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Chromosome Structural Elements/Rome 2005
EMBO WORKSHOP 2005
CHROMOSOME STRUCTURAL ELEMENTS: FROM DNA SEQUENCE TO FUNCTION
Villa Mondragone, Monte Porzio Catone, Rome, Italy
September 29-October 3, 2005
Organizer:
Fiorentina Ascenzioni, Dipartimento di Biologia Cellulare e dello Sviluppo, University of Rome
“La Sapienza”, via dei Sardi 70, 00185 Rome, Italy
Co-organizers:
- Silvia Bacchetti, Istituto Regina Elena, via delle Messi d’Oro, 156, 00158 Rome, Italy
- Giuseppe Novelli, Dipartimento di Biopatologia e Diagnostica, University of Rome Tor
Vergata, via Montepellier 1, 00133 Rome, Italy
- Maria Savino, Dipartimento di Genetica e Biologia Molecolare, University of Rome “La
Sapienza”, P.le Aldo Moro 5, 00185 Rome, Italy
Person to whom enquiries may be addressed: Fiorentina Ascenzioni,
e-mail: [email protected]
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Chromosome Structural Elements/Rome 2005
Workshop Programme
Talks (T) 25 min + 5 min discussion; Short Talks (ST): 12 min + 3 min discussion, P, Posters
29/09/2005 Thursday
4-6 pm:
6 pm:
6:15-7:15 pm:
cancer.
Registration, hanging of posters
Welcoming remarks: Silvia Bacchetti/Fiorentina Ascenzioni
Lecture: Lucio Luzzatto (IT), Chromosomal and molecular basis of
Cocktails
30/09/2005 Friday
9.00-10.30am Session 1: Telomeres: structure, proteins and positioning
Chair: P. Donini (IT)
9:00 T1- Patrick Kaminker (USA), Dual function for a telomere-associated protein?
9:30 T2- Daniela Rhodes (UK), Towards the structure of the “30 nm” chromatin fiber.
10:00 ST1- Heico Schoiber (CH), Telomerase Helps Tether Telomeric Chromatin to the
Nuclear Periphery via Interaction with yKu
10.30-11.00am Coffee break
11 am -12.30pm
11:00 T3- Stefano Cacchione (IT), The role of DNA sequence in telomeric chromatin features
11:30 T4- Hans Lipps (DE), Telomere end-binding proteins control the formation of Gquadruplex DNA structures in vivo.
12:00 ST2- K. Lemke (Poland). Interaction of antitumor triazoloacridone C-1305 with guaninerich DNA: induction of structural changes in guanine triplets and stabilization of G-quadruplexes
12:15 ST3- H. Renauld (USA), Interstitial (sub)telomeric repeats: Punctuation marks of genome
dynamics?
12.30-2pm Lunch
2-4.30pm Session 2: Telomere replication and telomere length regulation
Chair: Virginia Zakian (USA)
2:00 T5- Virginia Zakian (USA), Pif1p family helicases: effects on telomerase.
2:30 T6- Eric Gilson (FR), New pathways of telomere length regulation in yeast.
3:00 T7- Arturo Londoňo-Vallejo (FR), Telomere homeostasis in humans: length control at
cell and single telomere levels.
3:30 ST4- S. Bekaert (Belgium), Reference values and basic determinants of telomere length
in a large middle-aged population.
3:45 ST5- D. Baird (UK), Telomere dynamics and instability.
4:00 ST6- M.A. Cerone (Canada) A human cell line that maintains telomeres in the absence of
telomerase and of key markers of ALT.
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Chromosome Structural Elements/Rome 2005
4.15 ST7- C.M. Counter (USA) Loss of hPot1 function leads to telomere instability and a cutlike phenotype.
4.30-5.00pm Coffee break
5:00-7:15pm Session 3: Chromosome replication and disjunction
Chair: Hans Lipps (DE)
5:00 T8- Michelle Debatisse (FR), Dynamics of DNA replication in mammalian somatic cells
5:30 T9- Silvano Riva (IT), Functional analysis of a human DNA replicator.
6:00 T10- Susan Smith (USA), Telomeres require special mechanisms for their compaction
and resolution at mitosis.
6:30 ST8- Peter Meister (CH), Spatial and temporal separation of replication and
recombination requires the intra-S checkpoint
6:45 ST9- M. Cornfort (USA), Excess of Radiation-Induced Dicentrics Involving Homologous
Chromosomes.
