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Tyler O. Kirby, M.D. West Coast Gynecologic Oncology 1005 Pinellas St. Clearwater, FL 33756 727-446-2111 (office) 727-447-2131 (fax) www.westcoastgynoncology.com Education Fellowship July 2003- June 2006 Gynecologic Oncology University of Alabama at Birmingham Birmingham, AL Residency July 1999- June 2003 Obstetrics and Gynecology University of Alabama at Birmingham Birmingham, AL Medical Education July 1995- June 1999 University of Alabama School of Medicine Birmingham, AL Doctor of Medicine Undergraduate Education August 1991- May 1995 University of Alabama Tuscaloosa, AL Bachelor of Science- Interdisciplinary Studies, New College Magna Cum Laude Professional Memberships American College of Obstetrics and Gynecology- Junior Fellow American Medical Association American Society of Clinical Oncologists American College of Surgeons- Resident/Fellow Section Society of Gynecologic Oncology- Candidate Member Florida Society of Gynecologic Oncologists Pinellas County Medical Association Florida Medical Association Publications Kirby TO, Huh WK, Alvarez RD. Immunotherapy of Ovarian Cancer- A Review. Expert Opinion on Biological Therapy. Vol 2(4):409 2002. Barnes MN, Berry WD, Straughn JM, Kirby TO, Leath CA, Huh WK, Grizzle WE, Partridge EE. A pilot study of ovarian cancer chemoprevention using medroxyprogesterone acetate in an avian model of spontaneous ovarian carcinogenesis. Gynecologic Oncololgy 2002;87(1):57-63. Kirby TO, Curiel D, Alvarez RD. Gene Therapy for Ovarian Cancer: Progress and Potential. Heme-Onc Clinics of North America. 2003 Aug;17(4):1021-50. Wilder, J. L.; Pavlik, E.; Straughn, J. M.; Kirby, T.; Higgins, R. V.; DePriest, P. D.; Ueland, F. R.; Kryscio, R. J.; Whitley, R. J.; Nagell, J. “Clinical implications of a rising serum CA-125 within the normal range in patients with epithelial ovarian cancer: a preliminary investigation.” Gynecologic Oncology 2003; 89(2): 233-5. Kirby TO, Huh, WK, Partridge, EE. HPV Triage of ASC-US Cervical Cytology- A Review of the Literature. Annals, Academy of Medicine, Singapore. 2003 Sep;32(5):590-5. Rein DT, Breidenbach M, Wu H, Han Tie, Haviv YS, Wang M, Kirby TO, Kawakami Y, Dall P, Alvarez RD, Curiel DT. Gene Transfer to Cervical Cancer with Fiber Modified Adenoviruses. International Journal of Cancer. Int J Cancer. 2004 Sep 20;111(5):698-704. McGwin G Jr, Willey P, Ware A, Kohler C, Kirby T, Rue LW 3rd. ����������������������������������� A focused educational intervention can promote the proper application of seat belts during pregnancy. J Trauma. 2004 May;56(5):1016-21 Kirby TO, Rivera A, Rein D, Wang M, Ulasov I, Breidenbach M, Kataram M, Contreras JL, Krumdieck C, Yamamoto M, Rotts MG, Haisma HJ, Alvarez RD, Mahasreshti PJ, Curiel DT. A novel ex vivo model system for evaluation of CRAds therapeutic efficacy and toxicity. Clin Cancer Res. 2004 Dec 15;10(24):8697-703. Numnum MT, Kirby TO, Leath CA, Jhala D, Huh WK, Alvarez RD, Straughn JM. A Prospective Evaluation of “See and Treat” in Women with HSIL (Moderate Dysplasia) Pap Smears. Journal of Lower Genital Tract Infectious Disease. 2005: 9(1):2-6. Kirby, Tyler O.; Allen, M. Elaine; Alvarez, Ronald D.; Hoesley, Craig J.; Huh, Warner K. High-Risk Human Papillomavirus and Cervical Intraepithelial Neoplasia at Time of Atypical Squamous Cells of Undetermined Significance Cytologic Results in a Population with Human Immunodeficiency Virus. Journal of Lower Genital Tract Disease. 8(4):298-303, October 2004 Leath CA, Straughn JM Jr, Estes JM, Kirby TO, Bhoola SM, Barnes MN, Kilgore LC, Alvarez RD. The impact of aborted radical hysterectomy in patients with cervical carcinoma. Gynecol Oncol. 