Download Hyatt Regency Bellevue | Bellevue, WA Poster Presentations

An AACR Special Conference
Metabolism and Cancer
June 7-10, 2015 | Hyatt Regency Bellevue | Bellevue, WA
Poster Presentations
Cancer Metabolic Pathways
A01 ADRB2 regulates phase II steroid metabolism and determines development of castration
resistant prostate cancer. Peder Rustøen Braadland, Helene Hartvedt Grytli, Håkon Ramberg, Betina Katz,
Lois Gauthier-Landry, Ralf Kellmann, Kurt Allen Krobert, Wanzhong Wang, Aud Svindland, Finn Olav Levy,
Viktor Berge, Gunnar Mellgren, Olivier Barbier, Kristin Austlid Taskén.
A02 OXPHOS inhibition and pentose phosphate pathway induction are early events priming
preneoplastic lesions toward HCC development. Marta A Kowalik, Giulia Guzzo, Andrea Morandi, Andrea
Perra, silvia Menegon, Maria M Angioni, Silvia Giordano, Paola Chiarugi, Andrea Rasola, Amedeo Columbano.
A03 Procyanidin B2 3,3”-di-O-gallate from grape seed causes metabolic alterations in prostate
cancer cells: 1H-, 13C- and 31P-NMRS-based metabolomics study. Komal Raina, Dileep Kumar, Rajesh
Agarwal, Chapla Agarwal.
A04 Differential dependence on sphingolipid metabolism in the normal and leukemic human
hematopoietic hierarchy. Stephanie Z Xie, Elisa Laurenti, Robin Ferrari, John E Dick.
A05 A dual-function metabolite repair enzyme is required for the coexistence of glycolysis and
pentose phosphate pathway. Francois Collard, Francesca Baldin, Isabelle Gerin, Jennifer Bolsee, Gaetane
Noel, Julie Graff, Carole Linster, Vincent Stroobant, Maria Veiga-da-Cunha, Didier Vertommen, Emile Van
Schaftingen, Guido Bommer.
A06, PR09
Thompson.
SHMT2 drives DNA/histone hypermethylation phenotype in cancer. Jiangbin Ye, Craig B
A07 Inhibiting radiation-induced reprogramming of breast cancer cells via metabolic
perturbation. Milana Bochkur Dratver, Ryan Tsuyoshi Siu, Sabrina Boyer, Andrea Nguyen, Patricia Frohnen,
Frank Pajonk, Erina Vlashi.
A08 The role of branched-chain amino acid metabolism in Myc-driven malignancies. Mario R
Fernandez, Vanessa A Damoulis, Wei Wang, Bernhard Radlwimmer, John L Cleveland.
A09 The role of asparagine in glutamine-independent proliferation of breast cancer cells. Natalya N
Pavlova, Craig B Thompson.
A10 SLC7A11 contributes to the pathogenesis of lung cancer. Xiangming Ji Ji, Jun Qian, Jamshedur
Rahman, Brad Harris, Megan Hoeksema, Heidi Chen , Rosana Eisenberg, Jamey Young.
A11 Myeloid-derived suppressor cells suppress immune surveillance and stimulate cancer cell
proliferation/metastasis through activation of mTOR pathway in lal-/- mice. Hong Du, Ting Zhao,
Xinchun Ding, Katlin Walls, Cong Yan.
A12 Establishment of myeloid lineage cell line that resembles myeloid-derived suppressive
cells. Cong Yan, Xinchun Ding, Lingyan Wu, Hong Du.
A13, PR10 Serine biosynthesis from glucose regulates folate availability. Caroline A Lewis, Brian P
Fiske, Michael E Pacold, Aaron M Hosios, Katherine R Mattaini, David M Sabatini, Matthew G Vander Heiden.
A14 Role of mitochondrial folate metabolism in cancer cell growth and proliferation. Gregory S
Ducker, Mark B Esposito, Yibin Kang, Joshua D Rabinowitz.
An AACR Special Conference
Metabolism and Cancer
June 7-10, 2015 | Hyatt Regency Bellevue | Bellevue, WA
Poster Presentations
A15 Cancer cells with defective mitochondria require InsP3R-mediated calcium signals for
survival. Fabian Jana, Alenka Lovy, Jordi Molgo, Kevin Foskett, Cesar Cardenas.
