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TECHNOLOGY, PRODUCTS, MARKETS AND SERVICE OPPORTUNITIES A NEW MEDICINE PUBLICATION VOLUME 5, NUMBER 1-12 INDEX SEPTEMBER 2000 TABLE OF CONTENTS LUNG CANCER SCREENING STATE-OF-THE-ART IN THE MANAGEMENT OF CANCER KIDNEY CANCER — PART IV IMMUNOTHERAPHY/TUMOR VACCINES ADOPTIVE IMMUNOTHERAPY 1022 1022 Tumor-infiltrating Lymphocytes (TILs) 1022 Tumor-Sensitized Lymph Node Cells 1023 Autolymphocyte Therapy (ALT) 1023 Dendritic Cells (DC) 1023 ACTIVE SPECIFIC IMMUNOTHERAPY 1024 Autologous Tumor Vaccines 1024 Autologous Tumor-Derived Heat Shock Protein-Peptide Complex-96 (HSPPC) Vaccine 1024 Tumor-Specific, Mutated, von Hippel-Lindau Peptides 1024 CD40 Ligand (CD40L) 1025 LUNG CANCER — PART I ETIOLOGY AND GLOBAL EPIDEMIOLOGY GLOBAL EPIDEMIOLOGY 1041 TRIAD EPIDEMIOLOGY 1042 Low-dose Helical Computed Tomography (CT) 1076 Surgery 1115 Sputum Cytology 1078 Radiation Therapy (RT) 1116 TREATMENT OF PRIMARY SCLC 1114 Breath Analysis 1079 Thoracic radiation therapy (RT) 1116 Molecular Markers 1079 Prophylactic cranial irradiation (PCI) 1080 Brush Cytology 1080 Endoscopy/Bronchoscopy 1080 Biopsy 1083 Noninvasive Imaging 1083 Chemotherapy 1116 1117 Combination chemotherapy 1117 Single-agent chemotherapy 1118 Intensive chemotherapy/ chemoradiotherapy 1124 1126 Computed tomography (CT) 1083 Nuclear medicine 1083 MANAGEMENT OF REFRACTORY/RELAPSED SCLC 1084 Drug Resistance in SCLC 1126 Second-line Chemotherapy 1127 HISTOLOGY AND CLASSIFICATION LUNG CANCER — PART III SMALL CELL LUNG CANCEREPIDEMIOLOGY, TUMOR MARKERS, STAGING, PROGNOSIS, DISEASE MONITORING, AND CURRENT TREATMENT STRATEGIES EPIDEMIOLOGY 1105 TUMOR MARKERS 1106 Gemcitabine 1127 Topotecan 1127 Paclitaxel 1127 LUNG CANCER — PART IV NON-SMALL-CELL LUNG CANCEREPIDEMIOLOGY, TUMOR MARKERS, DIAGNOSIS, STAGING, AND PROGNOSIS Oncogenes and Tumor Suppressor Genes 1106 Neuroendocrine Markers 1106 Gender Variations in the Incidence of NSCLC 1129 1106 Age Factors in the Incidence of NSCLC 1131 Stage at Diagnosis 1131 Survival 1131 NSCLC Incidence by Histologic Type 1131 DIAGNOSIS, STAGING, PROGNOSIS AND DISEASE MONITORING Serum Markers 1107 1042 Lung Cancer in Europe 1042 Neuron-specific enolase 1108 Lung Cancer in Japan 1042 Pro-gastrin-releasing peptide 1108 1043 Chromogranin A 1108 1043 Multiple serum markers 1108 Tobacco Smoking 1114 1076 Lung Cancer in the USA ETIOLOGY Positron emission tomography (PET) Chest X-ray PRESENTATION AND DIAGNOSIS Lymphokine-activated Killer (LAK) Cells 1074 TUMOR MARKERS 1129 1133 Environmental Factors 1045 Angiogenesis Markers Hereditary Factors 1045 Detection of Tumor Cells in Bone Marrow 1111 DIAGNOSIS AND SCREENING 1135 Noninvasive Imaging 1112 Noninvasive Imaging 1135 LUNG CANCER — PART II SCREENING, DIAGNOSIS, AND CLASSIFICATION 1109 EPIDEMIOLOGY Bone Scans 1112 Scintigraphy 1112 Hereditary Factors 1133 Other Biomarkers 1135 Electron beam tomography (EBT) COPYRIGHT © 2000 NEW MEDICINE INC. UNAUTHORIZED PHOTOCOPYING, DISTRIBUTION OR ELECTRONIC STORAGE IS PROHIBITED BY LAW. 1135 FUTURE ONCOLOGY Positron emission tomography (PET) In vitro Approaches Curative Surgery SEPTEMBER 2000 1150 1135 Minimally invasive surgery 1135 Video-assisted thoracic surgery (VATS) 1152 Spindle Poisons 1191 Anhydrovinblastine 1191 BMS-184476 1191 1152 Maytansinoid immunoconjugates 1191 1153 PG-TXL 1192 1153 Taxoprexin 1192 T67 1192 1151 Cell-associated transferrin receptor (TfR) 1135 Cyfra 21-1 1135 DR-70 1136 External Beam Radiotherapy 1136 Intensity Modulated Radiation Therapy (IMRT) 1155 Brachytherapy 1155 Exatecan mesylate 1192 1155 TAS-103 1192 1155 XR5000 1193 1156 Antifolates 1193 1156 Alimta 1193 S-1 1193 Gastrin-releasing protein receptor (GRPr) Surgery in Lung Metastases RADIOTHERAPY (RT) Heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 1136 Intraluminal brachytherapy Homeobox (HOX) genes 1141 Intraoperative brachytherapy MAb 28K29 1142 Micrometastases detection 1142 Proton-beam Radiotherapy CHEMOTHERAPY Types of Chemotherapy in NSCLC 1164 Topoisomerase I Inhibitors 1192 Microsatellite alterations 1142 Telomerase 1142 Single-agent chemotherapy 1164 1143 Combination chemotherapy 1164 Decitabine 1193 High-dose chemotherapy 1166 FMdC 1193 STAGING 2 VOLUME 5, NUMBER 1-12 INDEX Revisions in the International System for Staging Lung Cancer 1143 Noninvasive Imaging 1143 Novel Chemotherapeutics Approved for the Treatment of NSCLC 1166 BIOLOGIC AGENTS Nucleosides Platinum-based Agents 1193 1202 Nedaplatin 1202 1166 CT staging 1143 Oxaliplatin 1203 FDG PET imaging 1143 Interleukin 2 (IL-2) 1166 1203 MR scanning 1144 Interferon β (IFN-β) Satraplatin 1166 Other Agents 1203 Surgical Staging 1144 MULTIMODALITY THERAPY 1167 Bendamustin 1203 Adjuvant Chemotherapy 1167 CHS 828 1203 Chemoradiotherapy 1168 CI-994 1204 Irofulven 1204 Temozolomide 1204 Tirapazamine 1204 Mediastinotomy/ mediastinoscopy 1144 Thoracoscopy and video-assisted thoracoscopy (VATS) 1144 Intra-operative sentinel lymph node mapping Molecular Substaging PROGNOSIS Serum Markers Tissue Pathology Angiogenesis evaluation 1144 1145 1146 1146 1147 1147 Genetic Tests 1147 FDG PET Imaging 1148 LUNG CANCER — PART V NON-SMALL-CELL LUNG CANCERCURRENT MANAGEMENT STRATEGIES EPIDEMIOLOGY BY AGE AND STAGE IN THE USA 1150 Incidence of NSCLC by Gender and