Incorporated (P.I.: de Muinck)
Left Atrial Appendage Isolation Device to Reduce Stroke
Annual Direct costs: $16,850
3/1/04-2/28/06
2%
Netherlands’s Heart Foundation (NHS 2001.047) (P.I.: de Muinck)
6/1/02-6/1/05
Enhancement of Myocardial Angiogenesis through Targeting of CD13/APN, a Novel Angiogenic Target
and Regulator
NMT Medical, Inc. (P.I.: de Muinck)
Pilot Study with Prototype PFO Closure Device
Annual Direct Costs: $21,223
5/10/05-12/31/05
2%
Medtronic Bio-Medicus, Inc. (P.I.: de Muinck)
Filterwire Pilot Study
Annual Direct Costs: $11,244
6/13/05-9/30/05
2%
Boston Scientific (Steiner)
3/21/05-9/21/05
Non-GLP Feasibility Study of the Sensor Tip / Sensor Needle Stiletto Injection Catheter
Annual Direct costs: $4,780
2%
P50 HL63609 NHLBI (sub BIDMC) (Simons)
Endothelial Cell Signaling and Cardiac Angiogenesis
Annual Direct Costs: $229,504
4/1/02-3/31/05
10%
NHLBI (SCOR P50 HL 63609) (Simons)
Syndecan signaling in angiogenesis
Annual Direct Costs $229,504
4/1/02-4/1/05
10%
Bristol-Meyers Squibb (Pearlman)
Assessment of Arterial Wall Imaging with an RP 845 Analog
Annual Direct Costs $10,645
9/8/05-11/8/05
2%
Cordis Corp. (Simons)
10/25/02-10/31/04
20%
Preclinical Evaluation of Angiogenesis/Tissue Engineering prototype formulations and device(s) for
treatment of Ischemic Heart Disease and Congestive Heart Failure
Annual Direct Costs: $426,234
Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D.
Page 11
Eli Lilly and Company (Simons)
Service Laboratory Agreement
Annual Direct Costs: $225,000
12/1/02-11/30/03
20%
Guidant (Simons)
Evaluation of Myocardial Delivery in Pigs
Annual Direct Costs: $180,898
9/30/02-9/29/03
10%
NMT Medical Inc. (P.I.: de Muinck)
A Novel Bioresorbable Septal Occlunder
Annual Direct Costs: $104,000
4/1/05-12/2/09
30%
5R01HL056803 NHLBI (Maulik)
Subcontract PI: de Muinck
Subcontract title: Angiogenesis in Disease Model
Annual Direct Costs of subcontract: $76,888
12/1/07-8/1/09
20%
5R01AG023590-04 NHLBI (Shworak)
3OST1 Deficiency and Cardiovascular Disease
Annual Direct Costs: $160,000
2/15/05-9/1/09
10%
Departmental funds, Department of Medicine, Section of Cardiology
9/1/2008-9/1/09
40%
Present:
Linköping University start-up funds:
Salary (100%) for research assistant professor
Annual Direct Costs: $ 61,505
Salary (100%) for post-doctoral candidate
Annual Direct Costs: $ 50,317
Bench fee
Annual Direct Costs: $ 139,762
4/1/10-4/1/14
4/1/10-4/1/14
4/1/10-4/1/13
FORSS (P.I.: de Muinck)
Prevention in Periperal Arterial Disease (PREPAID)
Annual Direct Costs: $ 27,895
1/1/10-1/1/11
1R43HL097464-01 SBIR (P.I.: de Muinck)
Myocardial Infarction Therapeutics
Annual Direct Costs: $ 132,901
8/1/09-7/31/10
Departmental funds, Department of Physiology,
Dartmouth Medical School
Stipend for one graduate student
9/1/08-04/31/10
TEACHING EXPERIENCE/CURRENT TEACHING RESPONSIBILITIES:
Teaching activities at Linköping’s University September 2009 - onward:
25%
Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D.