A16 Restoration of gefitinib sensitivity and upregulation of BIM by simvastatin in T790M mutated
non-small cell lung cancer cells . Mo Jin Young, Lim Jeong Uk , Lee Hwa Young , Kim In Kyoung , Lee Sang
Haak .
A17 Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate
redox homeostasis and tumor growth. Lingtao Jin, Dan Li, Gina Alesi, Jun Fan, Hee-Bum Kang, Lu Zhou,
Titus Boggon, Peng Jin, Robert Egnatchik, Ralph DeBerardinis, Kelly Magliocca, Chuan He, Martha Arellano,
Hanna Khoury, Dong Shin, Fadlo Khuri, Sumin Kang.
A18 Changes in cholesterol metabolism support high density cell growth and therapeutic resistance
in glioblastoma multiforme. Diane M Kambach, Tamalee Kramp, Jie Liu, Michael L Oshinsky, Federico
Bernal, Jayne M Stommel.
A19 A Novel Cell Line Model for Chromophobe Renal Cell Carcinoma, UOK276, Derived from an
Aggressive Sarcomatoid Differentiated Tumor. Youfeng Yang, Cathy D. Vocke, Christopher J. Ricketts,
Darmood Wei, Hesed M. Padilla-Nash, Shawna L. Boyle, Robert Worrell, Thomas Ried, Maria J. Merino, W.
Marston Linehan.
A20 Mitochondrial phosphoenolpyruvate carboxykinase (PCK2) regulates metabolic adaptation and
enables glucose-independent tumor cell growth. Emma E Vincent, Alexey Sergushichev, Takla Griss,
Maxime N Artyomov, Russell G Jones.
A21 ACC1 is required for prostate cancer initiation, but not progression? Amanda L Davis, Kristen
Scott, Wu Jiansheng, Yong Q Chen, Steven J Kridel.
A22 An LKB1-CRTC1 circuit regulates glycosylated COX-2 and predicts drug response in lung
cancer. Chunxia Cao, Ruli Gao, Min Zhang, Antonio L. Amelio, Mohammad Fallahi, Zirong Chen, Yumei Gu,
Chengbin Hu, Eric A. Welsh, Brienne E Engel, Eric Haura, W. Douglas Cress, Lizi Wu, Maria Zajac-Kaye,
Frederic J. Kaye.
A23 Reversible metabolic changes in human melanoma cells enable distant metastasis. Elena
Piskounova, Michalis Agathocleous, Sara Mann, Ralph DeBerardinis, Sean J Morrison.
A24, PR03 P53 inhibits the expression of the pyrimidine catabolic gene Dihydropyrimidine
dehydrogenase (DPYD). Prashanth Ravishankar Gokare, Niklas Finnberg, Jenny Dai, Wafik El-Deiry.
A25 Tumor metabolism as a driver of lethal prostate cancer. Rachel S Kelly, Jennifer A Sinnott,
Jennifer R Rider, Ericka Ebot, Travis Gerke, Kathryn L Penney, Michaela Bowden, Andreas Pettersson,
Massimo Loda, Meir Stampfer, Philip Kantoff, Neil E Martin, Edward L Giovannucci, Svitlana Tyekucheva,
Matthew Vander Heiden, Lorelei A Mucci.
A26 Quantifying acetate uptake and contribution to fatty acid metabolism in hypoxic cancer
cells. Vinay Bulusu, Sergey Tumanov, Jurre J. Kamphorst.
An AACR Special Conference
Metabolism and Cancer
June 7-10, 2015 | Hyatt Regency Bellevue | Bellevue, WA
Poster Presentations
A27 European Network NGS-PTL preliminary data: Whole exome sequencing identifies mutations of
ALDH2, RETSAT, HSPG2, CHPF and other metabolic genes as a novel functional category in Acute
Myeloid Leukemia. Giorgia Simonetti, Antonella Padella, Ilaria Iacobucci, Italo Do Valle, Gabriele
Fontanarosa, Elisa Zago, Francesca Griggio , Marianna Garonzi, Simona Bernardi, Cristina Papayannidis,
Maria Chiara Abbenante, Giovanni Marconi, Giorgio Melloni, Laura Riva, Viviana Guadagnuolo, Mariachiara
Fontana, Samantha Bruno, Elisa Zuffa, Eugenia Franchini, Annalisa Astolfi, Carmen Baldazzi, Elisa Dan,
Barbara Sinigaglia, Michele Cavo, Nicoletta Testoni, Emanuela Ottaviani, Pier Giuseppe Pelicci, Marco Sazzini,
Alberto Ferrarini, Massimo Delledonne, Daniel Remondini, Giovanni Martinelli.
