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«Rossiyskiy Onkologicheskiy Zhurnal» № 3 2013
Abstracts of the articles
RO-1303-004
Modern treatment in patients with malignant plevral effusions resistent to sistem therapy
M.B. Bychkov, К.S. Titov, V.A. Gorbunova, D.V. Filonenko, L.V. Demidov, M.V. Kiselevskiy, Е.М.
Trechalinа
N.N.Blokhin Russian Cancer Research Center of the Russian Academy of Medical Sciences, 115478,
Moscow, Russian Federation
Abstract: The clinical efficacy and tolerability of intrapleural sclerotherapy using a binary catalyst system
"teraftal + ascorbic acid" and intrapleural immunotherapy with allogeneic LAK cells and low-dose
recombinant interleukin-2 (roncoleukin) in patients with tumor (metastatic) pleurisy at various chemoresistant
malignancies was studied. The results showed that this treatment is highly effective (objective response
when sclerotherapy was 82%), and immunotherapy (IL-2/LAK - 92.4% and IL-2 - 80%), relatively rarely give
recurrences and satisfactorily tolerated patients .
Key words: tumor pleurisy, sclerotherapy, the binary catalyst system pleurodesis, immunotherapy,
interleukin-2, LAK cells.
RO-1303-009
Differential diagnosis of surgical gastrointestinal complications in patients with non-Hodgkin’s
lymphomas
S.N.Nered, V.A. Shalenkov, I.S.Stilidi, E.A.Osmanov
N.N.Blokhin Russian Cancer Research Center of the Russian Academy of Medical Sciences, 115478,
Moscow, Russian Federation
Abstract: The study includes 190 patients with nodal and extranodal non-Hodgkin's lymphoma who
developed or suspected surgical complications (bleeding, perforation, stenosis) in the gastro-intestinal tract
(GIT). Complications in 134 patients occurred in the area of the gastrointestinal tumor lesions, 19 - in
different parts of the gastrointestinal tract, which were not involved in the neoplastic process. In 37 patients
suspected acute surgical pathology was not confirmed, it was caused by the side effects of anticancer drugs.
Examination algorithm and a set of diagnostic features used to distinguish the true surgical complications
from side effects of chemotherapy were presented.
Key words: lymphoma, gastrointestinal bleeding, perforation, stenosis.
RO-1303-014
Interaction of trypsin proteinases and kinin system in perifocal tissue of polyps and malignant
tumors of the colon
1
1
1
2
O.I. Kit , Yе.M. Frantsiyants , L.S. Kozlova , A.L. Terpugov
1
Rostov scientific and research institute of oncology of the Ministry of Health of Russia, 344037, Rostov-on2
Donu; Russian Federation; City hospital №. 6, Rostov-on-Donu, Russian Federation
Abstract: Perifocal tissue of malign tumor and polyps of the colon lower part were studied. It has been
determined that trypsin-like proteinases which are moderately activated in perifocal area of polyps can
perform sanitation and protection functions for this area, preventing free penetration of metabolites from the
polyp head into surrounding tissues. In the studied areas of polyps, kinin system is physiological type
activated, with increased content of prekallikrein and growing activity of carboxypeptidases. The conclusion
has been made that the turning point in change of neoplasm status may prove to be keeping or disturbing
balance of the trypsin-like proteinases and kinin system interacting with the adjacent organ homeostasis
regulation systems. Supposedly, disturbing the physiological balance in activity of kinin system and trypsinlike proteinases of perifocal tissue of polyps can entail malignization thereof.
Key words: colon, polyps, malign tumors, perifocal tissue, kinin system.
RO-1303-017
Morphological changes during Geren carcinoma after cryoablation, a local microwave hyperthermia
and their combination
1
2
1
V.H. Samеdov , L.A. Naleskina , V.D.Zakharychev
1
National Medical Academy of Postgraduate Education named after P.L.Shupyk Ministry of Health of
2
Ukraine, 04112, Kiev, Ukraine; R.E.Kavetsky Institute of Experimental Pathology, Oncology and
Radiobiology of NAS of Ukraine, 03022, Kiev, Ukraine
Abstract: A morphological and morphometric study of Guerin carcinoma after cryoablation, local microwave
hyperthermia and their combination was performed. Combined exposure was associated with decreased
adhesion of tumor cells, increasing the area of necrotic tissue and more expressed angionecrosis compared
with independent use of cryoablation or microwave hyperthermia. The results suggest a more expressed
degradation of the Guerin carcinoma tumor tissue by the combined use of low temperatures and microwave
hyperthermia.
Key words: cryosurgery, local microwave hyperthermia, Guerin carcinoma.