Page 12
Fellows and Students:
- Medical Bioscience Master students:
2010: S. Basnet: 30 credit-point project: Dendritic Cells in Acute Myocardial Infarction
2010: S. Koppal: 15 credit-point project: Dendritic Cells in Atherosclerotic Plaque
Teaching activities at Dartmouth Medical School August 2002 - September 2009:
Medical School
- Cardiovascular Physiology in Medical Physiology 110
- Pharmacology small group (2nd year med. students)
- Advanced Medical Sciences ( 4th year med. students)
- Graduate Program in Experimental and Molecular Medicine: Advanced Systems Physiology
(PEMM 271)
Thayer School of Engineering
- Cardiovascular Imaging (undergraduate level, ENGS 10)
Course Director:
- Advanced Cardiovascular Physiology (graduate level)
Fellows and Students:
- Cardiology fellows:
2002 – 2006: D. Baklanov, projects:
ƒ Cardiac MRI of iron labeled vascular smooth muscle cells, transplanted into the heart
after myocardial infarction in pigs
ƒ Comparison of retrograde coronary venous infusion versus direct intramyocardial
injection for delivery of therapeutics
ƒ 3D echocardiography guided intramyocardial injections
2003 – 2006: F. Redican, projects:
ƒ Inhibition of in-stent restenosis by oral copper chelation in porcine coronary arteries
ƒ Assessment of murine cardiac hemodynamics combined echocardiography and pressurevolume loop registration
-
Graduate students:
1995 – 2001: E. Lutgens (primary thesis advisor): Atherosclerosis, an Inflammatory Disease.
Graduated ‘cum laude’.
1997 – 2002: H. Schulten: (primary thesis advisor): Nitric Oxide in Arterial Remodeling.
2002 – 2003: C. Elinsky (primary thesis advisor): Identification of CD13/APN in Atherosclerotic
Plaque Angiogenesis leading to Plaque Rupture
2006 - 2008: R. McGarr 2008 Albert J. Ryan Fellowship recipient (primary thesis advisor):
Vessel Stabilization during Angiogenesis through CD13/Aminopeptidase N Mediated Cleavage of
Bradykinin and Kaladin
2006 onward: D. Pruthi 2009 Albert J. Ryan Fellowship recipient (primary thesis advisor):
Vascular Leukocytes in the Healing Infarct Wound
Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D.
Page 13
2008: M. Bilodeau (rotation)
2006: R. McGarr (rotation)
2006: D. Pruthi (rotation)
2006: J Qin (rotation)
2005: W. Donnely (rotation)
2005: J. Qin (rotation)
2004: S. Richardson (rotation)
2003: L. Emond (rotation)
Medical School students:
2006-2007: T. You Marsh Tenny Fellowship and AHA Northeast Affiliate Predoctoral
Fellowship recipient: Identification of Stage of Bloodvessel Development Annonced by
CD13/APN expression on Endothelial Cells
2005 – 2007: V. Popov: Optimization of NGR Peptide Sequence to Enhance CD13/APN Binding
-
Undergraduate students:
2009: R. Feder (rotation)
2009: M. Tibbo Howard Hughes Medical Institute Fellow
2008 – 2009: K. Halim Howard Hughes Medical Institute Fellow
2008 – 2009: M.H. Lee Howard Hughes Medical Institute Fellow
2008: J. Reibel (rotation)
2008: R. Feder (rotation)
2008: H Wang (rotation)
2007: L. Clarkson (rotation)
2005: S. Perry (rotation)
2005: A. Sjogren (rotation)
2004: S. Perry (rotation)
2004: C. Palac (rotation)
2004: F.E. McCarthy (rotation)
2003: A. Niles (rotation)
Regional Fellows:
2005: Jun Yu, home institution: Department of Pharmacology, Yale University Medical Center,
New Haven, CT, P.I. William Sessa. Purpose of training: learn arterial angiography in the mouse
hind limb.
International Fellows:
2008-2009: D. Lipman, home institution: Radboud University Medical Centre, Nijmegen, The
Netherlands. Purpose of training: introduction to vascular biology.
2006: R. van der Nagel, home institution: Hubrecht Laboratory, Utrecht, The Netherlands, P.I.
Leon de Windt. Purpose of training: learn mouse echocardiography
Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D.
Page 14
2005: A. Hirsch, home institution: Academic Medical Center, Amsterdam, The Netherlands, P.I.