A28 Bioenergetic analysis of primary human mammary epithelial cells (hMECs). Elizabeth M Henchey,
Sallie S Schneider, D. Joseph Jerry, Nagendra Yadava.
A29 Frequency and circadian timing of eating may influence metabolic risk of breast
cancer. Catherine R Marinac, Dorothy D Sears, Linda C Gallo, Loki Natarajan, Caitlin Breen, Ruth E Patterson.
A30, PR08 Genome-wide screen reveals role for lipid homeostasis in protein scavenging. Michel
Nofal, Tim Wang, Lukas Tanner, David M Sabatini, Josh D Rabinowitz.
A32 Structural and Molecular Mechanisms of Human Hexokinase 2 in Cancer Metabolism and
Apoptosis. Wael Rabeh.
A33 CD38 and Nampt Regulate Tumor Cell Metabolism Through Modulation of NAD+. Jeffrey P
Chmielewski, Frances Wheeler, Scott Cramer, Shi Lihong, Joseph Sirintrapun, Steven J Kridel.
A34 Impact of a Lifestyle Intervention on Metabolic Pathways: Results from the Diet, Exercise,
Emotional Processing, and Mindfulness (DEEM) intervention. Claire Jungyoun Han, Larissa Korde, Scott
Reding, Kerryn Reding.
A35 Cytosolic reductive carboxylation is required for mitochondrial redox homeostasis during
anchorage-independent cell growth. Lei Jiang, Alexander Shestov, Lance S Terada, Nicholas D Adams,
Michael T McCabe, Beth Pietrak, Stan J Schimidt, Benjamin Schwartz, Ralph J DeBerardinis.
A36 Amino acids rather than glucose accounts for the majority of cell mass in rapidly proliferating
mammalian cells. Aaron M. Hosios, Vivian C. Hecht, Marc Johnson, Jeffrey C. Rathmell, Scott R. Manalis,
Matthew G. Vander Heiden.
A37 The Bcl-2 family protein Noxa regulates cellular energetics and reveals novel pathways in
cancer metabolism. Eric A Hanse, Xazmin Lowman, David Bernlohr, Ameeta Kelekar.
A38 Mimp/Mtch2 a genetic link between breast cancer and obesity. Yamit Bar-Lev , Hadas Tsivion,
Gideon Y Stein, Sari Natan, Miriam Shaharabany , Ilan Tsarfaty.
A39 Identification and biostatistical analysis of conserved metabolic profiles in breast tumors from
transgenic mouse models. Chen Dai, Laurie Littlepage, Jun Li.
A40 PML supports KRAS driven lung cancer growth via metabolic reprogramming. Smita Rindhe,
Niranjan Venkateswaran, Mahesh Padanad, Andrea Rabellino, Margherita Melegari, Pier Paolo Scaglioni.
A41 Leveraging metabolic dependencies in cancer: cysteine addiction in pancreatic cancer
cells. Michael A Badgley, Carmine F Palermo, Stephen A Sastra, Brent R Stockwell, Kenneth P Olive.
An AACR Special Conference
Metabolism and Cancer
June 7-10, 2015 | Hyatt Regency Bellevue | Bellevue, WA
Poster Presentations
A42 Exploring differential metabolic plasticity for treatment of cancer. Maria J. Rodriguez-Colman,
Maaike Meerlo, Nanda Verhoeven-Duif, Boudewijn Burgering.
A43 BRAF-mutated melanomas exhibit distinct metabolic programs that may determine therapeutic
response. Keisha N Hardeman, Chengwei Peng, Bishal Paudel, Darren Tyson, Jamey D Young, Vito
Quaranta, Joshua P Fessel.
