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«Rossiyskiy Onkologicheskiy Zhurnal» № 2 2014
Abstracts of the articles
RO-1402-004
EXTENSIVE LIVER RESECTION WITH PREOPERATIVE CHEMOTHERAPY FOR COLORECTAL
METASTASES WITH HIGH RISK OF COMPLICATIONS
1
2
1,
3
2
Yu.I. Patyutko , K.G. Mamontov , A.G. Kotelnikov A.A. Ponomarenko , A.F. Lazarev
1 N. N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences, 115478, Moscow,
Russian Federation; 2 Altai branch of N. N. Blokhin Russian Cancer Research Center under the Russian Academy of
Medical Sciences,656049, Barnaul, Russian Federation; 3 State Scientific center of coloproctology, 123423, Moscow,
Russian Federation
Objective: to study influence of preoperative chemotherapy on postoperative complications rate.
Material and methods: an analysis of 455 cases of extensive liver resection. 229 (56%) patients didn’t
receive neoadjuvant chemotherapy, 176 (44%) — received preoperative chemotherapy. 216 (53%) patients
had bilobar lesions, 156 (39%) — had multiple metastases, 168 (42%) — had synchronous metastases, 237
(58%) — had metachronous metastases. 60 (15%) patients in addition to liver lesions, had been resected for
extrahepatic metastases. Results: bevacizumab inckusion to preoperative regional chemotherapy did not
lead to increase of postoperative complication rate.
Conclusion: Postoperative complication rate didn’t significantly differ in all groups of treatment, regardless of
liver resection volume. Extension of liver resection from standard hepatectomy to extensive, leads to
statistically significant increase of acute hepatic failure. Acute hepatic failure takes the first place among
complications (21%).
Key word s: colorectal cancer metastases; preoperative chemotherapy; complications.
RO-1402-012
COMBINED OPERATIONS IN CONJUNCTION WITH INTRACAVITARY CHEMOTHERAPY FOR
TREATMENT OF PATIENTS WITH PERITONEAL MESOTHELIOMA. IMMEDIATE RESULTS.
EXPERIENCE OF THE THO- RACIC DEPARTMENT OF THE N. N. BLOKHIN RUSSIAN CANCER
RESEARCH CENTER OF RAMS
A. G.Abdullaev, B. E.Polotskiy, D M. I.avydov
N. N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences, 115478, Moscow
The paper presents a detailed analysis of the immediate results of the treatment of patients with peritoneal
mesothelioma who underwent cytoreductive surgery combined with intracavitary hyperthermia
chemoperfusion in the thoracic department of the N. N. Blokhin Russian Cancer Research Center in the
period from 2008 to 2013.
Key word s: mesothelioma of the peritoneum; intracavitary hyperthermic chemoperfusion; cytoreductive
surgery.
RO-1402-016
ASSOCIATION BETWEEN THE MORPHOLOGICAL CHARACTERISTICS OF GROWTH AND THE
CLINICAL COURSE OF ORAL CANCER
V.H. Samеdov1, L.A. Naleskina2, V.D.Zakharychev1
1P.L.Shupyk National Medical Academy of Postgraduate Education, 04112, Kiev, Ukraine; 2R.E.Kavetsky Institute of
Experimental Pathology, Oncology and Radiobiology of NAS of Ukraine, 03022, Kiev, Ukraine
Clinical-morphological study based on the clinical data of 122 patients with malignant neoplasms of tongue
and oral mucosa was conducted aimed at establishing an association between the morphological
characteristics of malignant tumors and symptomatic progression of the tumor process conducted after
treatment. It was demonstrated that all tumors with epithelial genesis, 107 represented a keratinizing
squamous carcinoma, and the degree of differentiation prevailed moderately differentiated tumors (113
cases). Retrospective evaluation of the malignancy degree of tongue and oral mucosa tumors, according to
recommendations in literature, conducted before treatment, showed a prevalence in all groups studied
tumors grade III compared to II and a small number of tumors with I degree of malignancy. When comparing
the degree of malignancy of squamous cell carcinoma in each studied group of patients with clinical
diagnosis of tumor progression: the time of relapse and regional metastases after treatment established an
association between these indicators. The most aggressive growth characterized by squamous cell
carcinoma grade III, despite the pronounced signs of keratinization in most tumors. The most effective was
the complex treatment of patients with combined effects of CRT + CD and microwave hyperthermia.
Reported patterns give rise to speak about the possibility of using morphological grade squamous cell
carcinoma of tongue and oral mucosa, as a predictive clinical and morphological parameters of the flow of
the tumor process.