Age 1150 Incidence of NSCLC by Stage 1150 First-year and Five-year Survival by Stage Treatment Approaches by Stage SURGERY 1150 1150 1150 Neoadjuvant/Induction Chemotherapy and Trimodality Therapy 1168 OTHER TREATMENT MODALITIES 1181 Laser Ablation 1181 Photodynamic Therapy (PDT) 1181 NOVEL FORMULATIONS AND DRUG DELIVERY APPROACHES 1205 Photofrin 1182 LumaCare LC-051 1183 Onco TCS 1205 PH-10 1183 Liposome-encapsulated paclitaxel 1205 Hyperthermia 1183 Lipid Formulations Aerosol Delivery 1205 1205 BSD-2000/3D System 1184 Perfusion-induced systemic hyperthermia (PISH) Aerosol doxorubicin 1206 1184 Aerosol retinoids 1206 1184 Aerosolized GM-CSF 1206 Inhaled RFS 2000 1206 Cryotherapy Radiofrequency bronchoscopic surgery with cryotherapy Stents 1184 1185 Silicone stents 1185 Expandable metallic stents 1185 LUNG CANCER — PART VI NOVEL AGENTS/FORMULATIONS IN DEVELOPMENT NOVEL CHEMOTHERAPEUTICS 1190 COPYRIGHT © 2000 NEW MEDICINE INC. 949. 830. 0448. ANGIOGENESIS INHIBITORS Matrix Metalloproteinase Inhibitors (MMPI) 1206 1206 BMS-275291 1207 Marimastat 1207 Neovastat 1207 Prinomastat 1208 Angiostatin and Endostatin 1208 Squalamine 1208 FUTURE ONCOLOGY VEGF Antagonists VOLUME 5, NUMBER 1-12 INDEX 1208 Angiozyme 1208 rhuMAb-VEGF 1209 Pantacea Radiosensitizers KIN-806 SEPTEMBER 2000 1219 Telomerase 1261 1219 1219 p53 mutations and other genetic markers 1262 1264 1266 Semoxind 1209 Motexafin gadolinium 1219 Cytokeratin (CK) Other Agents 1209 RSR-13 1220 BN-50730 1209 Hyaluronic acid (HA) and hyaluronidase (HAase) REGULATION Cell Cycle Regulation 1209 Proton Beam Therapy CHEMOPREVENTION 1220 1221 Cystoscopy/Biopsy 1266 HISTOPATHOLOGY AND BLADDER CANCER TYPES 1267 1209 Vitamins 1221 Flavopiridol 1209 UCN-01 1210 Nonsteroidal Anti-inflammatory (NSAI) Drugs/Derivatives 1221 Transitional Cell Carcinoma (TCC) 1267 Celecoxib 1221 Squamous Cell Carcinoma 1267 Exisulind 1221 Adenocarcinoma 1267 Approaches Targeting the Epidermal Growth Factor Receptor (EGFr) 1210 ABX-EGF 1210 Retinoids 1222 Trastuzumab 1210 Thymalfasin 1223 ZD 1839 1211 Farnesyl Tranferase Inhibitors (FTI) 1211 R11577 1211 SCH 66336 1211 Approaches Targeting p53 1211 rAd/p53 1211 RPR/INGN 201 1212 ONYX-015 Agents Targeting Other Markers G3139 ISIS 3521 IMMUNOTHERAPY/VACCINES 1227 1212 1213 1213 1214 1214 Dendritic cells expressing CEA 1216 1216 1217 1217 Vaccines Against MUC-1-expressing Tumors 1217 BLP-25 1217 1218 HER2 Peptide Vaccine 1218 Radioimmunoconjugates PATHOGENESIS EPIDEMIOLOGY 1228 1228 Global Incidence and Mortality 1228 USA Incidence 1228 1219 1219 UPDATE ON TAXANES 1025 Taxol 1025 Taxotere 1026 CLINICAL INDICATIONS 1026 Ovarian Cancer 1026 Breast Cancer 1027 Lung Cancer 1028 Other Cancer Indications 1028 THE OUTLOOK FOR TAXOL AND ITS COMPETITION 1028 Taxane Sources and Production Processes Gender 1228 Age 1229 Aphios 1029 1229 Cytoclonal Pharmaceutics 1029 1229 Dabur India 1029 NaPro BioTherapeutics 1029 Phytogen Life Sciences 1029 Phyton 1030 Samyang Genex 1030 Xechem International 1030 USA Prevalence TUMOR MARKERS BLADDER CANCER — PART II SCREENING, DIAGNOSIS, STAGING AND FOLLOW-UP SCREENING 1250 DIAGNOSIS AND FOLLOW-UP 1253 In Vitro Testing Approaches Generic Paclitaxel 1028 1030 1253 Faulding 1030 1255 IVAX/Immunex 1031 ImmunoCyt 1255 Mylan Pharmaceuticals 1032 Quanticyt 1255 Sicor 1032 1256 SuperGen 1032 Yew Tree Pharmaceuticals 1032 Urine cytology/cytopathology Bladder tumor antigen (BTA) Nuclear matrix proteins (NMP) 1258 Vaccines Against Tumors Expressing HER2 RADIATION THERAPY 1226 Health Factors Recombinant viruses expressing CEA protein or peptides 1214 Mitumomab (BEC2) Environmental and Occupational Exposure 1212 1213 Fucosyl-GM1-keyhole limpet hemocyanin (KLH) conjugate vaccine 1225 1227 SRL172 Vaccines Against Gangliosideexpressing Tumors Tobacco Smoking Lifestyle Factors 1213 Anti-CEA antibodies 1225 1267 ANTICANCER DRUGS AND MARKETS COMMERCIAL PRODUCTS ETIOLOGY 1212 Cytokine-producing Tumor Vaccines Vaccines Against CEA-expressing Tumors BLADDER CANCER — PART I ETIOLOGY, EPIDEMIOLOGY AND TUMOR MARKERS STAGE AND GRADE NMP-22 1258 BCLA-4 1260 Abbott Laboratories 1032 1261 Baker Norton Pharmaceuticals/Ivax 1032 Fibrin/fibrinogen degradation products (FDP) COPYRIGHT © 2000 NEW MEDICINE INC. 949. 830. 0448. Novel Formulations 1032 3 FUTURE ONCOLOGY SEPTEMBER 2000 Cell Therapeutics 1033 Mixed-backbone ODN (MBO) 1233 EnzyMed 1033 Morpholino ODN 1236 1033 Peptide nucleic acid (PNA) linkage ODN 1236 Locked nucleic acid (LNA) ODN 1237 Guilford Pharmaceutical MacroMed 1033 Matrix Pharmaceutical 1034 NeoPharm 1034 Phytogen Life Sciences 1034 Delivery Strategies and Entry into Cells 1237 Pharmacia & Upjohn 1034 Virus-mediated transfer Protarga 1034 Attachment of lipophilic groups 1238 SuperGen 1035 Fusogenic peptides 1238 1237 STS Particles/Medisperse 1035 Phenoxazine-modified ODN 1238 Xechem International 1035 Streptolysin O 1239 1036 Electroporation 1239 Aventis 1036 Microinjection 1239 Bristol-Myers Squibb 1036 Scrape-loading 1239 Novel Taxanes and Analogs ODN Conjugated to Radioisotopes 1278 CLINICAL CONSIDERATIONS 1278 Toxicity 1278 Administration Route 1278 Oral delivery 1278 Pulmonary delivery 1279 Combination Therapy 1279 Starburst polyamidoamine (PAMAM) dendrimers 1241 Copolymers 1245 Amphiphiles 1245 Porphyrins 1246 Carrier-ligand