R. de Winter. Purpose of training: learn mouse cardiac ischemia-reperfusion model
International Course
2002: Graduate course ‘Vascular Biology’ Cardiovascular Research Institute Maastricht
(CARIM), University of Maastricht, The Netherlands
INVITED PRESENTATIONS:
- 2010:
‘Forskning i Framkant’ seminar, Institute for Medicine and Health, Linköping’s University,
March 11, Linköping, Sweden
Life Science Seminar, Institute for Clinical and Experimental Medicine, Linköping’s University,
February 4, Linköping, Sweden
Celdara Medical, LLC, board meeting, January 22, Lebanon, NH, USA
- 2009:
CMIV board meeting, December 14, Linköping, Sweden
IMH-LiTH ‘Julbord’ meeting, December 8, Linköping, Sweden
IMH-full-day meeting, November 5, Linköping, Sweden
CMIV post-graduate course, September 16 – 17, Kolmården, Sweden
Department of Cardiology, Linköping University Hospital, June 10, Linköping, Sweden
Department of Pharmacology & Therapeutics, The James Hogg iCAPTURE Centre for
Cardiovascular and Pulmonary Research, May 26, Vancouver, BC, Canada
Department of Cardiology, St. Paul’s Hospital, May 13, Vancouver BC, Canada
NIH Cardiovascular Imaging Symposium, April 30 – May 1, National Institutes of Health,
Bethesda, MD
Center for Molecular Medicine, April 24, Karolinska Institute, Stockholm, Sweden.
Faculty of Health Sciences, Linköping University, April 22, Linköping, Sweden
Medical School Duluth, March 30 – April 1, Duluth, MN
- 2008:
Heart and Lung Institute at St Paul’s Hospital, Dec.18, 2008, Vancouver, BC, Canada
James Hogg iCAPTURE Centre at St. Pauls’ Hospital, Dec. 17, 2008, Vancouver, BC, Canada
Regional Cardiology Meeting, Nov. 25, 2008, Roermond, The Netherlands
Department of Medicine, University Hospital Galway, Nov. 21, 2008, Galway, Ireland
REMEDI, National Centre for Biomedical Engineering Science, National University of Ireland,
Galway, Nov. 20, 2008, Galway, Ireland
Department of Cardiology, Vancouver General Hospital, University of British Columbia, Sept.
15, 2008, Vancouver, BC, CA
Department of Cardiology, University Hospital Haugeland, February 15, 2008, Bergen, N
Department of Experimental Medical Science, Faculty of Medicine, Lund University, February
13, 2008, Lund, SE
Department of Pharmaceutical Sciences, Northeastern University, January 17, 2008, Boston, MA
- 2007:
Eight Annual Dartmouth Nanomaterials Symposium, Thayer School of Engineering, Dartmouth
College, October 27, 2007, Hanover, NH
Boehringer Ingelheim Pharmaceuticals Inc., September 14, 2007, Ridgefield, CT
G.E., Global Research Center, June 27, 2007, Niskayuna, NY
Bentley Pharmaceuticals, February 23, 2007, Exeter, NH
Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D.
Page 15
-
-
-
-
-
DSM Biomedical, February 15, 2007, Geleen, NL
Department of Cardiology, University Hospital Groningen, December 14, 2007, Groningen, NL
2006:
NMT Medical Inc. private breakfast meeting, October 22, 2006, Washington DC
Edelman lab., Massachusetts Institute of Technology, June 22, 2006, Cambridge, MA
Department of Cardiology, Twee Steden Ziekenhuis, May 31, 2006, Tilburg, NL
Experimental Biology, April 1-5, 2006, San Fransisco, CA
2005:
Department of Cardiology, VieCuri Medisch Centrum Noord Limburg, December 20, 2005,
Venlo, NL
Department of Cardiology, Academic Medical Center, December 15, 2005, Amsterdam, NL
Department of Cardiology, University Hospital Utrecht, December 14, 2005, Utrecht, NL
Material Sciences Program, University of New Hampshire, December 1, 2005, Durham, NH
International Center for Integrative Medicine Symposium: Degenerative Disease – Regenerative
Medicine, Treating Causes not Consequences, , Sept. 16-18, 2005, Grand Rapids, MI
The Jackson Laboratory, April 28, 2005, Bar Harbor, ME
2004:
Centers for Molecular and Regenerative Medicine, Maine Medical Center Research Institute,
December 9, 2004, Scarborough, ME
Third Annual Biological Therapeutics Symposium: Therapeutic Angiogenesis and Myogenesis,
November 6, 2004, Atlanta, GA
Joint Workshop on Stem and Mesenchymal Cells, Vasculogenesis and Angiogenesis, Maine
Medical Center, Dartmouth Medical School, May 9-10, 2004, Lebanon, NH
2003:
Second Annual Biological Therapeutics Symposium: Clinical Trials in Cell and Angiogenic
Therapies, November 8, 2003, Orlando, FL
New England Working Group Molecular Imaging Symposium, July 25, 2003, Yale, CT
Society for Interventional Radiology Annual Scientific Meeting, March 30, Salt Lake City, UT
2002:
New England Cardiac Catheterization Conference, October 4-5, 2002, Stowe, VT
BIBLIOGRAPHY:
Journal Articles:
1.