A44 Expression of metabolic genes is associated with prognosis in breast cancer. Abdul Aziz Bin
Aiderus, Michael A Black, Anita K Dunbier.
A45 Glutaminase inhibitors suppress pyrimidine synthesis and promote DNA replication stress in
VHL-deficient human renal cancer cells. Arimichi Okazaki, Paulo Gameiro, Stephanie Yazinski, Gregory
Stephanopoulos, Lee Zou, Othon Iliopoulos.
A46, PR05 Aspartate metabolism links the urea cycle with nucleic acid synthesis in cancerous
proliferation. Shiran Rabinovich, Keren Yizhak, Qin Sun, Alexander Brandis, Daniel Helbling, David
Dimmock, Sandesh Nagamani, Eytan Ruppin, Ayelet Erez.
A47
The Regulation of TIGAR. Pearl Lee, Eric C Cheung, Karen H Vousden.
A48 Metabolic adaptations to serine starvation. Christiaan F. Labuschagne, Oliver D.K. Maddocks,
Karen H. Vousden.
A49
MondoA-TXNIP acts as a metabolic checkpoint for coordinated cell growth. Zhizhou Ye.
A50 Mitochondrial Metabolism Gene Variants are associated with Risk and Survival in Epithelial
Ovarian Cancer (EOC). Ganna Chornokur, Hui-Yi Lin, Alvaro Monteiro, Joellen Schildkraut, Ellen L Goode,
Paul DP Pharoah, Simon A Gayther, Susan Ramus, Thomas A Sellers, Catherine M Phelan.
Therapeutic Targets From Cancer
A51 Targeting mTOR metabolism for glioblastoma cancer therapy. Anita Tandle, Tamalee Kramp,
Philip Tofilon, Kevin Camphausen.
A52 Overcoming mitochondrial oxidative phosphorylation-mediated resistance to targeted
therapies in melanoma. Vashisht Gopal Yennu-Nanda, Zeping Hu, Victoria M Thiele, Tim Heffernan, Maria
DiFrancesco, Joe Marszalek, Ralph Deberadinis, Michael A Davies.
A53 Anti-proliferative, anti-angiogenic and pro-apoptotic actions qualify Nigella sativa as taxane
therapy adjuvant in ovarian cancer. Rajani Mathur, Mukesh Tiwari.
A54 Changes in fatty acid profile indicate a chemo-preventive response to navy bean extract in an
inflammation-associated colorectal cancer mouse model. Thushanthi H Perera, Matthew R, Young, Shakir
M. Saud, Christopher R. Dextras, Yava L. Jones-Hall, Edward D. Karoly, Brante P Sampey, Young S Kim,
Nancy H. Colburn, Gerd Bobe.
A55 Novel nilotinib derivatives inhibit cell proliferation by targeting 5’ AMP-activated protein kinase
in hepatocellular carcinoma. Jung-Chen Su, Ting-ting Hsueh, Jui-Wen Huang, Chung-Wai Shiau.
A56 Targeting of NAD Metabolism: Potential Novel Therapy for Neuroblastoma. Regina M Graham,
Branko Cuglievan, Ahmad T Alshareef, Steven Vanni.
An AACR Special Conference
Metabolism and Cancer
June 7-10, 2015 | Hyatt Regency Bellevue | Bellevue, WA
Poster Presentations
A57 Modulation of tumor cell proliferation and autophagy by inhibiting cathepsin S protease under
extracellular acidification in pancreatic ductal adenocarcinoma. Tzu-Chin Wu, Chien-Yu Liao, Tzu-Yuan
Chang, Chun-Cheng Lin, Wun-Shaing Wayne Chang.
A58 Temporal dynamics underpin metabolism-driven cancer therapy cross-resistance. Aaron
Goldman, Andrew Dhawan, Ragini Medhi, Mohammad Kohandel, Shiladitya Sengupta.
A59 CHAF1A blocks neuroblastoma differentiation and promotes tumor growth via metabolic
reprogramming. Myrthala Moreno-Smith, Zaowen Chen, Eugene S Kim, Jason M Shohet, Eveline Barbieri.
A60 Inhibition of growth of bladder cancer cells by compounds that affect glucose
metabolism. Michael A Lea, Mansour Altayyar, Charles desBordes.