conjugates 1246 Controlled-released carriers 1247 Virosomes 1247 British Technology Group (BTG) 1036 Osmotic-loading or osmotic-lysis 1239 Indena 1036 Syringe-medicated loading 1239 The Lipsome Company (TLC) 1037 Hormone carriers 1239 Taxolog 1037 Spherulites 1240 ONCOLOGY TRENDS PRODUCT MARKETS — PART I Xechem International 1037 Cationic lipid facilitators (lipids and liposomes) 1240 PLATINUM-BASED ANTICANCER AGENTS 1046 Next Generation of Tubulin Stabilizing Drugs/Spindle Poisons 4 VOLUME 5, NUMBER 1-12 INDEX SPECIAL REVIEW 1037 Cisplatin 1046 Apramycin 1037 Carboplatin 1047 D-24851 1037 Oxaliplatin 1047 Discodermolide 1038 Eleutherobin 1038 Epothilones 1038 Halimide 1038 LY355703 1038 SYNTHETIC NUCLEIC ACID SEQUENCE CONSTRUCTS AS ONCOLOGY THERAPEUTICS — PART II TYPES OF SYNTHETIC NUCLEIC ACID CONSTRUCTS IN DEVELOPMENT AS ONCOLOGY THERAPEUTICS 1269 Antisense Oligos 1269 Laulimalide and isolaulimalide 1039 Triplex-Forming ODN (TFO) 1269 T138067 Catalytic Nucleic Acids/Ribozymes 1270 1039 Hammerhead ribozymes TECHNOLOGY UPDATE SYNTHETIC NUCLEIC ACID SEQUENCE-SPECIFIC CONSTRUCTS AS ONCOLOGY THERAPEUTICS — PART I MECHANISM OF ACTION 1229 DESIRABLE ATTRIBUTES OF SYNTHETIC NUCLEIC ACID SEQUENCES AS THERAPEUTICS 1230 Sequence Structure and Length 1230 1271 Minizyme 1271 Maxizymes 1271 Hairpin ribozymes 1271 Snorbozymes 1272 Deoxyribozymes or DNA enzymes (DNAzymes) 1272 Dy-Tex ribozyme analogs Chimeric Nucleotides 1272 1272 Intracellularly Produced Antisense RNA and DNA 1273 TOPOISOMERASE I INHIBITORS 1048 Topotecan 1049 Irinotecan 1050 THYMIDYLATE SYNTHASE INHIBITORS/ ANTIFOLATES AND RELATED AGENTS 1050 Capecitabine 1051 Raltitrexed 1051 UFT 1051 ONCOLOGY TRENDS PRODUCT MARKETS — PART II HORMONE MODULATING DRUGS 1084 Antiestrogens 1085 Tamoxifene 1085 Raloxifene 1085 Toremifene 1086 Aromatase Inhibitors 1086 Anastozole 1087 1274 Exemestane 1088 1230 Aptazymes 1275 Fadrozole 1088 1230 Aptamers as diagnostics 1276 Formestane 1089 Methylphosphonate (M=P) ODN 1231 BIOLOGICAL ACTIVITY OF ODN Backbone Modifications and Consequences Phosphorothioate (P=S) ODN N3’-P5’ phosphoramidate (P=A) ODN 1232 Aptamers 1276 Letrozole 1089 CpG-containing ODN 1276 Antiandrogens 1089 G-rich ODN 1277 COPYRIGHT © 2000 NEW MEDICINE INC. 949. 830. 0448. Bicalutamide 1090 FUTURE ONCOLOGY VOLUME 5, NUMBER 1-12 INDEX SEPTEMBER 2000 Cyproterone acetate 1090 Interferon α-2a 1099 Flutamide 1090 Interferon α-2b 1099 Goserelin 1090 Rituximab 1099 Leuprolide acetate 1091 Trastuzumab 1101 Nilutamide 1091 ADJUNCT THERAPIES 1101 1091 Amifostine 1101 Alitretinoin 1091 Colony Stimulating Factors 1102 Anthracyclines 1092 Filgrastim 1102 Daunorubicin 1092 Lenograstim 1102 Epirubicin 1092 Sargramostim 1102 Liposomal daunorubicin 1092 Octreotide Acetate 1103 Liposomal doxorubicin 1092 Oprelvekin 1103 Mitoxantrone 1094 Pamidronate Disodium Valrubicin 1094 OTHER CHEMOTHERAPEUTICS Busulfan 1094 Carmustine Wafer 1094 Etoposide Phosphate 1095 Flutarabine 1095 Gemcitabine 1095 Liposomal Cytarabine 1095 Methoxsalen 1096 Porfimer Sodium 1096 Temozolomide BIOLOGICALS 1096 1098 Aldesleukin 1098 Denileukin Diftitox 1098 Interferon α 1099 1104 MEETING COVERAGE CHEMOTHERAPY IN NON-SMALL CELL LUNG CANCER (NSCLC) FROM THE 35TH ANNUAL MEETING OF THE AMERICAN SOCIETY OF CLINICAL ONCOLOGY, ATLANTA, GA; MAY 15-18, 1999 APPROACHES TO MAXIMIZE THE ROLE OF CHEMOTHERAPY IN NSCLC Postoperative Adjunct Chemotherapy in Resected Disease Neoadjuvant Chemotherapy in Resectable Disease 1052 Neoadjuvant Chemoradiotherapy in Resectable Disease 1058 Induction Chemotherapy and Concomitant Chemoradiotherapy in Unresectable Stage III Disease 1059 Concurrent Versus Sequential Chemoradiotherapy in Unresectable Disease 1060 Postoperative Chemotherapy with or without Radiotherapy in Resected Disease 1060 COMMERCIALLY AVAILABLE CHEMOTHERAPEUTICS IN CLINICAL TRIALS IN ADVANCED DISEASE 1061 Two-drug Combination/ Multimodality Therapies 1061 Platinum-based chemotherapy regimens 1061 Taxane-based combinations 1066 Other combinations 1066 Monochemotherapies 1067 Docetaxel 1067 Paclitaxel 1069 Vinorelbine 1070 Irinotecan 1070 Multidrug Regimens in Advanced Disease 1070 5 1053 Three-drug platinumcontaining regimens 1070 1053 A dose-intensive 4-drug combination 1071 LIST OF EXHIBITS TITLE Historic and Forecast Taxane Sales in the USA and Abroad PAGE XXXX Estimated Cases under Treatment with Taxol and Taxotere Worldwide (1997-1999) XXXX Competitive Strategies in the Paclitaxel Market Estimated Incidence of Lung Cancer Around the World by Gender in 1999 Estimated Mortality of Lung Cancer Around the World by Gender in 1999 XXXX 1043 TITLE PAGE Global Sales of Selected Anticancer Drugs and Related Products 1054 Select Platinum-based Drugs in Development 1057 Selected Topoisomerase I (Topo I) Inhibitors in Development 1062 Selected Thymidylate Synthase Inhibitors and Related Agents in Development 1068 Estimated Number of Smokers over 18 Years-of-Age in the USA in 1999 by Gender and Age 1076 Lung Cancer Incidence in Europe by Country and Gender in 1999 1047 Estimated Number of Smokers by Average Cigarettes Smoked per Day in the USA in 1999 by Gender and Age 1079 Lung Cancer Deaths by Gender in Europe by Country in 1999 1048 Projects Funded by the NCI Early Detection Research Network 1081 Lung Cancer Incidence and Deaths in the Triad in 1999 1053 Epidemiology of Lung Cancer in the USA by Type in 1999 1087 1044 COPYRIGHT © 2000 NEW MEDICINE INC. 949. 