Download C oleus F orskohlii C itrus A urantium C affè V erde P iper

• CONTROLLO DEL PESO*
• Astell KJ, Mathai ML, Su XQ.
A review on botanical species and
chemical compounds with appetite
suppressing properties for body
weightcontrol. Plant Foods Hum Nutr.
2013 Sep;68(3):213-21.
• Shivaprasad HN, et al.
Effect of Coleus forskohlii extract on
cafeteria diet-induced obesity in rats.
Pharmacognosy Res. 2014 ;6(1):42-50.
• Godard MP, Johnson BA, Richmond SR
Body composition and hormonal
adaptations associated with forskolin
consumption in overweight and obese
men. Obes Res 2005; 13(8):1335–1343.
• Badmaev V, Majeed M, Conte A, Parker
JE. Diterpene forskolin: a possible new
compound for reduction of body
weight by increasing lean body mass.
Townsend Lett 2001;June:115.
• Henderson S, et al.
Effects of coleus forskohlii
supplementation on body composition
and hematological profiles in mildly
overweight women. J Int Soc Sports
Nutr. 2005 Dec 9;2:54-62.
.
•AZIONE TERMOGENICA*
• Preuss HG, DiFerdinando D, Bagchi M,
Bagchi D. Citrus aurantium as a
thermogenic, weight-reduction
replacement for ephedra: an overview.
J Med. 2002;33(1-4):247-64.
• Zheng X, Guo L, Wang D, Deng X.
p-Synephrine: a novel agonist for
neuromedin U2 receptor. Biol Pharm
Bull. 2014;37(5):764-70.
• Stohs SJ, Preuss HG, Shara M. A
review of the human clinical studies
involving Citrus aurantium (bitter
orange) extract and its primary
protoalkaloid p-synephrine. Int J Med
Sci. 2012; 9 (7);527-38.
• Peixoto JS, et al. Effects of Citrus
aurantium (bitter orange) fruit extracts
and p-synephrine on metabolic fluxes
in the rat liver. Molecules.2012 May
16;17(5):5854-69.
•PERDITA DEL PESO*
• Fugh-Berman A, Myers A.
Citrus aurantium, an ingredient of
dietary supplements marketed for
weight loss: current status of clinical
and basic research. A Exp Biol Med
(Maywood). 2004 Sep;229(8):698-704.
• Stohs SJ, Preuss HG, Shara M.
The safety of Citrus aurantium (bitter
orange) and its primary protoalkaloid
p-synephrine. Phytother Res. 2011
Oct;25(10):1421-8.
• Kaats GR, Miller H, Preuss HG, Stohs SJ.
A 60day double-blind, placebocontrolled safety study involving
Citrus aurantium (bitter orange)
extract. Food Chem Toxicol. 2013
May;55:358-62..
•CONTROLLO DEL PESO*
• Onakpoya I, Terry R, Ernst E
The use of green coffee extract as a
weight loss supplement: a
systematic review and meta-analysis
of randomised clinical trials.
Gastroenterol Res Pract. 2011;2011.
pii: 382852.
• Shimoda H, Seki E, Aitani M. Inhibitory
effect of green coffee bean extract
on fat accumulation and body weight
gain in mice. BMC Complementary
and Alternative Medicine. 2006;6:9.
•AUMENTO DEL
METABOLISMO*
• Ruan Z, et al.
Metabolomic
analysis of amino acid and
energy metabolism in rats
supplemented with chlorogenic acid.
Amino Acids. 2014 Sep;46(9):2219-29.
• Cho A-S, Jeon S-M, Kim M-J, et al.
Chlorogenic acid exhibits antiobesity property and improves lipid
metabolism in high-fat diet-inducedobese mice. Food and Chemical
Toxicology. 2010;48(3):937–943.
• Zheng G, Qiu Y, Zhang QF, Li D.
Chlorogenic acid and caffeine in
combination inhibit fat accumulation
by regulating hepatic lipid
metabolism-related enzymes in mice.
Br J Nutr. 2014 Sep 28;112(6):1034-40.
•ANTIOSSIDANTE*
• Yun N, Kang JW, Lee SM. Protective
effects of chlorogenic acid against
ischemia/reperfusion injury in rat
liver: molecular evidence of its
antioxidant and anti-inflammatory
properties. J Nutr Biochem. 2012
Oct;23(10):1249-55.
Piper Nigrum
• Litosch I, Hudson TH, Mills I, Li SY.
Forskolin as an activator of cyclic
AMP accumulation and lipolysis in rat
adipocytes. Mol Pharmacol 1982;
22(1):109-115
• Okuda H, Morimoto C, Tsujita T.
Relationship between cyclic AMP
production and lipolysis induced by
forskolin in rat fat cells. J Lipid Res
1992;33:225-231.
Caffè Verde
•AZIONE LIPOLITICA*
Citrus Aurantium
Coleus Forskohlii
Line duo è un integratore alimentare in una nuova e più attiva formulazione ottenuta grazie all'azione combinata dei suoi ingredienti che favoriscono, in presenza di un
regime alimentare ipocalorico, un'efficace riduzione del peso corporeo. Il controllo ponderale si ha grazie al marcato effetto termogenico del Citrus Aurantium, che unito al
Coleus Forskohlii, importante per il suo effetto lipolitico, favorisce il controllo del senso di fame. L’attività sul metabolismo di entrambi, è ulteriormente rafforzata dalla
presenza del Caffè verde e del Piper nigrum utile a migliorare l'assorbimento dei vari componenti. Grazie ai suoi quattro ingredienti, Line duo, favorisce il rapido recupero
della linea in modo concreto e naturale.
•ANTINFIAMMATORIO e
ANTIOSSIDANTE*
• Bae GS, et al. Inhibition of
lipopolysaccharide-induced
inflammatory responses by piperine.
Eur J Pharmacol. 2010 Sep 10;642(13):154-62
• Agbor GA, et al. Piper species protect
cardiac, hepatic and renal
antioxidant status of atherogenic
diet fed hamsters.Food Chem. 2012
Oct 1;134(3):1354-9.
• Tasleem F , et al. Analgesic and antiinflammatory activities of Piper
nigrum L. Asian Pac J Trop Med. 2014
Sep;7S1:S461-8.
•ANTIDEPRESSIVO*
• Mao QQ, Xian YF, Ip SP, Che CT.
Involvement of serotonergic system
in the antidepressant-like effect of
piperine. Prog Neuropsychopharmacol
Biol Psychiatry. 2011 Jun 1;35(4):11447.
•ALTRE PROPRIETA'*
• BrahmaNaidu P, et al. Mitigating
efficacy of piperine in the
physiological derangements of high
fat diet induced obesity in Sprague
Dawley rats. Chem Biol Interact. 2014
Sep 25;221:42-51.
• Choi S, Choi Y, Choi Y, Kim S, Jang
J, Park T.Piperine reverses high fat
diet-induced hepatic steatosis and
insulin resistance in mice. Food
Chem. 2013 Dec 15;141(4):3627-35.
• Butt MS, et al. Black pepper and
health claims: a comprehensive
treatise.Crit Rev Food Sci Nutr.
Nutr 2013;53(9):875-86.