RO-1303-021
Relationship between argyrophilic proteins of nucleolar organizer regions and antigen ki-67 with
clinical and morphological parameters and survival in lung adenocarcinoma
1
2
3
3
3
D.S. Kobyakov , V.V. Klimachev , A.M. Avdalyan , I.P. Bobrov , A.F. Lazarev
1
2
Kogalymskaya City Hospital, 628481, Kogalym, Russian Federation; The Altai State of Medical University
3
of the Ministry of Health of Russia, 656038, Barnaul, Russian Federation; Altay branch of N.N.Blokhin
Russian Cancer Research Center of the Russian Academy of Medical Sciences, 656049, Barnaul, Russian
Federation
Abstract: Investigated argyrophilic proteins associated with nucleolar organizer regions (Ag-NOR proteins)
and Ki-67 antigen in lung adenocarcinoma. Defined tumor with low and high content of Ag-NOR proteins and
proliferation index (PI) Ki-67. The content of Ag-NOR proteins had a relationship with the clinical and
morphological parameters: parameters T, N, tumor size to 3 cm or more, stage of the disease. Survival of
patients with lung adenocarcinoma is better in tumors with a low content of Ag-NOR proteins or PI Ki-67.
High survival rate associated with low content of Ag-NOR proteins and PI Ki-67, low - with high content of
Ag-NOR proteins and PI Ki-67, intermediate - with opposite values of the content of Ag-NOR proteins and PI
Ki-67. Tumor size, parameter N and content of Ag-NOR proteins had an independent effect on survival. In
lung adenocarcinoma with no metastasis to lymph nodes survival related to the size of the tumor, with
metastases - with content of Ag-NOR proteins. Mutual study of Ag-NOR proteins and antigen Ki-67 has
differential diagnostic and prognostic value in lung adenocarcinoma.
Key words: argyrophilic proteins of nucleolar organizer regions, Ki-67, lung adenocarcinoma.
RO-1303-027
The influence of neutrophil elastase inhibitors on mice with the pancreatic cancer survival during
experiment.
I.V. Berezovsky, S. D. Fokeev
The Altai State of Medical University of the Ministry of Health of Russia, 656038, Barnaul, Russian
Federation
Abstract: Inhibitor neutrophil elastase (ZD0892) increases mice survival with the pancreatic cancer in
experiment. This effect amplifies at application of ZD0892 with xelody (antimetabolite, antineoplastic drug,
fluoropyrimidine carbamate derivative), which inhibits primary tumor growing in the pancreatic cancer.
Key words: pancreatic cancer, survival, inhibitor neutrophil elastase, xelody.
RO-1303-030
Effect of HER2-Neu expression in primary tumor on the efficacy of adjuvant polychemotherapy in
patients with stage I-II small cell lung cancer
A.P. Kolesnik
Zaporozhye State Medical University, 69035, Zaporozhye, Ukraine
Abstract: Lung cancer is a “world leader” in structure incidence and mortality from malignant disease.
Surgery is the main treatment that can completely treat patient. But, nearly 50% of patients had disease
progression after operation due to presents of micro metastases in time of operation. That’s why necessary
to indicate group of patients who needs adjuvant chemotherapy for increasing survival of patients. It is
possible to indicate group of patients with the help of molecular markers. The aim of our study is to
investigate effectiveness of adjuvant chemotherapy in early non-small cell lung cancer patients due to
expression of HER2-Neu in primary tumor. Evaluation of HER2-Neu expression was conducted in 243
patients. HER2-Neu hyperexpression was detected in 70 (28,8%) patients, and absence of HER2-Neu
expression in 173 patients (71,2%). We did not identify relationships between HER2-Neu expression in
primary tumor and sex, age of patients, location, histologic form, morphologic differentiation of tumor, T
criteria. However, patients with N1 and accordingly stage II more frequently defined HER2-Neu hyper
expression (р=0,0001 and р=0,001). Moreover, decrease survival was defined in patients with early stages
non-small cell lung cancer with HER2-Neu hyper expression in primary tumor (р<0,0001). There is a
significant effect after adjuvant chemotherapy in patients with low HER2-Neu expression. It helps to
individualize adjuvant chemotherapy and avoid groundless toxic therapy prescription.
Key words: Non-small cell lung cancer; survival; prognosis; adjuvant chemotherapy.
RO-1303-036
Isolated metastases in soft tissue of the chest wall in ovarian cancer: case report
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2
1
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I.V. Kolyadina , D.V. Komov , M.V. Cherkasova , S.V. Khokhlova ,
1,2
1
N.F. Orel , I.V.Poddubnaya
1
2
Russian Medical Academy of Postgraduate Education, 123995, Moscow, Russian Federation; N.N.Blokhin
Russian Cancer Research Center of the Russian Academy of Medical Sciences, 115478, Moscow, Russian
Federation
Abstract: Case report of isolated metastatic soft tissue of the chest wall in a patient 45 years old with
pretreated ovarian cancer. Relapse appeared 16 months later after primary treatment and was a solid tumor
in the soft tissues of the chest wall, under the right breast tissue, was verified by cytology, morphology,
immunohistochemistry and laboratory (increasing CA 125). The patient received the combination treatment:
excision of metastasis and following chemotherapy in RCRC.