830. 0448. TITLE PAGE Antiestrogen Drugs in Development Adverse Cardiac Events with Herceptin Incidence and 5-year Survival Estimates of Patients with Small-Cell Lung Cancer in the USA Estimated Incidence of Small-Cell Lung Cancer in the Triad in 1999 Selected Tumor Markers Associated with Small-Cell Lung Cancer Standard treatment Options for Small-Cell Lung Cancer Estimated Small-Cell Lung Cancer Cases by Type of Treatment in the USA in 1999 Combination and Multimodality Clinical Trials in Small-cell Lung Cancer Histologic Classification of NSCLC and Estimated Incidence in the USA in 2000 1097 1102 1107 1109 1110 1115 1117 1119 1132 FUTURE ONCOLOGY VOLUME 5, NUMBER 1-12 INDEX SEPTEMBER 2000 TITLE PAGE TITLE Staging of NSCLC 1134 Biomarkers Associated with NSCLC Estimated Mortality of Bladder Cancer by Age Group in the USA in 2000 1238 1137 Potential Numbers of Chemotherapy Regimens for the Treatment of Lung Cancer 1192 1242 1151 Selected Agents in Development for the Treatment of Lung Cancer 1194 Estimated Incidence of NSCLC by Gender and Age Phase II and III Combination and Multimodality Clinical Trials in NSCLC In Vitro Tests for the Screening, Diagnosis, and Monitoring of Bladder Cancer 1251 Comparison of BTA Stat and Cytology in Bladder Cancer Monitoring 1258 Comparisons of UBC, BTA and NMP-22 Tests 1268 Incidence of Bladder Cancer by Histologic Type in the USA in 2000 1271 Estimated Bladder Cancer Mortality in Europe by Country and Gender in 2000 1235 Basis for Staging of Bladder Cancer 1273 Incidence of Bladder Cancer by Stage in the USA in 2000 1275 Estimated Incidence of Bladder Cancer by Age Group in the USA in 2000 1236 Incidence of Bladder Cancer by Grade in the USA in 2000 1277 Estimated Bladder Cancer Incidence in Europe by Country and Gender in 2000 1234 1157 Novel Chemotherapeutics Approved in the USA for the Treatment of NSCLC 1159 1169 PAGE Markers Associated with Bladder Cancer Estimated Mortality of Bladder Cancer Around the World by Region and Gender in 2000 1232 1154 Treatment Options and Prognosis by Stage TITLE Estimated Incidence of Bladder Cancer Around the World by Region and Gender in 2000 1231 Estimated Stage Distribution at Diagnosis and 1-year and 5-year Survival of NSCLC Patients by Stage in the USA in 2000 1153 First-line Treatment of NSCLC by Stage in 2000 PAGE INDEX OF COMPANIES & INSTITUTIONS 12 de Octubre Hospital 1123 Abbott Laboratories 1029, 1032, 1080, 1089, 1091, 1194, 1199, 1200, 1201 6 Abgenix 1194, 1210 Ambion 1252 AMDL 1136 American Home Products (AHP) 1031, 1055, 1097, 1194 Berlex Laboratories Auckland Hospital 1123 AVAX Technologies 1062 Betticher Institute of Medical Oncology 1123 BICO 1184 BioChem Pharma 1195 Biocontrol Technology 1184 BioInvent International 1194 Amgen 1055, 1089, 1090, 1102, 1120 Aventis 1025, 1026, 1036, 1037, 1049, 1118, 1054, 1055, 1160, 1091, 1095, 1102, 1194, 1197, 1198, 1209, 1222 AccuMed International 1078, 1079 Amgen-Kirin 1055, 1102 Aventis Pasteur 1201, 1215 Addenbrookes NHS Trust 1264 Amrad 1102 AVI BioPharma 1236 ADL (Germany) 1259 AnorMED 1057, 1194 Axcan Pharma Advanced Bioscience Lab 1081 Amos Cancer Center 1120 Ansan 1201 Anthra Pharmaceuticals 1094 Baker Norton Parmaceuticals Antigenics 1024 Banyu 1062 Antisoma 1194 Bard Diagnostic Sciences 1257 Barnes-Jewish Hospital 1083 Bar-Ilan Research and Development 1201 Academisch Ziekenhuis der Vrije Universiteit 1119 Access Pharmaceuticals 1057 Aeterna Laboratories 1194, 1207 Agouron Pharmaceuticals 1068, 1069, 1194, 1208 Akademiska Hospital Akorn Albert Einstein Cancer Center 1146 1183 1166, 1215 American Pharmaceutical Partners (APP) Auckland Cancer Research Laboratory 1063, 1193, 1202 Aphios 1046 1029 Aquila Biopharmaceuticals 1200, 1217 1194 Alza 1032, 1054, 1055, 1057, 1089, 1092, 1101, 1123, 1159, 1241 1195 biosyn 1167 Bio-Technology General 1029 Boehringer Ingelheim 1031, 1200 Boston Scientific 1185 Brandford University 1097 Arthur G. James Cancer Hospital & Richard J. Solove Research Institute 1206, 1220 AltaRex BioStratum 1259 1247 1094 1252, 1257 BioNumerik Pharmaceuticals 1062, 1068, 1195 Boston Medical Center Alkermes Almirall Prodesfarma 1251 Bion Diagnostic Sciences Battelle Pulmonary Therapeutics Aronex Pharmaceuticals 1057, 1194 1194, 1220 Biomoda Barr Laboratories 1054, 1083, 1085 1253 Allos Therapeutics 1195, 1217 1245 Alcoa 1034 1062 Biomira Boehringer Mannheim 1055, 1057, 1109 Armand-Frappier Institute 1052, 1156 1031, 1032 1165 1082 1272 Allegheny University 1184 Biomeasure 1054, 1095 Arcturus Engineering Albert Einstein College of Medicine Allegheny General Hospital 1162 Azienda Ospedaliera San Luigi Gonzaga Bethany Medical Center Asahi Chemical Industry 1142 Bayer 1194, 1206 1081, 1096, 1206, 1252 Bayer Diagnostics 1141 Baylor College of Medicine 1206, 1253, 1274 Asta Medica 1037, 1046, 1118, 1200, 1211 Beaufour Ipsen 1194, 1209 AstraZeneca 1051, 1054, 1055, 1057, 1068, 1085, 1087, 1088, 1090, 1097, 1193, 1194 Beckman Coulter 1197, 1219 Bedford Laboratories 1046, 1092 Atairgin Technologies 1081 Beijing Tumor Institute Beki Diagnostics COPYRIGHT © 2000 NEW MEDICINE INC. 949. 830. 0448. 