2.
3.
4.
5.
6.
De Muinck E, Wagner G, v.d. Ven LLM, Lie KI. Comparison of the effects of two doses of
Bisoprolol on exercise tolerance in exercise induced stable angina pectoris. Eur Heart J
1987;suppl.M:31-35.
De Muinck E, Wagner G, van der Ven LLM, Lie KI. El Bisoprolol en la angina de pecho estable
inducido por el esfuerzo. Drugs of Today 1989;suppl.2:55-62.
De Muinck E, Lie K.I. Safety and efficacy of betablockers in the treatment of stable angina
pectoris. J Cardiovasc Pharmacol 1990;suppl.5:S123-S128.
De Muinck E, Lie KI, von Mengden HJ, Reck R, Verkenne P. Bisoprolol in myocardial infarction.
J Cardiovasc Pharmacol 1990;suppl.5:S196-S200.
De Muinck E, Ven van der L, Buchner-Moell D, Lie K, on behalf of the MIRSA study group.
Comparison of the safety and efficacy of bisoprolol versus atenolol in stable exercise induced
angina pectoris. A Multicentre International Randomized Study on Angina Pectoris (MIRSA). J
Cardiovasc Pharmacol 1992;19:870-875.
De Muinck ED, van Dijk RB, den Heijer P, Meeder J, Lie KI. Autoperfusion balloon catheter for
Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D.
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complicated angioplasty: a prospective study with retrospective controls. Int J Cardiol 1992;37:317327.
Van de Ven LLM, de Muinck ED, van Herwaarden RHBM, Buchner-Möll D, Lie KI. Een
vergelijkend onderzoek naar het anti-angineuze effect van bisoprolol (Emcor®) en atenolol. Een
Multicenter Internationale Gerandomiseerde Studie bij Angina Pectoris (MIRSA). J Drugther Res
1992;9:268-273.
Pentinga M, Meeder JG, Crijns HJGM, de Muinck ED, Wiesfeld A, Lie KI. Late onset
atrioventricular nodal tachycardia. Int J Cardiol 1993;38:293-298.
Rakhorst G, Verkerke GJ, de Muinck ED. Hart en pomp, mechanische circulatie ondersteuning.
Klinische Fysica 1993;2:74-80.
Verkerke GJ, de Muinck ED, Rakhorst G, Blanksma PK. The P.U.C.A. pump: a left ventricular
assist device. Artif Organs 1993;17:365-368.
Van Dijk RB, den Heijer P, de Muinck ED, Lie KI. Internal balloon tamponade: a non-surgical
method for removal of accidentally placed sheaths from the subclavian artery. Cath Cardiovasc
Diagn 1993;29:325-328.
De Muinck ED, Angelini P, van Dijk RB, Verkerke GJ, Rakhorst G, Lie KI. In vitro flow of fresh
human blood through autoperfusion balloon catheters. Cath Cardiovasc Diagn 1993;30:58-62.
De Muinck ED, Meeder JG, Magielse CPE, Bom VJJ, Verkerke GJ, Lie KI. Hemolysis in fresh
human blood with a new hemoperfusion pump to prevent myocardial ischemia during coronary
angioplasty. Technology and Health Care, 1993;1:165-170.
De Muinck ED, Meeder JG, Magielse CPE, Bom VJJ, van Dijk RB, Verkerke GJ, Lie KI.
Hemoperfusion during coronary angioplasty: first European experience with a new hemoperfusion
pump. Artif Organs 1994;18:517-522.
Rakhorst G, Verkerke GJ, Hensens AG, de Muinck ED, Blanksma PK, Pillon M, Juffer M. In vitro
evaluation of the influence of pulsatile intraventricular pumping on ventricular pressure patterns.
Artif Organs 1994;18:494-499.
De Muinck ED, Verkerke GJ, Rakhorst G, van Dijk RB, Lie KI. Myocardial protection during
coronary angioplasty with autoperfusion and forced perfusion: an in vitro comparison. Int J Artif
Organs 1994;17:83-87.