Key words: ovarian cancer, isolated metastatic soft tissue of the chest wall, combination treatment ovarian
cancer.
RO-1303-038
New method of jejunogastroplasty after gastroectomy during gastric cancer
,2
A.G.Baryshev¹ , N.V.Khachaturyan²
¹State Institution of health Regional clinical hospital №1 Ministry of Health Krasnodar region 350086,
Krasnodar, Russian Federation; ²Kuban State medical university of the Ministry of Health of Russia, 350004,
Krasnodar, Russian Federation
Abstract: The authors have developed a method of reservoir jejunogastroplasty after total gastroectomy
during cancer of the stomach. The peculiarities of the digestive system function after total gastroectomy with
various methods of esophagojejunostomy after lymphadenectomy D1, D2-3 were studied. The results show
the advantages of jejunogastroplasty over standard variants of esofagoenterostomy.
Key words: gastric cancer, total gastrectomy, jejunogastroplasty.
RO-1303-042
Specific immunotherapy and cellular immunity in patients with cervical cancer
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3
A. F. Lazarev, D. K. Kenbayeva, Z. A.Manambayeva
1
Altay branch of N.N.Blokhin Russian Cancer Research Center of the Russian Academy of Medical
2
Sciences, 656049, Barnaul, Russian Federation; City Cancer Center Astana, 010000, Astana, Republic of
3
Kazakhstan; State Medical University, Semey, 071400, Semey, Republic of Kazakhstan
Abstract: The influence of a combination antineoplastic and immunotherapies on a condition of a cellular
immunity in patients with cervical cancer of stage I-IIA is defined. Decrease in indicators of immunity system
in the surveyed patients and moderate dynamics of their increase is revealed during the treatment, not being
accompanied by adequate restoration of killer cells number.
Key words: cancer of uterus neck; specific immunotherapy; cellular immunity.
RO-1303-045
Stenting during cardio-esophageal cancer recurrence in the area of esophago-intestinal anastomosis
after gastroectomy
R.K. Medeubaev
Astana Medical University, 010000, Astana, Republic of Kazakhstan
Abstract: The purpose of the study - the restoration of patency during recurrent stenosing esophageal
cancer.
69 years old patients with relapsed cardio-esophageal cancer, accompanied by stenosis of the anastomosis
were examined. Successfully performed balloon dilatation, stenting self-expanding stent Hanarostent HEV18- 90-070,, restored the possibility of enteral nutrition. Stenting for recurrent cancer can be recommended
as an alternative to re-operation.
Key words: stenting, cancer of the esophagus, cardio-esophageal cancer, enteral nutrition.
RO-1303-047
Health care services use by patients who died from oncological diseases during the last year of their
lives
S.N. Maltsev
Omsk regional clinical oncological dispensary, 644013, Omsk, Russian Federation
Abstract: Medical aid appealability of 568 people who died from oncological diseases during the last year of
their lives has been analysed. The investigated cohort consisted of 288 men, 280 women at the age from 24
to 94. The statistics of various medical aid appealability is mentioned below.
Key words: appealability, death rate, oncological diseases, elderly people.
RO-1303-049
Criteria for the definitive diagnosis of melanoma, by creation of a scorecard
S.A.Yargunin, I.S. Davidenko
Clinical Oncological Center No1 of Health Department of Krasnodar Region, 350040, Krasnodar, Russian
Federation
Abstract: Melanoma of a skin is thought to be one of the most aggressive tumors with unpredictable
prognosis because of a high potency of local growth, local and remote metastases, and dissemination.
Regarding this point very important aspect is an adequate assessment of patients and proper therapy
administration according to a disease stage. Options for effective diagnosis is to create a single user
registration card will allow to create the uniform Russian Federation register of patients with a skin
melanoma and will help to introduce an international treatment standard with distribution of patients on
stages and substages.
Key words: melanoma of a skin, morfo-statistical assessment, early diagnostics, malignant neoplasms.
RO-1303-052
Family medullary thyroid cancer: etiology, pathogenesis, diagnosis (part I).
M. Yu. Yukina, E.A. Troshina, D.G.Beltsevich, P.O.Rumyantsev
Federal Endocrinological Research Center, 117036, Moscow, Russian Federation
Abstract: Medullary thyroid cancer (MTC) represents 2-8 % of thyroid malignancies. Predominantly MTC
have sporadic nature but 20-30% of cases are hereditary caused by germ line missense mutation in RET
gene with autosomal dominant inheritance. There are precise genotype-phenotype correlations of RET
mutation location (genotype) with tumor manifestation age, disease aggressiveness, presence of
components of multiple endocrine neoplasia syndrome 2a and 2b types (phenotype). MTC is considering as
slow-growing tumor but early metastasizing. Regional metastases frequently involve neck and mediastinal
lymph nodes, distant – lungs, liver and bones. Calcitonin – highly sensitive biomarker of either primary or
recurrent MTC.
Key words: medullary thyroid cancer, sporadic, hereditary, RET mutation, calcitonin.