1259 1109, 1252 Brigham and Women’s Hospital 1145, 1181, 1247 Bristol-Myers Squibb (BMS) 1025, 1026, 1027, 1028, 1029, 1030, 1032, 1036, 1037, 1038, 1046, 1047, 1051, 1054, 1057, 1093,1095, 1101, 1117, 1118, 1122, 1161,1163, 1191, 1192, 1193, 1195, 1196, 1200, 1201, 1203, 1207 FUTURE ONCOLOGY British Biotech VOLUME 5, NUMBER 1-12 INDEX 1195, 1197, 1207 British Columbia Cancer Agency 1162, 1241 British Technology Group (BTG) 1036, 1062 Brooke Army Medical Center 1033 Clatterbridge Centre for Oncology 1124 Clayton Foundation for Research 1201 Cleveland Clinic Foundation 1186, 1208, 1254, 1259 1185 ClinSites 1033 Bryn Mawr College 1200 COBE BCT 1081 BSD Medical 1184 Codon Pharmaceuticals 1270 Burnham Institute 1197 Columbia University 1246 1142 Community Hospital of Hamburg Bryan Cancer Diagnostics Cancer Research Campaign 1033, 1057, 1192, 1193, 1194, 1198, 1202, 1204, 1252, 1264 Cancer Research Center of Hawaii 1039 1199 Genelabs Biotechnology 1197 Eastern Virginia Medical School 1082, 1250 Genentech 1026, 1027, 1054, 1099, 1101, 1197, 1209, 1210 Eichrom Technologies 1242, 1252, 1261 General Biologicals Eli Lilly 1038, 1047, 1048, 1054, 1068, 1085, 1086, 1095, 1097, 1159, 1161, 1193, 1196, 1201, 1222 Ellis Fischel Cancer Center 1132 1097 Enzon 1099, 1196 1082, 1196, 1218 1257 Cornell University 1030, 1172, 1217 Coulter Pharmaceutical Cell Genesys Cross Cancer Center Cell Therapeutics (CTI) 1033, 1062, 1192, 1195, 1196 Gem Pharmaceuticals 1196, 1208 Cedars-Sinai Medical Center 1180 1195, 1221, 1222 Eastern Cooperative Oncology Group (ECOG) 1162, 1211, 1212 EntreMed C. R. Bard Cell Pathways 1197 Endorecherche Corixa 1195, 1196 1077 GelTex Pharmaceuticals 1097 1185 1022 1058 GE Medical Systems Duramed Pharmaceuticals Cordis 1101 Catholic University Galena 1185 Cangene 1195, 1211 1172 DuPont Pharmaceuticals 1097, 1113, 1114 Cook Cancer Therapeutics Canji 1122 Consultants in Blood Disorders and Cancer SEPTEMBER 2000 Cyclex 1100 1136, 1218 1035, 1057, 1201 CytImmune Sciences 1196 1031 1259 General Hospital of Bolzano (Italy) 1266 GeneSense Technologies 1197 Genetica 1081 Genetics Institute 1102 Genetix Pharmaceuticals 1197 Genetronics Biomedical 1239 Gensia Sicor 1032 Genta 1236, 1197, 1212 EnzyMed 1033 EORTC 1267 Genzyme Molecular Oncology EpiGenesis 1279 G. Gaslini Children’s Hospital 1241 Esteve 1200 Georg-August-University 1140, 1195 1113 Europe Organization for the Research and Treatment of Cancer (EORTC) 1161, 1163, 1171, 1203, 1204, 1206, 1207, 1217 Georgetown University 1034, 1199, 1216 Exiqon Gesellshaft für Biotechnologische Forschung 1038 Geron 1252, 1261 Cellcor 1023 Cytoclonal Pharmaceutics (CPI) 1029, 1196 Celltech Group 1207 Cytogen 1023 Faulding CytoGenix 1274 Feist-Weiller Cancer Center Cytoskeleton 1037 Ferrer Internacional Cytyc 1079 Ferring 1030 Glaxo Wellcome 1054, 1055, 1062, 1068, 1275 Cytovia 1195 Finnish Institute of Occupational Health 1130 Glaxo SmithKline 1163, 1196, 1197, 1198, 1218 1259 Glycosyn Pharmaceuticals 1062 1201 Centers for Disease Control and Prevention (CDC) Centre de Recherches de Biochimie Macromoleculaire Centre Hospitalier Intercommunal Centre of Molecular Immunology (CIM) Centre Pluridisciplinaire d’Oncologie 1042 1245 1029 1263 1098, 1099 Gilead Sciences 1062, 1092, 1238, 1274, 1275 Dabur India Fisher Diagnostics 1202 Daiichi Pharmaceutical 1062, 1192, 1196 Fisher Scientific 1259 Goodwin Biotechnology Daikin Industries Fletcher International 1195 Gothenburg University 1059, 1170 1196, 1219 Food and Drug Administration (FDA) 1255, 1256, 1258, 1259 Grant Laser Center 1182 Graves Gilbert Clinic 1172 Dana-Farber Cancer Institute 1069, 1195, 1196, 1210 Florida State University (FSU) 1037 Greenlane Hospital 1123 Fordham University 1024 Gregorio Marañón Hospital 1123 Dartmouth Medical 1198 Grelan Pharmaceutical 1195 David Bull Labs 1030 Foundation for Blood Research 1133 David Grant Medical Center 1120 Davis Cancer Center 1120 Dendritech 1244 Dainippon Pharmaceutical 1199 Centocor 1054 Dako 1255 Chiba University 1178 Children’s Hospital, Boston 1196, 1197 1029 Chiron 1054, 1095, 1098, 1166, 1196, 1200 ChromaVision Medical Systems 1029, 1030, 1255 1203 1123 ChiRex 1237 1251 Chugai Pharmaceutical 1046, 1055, 1095, 1098 DepoTech 1095, 1096 DiagnoCure 1251, 1253, 1255 Fox Chase Cancer Center 1205, 1209, 1215 Fred Hutchinson Cancer Research Center 1218 Free University Hospital (The Netherlands) 1162 1247 Guilford Pharmaceuticals 1033, 1054, 1094, 1095 Hadassah Medical Center (Israel) 1257 Harbor Branch Oceanographic Institution (HBOI) 1038 Harefield Hospital 1184 Harvard School of Public Health 1130 Ci-Tec 1183 Diatide 1112 Frei-Universitat Berlin CIBA Vision 1229 Dow Corning 1241 Ciphergen Biosystems 1082, 1250, 1252 Draxis Health 1032 Freie Universitat Berlin (Germany) 1256, 1266 Drug Royalty 1029, 1030 Fujirebio 1136, 1251 Harvard University Medical School 1196, 1197, 1247 Circon Duke University Medical Center 1082, 1097, 1144, 1145, 1153, 1176, 1216 Fujisawa 1046, 1196 Hauser 1196, 1198 Helsinki University Central Hospital City of Hope National Medical Center 1081 1272 Galderma Research & Development COPYRIGHT © 2000 NEW MEDICINE INC. 949. 830. 0448. 