De Muinck ED. Nieuwe dottertechniek. Samenvatting proefschrift. Tijdschr Gerontol Geriatr
1994;25:173.
De Muinck ED. Pompje maakt ook dotteren bij erg zwak hart mogelijk. Mens en Wetenschap
1994;6:390.
De Muinck ED, den Heijer P, van Dijk RB, Crijns HJGM, Hillege JL, Twisk SP, Lie KI.
Autoperfusion balloon versus stent for acute or threatened closure during coronary angioplasty. Am
J Cardiol 1994;74:1002-1005.
De Muinck ED. Geforceerde coronair perfusie tijdens percutane transluminale coronair
angioplastiek. Modern Medicine 1995;February:107-109.
De Muinck ED. Distal coronary hemoperfusion during percutaneous transluminal coronary
angioplasty. Samenvatting proefschrift. Cardiologie 1995;2:84.
Meijer J, de Haan S, de Muinck ED. Geforceerde coronair perfusie tijdens percutane transluminal
coronair angioplastiek: verpleegkundige aspecten. Cordiaal 1995;February:25-30
De Muinck ED. Distal coronary hemoperfusion during percutaneous transluminal coronary
angioplasty. Cardiologie 1995;2:241-247.
De Muinck ED. Bail-out coronary angioplasty. J Invasive Cardiol 1995;7,suppl B:32B-38B.
De Muinck et al. The Perfusion Angioplasty Symposium. Panel discussion. J Invasive Cardiol
1995;7,suppl B:50B-56B.
Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D.
Page 17
26. De Muinck ED, den Heijer P, van Dijk RB, Crijns HJGM, Hillige HL, Lie KI. Distal coronary
hemoperfusion during percutaneous transluminal coronary angioplasty. Cath Cardiovasc Diagn
1996;37:233-240.
27. De Muinck ED, de Swart JBRM, van Ommen GVA, Bär FWHM. Het gebruik van intracoronaire
stents. Hartbulletin 1996;67-71.
28. van de Ven LLM, Crijns HJGM, De Muinck ED, van Gelder IC, van Wijk LM Lie KI.
Electrophysiologic and antiarrhythmic effects of intravenous Bisoprolol in atrioventricular nodal
reentry tachycardia. Current Therapeutic Research 1996;57:950-958.
29. Rodriguez LM, Smeets JLRM, Timmermans C, Blommaert D, van Dantzig JM, De Muinck ED,
Wellens HJJ. Radiofrequency catheter ablation of sustained monomorphic ventricular tachycardia
in hypertrophic cardiomyopathy. Cardiovasc. Electrophysiol. 1997;8:803-806.
30. De Muinck ED, van Gilst W, van der Laarse A, Doevendans PAFM. Molecular Cardiology. Part 3:
restenosis. Cardiologie 1997;4:469-476.
31. Palmen M, van der Zee R, Daemen MJAP, De Muinck ED, Lucassen AJN, Doevendans PAFM.
Molecular Cardiology. Part 6: Cardiac angiogenesis and growth factors. Cardiologie, 1998;5:406413.
32. Hofstra L, De Muinck ED, Doevendans PAFM. Molecular Cardiology. Part 7: Apoptosis in the
cardiovascular system. Cardiologie 1998;5:589-593.
33. Doevendans PA, Daemen MJ, De Muinck ED, Smits JF. Cardiovascular phenotyping in mice.
Cardiovasc. Res. 1998;39:34-49.
34. Lutgens E, Daemen M, Kockx M. Doevendans PA, Hofker M, Havekes L, Wellens HJJ, de
Muinck ED. Atherosclerosis in APOE*3 Leiden Transgenic Mice from Proliferative to
Atheromatous Stage. Circulation 1999;99:276-283.
35. Lutgens E, de Muinck ED, Kitslaar PJ, Tordoir JH, Wellens HJJ, Daemen MJ. Biphasic pattern of
cell turnover characterizes the progression from fatty streaks to ruptured human atherosclerotic
plaques. Cardiovasc. Res. 1999;41:473-479.
36. Lutgens E, Daemen M, de Muinck ED, Debets J, Leenders P, Smits JF. Chronic myocardial
infarction in the mouse: cardiac structural and functional changes. Cardiovasc. Res. 1999;41:586593.
37. Engelen D, Gorgels Ap, Cheriex EC, de Muinck ED, Oude Ophuis AJ, Dassen WR, Vainer J, van
Ommen VG, Wellens HJJ. Value of the electrocardiogram in localizing the occlusion site in the
left anterior descending coronary artery in acute anterior myocardial infarction. J. Am. Coll.