A61 Tumor metabolic remodeling can modulate anti-cancer drug response: CPI-613 attack on tumor
cell mitochondrial metabolism is mediated by metabolite availability. Shawn D. Stuart, Moises
Guardado, Michael Dahan, Paul M. Bingham, Zuzana Zachar.
A62 Chemoresistance through the intratumoral metabolism of dichloroacetate. Stephan C Jahn,
Mohamed H Solaymen, Ryan J Lorenzo, Taimour Langaee, Peter W Stacpoole, Margaret O James.
A63 Identification of small molecules for GBM study. Sang Kyun Lim, Yufeng Shi, Qiren Liang, Inga
Nazarenko, Shuguang Wei, Maya Palnitkar, Yanjiao Li, Woosung Cho, Noelle Williams, Bruce Posner, Jef De
Brabander, Luis F. Parada.
A64 Targeting HSP90 with Ganetespib for Targeted Therapy of Gastric Cancer. Hanqing Liu, Peishan
Zhang, Zhiquan Liang, Lingling Ruan, Caixia Lian, Jian Lu, Ye Hua, Haifeng Shi, Keping Chen, Zhigang Tu.
A65 IACS-10759: A novel OXPHOS inhibitor that selectively kills tumors with metabolic
vulnerabilities. Marina Protopopova, Madhavi Bandi, Yuting Sun, Jennifer Bardenhagen, Christopher
Bristow, Christopher Carroll, Edward Chang, Ningping Feng, Jason Gay, Mary Geck Do, Jennifer Greer,
Marina Konopleva, Polina Matre, Zhijun Kang, Gang Liu, Florian Muller, Timothy Lofton, Timothy McAfoos,
Melinda Smith, Jay Theroff, Jing Han, Yuanqing Wu, Lynda Chin, Giulio Draetta, Philip Jones, Carlo Toniatti,
M. Emilia Di Francesco, Joseph R Marszalek.
A66, PR02 A small molecule inhibitor of PHGDH reveals coordination between serine synthesis and
5,10-methylene tetrahydrofolate utilization. Michael E Pacold, Kyle Brimacombe, Brian P Fiske, Caroline A
Lewis, Sung Won Cho, Richard Possemato, Min Shen, Jason Rohde, Kenneth D Westover, Nathanael S Gray,
Matthew Vander Heiden, Matthew B Boxer, David M Sabatini.
A67 The mTOR inhibitor, everolimus, enhances the cytotoxicity of Pseudomonas-based
immunotoxins: Mechanistic insights. Antonella Antignani, Lesley Mathews-Griner, Mark Ferrer, Nathan
Simon, Evan Angelus, Manjie Huang, Ira Pastan , Craig Thomas, David J FitzGerald.
A68 Metabolic targeting of oncogene MYC by selective activation of the proton-coupled
monocarboxylate family of transporters. Lei Gan, Ruijuan Xiu, Ping Ren, Ming Yue, Hexiu Su, Guoli Guo,
Daibiao Xiao, Hudan Liu, Guoliang Qing .
A69 Use of selective drugs to target metastatic cancer cells for elimination. Stephen J Ralph, Rhys
Pritchard, Sara Rodríguez-Enríquez, Rafael Moreno-Sánchez.
An AACR Special Conference
Metabolism and Cancer
June 7-10, 2015 | Hyatt Regency Bellevue | Bellevue, WA
Poster Presentations
A70 Targeting pediatric bone sarcoma stem cell with metabolic inhibitors. Matteo Trucco, Nino
Rainsusso, Piti Techavichit, Ronald Bernardi, Ryan Shuck, Laura Satterfield, Wendy Allen-Rhoades, Larry
Donehower, David Loeb, Jason Yustein.
A71 Investigating the functional contribution of TANK Binding Kinase 1 to metabolic regulation in
pancreas cancer. Victoria H Burton, Rolf A Brekken.
A72 Novel NAMPT inhibitors for the treatment of Pancreatic cancer. Dinesh Chikanna, Anirudha
Lakshminarasimhan, Vinayak Khairnar, Sunil Panigrahi, Anuradha Ramanathan, Narasimha Rao, Kishore
Narayanan, Sreevalsam Gopinath, Raghuveer Ramachandra, Shekar Chelur, Chetan Pandit, Murali
Ramachandra.
