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Transcript
®
Plant
Sterols
ActiFolate™
PharmaSoy
®
UltraMeal Plus
with Beta-Sitosterol and Other Plant Sterols
Nutritional Support for Healthy Cholesterol Levels
The National Cholesterol Education Program of the
National Institutes of Health (NIH) recommends the consumption
of 2 grams of plant sterols daily to promote healthy cholesterol
levels. And the American Heart Association recognizes the
possible cholesterol-lowering effects of soy protein and adds it to
the limited number of foods it recommends individuals eat daily
to reduce heart disease risk. UltraMeal Plus provides both plant
sterols and soy protein—along with body-ready folates for
UltraMeal®
Plus
healthy homocysteine metabolism—in a delicious, heart-healthy
meal replacement beverage.
Patient Benefits:
• Specifically formulated to provide:
Healthy
Heart
Support
❤
15 grams of soy protein per serving from PharmaSoy®
❤
2 grams of plant sterols per serving—including 1 gram of
beta-sitosterol per serving
❤
4-5 grams of fiber per serving (varies by flavor)
❤
ActiFolate™—a proprietary blend of body-ready
folates including L-5-methyl tetrahydrofolate
❤
A low-glycemic-index meal option of only 160 calories
❤
A full complement of vitamins and minerals, including
dairy-free calcium and chromium
• Available in 2 delicious, dairy-free flavors for a convenient and
healthy meal
• Comes with easy-to-follow program instructions and dietary
recommendations
A scientifically based formula with a unique combination of natural
ingredients for comprehensive cardiovascular health support.
The superior nutrition of UltraMeal combined with plant sterols—
including beta-sitosterol—for maintaining healthy cholesterol levels.
Scientifically Formulated for a Natural Approach
Beta-sitosterol is the most prevalent plant sterol (of over 40),
It is estimated that over 102 million American adults have
accounting for approximately 50% of dietary plant sterols
blood cholesterol levels above a desirable range, and over
from fruit and vegetable sources. Since over half of American
22 million have elevated cardiovascular health concerns—
adults do not meet the minimum recommended consumption
both of which are scientifically linked to unhealthy body
of five servings of fruits and vegetables per day, adding
composition (excess body fat).
plant sterols with UltraMeal Plus may be an appropriate
recommendation for those patients wishing to promote
26-Year Incidence of Coronary Heart Disease
<50 years
cardiovascular health.
50+ years
Incidence of CHD per 1,000
800
PharmaSoy®—Even More Support for CV Health
700
600
PharmaSoy is a technologically advanced blend that includes
440
superior soy protein and isoflavones. Just two servings of
500
366
UltraMeal Plus provide 30 grams of high quality soy
400
333
292
300
268
200
100
223
177
M <25
W <25
179
119
76
0
include 25 grams of soy protein a day may reduce the risk
350
255
protein. Diets low in saturated fat and cholesterol that
of heart disease. Soy protein has also been shown to
have cholesterol-lowering effects.
M 25-29 W 25-29
M 30+
W 30+
BMI Levels
Adapted from Hubert HB et al. Circulation 1983;67:968-77.
ActiFolate™—CV Support in a Body-Ready Form
UltraMeal Plus provides a proprietary blend of body-ready
UltraMeal Plus is a research-based meal replacement
folates—ActiFolate—to promote healthy methylation and
featuring the great taste, convenience, and nutrition of the
homocysteine levels.2-4 Homocysteine levels within a
family of UltraMeal formulas that promote healthy body
normal range support healthy cholesterol metabolism
composition—combined with the NIH-recommended
and overall cardiovascular health.5-8
nutrition of plant sterols—to promote healthy cholesterol.