Key word s: tongue cancer; cancer of the oral mucosa; an association; squamous keratinizing nonketorazing cancer; tumor grade.
RO-1402-022
RESEARCH OF TOPOISOMERASE IIΑ ACTIVITY IN CONJUNCTION WITH CLINICAL AND
MORPHOLOGI- CAL PARAMETERS AND PROLIFERATION (TO IDENTIFY ARGYROPHILIC PROTEINS
OF NUCLEOLAR ORGANIZER REGIONS AND ANTIGEN KI-67) IN SQUAMOUS CELL CARCINOMA OF
THE LUNG
D.S. Kobyakov1, E. Yu. Bychkova 2, A.M. Avdalyan2, I.P. Bobrov3, S. A. Lazarev2, N.M. Kruglova2, Е.L.
Lushnikova4, A.F. Lazarev2, L.M. Nepomnyashchikh4
1Kogalym City Hospital, 628481, Kogalym, Russian Federation; 2Altai branch N.N. Blokhin Russian Cancer Research
Center under the Russian Academy of Medical Sciences, 656049, Barnaul, Russian Federation; 3Altai Medical
University, 656038, Barnaul, Russian Federation; 4Scientific Research Institute of Regional Pathology and
Pathomorphology of the Siberia Region under the Russian Academy of Medical Sciences, 630117, Novosibirsk, Russian
Federation
Topoisomerase IIα (TopoIIα), argyrophilic proteins associated with nucleolar organizer regions (Ag-NOR) and
antigen Ki- 67 in squamous cell carcinoma of the lung were investigated. Defined Tumors with low and high
TopoIIα, Ag-NOR and Ki- 67 were defined. TopoIIα had a relationship with clinical and morphological
parameters (value T, greatest dimension, stage of disease and tumor differentiation) and proliferation
markers (Ag-NOR, Ki-67). Survival of patients with squamous cell carcinoma of the lung with low content of
TopoIIα is better as compared with high content of TopoIIα. Survival of patients depends on the mutual
content of TopoIIα and clinical and morphological parameters (value N, stage of disease), prolifera- tion
markers (Ag-NOR). TopoIIα and Ag-NOR are independent prognostic factors. Mutual research of TopoIIα
with clinical and morphological parameters and Ag-NOR has prognostic value in squamous cell carcinoma of
the lung.
Key word s: topoisomerase IIα; argyrophilic proteins of nucleolar organizer regions; Ki-67; squamous cell
carcinoma of the lung.
RO-1402-027
ORGANIZATION OF MEDICO-SOCIAL WORK IN MEDICAL INSTITUTIONS, WHICH PROVIDE SPECIALIZED AND HIGH-TECH CARE FOR CHILDREN HEMATOLOGIC MALIGNANCIES
E.V.Zhukovskaya, G.A. Novichkova
Dmitry Rogachev Federal Research and Clinical Center , 117997, Moscow, Russian Federation
The steadily increasing importance of medical and social measures, focused on patients with
oncohaematology pathology. It is extremely important to identify the most significant problems in the practice
of doctor working on a profile “child oncohaematology” during the expert work to develop measures to
optimize this type of activity in the modern world. There results of the survey of experts in 40 largest Russian
clinics are submitted. These features of oncology specialists at the whole stages of treatment could impact
the possibility of access to social benefits guaranteed by the state to families with disabled children.
Necessary to improve the rehabilitation of patients to end their terms of disability was accompanied by a
successful social integration in society.
Key word s: oncohematology; disability; expertize of temporary unemployment; social benefits.
RO-1402-032
GESTATIONAL TROPHOBLASTIC DISEASE: CLASSIFICATION AND PROGNOSTIC FACTORS (part II)
D.A.Bistritskaya, M.N.Tikhonovskaya, L.A.Mescheryakova, V.V.Kuznetsov, I.Yu.Davidova
N. N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences, 115478,
Moscow, Russian Federation
Study of factors affecting the prognosis of malignant trophoblastic tumors, allow adequate treatment plan .
Histological form trophoblastic tumor has important prognostic value. Chorionic carcionoma and epithelioid
tumors are characterized by a worse prognosis, it is difficult to predict the prognosis for placental
trophoblastic tumor and the most favorable prognosis is expected in the invasive and metastatic hydatidiform
mole. Important prognostic factors are the age of the patient, the outcome of the previous pregnancy
disease, length of history, the initial level of beta-human chorionic gonadotropin tumor size, location, size and
number of metastases. Inadequate chemotherapy prior to standard treatment, contributes to the emergence
of drug resistance of tumors and significantly worsens the prognosis. Modern FIGO classification 2000.,
includes clinical staging scale and prognostic factors based on which you plan to standard chemotherapy
trophoblastic tumors.
