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G. ELIAVA INSTITUTE OF BACTERIOPHAGE, MICROBIOLOGY AND VIROLOGY T he Institute is wellknown as a pioneer in the field of phage research and applied microbiology. It was established in 1923 by the Georgian scientist George Eliava and his FrenchCanadian colleague Felix D'Herelle, the discoverer of bacteriophages. At present, the institute’s staff is more than 100 scientists, 38 PhDs. Its research is supported by the Georgian government and through grants from international organizations. The Institute offers multidisciplinary expertise focused on the isolation and use of phages against bacterial pathogens of human, animal and plant origin (e.g. practical application of therapeutic, prophylactic and diagnostic bacteriophages against a variety of bacterial infections) Further more, the Institute has strong research programs in the field of food microbiolo gy, environment, infectious immunology/virology, and biodefence. More than 15 effective bacteriophage preparations were elaborated and produced commercially at the Institute. For example, IBMV was used for prophylaxis and treat ment throughout the former Soviet Union, in the Public Health network and in mil itary forces. Throughout the 1970s1980s, phage preparations such as Pyophage, Intestyphage, Pyoceaneus bacteriophages, Intravenous Staphylococcus bacteriophage, Dysenterial bacteriophage were recognized at national and international exhibitions and became brands known worldwide. At present, the main research areas are the following: • Investigation of the etiological structure of human and animal bacterial dis Working on phage isolation and screening 58 eases, including antibioticresistant nosocomial infections; ADDRESS G.Eliava Institute of Bac teriophage, Microbiology and Virology 3 Gotua St., Tbilisi 0160, Georgia Tel: +995 32 374227 +995 32 371782 Fax: +995 32 331609 +995 32 382762 www.geocities.com/ HotSprings/Spa/5386, www.ibmv.caucasus.net Marina Tediashvili, Director m_tediash.ibmv@ caucasus.net • Selection and detailed characterization of a variety of spe cific diagnostic and therapeutic bacteriophages; • Elaboration of biological preparations; vaccines, immuno logic serums, bacteriophages and enzymes against highly conta gious human and animal pathogens; • Ecological monitoring of the bacterial pollution in water environments. • Development of novel strategies for phagebased biocon trol of plant bacterial diseases. Technologies available for Licensing and/or Partnering: (1) Therapeutic bacteriophages (phages) for prophylaxis and treat ment of bacterial diseases such as Staphylococcus, Streptococcus, E. coli, Pseudomonas, Proteus, Salmonella, Shigella, Serratia, Klebsiella, Enterobacter, Yersinia sp., Erwinia, etc. Most of these phages have been commercially produced and widely used in clinics throughout the countries of the former Soviet Union. (2) Phage typing. A number of original phage typing patterns has been devel oped for epidemiology studies (Salmonella typhimurium, Salmonella typhi, Salmonella paratyphi A, B, Shigella, Proteus, Yersinia, Pseudomonas) for identify ing the source of infection and its spread in the environment. A system con structed for S. typhimurium (I. Chirakadze, 1979) has been adopted by the World Health Organization and recommended for use in developing countries. Bacteriophage specific to Proteus vulgaris (3) A Study of bioactive substances of bacterial origin. Hyaluronidase isolated from Staphylococcus aureus strain has been successfully proved in clini cal studies for treating postoperational and burn scars. (4) Research on endemic Caucasian lactic acid bacteria. A collection enu merating about 100 lactobacilli and lactococci has been created, among them Lactobacillus delbrueki, ssp. Lactis, Lactobacillus acidophilus, Lactobacillus casei, Streptococcus thermophilus, Enterococcus faecium, etc. (5) Immune preparations (vaccine, serums, diagnosticums) for detection, diagnostics, preventions and treatment of bacterial diseases like Anthrax, Phages attacking Proteus vul garis Brucellosis, Staphylococcal infections, etc. have been elaborated at the Eliava Institute. 59