Dietary Fiber—For CV Health and More
Plant Sterols—A “Plus” for CV Health
Two servings of UltraMeal Plus provide almost half the
Plant sterols (which include beta-sitosterol) have been
minimum daily fiber recommendation to support not only
recommended by the NIH to promote cardiovascular health
cardiovascular health but also gastrointestinal health,
in combination with healthy lifestyle changes, such as a
insulin management, and a healthy body composition.9-12
diet low in saturated fat and cholesterol, regular exercise,
and maintaining a healthy body composition (lean muscle1
Excellent Source of Calcium
to-fat ratio). Foods containing at least 0.65 grams per
UltraMeal Plus also provides 600 mg of dairy-free calcium
serving of plant sterol esters, eaten twice a day with
(60% RDI) from PharmaSoy. Calcium, along with regular
meals for a daily total intake of at least 1.3 grams, as part
exercise and a healthy diet, can play a significant role in
of a diet low in saturated fat and cholesterol, may reduce
reducing the rate of bone loss or bone thinning and in
the risk of heart disease. A serving of UltraMeal Plus
protecting bone strength.
supplies 2 grams of plant sterols.
A Healthy Lifestyle Approach
Other Features of UltraMeal Plus
Cardiovascular health can be impacted by hereditary
influences, excess body fat, or a diet high in saturated
Low Glycemic Index
fat and cholesterol or low in fiber. The NIH recommends
UltraMeal Plus has a low glycemic index, making it an
healthy lifestyle changes to reduce the risk of coronary
appropriate source of nutrition for patients with blood sugar
heart disease and help lower LDL cholesterol levels. A
concerns. UltraMeal Plus is sweetened naturally with fructose—
healthy diet and regular exercise program are an integral
which is found in fruits and is the preferred sugar source to
part of the UltraMeal Body Composition Program.
promote healthy blood sugar management.13
1
UltraMeal Plus may also be used as a complement to
a lifestyle changes program to promote cardiovascular
Taste and Variety
Available in delicious Natural Vanilla and Natural Dutch
Chocolate—the most popular flavors in the UltraMeal line.
and overall health.
Convenience
Compliance is Key
Mixes easily with water and travels well to make a healthy meal
Achieving and maintaining optimal clinical outcomes
anywhere—at home, at work, or on the go.
requires patient compliance—which is why UltraMeal Plus
was developed in the tradition of UltraMeal products to
Value
meet the taste and busy lifestyle demands of your patients.
For a little more than $2.50 per serving at the suggested retail
price, UltraMeal Plus is an inexpensive, high quality meal
option for your patients.
LDL Cholesterol Goals and Lifestyle Change
Recommendations for Different Risk Categories1
Risk Category
LDL Goal
LDL Level at which to
Initiate Lifestyle Changes
Coronary Heart Disease
or High CHD Risk
<100 mg/dL
≥100 mg/dL
Moderate Risk
<130 mg/dL
≥130 mg/dL
Low Risk
<160 mg/dL
≥160 mg/dL
Quality and Purity You Can Trust
UltraMeal Plus is researched, developed, and manufactured
by Metagenics, Inc. and features only natural ingredients and
non-genetically engineered, identity-preserved soy protein.
To complement restricted diets, UltraMeal Plus is free of
gluten, wheat, yeast, egg, dairy, as well as artificial colors,
Major risk factors for CHD include cigarette smoking, hypertension, low HDL
cholesterol, family history of premature CHD, and age (M 45+, W 55+).
Healthcare practitioners worldwide have recommended
the UltraMeal Program and UltraMeal products for their
patients—who continually remark on the delicious taste,
convenience, and the enhanced energy and well-being
they experience while promoting their health with the
sweeteners, and flavors.
UltraMeal is manufactured according stringent standards
with the health of your patients in mind. In addition, the
Functional Medicine Research Center—the research arm of
Metagenics—has conducted on-site human clinical trials
with UltraMeal Plus.
UltraMeal Program.
For over 13 years the UltraMeal family of products has
been in clinical use worldwide. UltraMeal Plus represents
the latest innovation in promoting patient health with
lifestyle-friendly nutrition.