2004 Oct;95(1):204-7. Kirby TO, Huh, WK. HPV Triage of Patients with ASC-US Cervical Pap Smears. Sexuality, Reproduction, & Menopause. Sept 2004. Daniel T. Rein, Martina Breidenbach, Tyler O. Kirby, Tie Han, Gene P. Siegal, Gerd J. Bauerschmitz, Minghui Wang, Dirk M. Nettelbeck, Masato Yamamoto, Peter Dall, Akseli Hemminki and David T. Curiel. A Fiber Modified SLPI Promoter Based Conditionally Replicating Adenovirus For Treatment of Ovarian Cancer. Clin Cancer Res. 2005 Feb 1;11(3):1327-35. Case AS, Kirby TO, Conner MG, Huh WK. A case report of rhabdomyosarcoma of the uterus associated with uterine inversion. Gynecol Oncol. 2005 Mar;96(3):850-3 Kirby TO, Bhoola SM, Roconni RP, Numnum MT, Kendrick JE, Wright J, Fowler W, Mutch DG, Huh WK, Straughn JM. Patterns of Recurrence and Outcome in Stage I/II Vulvar Cancer Patients after Negative Superficial Inguinal Lymphadenectomy. Gynecologic Oncology. Aug; 98(2): 309-312. Huh WK, Kirby TO, Partridge EE. HPV Triage of Patients with ASC-US on Cervical Pap Smear. Journal of the Korean-American Medical Association. 2003 Nov 30; 9(1): 35-42. Whitney A Spannuth, MD; Tyler O Kirby, MD; Michael G Conner, MD; Warner K Huh, MD. Gamma Mode of Infiltration Associated With Poor Prognosis In Malignant Teratoma of The Ovary: A Case Report. Gynecol Oncol. 2005 Jul;98(1):155-7 Kirby TO, Leath CA, Kilgore LC. Surgical Staging in Endometrial Cancer. Oncology. Vol 20(1):45-63. Leath CA 3rd, Straughn JM Jr, Kirby TO, Huggins A, Partridge EE, Parham GP. Predictors of outcomes for women with cervical carcinoma. Gynecol Oncol. 2005 Aug 29. Recurrent Basosquamous Cell Carcinoma of the Vulva. Kimball KJ, Straughn JM, Conner MG, Kirby TO. Gynecologic Oncology. Accepted 2/06. Lipoxygenase Pathway Receptor Expression in Ovarian Cancer. Rocconi RP, Kirby TO, Seitz R, Beck R, Straughn JM, Stoff-Khalili M, Defoe S, Barnes MN, Alvarez RD, Huh WK. Submitted International Journal of Gynecologic Cancer, June 2006. Estes JM, Kirby TO, Huh WK. Autoclave sterilization of instruments used on women with cervical neoplasia is an effective method of eradicating residual human papillomavirus DNA: a polymerase chain reaction-based evaluation. J Low Genit Tract Dis. 2007 Jan;11(1):12-7. Estes JM, Leath CA 3rd, Straughn JM Jr, Rocconi RP, Kirby TO, Huh WK, Barnes MN 3rd. Bowel resection at the time of primary debulking for epithelial ovarian carcinoma: outcomes in patients treated with platinum and taxane-based chemotherapy. J Am Coll Surg. 2006 Oct;203(4):527-32. Presentations Kirby TO, Huh WK, Hoesley C, Allen ME, Straughn JM, Alvarez RD, Niwas S. Prevalence of Cervical Intraepithelial Neoplasia and HPV in HIV patients with ASCUS Pap Smears. Poster Presentation at the 33rd Annual Meeting of the Society of Gynecologic Oncologists, Miami, FL. 2002. Wilder JL, Pavlik EJ, Straughn JM, Kirby TO, Higgins RV, Kryscio RJ, Whitley RJ, Van Nagell JR. Clinical Implications of a Rising Serum CA125 within the Normal Range in Patients with Epithelial Ovarian Cancer. Poster Presentation at the 33rd Annual Meeting of the Society of Gynecologic Oncologists, Miami, FL 2002. Barnes MN, Berry WD, Straughn JM, Kirby TO, Leath CA, Huh WK, Grizzle WE, Partridge EE. A controlled trial of ovarian cancer chemoprevention using medroxyprogesterone acetate in an avian model of spontaneous ovarian carcinogenesis. Poster Presentation- American Society of Clinical Oncology, Orlando, FL. 2002. McGwin G, Willey P, Ware A, Kohler C, Kirby T, Rue LW. A Focused Educational Intervention Can Promote The Proper Application Of Seat Belts During Pregnancy. Poster Presentation- American Association for Surgery of Trauma. Minneapolis, MN. September 2003. Tyler O. Kirby, MD, M. Elaine Allen, MD, Ronald D. Alvarez, MD, Craig J. Hoesley, MD, Warner K. Huh, MD.High-Risk Human Papillomavirus and Cervical Dysplasia at Time of ASCUS Cytology in an HIV Population. Oral Presentation at the 2004 Biennial Meeting of the American Society for Colposcopy and Cervical Pathology, Orlando, FL. 2004. Tyler O. Kirby, Snehal M. Bhoola, Rodney P. Rocconi, T. Michael Numnum, James E. Kendrick, Warner K. Huh, J. Michael