1029, 1031, 1032 1175, 1177 7 FUTURE ONCOLOGY VOLUME 5, NUMBER 1-12 INDEX HemoCleanse 1184 Herbert Irving Comprehensive Cancer Center 1166 Hoag Cancer Center 1199 Hoffmann-La Roche 1050, 1054, 1055, 1057, 1069, 1089, 1099, 1101, 1102, 1194, 1197 Hood Laboratories 1185 Hôpital Arnaud de Villeneuve 1119 1198 Karolinska Institute Indena 1036 Kay Kendall Leukaemia Fund 1198 Indiana University 1089, 1173, 1174 Inex Pharmaceuticals 1062, 1198 InNova 1029 Innovir Laboratories 1241 Inselspital 1171 INSERM 1130, 1240 1237 Kellogg Cancer Center 1144 Kent Cancer Centre 1214 Kimeragen 1273 Kinki University School of Medicine 1171 Klinge Pharma 1097, 1102, 1200, 1203 Klinge Pharmaceuticals 1097 1036 Klinikum Grosshadern (Germany) 1135, 1184 1062 Kliniken Ibbenbüren 1120 Konica 1259 Hospital Duran i Reynals 1113, 1114, 1173 Institute for Drug Development, Cancer Therapy and Research Center 1036 Hospital Großhansdorf 1122 Institute of Biostructure Hospital Gauting 1122 Institut de Genetique Moleculaire de Montpellier 1238 Hospital Arnaud de Vilanova 1179 Institut Curie Hospital de Cruces 1173 Institut Henri Beaufour Hospital del Mar 1180 Hôpital Ste-Marguerite 1121 Hospital General Universitario de Alicante (Spain) 1265 Hospital Vall d’Hebron 8 Incyte Genomics 1024, 1157 Hoechst Celanese SEPTEMBER 2000 1101 Kosan Biosiences 1038 KS Biomedix 1214 Institute of Cancer Research 1198 Kurume University School of Medicine 1178 Institute of Pathology, Berlin Kymed 1097 1183 1135 International Agency for Research on Cancer 1130, 1227 1099 IDEC Pharmaceuticals 1049, 1054, 1099, 1100 IDL Biotech IDT IGT Pharma 1146, 1251, 1265 1184 1191, 1197 Ilex Oncology 1063, 1068, 1196, 1197, 1207 Imatron 1135 ImClone Systems 1197, 1217 Immune Response 1246 Immunex 1025, 1031, 1032, 1054, 1055, 1094, 1103, 1194, 1201, 1210 Immuno-Designed Molecules (IDM) 1199 ImmunoGen Immunomedics Immunotech 1191, 1197, 1198 1197, 1219 1219 1254 MBG Technologies 1183 M. D. Anderson Cancer Center (MDACC) 1024, 1033, 1035, 1057, 1062, 1137, 1139, 1082, 1194, 1195, 1198, 1202, 1206, 1207, 1208, 1209, 1211, 1212, 1240, 1250, 1259 MDS Research Foundation 1037 Medarex 1199 1094 1168 Medical Research Council (MRC) Isis Pharmaceuticals 1198, 1213, 1233, 1236, 1246 ICN Pharmaceuticals Mayo Graduate School of Medicine 1032 1259 1197, 1219 1045, 1074, 1102, 1157, 1160, 1183, 1206, 1209, 1211 Leo Pharmaceutical Products 1233 IBC Pharmaceuticals 1195 Mayo Clinic Lemery Hybritech 1138, 1197 Maxim Pharmaceuticals ISIS Innovation Hybridon Hyseq 1198 Introgen Therapeutics 1198, 1212 1271 1089 Maxia Pharmaceuticals 1030 Humbobolt-Universitat zu Berlin 1174 1243, 1252, 1258, 1259 Matrix Pharmaceutical 1034, 1057, 1062, 1193, 1198 Lachema 1136 Hygeia Hospital Matritech Medeva Hubei Medical University Hydro Med Sciences Kyowa Hakko Kogyo 1068, 1198, 1200, 1210 Massachusetts Institute of Technology 1033, 1181, 1246, 1252, 1259 Intracel 1252 1057 Istituto Nazionale per la Ricerca sul Cancro 1213 MedImmune Oncology 1159 Leukaemia Research Fund 1198 Medisperse 1035 Lexigen Pharmaceuticals 1198 Memorial-Sloan Kettering Cancer Center 1074, 1172, 1176, 1197, 1199, 1200, 1206, 1217 1198, 1203 Lexon 1142, 1252 Istituto Nazionale per lo Studio e la Cura dei Tumori 1164 Ligand Pharmaceuticals 1091, 1092, 1097, 1098 Istituto Nazionale Tumori 1142, 1179 The Liposome Company 1037, 1055, 1093 Mentor Ivax 1029, 1031, 1032 Lithuanian Oncology Center 1167 1088 Loma Linda University Medical Center 1156, 1220 Merck KGaA 1197, 1199, 1217, 1256 Janssen Janssen Biotech 1035, 1057, 1201 Janssen Pharmaceutica Japan Tobacco 1198 1194, 1195 Johann Wolfgang Goethe Universitat 1245 Johns Hopkins University 1033, 1034, 1074, 1081, 1192, 1195, 1197 Johnson & Johnson 1054, 1055, 1185, 1211 Johnson & Johnson Research 1239 Johnson Matthey 1057, 1203 Jonsson Comprehensive Cancer Center 1210 Josai University 1269 Kagoshima University 1069 Imperial Cancer Research Fund (ICRF) 1062, 1194, 1195, 1199, 1201 Kaiser Permanente Kaplan Cancer Center Imperial Cancer Research Technology (ICRT) 1199, 1201 Karmanos Cancer Institute Karo Bio 1097 1209, 1228 Lombardi Cancer Center 1081 Louisiana Oncology Associates 1172 Menssana Research 1079 1252, 1261 Merck 1062, 1097, 1221 Metaxas Memorial Cancer Hospital 1159, 1180 MGI Pharma 1055, 1199, 1204 Michigan Molecular Institute 1244 Microvasive 1185 Louisiana State University Health Sciences Center 1263 Lucca Hospital 1173 Middlesex Hospital-Meyerstein Institute 1119 Ludwig-Maximilians University 1135 Miravant Medical Technologies 1182 LumaCare 1183 Moffitt Cancer Center 1141 Lungenklinik 1155 Montana State University 1029 Lynx Therapeutics 1233 MacroMed 1030, 1033 Mallinckrodt 1112 Magainin Pharmaceuticals 1198, 1208 Marie Lannelongue Hospital 1151 1211 Martek Biosciences 1200 1141 Massachusetts General Hospital 1181, 1246, 1259, 1275 COPYRIGHT © 2000 NEW MEDICINE INC. 949. 830. 