®
UltraMeal Plus
with Beta-Sitosterol and other plant sterols
to promote healthy cholesterol levels
UltraMeal Plus
®
with Beta-Sitosterol
and other plant sterols to promote healthy cholesterol levels
Nutrient Profile of UltraMeal Plus:
References:
Caloric Distribution
Percent of Total Energy
Protein . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38% of calories
Carbohydrate . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51% of calories
Fat . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11% of calories
1. Third Report on the National Cholesterol Education Program
(NCEP) Expert Panel on Detection, Evaluation and Treatment
of High Blood Cholesterol in Adults (Adult Treatment Panel
III). National Heart, Lung and Blood Institute of the NIH.2002.
Nutritional Information per Serving (all flavors)
Serving size . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 scoops (50 g)
Servings per container . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14
Calories . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 160
Fat . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 g
Cholesterol* . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0 mg
Sodium† . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170-180 mg
Potassium† . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 510-660 mg
Total Carbohydrate. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24 g
Simple. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 g
Complex . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 g
Dietary Fiber† . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4-5 g
Protein. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 g
Soy Isoflavones . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 mg
Each Serving Contains:
Vitamin A (as retinyl palmitate) . . . . . . . . . . . . . . . . . . 1,750
Vitamin D (as cholecalciferol) . . . . . . . . . . . . . . . . . . . . . . 200
Vitamin C (as ascorbic acid) . . . . . . . . . . . . . . . . . . . . . . . . . 60
Vitamin E (as d-alpha tocopheryl acetate). . . . . . . . . . 11
Thiamin (as thiamin hydrochloride) . . . . . . . . . . . . . . . . 750
Riboflavin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 850
Niacin (as niacinamide) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10
Pantothenic Acid (as D-calcium pantothenate) . . . . . . . 5
Vitamin B6 (as pyridoxine hydrochloride) . . . . . . . . . . . . 25
Vitamin B12 (as methylcobalamin & cyanocobalamin) . 30
Biotin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 150
Folate†† (as folic acid, L-5-methyl. . . . . . . . . . . . . . . . . . . 500
tetrahydrofolate†††, and 5-formyl tetrahydrofolate)
Vitamin K . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 40
Calcium (as calcium phosphate) . . . . . . . . . . . . . . . . . . . 600
Iron (as ferrous fumarate) . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
Phosphorus . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 460
Iodine (as potassium iodide) . . . . . . . . . . . . . . . . . . . . . . . . 75
Magnesium (as magnesium citrate)† . . . . . . . . . . 180-190
Zinc (as zinc citrate) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9
Copper (as copper gluconate) . . . . . . . . . . . . . . . . . . . . . . . . . 1
Manganese (as manganese gluconate) . . . . . . . . . . . . . . . 1
Molybdenum (as molybdenum amino acid chelate) 75
Chromium (as chromium polynicotinate) . . . . . . . . . . 100
Selenium (as selenomethionine) . . . . . . . . . . . . . . . . . . . . 35
% U.S. RDI
IU . . . . . . . . . . . . . . . . . . . . 35
IU . . . . . . . . . . . . . . . . . . . . 50
mg. . . . . . . . . . . . . . . . . . 100
IU . . . . . . . . . . . . . . . . . . . . 35
mcg . . . . . . . . . . . . . . . . . . 50
mcg . . . . . . . . . . . . . . . . . . 50
mg . . . . . . . . . . . . . . . . . . . 50
mg . . . . . . . . . . . . . . . . . . . 50
mg . . . . . . . . . . . . . . . . 1250
mcg. . . . . . . . . . . . . . . . . 500
mcg . . . . . . . . . . . . . . . . . . 50
mcg. . . . . . . . . . . . . . . . . 125
mcg . . . . . . . . . . . . . . . . . . 50
mg . . . . . . . . . . . . . . . . . . . 60
mg . . . . . . . . . . . . . . . . . . . 17
mg . . . . . . . . . . . . . . . . . . . 46
mcg . . . . . . . . . . . . . . . . . . 50
mg . . . . . . . . . . . . . . . . . . . 45
mg . . . . . . . . . . . . . . . . . . . 60
mg . . . . . . . . . . . . . . . . . . . 50
mg . . . . . . . . . . . . . . . . . . . 50
mcg. . . . . . . . . . . . . . . . . 100
mcg . . . . . . . . . . . . . . . . . . 83
mcg . . . . . . . . . . . . . . . . . . 50
Other Ingredients (Vanilla): Soy protein isolate (PharmaSoy®), fructose, maltodextrin,
soy fiber, phytosterols, corn bran, natural flavors, lecithin, olive oil, xanthan,
carrageenan, and cellulose gum.