7:00 ST10- B. Meier (USA), The C. elegans catalytic subunit of telomerase TRT-1 and DNA
damage signaling.
7.15 ST11- S. Bailey (USA), Telomeres and Double-Strand Breaks: Tying up Loose Ends.
01/10/2005 Saturday
9.00-10.30am Session 4: Centromeres, DNA sequences and chromatin plasticity
Chair: Brenda Grimes (USA)
9:00 T11- Beth A. Sullivan (USA), Centromeric Chromatin is a Continuous, Dynamic
Domain that Permits Gene Expression
9:30 T12- Christine Farr (UK), Topoisomerase II: untangling its contribution at centromere
10:00 T13- Giuliano Della Valle (IT), Dissecting Cenp-C function in mammalian centromeres
10.30-11am Coffee break
11.00am -12.15pm Session 4 continued
11:00 T14- W.C. Earnshaw (UK), Genetic analysis of chromosome segregation in vertebrate
cells.
11:30 ST12- C. Desmaze (FR), Chromatin structure and dynamics in the formation of
chromosome aberrations.
11:45 ST13- C. Woo (USA), Long-range Nucleosome Mapping of the HOX Gene Cluster.
12:00 ST14- J. Fajkus (CZ), Minisatellite telomeres in the family Alliacae are lost with
divergence of the genus allium.
12.30 –3.30 pm Poster session with Lunch
3.30pm
6pm
7:30pm
Departure for Rome by turist coach
Guided visit to part of the Musei Capitolini and the Campidoglio (City Hall
of Rome)
Cocktails and dinner on the adjoining Terrazza Caffarelli
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Chromosome Structural Elements/Rome 2005
02/10/05 Sunday
9-10:30am Session 5: De novo centromeres assembly and Chromosome Engineering
Chair: W.C. Earnshaw (UK)
9:00 T15- Brenda Grimes (USA), Segregation of human artificial chromosomes in mouse
cells.
9:30 T16- T. Voet, (Belgium), Optimisation and exploitation of a chromosomal vector
10:00 ST15- N. Mestrovic (Croatia), The MEL-172 satellite DNA library in parthenogenetic
meloidogyne species: conserved pattern of nucleotide variability along the monomers
11.30-11.00am Coffee break
11.00am -12.30pm Session 5 continued
Chair: Christine Farr (UK)
11:30 T17- H. Masumoto (JPN), Chromatin assemblies required for de novo human artificial
chromosome formation.
12:00 T18- Fiorentina Ascenzioni (IT), Human minichromosomes: expression vectors for
human genes.
12.30-3pm Poster session with Lunch
3.00-4.00pm Lecture: Giorgio Bernardi (IT), Chromatin structure in interphase nuclei of
vertebrates and the formation GC-rich isochores.
4:00-4.30pm Coffee break
4.30-6:00pm session 6: Chromosomes organization and gene evolution
Chair: Giuseppe Novelli (IT)
4:30 T19- M. Cremer (DE), Nuclear architecture in the light of conserved higher order
chromatin arrangements.
5:00 T20- Mariano Rocchi (IT), Centromere repositioning in evolution.
5:30 T21- Novelli Giuseppe (IT), The role of the nuclear envelope in genome organisation.
Closing remarks: Silvia Bacchetti and Giuseppe Novelli
2/10-2005 or 3/10/05 Departure
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Chromosome Structural Elements/Rome 2005
Posters*
P1 - C. Auriche (IT), Chronic Chromosome Instability in Humanized Yeast
P2 - C. Azzalin (CH), The human RNA surveillance factors UPF1 and EST1A/SMG6 are
essential
for S-phase progression and DNA repair.
P3 - M. Babar (Pakistan), Identification of bacterial blight resistance genes Xa4 in Pakistani rice
germplasm using PCR based markers.
P4 - S. Carrabino (IT), Polyethylenamine/albumin complexes display high transfection
efficiency in confluent and polarized human respiratory epithelial cells.
P5 - I. Draskovic (FR), Molecular mechanisms of alternative lengthening of telomeres (ALT) in
human cancers.
P6 – A. Farsetti (IT), Primary cultures of prostate luminal cells as a model for an integrated
approach to prostate cancer: isolation, characterization and gene profiling.