Cardiol. 1999;34:389-395.
38. Lutgens E, Gorelik L, Daemen MJ, de Muinck ED, Grewal IS, Koteliansky VE, Flavell RA.
Requirement for CD 154 in the progression of atherosclerosis. Nature Med., 1999;5:1313-1316.
39. Hofstra L, Liem H, Dumont E, Boersma H, van Heerde W, Doevendans P, de Muinck ED, Wellens
HJJ, Kemerink G, Reutelingsperger C, Heidendal G. Visualisation of cell death in vivo in patients
with acute myocardial infarction. Lancet 2000;356:209-212.
40. F. Bär, J. Vainer, Stevenhagen J, Neven K, Aalbregt R, Oude Ophuis T, van Ommen V, de Swart
H, de Muinck ED, Dassen WR, Wellens HJJ. Ten years experience with early angioplasty in 759
patients with acute myoacardial infarction . J. Am. Coll. Cardiol. 2000;36:51-58.
41. Dumont E, Hofstra L, van Heerde W, van den Eijnde S, Doevendans P, de Muinck ED, Daemen
M, Smits J, Frederik P, Wellens H, Daemen M, Reutelingsperger Ch. Cardiomyocyte Death
Induced by Myocardial Iscyhemia and Reperfusion. Circulation 2000;102:1564-1568.
42. Kliffen M, Lutgens E, Daemen M, de Muinck ED, Mooy C, de Jong P. The APOE*3-Leiden
mouse as an animal model for basal laminar deposits. Br J Ophtalmol 2000;84:1415-1419.
43. W. Rompelberg, S. Haegmans, E. de Muinck. Foliumzuur: een nieuwe manier in de behandeling
Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D.
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van vaatvernauwing? Cordiaal 2000;21:155-157.
44. Lutgens E, de Muinck ED, Heeneman S, Daemen MJ. Compensatory enlargement and stenosis
develop in apoE(-/-) and apoE*3-Leiden transgenic mice. Arterioscler Thromb Vasc Biol
2001;21:1359-65.
45. Bech GJ, de Bruyne B, Pijls NH, de Muinck ED, Hoorntje JC, Escaned J, Stella PR, Boersma E,
Bartunek J, Koolen JJ, Wijns W. Fractional flow reserve to determine the appropriateness of
angioplasty in moderate coronary stenosis: a randomized trial. Circulation 2001;103:2928-2934.
46. Chamuleau SA, Tio RA, de Cock C, de Muinck ED, Pijls NH, van Eck-Smit BL, Koch KT,
Meeuwissen M, Dijkgraaf MG, de Jong A, Verberne HJ, van Liebergen RA, Laarman GJ, Tijssen
JG, Piek JJ. Prognostic value of coronary blood flow velocity and myocardial perfusion in
intermediate coronary narrowings and multivessel disease. J Am Coll Cardiol 2002;39:852-858.
47. Mandinov LA, Mandinova A, Kyurkchiev S, Kjurkchiev D, Kehayov I, Kolev V, Soldi R, Bagala
C, de Muinck ED, Lindner V, Post MJ, Simons M, Bellum S, Prudovsky I, Maciag T. Copper
chelation represses the vascular response to injury. Proc Natl Acad Sci U.S.A. 2003;100:6700.
48. Khurana R, Zhuang ZZ, Bhardway S, Murakami M, de Muinck E, Yla-Herttuala S, Ferrara N,
Martin J, Zachary I, Simons M. Angiogenesis dependent and independent phases of intimal
hyperplasia. Circulation 2004;110:2436-2443.
49. Baklanov DV, de Muinck ED, Thompson CA, Pearlman JD. Novel double contrast MRI technique
for intramyocardial detection of percutaneously transplanted autologous cells. Magn Reson Med
2004;52:1438-1442.
50. Baklanov DV, de Muinck ED, Simons M, Moodie KL, Arbuckle BE, Thompson CA, Palac RT.
Live 3D echo guidance of catheter-based injections. Cathet Cardiovasc Intervent 2005;65:340-345.
51. Jun Yu, Ebo D. de Muinck, Zhenwu Zhuang, Mary Drinane, Katalin Kauser, Gabor M. Rubanyi,
Hu Sheng Qian,Takahisa Murata, Bruno Escalante, and William C. Sessa. Endothelial nitric oxide
synthase is critical for ischemic remodeling, mural cell recruitment, and blood flow reserve. PNAS
2005;102:10999-11004.