0448. Mount Sinai Comprehensive Cancer Center 1176 Mount Sinai School of Medicine 1024, 1082 MPI Research 1068 Munich University Medical School 1184 Mylan Pharmaceutical 1029, 1032, 1085 FUTURE ONCOLOGY VOLUME 5, NUMBER 1-12 INDEX Myriad Genetics 1199 Nexagen Nanodesign 1097 Nexell Therapeutics NaPro BioTherapeutics 1029, 1030, 1031, 1032 National Cancer Center Hospital East 1157, 1174 National Cancer Center Hospital 1120 1275 1142, 1241 NeXstar Pharmaceuticals 1030, 1054, 1055, 1062, 1275 National Cancer Institute (Italy) 1240 National Cancer Institute of Canada 1125, 1207 National Center for Health Statistics (NCHS) National Hospital (Republic of South Africa) National Human Genome Research Institute (NHGRI) 1042 1177 1263 1094, 1195, 1257 Palmerston North Hospital 1123 Panum Institute 1236 Parke-Davis 1197 Nordic Drugs 1030 Peptech 1199 Northwest Biotherapeutics 1199 PerImmune 1261 1097, 1197, 1199, 1204 Pfizer 1097, 1194, 1199, 1202, 1208 Norton Healthcare 1031 Novalon Pharmaceutical 1097 Pharmachemie 1032, 1046, 1085, 1201 Norvartis 1032, 1054, 1055, 1087, 1088, 1089, 1103, 1112, 1198, 1229 Novartis Horsham Research Centre Pharmacia 1191, 1198, 1199, 1205, 1221 Pharmacia & Upjohn 1034, 1049, 1054, 1062, 1088, 1092, 1118 1279 Pharmacyclics Novartis Pharma KK 1103 PharmaGenix Novo Nordisk 1097 PharmaMar Novocastra Laboratories 1263 Phillips Petroleun 1253 Novogen 1097 Photogen Technologies 1183 Novopharm Biotech 1202 Phytogen Life Science 1029, 1030, 1032, 1034 Nycomed Amersham 1032, 1054, 1112, 1113, 1199 Robert H. Lurie Comprehensive Cancer Center 1081, 1168 Robert Wood Johnson (RWJ) Medical School 1182, 1199, 1272 1274 1063, 1199 Pierre Fabré Medicament 1086, 1089 Roche Diagnostics 1108, 1109, 1136, 1250, 1251, 1252, 1264 Rotterdam Cancer Institute Royal Brompton Hospital 1158 Royal Marsden Hospital 1214 Rüsch 1185 Rush-Presbyterian St. Luke’s Medical Center 1174 Russian Academy of Medical Sciences 1135 Rutgers University 1062 1094 Saiseikai Central Hospital 1152 1200 Nycomed Pharma 1094 Pierre Fabre Oncologie 1063 Sakai Chemical Industry Ohio State University 1220 Policlinico Hospital 1181 Samyang Genex National Institute for Occupational Safety and Health (NIOSH) 1227 Oncology St. Gallen 1123 Praecis Pharmaceuticals 1089 San Antonio Cancer Institute Oncometrics 1078 1201 Sangtec Medical National Institute of Dental and Craniofacial Research (NIDCR) Princeton University Oncor 1270 Professional Compounding Centers of America 1274 Onyx Pharmaceuticals 1199, 1212 Progen Industries 1200 Optivus Progenics Pharmaceuticals National Kyushu Cancer Center 1171, 1178 National Naval Medical Center 1133 National Research Council National Shikoku Cancer Center Hospital National Taiwan University Hospital 1197 1169 Onyvax 1200 1220 ORCA Biosciences 1082 Orebro Medical Centre Hospital Organon Teknika Orion Pharma Orphan Medical 1181 National University Hospital/Rigshospitalet (Denmark) 1179 Nebraska Medical Center 1245 Ortho Biotech, Janssen-Cilag 1200, 1217 1175 Proligo 1237 1023 Protarga 1023, 1055 1170 1030, 1033 1191 1109, 1251 Sankyo 1097 1094 Osaka Central Hospital 1252, 1257 Prolifix 1054, 1055, 1086 1222 Roy Castle International Centre for Lung Cancer Research (RCIC) 1136, 1142, 1198 Polymedco 1112 1275 Roswell Park Cancer Institute 1036, 1191 Oncogene Research Products 1081 National Institutes of Health (NIH) 1022, 1076, 1142, 1263 1269 Roberts Pharmaceutical Rockefeller University 1081, 1168 1202 National Cancer Institute (NCI) 1022, 1024, 1025, 1035, 1038, 1042, 1045, 1059, 1063, 1068, 1076, 1077, 1078, 1079, 1080, 1082, 1086, 1100, 1101, 1114, 1121, 1123, 1130, 1141, 1152, 1183, 1184, 1194, 1196, 1197, 1198, 1199, 1200, 1201, 1203, 1204, 1205, 1206, 1207, 1211, 1212, 1215, 1216, 1220, 1228, 1270 Paladin Labs Nippon Kayaku Northwestern University National Cancer Center Hospital SEPTEMBER 2000 1034, 1192, 1200 QLT Phototherapeutics 1054, 1096, 1162 1055 Sanofi-Synthelabo 1047, 1054, 1163, 1200, 1203, 1204 Santa Creu i Sant Pau 1123 Sapporo City General Hospital 1180 Sarah Cannon Cancer Center 1172, 1177, 1192 Schering AG 1054, 1090, 1100, 1167, 1275 Schering-Plough 1054, 1055, 1086, 1090, 1096, 1097, 1098, 1099, 1101, 1159, 1195, 1199, 1200, 1204, 1211 Rajavithi Hospital 1175 Rakepoll Holding 1032 Regina Elena Cancer Institute 1173 SciClone Pharmaceuticals Regina Elena Institute for Cancer Research 1239 Scotia Pharmaceuticals 1182, 1200 Scripps Institute of Oceanography 1038, 1198 1222 Osaka University Medical School 1069 OSI Pharmaceuticals 1199 Ospedale Bellaria-Maggiore 1182 Research Corporation Technologies (RCT) 1046 Netherlands Cancer Institute 1033, 1034, 1124 Ospedale S. Andrea 1178 Research Genetics 1081 Ospedale San Giovanni 1036 Scripps Research Institute 1038, 1198 Neuromedica Ospedale Santa Maria delle Croci Research Triangle Pharmaceuticals (RTP) 1035 1147 Seinajoki Central Hospital (Finland) NeoPharm 1034, 1199, 1205 NeoRx 1113 1034 New York Hospital/ Cornell Medical Center 1077 New York State University 1034 Otsuka Pharmaceutical 1063, 1068, 1069, 1199 New York University 1063 Oxford Glycosciences 1082 Newcastle General Hospital 1036 Pacific BioTechnologies 1029 Rhône-Poulenc Rorer (Aventis) 1025, 1063, 1123 Ribosepharm 1200, 1203 Ribozyme Pharmaceuticals (RPI) 1200, 1208, 1271 COPYRIGHT © 2000 NEW MEDICINE INC. 949. 830. 0448. 