A73 Metabolite profiling reveals the glutathione biosynthetic pathway as a therapeutic target in
triple negative breast cancers. Alexander Beatty, Lauren Fink, Alexander Strigun, Ulrike Rennefahrt, Erik
Peter, Regina Reszka, Hajo Schiewe, Jeffrey R Peterson.
A74
Preclinical evaluation of a fatty acid synthase inhibitor in pancreatic cancer. Roshan A Ahmed.
A75 Translational studies of a first-in-class FASN Inhibitor, TVB-2640, linking preclinical studies to
clinical laboratory observations in solid tumor patients. Doug Buckley, Tim Heuer, Marie O'Farrell, Bill
McCulloch, George Kemble.
A76 AMPK activation potentiates apoptosis induction in Myc driven breast cancer cells. Heidi M
Haikala, Elsa Marques, Vilja Eskelinen, Anni Nieminen-Viheriäranta, Liina Nevalaita, Daniel Laajala, Tero
Aittokallio , Panu Kovanen, Päivi Heikkilä, Marjut Leidenius, Juha Klefström.
A77 Corilagin, a new anticancer herbal medicine: The molecular mechanisms of growth and
metastasis inhibitory in liver and ovarian cancers. Yanlin Ming , Luoqi Jia , Zhizhong Zheng , Hongyan Jin,
Lianghua Chen, Yinghua Yu, Shaosong Liu, Yanlin Ming.
A78 Exploring the glucose metabolism for anticancer therapy of multidrug resistance (MDR)
leukemic cells. Rodrigo Curvello, Gabriela Fioresi Bartipaia, Manoel Domingos dos Santos Neto, Natalia
Brosso Vieira, Amanda Siena, Maria Cristina Carlan Silva, Giselle Zenker Justo, Ana Carolina Santos de Souza.
A79, PR01 Role of mitochondrial folate transporter in metabolism of tumor cells. Ilya Kovalenko,
Laura Schöckel, Andrea Glasauer, Andrea Haegebarth, Sven Christian.
A80 Effects of in vitro stimulation of chimeric antigen receptor modified CD4+ and CD8+ central
memory T cells.”. Danielle L. Oliver, Natalia Steevens, Cameron Turtle.
A81 Fuel switch from glucose to lactate is dependent on tumor size in triple negative breast
cancer. Narumi Harada, Narumi Harada, Francesco A Mauri, Laura Kenny.
A82 Identification of NSCLC patients with high tumor glucose uptake by 18F-FDG-PET. Anne M
Hendriks, Adrienne H Brouwers, Joop D Lefrandt, Wim J Sluiter, Wim Timens, Harry J. M. Groen, Elisabeth G.
E. de Vries, Mathilde Jalving.
A83 Inhibiting mitochondrial ATP synthase with Oligomycin A enhances the kinetics of oncolytic
reovirus-induced apoptosis in vitro. Matthew Clarkson, Siyuan Yin, Mio Tsutsui, David Andrews, Randal
Johnston.
An AACR Special Conference
Metabolism and Cancer
June 7-10, 2015 | Hyatt Regency Bellevue | Bellevue, WA
Poster Presentations
A84 Regulation of 6-Phosphofructo-2-Kinase (PFKFB3) by Estradiol and Implications for the
Treatment of ER+ Metastatic Breast Cancer. Yoannis Imbert-Fernandez, Brian Clem, Gilles Tapolsky,
Jason Chesney.
A85 Concurrent targeting of glutamine and asparagine metabolism produces synergistic inhibition
of tumor cell proliferation. Cicely L Schramm, Zhi Xie, Erick Kindt, Wenlin Li, Fang Wang, Valeria R Fantin.
A86 LRP16, Interacting with PKR, Prolongs NF-kappaB Activation and Drives Colorectal Cancer
Tumorigenesis. Xiaolei Li, Zhiqiang Wu, Weidong Han.
A87 Targeting the mitochondrial quality control machinery in acute myeloid leukemia. Danny V
Jeyaraju, Veronique Voisin, Ashwin Ramakrishnan, Rose Hurren, Neil Maclean, Marcela Gronda, Mark Minden,
Gary Bader, Aaron D Schimmer.