Key word s: malignant trophoblastic tumor; choriocarcinoma; standard chemotherapy; prognostic factors;
treatment planning; classification.
RO-1402-036
INTRAOPERATIVE RADIATION FOR BREAST CANCER
L.I. Korytova¹, G.M. Manikhas², E.A. Minaeva²
¹Russian Scientific center Radio and Surgical technology, 197759, Saint-Petersburg, Russian Federation;
²City clinical Oncology Dispensary, 197022, Saint-Petersburg, Russian Federation
Breast cancer is in the first place in the global structure of the women cancer incidence. Radiation therapy is
one of the methods in the treatment of breast cancer. This article focuses on one type of radiation therapy —
intraoperative radiation therapy. The data on the experience of using this method of treatment is published.
Key word s: radiation therapy; intraoperative radiation therapy; breast cancer.
RO-1402-040
HEREDITARY BREAST CANCER
A.F. Lazarev, N. S. Zadontseva, A. A. Gofman
Altai State Medical University, 656038, Barnaul, Russian Federation
Ten million new cases of a cancer and more than 6,2 million death from diseases of this group are registered
annually in the world. From 5 to 40% of malignant new growths of all anatomic localizations have a
hereditary etiology, and this percent increases in connection with growth of the general incidence.
The Cancer of a Mammary Gland (CMG) is the most widespread oncological pathology at women. Both in
the world, and in Russia, despite significant progress in development of approaches to diagnostics and to
CMG treatment within the last decades incidence, prevalence and mortality from CMG remain steadily high
and tend to growth.
Key word s: cancer of a mammary gland; hereditary syndromes; a hereditary cancer of the mammary gland;
contributing factors, genetic mutations.
RO-1402-046
DIFFERENT TYPES OF SENTINEL LYMPH NODE BIOPSY IN BREAST CANCER PATIENTS
K.V. Afanasyeva1, A.V. Petrovskiy2, M.I.Nechushkin 2, S.V.Shiryaev2, A.A.Zaytseva 1
1 I.M. Sechenov First Moscow State Medical University, 119991, Moscow, Russian Federation; 2 N. N.
Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences, 115478,
Moscow, Russian Federation
Novel data on biological features of tumors and diagnosis development have become an stimulus to reduce
surgical extension for breast cancer. Axillary lymph node dissection is associated with different
complications. That’s why a demand to verify regional lymph node status using biopsy has appeared.
Sentinel lymph node biopsy (SLNB) is performed in a few steps. First, a marker solution is introduced
intradermally or into breast parenchyma periareolarly or at the tumor site. Afterwards it goes with lymph flow
to the lymph node and accumulates in it, this first node is called sentinel (SLN). Its localization is variable but
most typically it could be found at the lateral margin of major pectoral muscle at the frontal axillar line. There
are currently 5 main methods of SLNB that are described in this article. These techniques differ in a
substance used and equipment needed to detect a SLN. All the methods are currently implemented routinely.
Many investigations has been performed worldwide that shows advantages and disadvantages of each
method which are described in the given article.
Key word s: breast cancer; sentinel lymph node; biopsy.
RO-1402-051
RADIOLOGIC METHODS IN EVALUATION OF PREVALENCE AND STRUCTURE OF IVC TUMOR
THROMBUS IN PATIENTS WITH RENAL CELL CARCINOMA
N.B.Vikhrova
N. N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences, 115478,
Moscow, Russian Federation
Renal cell carcinoma (RCC) is the most common primary tumor of the kidney; it accounts for approximately
3% of newly diagnosed cancers. The incidence of venous extension to the inferior vena cava (IVC) and renal
vein in RCC is markedly increased recently mostly due to the advances in diagnostic modalities. Knowledge
of the tumoral stage and determination of tumor thrombus extension at the time of diagnosis is essential for
prognosis and surgical planning. Nowadays abdominal ultrasound (US), computed tomography (CT) and
magnetic resonance (MR) scanning techniques are used for the detection and staging of RCC. In this study,
the accuracy of recent diagnostic tools in determination of IVC thrombus is outlined. Also the role of positron
emission tomography (PET) scanning is briefly addressed.
Key word s: kidney; renal cell carcinoma; tumor thrombus; inferior vena cava; ultrasound; computed
tomography; magnetic resonance tomography; positron emission tomography.