1257 Sequus Pharmaceuticals 1054, 1057, 1092 Serono Servier Group 1167, 1200 1200 9 FUTURE ONCOLOGY VOLUME 5, NUMBER 1-12 INDEX Shionogi 1057, 1200, 1202 Sicor 1032, 1057 Sicor de Mexico 1032 Transgene Triangle Pharmaceuticals Truman VA Hospital 1198 Siemens Medical Systems 1184 Ultrafine Chemicals Signal Pharmaceuticals 1097 Unimed Pharmaceuticals Tularik Southern Arizona VA HealthCare System 1205 Southern Research Institute 1196, 1199, 1200 Southwest Oncology Group (SWOG) 1163 Sparta Pharmaceuticals 1035, 1069, 1098 Spectral Imaging 1081 SR Pharma 1200 SRI International 1063 St. Luke’s Medical Center 1023 Stanford University 1213 Stehlin Foundation for Cancer Research 1049, 1063, 1201 STS Particles 1035 Sugen 1200, 1209 Sumitomo 1201 Sun Hill Glucose 1030 SUNY 1036 University of Copenhagen 1236, 1237 University Medical School of Pecs 1202 University of Delaware Uppsala University 1146 1132 University of Florida UroCor 1252 1039, 1192, 1201 1097 Unita Operativa di Oncologia Medica Unitech 1170 1058 Universita Cattolica del Sacro Cuore Universita degli Studi Université de Montreal University College London University Hospital, Groningen 1123, 1197 University of Gatzemeier 1122 University of Iowa 1033 University of London, School of Pharmacy 1057 University of Louisville School of Medicine University of Mainz 1178 1146, 1153 1272 1118, 1200 1124, 1177 University Hospital Nijmegen (The Netherlands) 1251 University Medical Center Nijmegen (The Netherlands) 1255, 1256 University Hospital, Rotterdam 1273 University of Kentucky 1063, 1201 1035, 1055 1095, 1096 SmithKline Beecham 1049, 1055, 1093, 1097, 1100, 1118, 1122, 1124, 1165 1247 1195, 1201 Sidney Kimmel Cancer Center SkyPharma 10 Tokushima Bunri University SEPTEMBER 2000 1222 1144 U.S. Bioscience 1046, 1055, 1101, 1121 Uath State University 1039 VA Northern CA Health Care System 1120, 1210 Valentis 1202 1182 ValiGen 1273 1166 Vanderbilt Cancer Center 1052 University of Maryland 1081, 1142, 1238 Vanderbilt University 1053, 1174, 1209, 1220 University of Massachusetts 1272, 1278 Veterans Affairs Hospital, Durham 1153, 1176 University of Medicine and Dentistry of New Jersey (UMDNJ) Veterans’ General Hospital-Taipei 1177 1269 ViaCirQ 1184 University of Miami School of Medicine 1266 Vincent T. Lombardi Cancer Research Center 1215 University of Michigan 1033, 1081, 1244, 1275 Vion 1202 Virgen del Rocío Hospital 1123 University of Milan 1147 University of Minnesota School of Medicine Virgen de la Victoria Hospital 1123 1147 Virginia Tech 1036 University of Missouri 1132 Virogenetics 1215 1193 Viventia Biotech 1202 University Hospital, Yugoslavia 1169 University of Montreal University Hospitals, Münster and Greifswald 1120 University of North Carolina VivoRx 1245, 1246 1037 Vysis 1252, 1263 University of Alabama at Birmingham 1233, 1277 University of Ottawa 1207 Wadley Institutes University of Padua 1115 Walther Cancer Institute SuperGen 1032, 1035, 1049, 1057, 1063, 1069, 1098, 1193, 1201, 1206 University of Alberta University of Pennsylvania 1039, 1058, 1183 Warner-Lambert Supratek Pharma University of Basel (Switzerland) University of Pennsylvania Health System’s Institute for Human Gene Therapy Wayne State University 1180 Weill Medical College 1217 University of Pittsburgh 1023, 1063, 1082, 1121, 1130, 1162, 1196, 1242, 1252, 1260 West Virginia University 1238 University of South Florida 1245 Syren Pharmaceuticals 1057 Taiho Pharmaceutical 1063, 1069, 1097, 1192, 1193, 1195, 1200, 1201 Takara Shuzo 1214, 1218 University of Arizona Cancer Center 1241 1205, 1208 1263 University of Bern 1247 University of Berne 1123 University of British Columbia 1197, 1241 Takeda Chemical Industries 1055, 1091, 1191, 1197, 1198 University of California 1194, 1199, 1200, 1202, 1264 Tampere University Hospital University of California Davis Cancer Center 1210 Tanabe Seiyaku 1151, 1257 1195 TAP Holdings 1055, 1091 Taxolog 1037 Temple University Cancer Center 1205 Teva 1032 Therakos 1096 Therion Biologics 1201, 1215, 1216 Thomas Jefferson University 1082, 1272, 1273 Tiefenau Hospital 1171 Titan Pharmaceuticals 1201 University of California San Diego Cancer Center 1197, 1198 University of California, Santa Barbara 1236 University of California, Los Angeles (UCLA) 1113, 1209 University of Cambridge 1264 University of Chicago Cancer Research Center 1165, 1192, 1203, 1212 University of Cincinnati 1159 University of Colorado 1081, 1200, 1209, 1270, 1275 1246 1081 1196 1173 1068, 1069, 1097 Washington State University 1029 Weston Park Hospital 1120 Whitehead Institute 1195 William Beaumont Hospital 1146 University of Texas 1033, 1035, 1194, 1195, 1196, 1198, 1199, 1202, 1240 Xechem International 1030, 1035, 1037 University of Texas at Austin Xillix Technologies 1080 Yale Cancer Center 1160 University of Texas Medical Branch 1272 1184 University of Texas Southwestern Medical Center 1082 Xenova Group 1063, 1193, 1202 Yale University 1081, 1133, 1202, 1264, 1270, 1275 Yew Tree Pharmaceuticals 1032 York Medical 1202 Zambon Group 1196 Zarix 1069 Zelenka Nursery 1029 Zeneca Diagnostics 1081 University of Wisconsin Comprehensive Cancer Center 1162, 1208 Zeneca Pharmaceuticals 1090 University of York Zenyaku Kogyo University of Tsukuba University of Vienna 1271 1176, 1255 University of Virginia Health Sciences Center 1268 University of Washington 1082, 1196, 1218 COPYRIGHT © 2000 NEW MEDICINE INC. 949. 830. 0448. 1097 Zentralkrankenhauses SanktJurgen-Strasse (Germany) 1167 1099 FUTURE ONCOLOGY VOLUME 5, NUMBER 1-12 INDEX SEPTEMBER 2000 NEW MEDICINE’S ONCOLOGY KNOWLEDGEBASE ( ) IS NOW ON THE WORLD WIDE WEB NEW MEDICINE’s Oncology KnowledgeBASE ( ) is an invaluable internet resource for anyone involved with drug development in the oncology field. 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