A88 Openers of voltage dependent anion channels are anti-Warburg agents that enhance
mitochondrial metabolism, decrease glycolysis, activate JNK and induce ROS-dependent killing of
cancer cells. David N DeHart, Monika Gooz, John J Lemasters, John J Lemasters, Eduardo N Maldonado.
A89 Glycolytic cancer cell metabolism suppressed by transplantation of exogenous normal
mitochondria into human breast cancer cells. Robert L Elliott, Xian-Peng Jiang, Jonathan F Head.
A90 Dichloroacetate can overcome drug resistance via decreased ABC drug transporter expression
and PDK2 inhibition. Santhi Achuthan, Richard Callaghan, Anneke C Blackburn.
A91 Over-the-counter melatonin supplementation in human subjects: A potentially novel
chronotherapeutic approach targeting the Warburg effect and fatty acid metabolism in breast cancer
therapy/prevention. David E. Blask, Robert T. Dauchy, Erin M. Dauchy, Steven M. Hill, Lulu Mao, Melissa M.
Wren, Mary M.C. Meyaski-Schluter, Lin Yuan.
A92 Aminomethylphosphonic acid inhibits human prostate xenograft tumor growth through
interfering glycine synthesis in the cancer cells. Keshab R Parajuli, Qiuyang Zhang, Sen Liu, Zongbing
You.
Signaling Pathways and Cancer Metabolism
B01 Multilevel interference with receptor-PI3K-mTORC1 signaling is key mechanism for anticancer
activity of fatty acid synthase inhibitors. Renate Wagner, Katharina Pröstling, Daniel Veigel, Gerald
Stübiger, Michael Grusch, Julian Weghuber, Christian Singer, Heidrun Karlic, Ramón Colomer, Bellinda
Benhamú, María Luz López-Rodríguez, Fausto Hegardt, Jordi García, Dolors Serra, Peter Valent, Thomas
Grunt.
B02 mTOR/S6K pathway- dependent metabolic reprogramming in cancer cells mediates resistance
to glycolytic inhibitors. Raju Pusapati, Min Gao, Anneleen Daemen, Georgia Hatzivassiliou, Jeffrey
Settleman.
B03 Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancers. Zhenghe
Wang.
B04 Regulation of metabolic adaptation pathways by coactivator SRC-2 in advanced metastatic
prostate cancer. Subhamoy Dasgupta, Nagireddy Putluri, Michael M Ittmann, Arun Sreekumar, Bert W
O'Malley.
An AACR Special Conference
Metabolism and Cancer
June 7-10, 2015 | Hyatt Regency Bellevue | Bellevue, WA
Poster Presentations
B05 Inhibition of ER/Stat3 signaling pathways drive the evolution of ER+ metastatic breast cancer
through the generation of ER-independent OXPHOShi self-renewing cells. Pasquale Sansone, Marjan
Berishaj, Qing Chang, Antonio Strillacci, Ferdinando Giacco, Jacqueline Bromberg.
B06 TSC2 loss induces aberrant choline lysoglycerophospholipid metabolism. Carmen Priolo,
Stéphane J. H. Ricoult, Damir Khabibullin, Harilaos Filippakis, Jane Yu, Brendan Manning, Clary Clish,
Elizabeth P Henske.
B07 Rb silencing and c-Myc overexpression-induced transformation of mesenchymal stem cells into
osteosarcoma cells requires ribonucleotide reductase -mediated DNA synthesis. Shih-Chieh Hung.
B08 Metabolic adaption in inflammatory macrophages through the modulation of Fe-S cluster
biogenesis factors. Wing-Hang Tong, Nunziata Maio, Tracey A Rouault.
B09 Mitochondrial Respiration controlled by survivin directs mitochondrial dynamics and tumor cell
invasion. Dayana B. Rivadeneira, M. Cecilia Caino, Jae Ho Seo, Alessia Angelin, Wallace C. Douglas, Lucia R.
Languino, Dario C. Altieri.