Straughn, Jr. Patterns of Recurrence and Outcome in Stage I/II Vulvar Cancer Patients After Negative Superficial Inguinal Lymphadenectomy. Oral Presentation at the 2004 GlaxoSmithKline National Fellows Forum, San Diego, CA. 2004 Kirby TO, Bhoola SM, Rocconi RP, Numnum TM, Kendrick JE, Huh WK, Straughn JM. Patterns of Recurrence and Outcomes in Stage I/II Vulvar Cancer Patients After Negative Superficial Inguinal Lymphadenectomy. Poster Presentation at the 2004 Biennial Meeting of the American Society for Colposcopy and Cervical Pathology, Orlando, FL. 2004. Numnum MT, Kirby TO, Leath CA, Jhala D, Huh WK, Alvarez RD, Straughn JM. A Prospective Evaluation of “See and Treat” in Women with HSIL (Moderate Dysplasia) Pap Smears: Is This an Appropriate Strategy? Oral Presentation at the 2004 Biennial Meeting of the American Society for Colposcopy and Cervical Pathology, Orlando, FL. 2004. Bhoola SM, Estes JM, Leath CA III, Kirby TO, Bunch P, Barnes MN III, Partridge EE, Alvarez RD. Weekly topotecan is well tolerated in the third-line or later treatment of patients with epithelial ovarian carcinoma (EOC) and may prolong time to disease progression. American Society of Clinical Oncology, New Orleans, 2004. Kirby TO, Straughn JM, Bhoola SM, Alvarez RD, Huh WK. Poor prognosis of taxane/platinum treated advanced stage ovarian cancer patients despite a negative second look laparotomy. American Society of Clinical Oncology, New Orleans, 2004. Daniel T. Rein, Martina Breidenbach, Minghui Wang, Tyler O. Kirby, Gene P. Siegal, Gerd J. Bauerschmitz, Peter Dall, Dirk M. Nettelbeck, Akseli Hemminki, Ronald D. Alvarez, David T. Curiel .A ������������������������������������������������������������������������������������������� Fiber Modified SLPI Promoter Based Conditionally Replicating Adenovirus for Treatment of Ovarian Cancer. Poster Presentation- 2004 American Society of Gene Therapy 7th Annual Meeting. June 2004. Bowel Resection at the time of primary cytoreduction improves disease-free survival in epithelial ovarian cancer patients and is associated with acceptable morbidity. C.A. Leath, JM Estes, JM Straughn, TO Kirby, WK Huh, LC Kilgore, RD Alvarez. Oral presentation- International Gynecologic Cancer Society Annual Meeting. Scotland. Bowel Resection at the time of primary cytoreduction improves disease-free survival in epithelial ovarian cancer patients and is associated with acceptable morbidity. C.A. Leath, JM Estes, JM Straughn, TO Kirby, WK Huh, LC Kilgore, RD Alvarez. Oral presentation, American College of Surgeons Annual Meeeting. New Orleans, LA. 2004. Utility of immunohistochemistry tissue array in the prediction of epithelial ovarian carcinoma response to therapy. Tyler O. Kirby, Warner K. Huh, Robert S. Seitz, James E. Kendrick, Yanling Wang, Rod Beck, Stephanie Defoe, Brian Z. Ring, Douglas T. Ross. Poster presentation, American Society of Clinical Oncology 2005 Annual Meeting, Orlando, FL. Estes JM, Kirby TO, Huh WK. Residual human papillomavirus DNA on vaginal specula and instruments used to treat women with cervical neoplasia. Obstetrics and Gynecology 105(4S):107S, 2005. (Abstract) Kirby TO, Numnum TM, Kilgore LC, Straughn JM. A prospective evaluation of a simulator-based laparoscopic training program for gynecology residents. 2006 CREOG & APGO Annual Meeting. Orlando, FL 2006. Lipoxygenase pathway receptor expression in advanced epithelial ovarian cancer. Rodney Rocconi, Tyler Kirby, Robert Seitz, Rod Beck, J. Michael Straughn Jr., Mack Barnes III, Ronald Alvarez, Warner Huh. Presented at 2007 38th Annual Meeting of Women’s Cancer, San Diego, CA. Predicting survival and optimal cytoreduction status and in women with epithelial ovarian cancer: A tissue microarray study. Warner Huh, Tyler Kirby, Rodney Rocconi, James E. Kendrick IV, Robert Seitz, Brian Ring, Rodney A. Beck, Douglas Ross. Presented at 2007 38th Annual Meeting of Women’s Cancer, San Diego, CA.