52. Li Shen, Ling Gao, Zhenwu Zhuang, Ebo DeMuinck, Heng Huang, Fillia Makedon, Justin
Pearlman. An interactive 3D visualization and manipulation tool for effective assessment of
angiogenesis and arteriogenesis using computed tomographic angiography. Proc. SPIE
2005;7544:848.
53. Zhen W. Zhuang, Ling Gao, Masahiro Murakami, Justin D Pearlman, Terry J Sackett, Michael
Simons, Ebo D. de Muinck. Multidetector row computed tomographic angiography with threedimensional volume rendering in rodents: non-invasive quantification of arteriogenesis. Radiology
2006; 240:698-707.
54. Baklanov DV, Moodie KM, McCarthy FE, Mandrusov E, Chiu J, Aswonge G, Cheng J, Chow M,
Simons M, de Muinck ED. Comparison of transendocardial and retrograde coronary venous
intramyocardial catheter delivery systems in healthy and infarcted pigs. Cath Cardiovasc Interv
2006: 68:416-423.
55. Mandinov L, Moodie KL, Mandinova A, Zhuang Z, Redican F, Baklanov D, Lindner V, Maciag T,
Simons M, de Muinck ED. Inhibition of in-stent restenosis by oral copper chelation in porcine
coronary arteries. Am J Physiol: Heart and Circulatory Physiology 2006;291:H2692-H2697.
56. Buehler A, van Zandvoort, MAJM, Stelt BJ, Hackeng TM, Schrans-Stassen BHGJ, Bennaghmouch
A, Hofstra L, Cleutjens JPM, Duijvestijn A, Smeets MB, de Kleijn DPV, Post MJ, de Muinck ED.
c-NGR a novel homing sequence for targeted molecular imaging of murine cardiac angiogenesis in
vivo. Arteriosclerosis Thrombosis and Vascular Biology 2006;26:2681-2687.
Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D.
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57. Sherman JA, Hall A, Malenka DJ, de Muinck ED, Simons M. Humoral and cellular factors
responsible for coronary collateral formation. Am J Cardiol 2006:89:1194-1197.
58. de Muinck ED, Nagy N, Tirziu D, Murakami M, Gurusamy N, Goswamy SK, Ghatpande S,
Engelman RN, Das DK, Simons M. Protection Against Myocardial Ischemia–Reperfusion Injury by
the Angiogenic Masterswitch Protein PR 39 Gene Therapy: The Roles of HIF1α Stabilization and
FGFR1 Signaling. Antioxidants & Redox Signaling 2007;9:437-445.
59. Listz Maurice R, Fromageau J, Roy Cardinal M-H, Doyley M, de Muinck E, Robb J, Cloutier G.
Characterization of Atherosclerotic Plaques and Mural Thrombi with Intravascular Ultrasound
Elastography: A Potential Method Evaluated in an Aortic Rabbit Model and a Human Coronary
Artery. IEEE-TITB 2008;12:290-298.
Reviews:
1. de Muinck ED, Simons M. Re-evaluating therapeutic neovascularization. J Mol Cell Cardiol
2004;36:25-32.
2. Ebo D. de Muinck, Craig Thompson, Michael Simons. Cell based regenerative therapy for
cardiovascular disease. Gene Ther 2006;13:659.
Editorials:
Ebo D. de Muinck, Michael Simons. Calling on reserves. Granulocyte colony stimulating growth
factor in cardiac repair. Circulation 2005;112:3033.
INVITED PAPERS:
Book Chapters:
E.D. de Muinck, J. D. Pearlman. Targeted Magnetic Resonance Imaging of Angiogenesis in the
Vascular System. In: Cardiovascular Molecular Imaging. Informa Health Care, New York, NY,
2007.
E.D. de Muinck. Atherosclerosis: Focus on Epigenetics and Nutrition. Taylor & Francis Group,
London, UK
Reviews:
E.D. de Muinck. Cell- and gene therapy for cardiac regenerative therapy. Antioxidant Redox
Signaling, 2009;11: 2025–2042.
L. W. Dobrucki, E.D. de Muinck, J.R. Lindner, A.J. Sinusas. Multimodality Imaging Approaches
to Angiogenesis. . J Nucl Med – Supplement, 2010: in press