Directions: Blend, shake, or briskly stir two level scoops into eight ounces of chilled
water.
Form: 25 oz. (700 g) Powder Container
* Information on cholesterol content is provided for individuals who, on the advice
of a physician, are modifying their dietary intake of cholesterol.
† Content varies according to flavor.
†† Featuring ActiFolate™—a proprietary blend of active folates.
††† As Metafolin® U.S. Patent Nos. 5,997,915; 6,254,904.
2. Bailey LB, Gregory JF. Polymorphisms of methylenetetrahydrofolate reductase and other enzymes: metabolic significance,
risks and impact on folate requirement. J Nutr 1999;129(5):919-22.
3. Deloughery TG, Evans A, Sadeghi A, et al. Common mutation
in methylenetetrahydrofolate reductase. Correlation with
homocysteine metabolism and late-onset vascular disease.
Circulation 1996;94(12):3074-78.
4. Donnelly JG. Folic acid. Crit Rev Clin Lab Sci 2001;38(3):183-223.
5. Venn BJ, Green TJ, Moser R, et al. Comparison of the effect of
low-dose supplementation with L-5-methyltetrahydrofolate
or folic acid on plasma homocysteine: a randomized,
placebo-controlled study. Am J Clin Nutr 2003;77(3):658-62.
6. Litynski P, Loehrer F, Linder L, et al. Effect of low doses of
5-methyltetrahydrofolate and folic acid on plasma
homocysteine in healthy subjects with or without the
677C➙T polymorphism of methylenetetrahydrofolate. Eur J
Clin Invest 2002;32(9):662-68.
7. Fohr IP, Prinz-Langenohl R, Brönstrup A, et al. 5, 10-Methylenetetrahydrofolate reductase genotype determines the plasma
homocysteine-lowering effect of supplementation with
5-methyltetrahydrofolate or folic acid in healthy young
women. Am J Clin Nutr 2002;75:275-82.
8. Nygard O, Vollset SE, Refsum H, et al. Total plasma
homocysteine and cardiovascular risk profile. The Hordaland
Homocysteine Study. JAMA 1995;274(19):1526-33.
9. Anderson JW, Gustafson NJ, Brayant CA, et al. Dietary fiber
and diabetes: A comprehensive review and practical
application. J Am Diet Assoc 1987;87(9):1189-97.
10. Anderson JW, Tietyen-Clark J. Dietary fiber: Hyperlipidemia,
hypertension, and coronary heart disease. Am J
Gastroenterology 1986;81(10):907-19.
11. Howarth NC, Saltzman E, Roberts SB. Dietary fiber and
weight regulation. Nutr Rev 2001;59(5):129-39.
12. Marlett JA, McBurney MI, Slavin JL. Position of the American
Dietetic Association: health implication of dietary fiber. J Am
Diet Assoc 2002;102(7):993-1000.
13. Uusitupa, MIJ. Fructose in the diabetic diet. Am J Clin Nutr
1994;59(3 Suppl):S753-S57.
MET874 Rev5/04
www.metagenics.com