P7 - M. Gezahagne (Ethiopia), Species distinctiveness between Trifolium quartinianum and
Trifolium steudneri.
P8- C. Keil (DE), Functional interactions of poly(ADP-Ribose)glycohydrolase with PARP-1 and
XRCC1
P9-– C. Lan (Taiwan), Significance of Topoisomerase 2a in association with Her2/neu in breast
cancer management.
P10- S-C. Liang (Taiwan), Chromosomal aberrations in malignant pleural effusion from lung
adenocarcinoma: varying cytogenetic abnormalities detected in relationship to gender and
smoking.
P11 - L-C. Lin (Taiwan), EGFR gene sequence in breast cancer patients in Taiwan.
P12 – C. Mondello (IT), Cellular transformation of telomerase immortalized human fibroblasts.
P13 – B. Mravinac (Croatia), What a difference “junk” DNAs make…..
P14 – V. Petrovic (Croatia), Intricate patterns of sequence divergence and conservation in an
organizationally complex Donax trunculus satellite DNA family.
P15 – G. Piaggio (IT), NF-Y dependent chromatin remodelling in proliferation and
differentiation.
P16 – S. Redon (FR), Protein-protein and protein-RNA interactions mediate the association of
human EST1a with telomerase.
P17 – E. Sykorova (CZ), Plant telomerases synthesizing human type of telomeres.
* Poster will be displayed for the duration of the meeting. Each poster has been assigned a
number according to the list above. Presenting authors are requested to stand alongside their
poster during the poster sessions.
Maximum size of the poster: 1.20cm high x 1.50 width cm
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Chromosome Structural Elements/Rome 2005
Travelling to Villa Mondragone
From Leonardo da Vinci-Fiumicino Airport
1. Take the Express Train (Leonardo Express) to Rome Termini Station (about E8). The
train leaves every 30 min (7 and 37 min after the hour) and takes about 30 min to reach
the Termini Station.
2. Take the local train to Frascati. Tickets for this train can be bought at the Airport Station.
The train for Frascati leaves every hour beginning at 5:46am. Following trains are at:
6:32am / 7:33am / 8:35am and then 52 min after the hour till 21:52pm.
3. At the Frascati Station take a taxi to Villa Mondragone or Hotel Villa Vecchia.
Notification of where you will be staying will be posted on the site at a later time.
4. Alternatively, take a taxi from the airport to Villa Mondragone or Villa vecchia (about
E60).
Please make sure to discuss the fare at departure.
From Ciampino Airport
1. Take the shuttle bus (leaving every 20 min till 23:30pm) or a taxi to Ciampino Train
Station. From there take the train to Frascati which leaves at: 4:49am / 6:02am / 6:50am/
7:47am / 8.53am / 10:08am and then at 8 min after the hour till 22:08pm.
2. From Frascati Station take a taxi to Villa Mondragone or Hotel Villa Vecchia.
Notification of where you will be staying will be posted on the site at a later time.
3. Alternatively take a taxi from Ciampino Airport to Villa Mondragone or Villa vecchia
(about E25). Please make sure to discuss the fare at departure.
Local Taxi companies
Taxi Frascati: 06/9422500
Alfredo Iacoangeli: Via G. Saragat, 2 00045 Genzano (RM) 328/3911794 06/9397592
Andrea Amore: 338/8888550, 328/3332022, 340/7240146
Migliori Gianni: 349/5860561
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Chromosome Structural Elements/Rome 2005
Venue
Villa Mondragone
Via Frascati 51, 0040 Monteporzio Catone, Rome
Tel +39 06 9420018
www.villamondragone.it
[email protected]
Accomodation
Hotel Villa Vecchia,
via Frascati 49, 0040 Monteporzio Catone, Rome
tel +39 06 94340096, fax, +39 069420568
www.villavecchia.it
[email protected]
Scientific Session
All lectures will be held in Sala degli Svizzeri
Poster will be displayed in Sala Riunioni
Meals and Refreshments
Coffee breaks and lunches will be served in Villa Mondragone
Sponsors:
Università degli Studi di Roma “La Sapienza”
Università degli Studi di Roma Tor Vergata
Istituto Pasteur-Fondazione Cenci Bolognetti
Ministero dell’Istruzione, dell’Università e della Ricerca
Applied Biosystems
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