B10 Non-invasive pharmacodynamic markers of the dual mTORC1/2 inhibitor AZD2014 in
combination with paclitaxel, in cisplatin resistant ovarian carcinoma xenografts. Anne-Christine LF
Wong Te-Fong, Efthymia Papaevangelou, Martin O Leach, Udai Banerji, Yuen-Li Chung.
B11 Metabolic reprogramming in breast cancer bone metastasis via Runx2-dependent AMPK and
IGF-1Rβ signaling crosstalk. Manish Tandon, Ahmad H Othman, Zujian Chen, Jitesh Pratap.
B12 Yes-Associated Protein: A master metabolic regulator In medulloblastoma. Anshu Malhotra,
Abhinav Dey, Anna Marie Kenney.
B13
Akt-independent PDK1 Signaling in Regulation of Purine Biosynthesis. Songon An.
B14 Targeting Heat Shock Protein 90 with Ganetespib for the Treatment of Lymphoma. Hanqing Liu,
Zhiquan Liang, peishan Zhang, Jingjing Zhao, Lingling Ruan, Yongjin Lu, Dongsheng Shang, Ying Sun,
Zhigang Tu.
B15 Metastatic breast tumors regulate gene expression at distal mammary sites that predicts patient
outcome. Jiyoung Lee, Russell Bainer, Casey Frankenberger, Daniel Rabe, sadiq Saleh, Morag Park, Gary An,
Yoav Gilad, Marsha Rich Rosner.
B16 Tumor suppressive functions of the urea cycle in renal cell carcinoma. Joshua D Ochocki, Nan Lin,
Bo Qiu, Daniel Ackerman, M. Celeste Simon.
B17 TRIM24 links epigenetics and metabolism in cancer. Kaushik N Thakkar, Shiming Jiang, Sabrina
Stratton, Michelle Barton.
B18 Intra-tumor lysophosphatidylinositol metabolites in a treatment naïve patient-derived bone
metastatic prostate cancer xenograft. Mark Titus, John Araujo, Jun Yang, Sumankalai Ramachandran,
Eleni Efstathiou, Patricia Troncoso, Christopher Logothetis, Nora Navone.
B19 LKB1-AMPK axis regulates the switch of Pyruvate Kinase M isoforms to tolerate nutritional
stress. Gopinath Prakasam, Rameshwar N.K. Bamezai.
An AACR Special Conference
Metabolism and Cancer
June 7-10, 2015 | Hyatt Regency Bellevue | Bellevue, WA
Poster Presentations
B20 PTP1B regulates the Moyamoya disease-associated E3 ligase, RNF213 and cellular dioxygenase
activity to allow breast tumor survival in hypoxia. Robert S Banh, Caterina Iorio, Richard Marcotte, Yang
Xu, Dan Cojocari, Anas Abdel Rahman, Judy Pawling, Ankit Sinha, Toshiaki Hitomi, Toshiyuki Habu, Akio
Koizumi, Sarah E Wilkins, Thomas Kislinger, Christopher J Schofield, James W Dennis, Bradly G Wouters,
Benjamin G Neel.
B21 An mTORC1-Mdm2-Drosha axis for miRNA biogenesis in response to glucose- and amino aciddeprivation. Peiying Ye, Yu Liu, Chong Chen, Fei Tang, Qi Wu, Xiang Wang, Chang-Gong Liu, Xiuping Liu,
Runhua Liu, Yang Liu, Pan Zheng.
B22 Acyl-CoA synthetase long-chain family member 3 dependent lipid homeostasis is required for
mutant KRAS driven lung cancer. Mahesh S Padanad, Georgia Konstantinidou, Chendong Yang,
Margherita Melegari, Niranjan Venkateswaran, Kimberly Batten, Kenneth E Huffman, Jerry W Shay, John D
Minna, Ralph J DeBerardinis, Pier P Scaglioni.
B23 Mutant NRAS regulates glycolysis in melanoma through ERK, mTOR and the
MYC/HIF1α/MondoA network of transcriptional regulators. Aparna D Rao, Lorey K Smith, Tiffany J
Parmenter, Grant A McArthur.
B24 Targeting Lactate Metabolism to Overcome PI3K/mTOR Resistance. Sunghee Park, Ching-yi
Chang, Rachid Safi, Robert Baldi, Jeff Jasper, Tingyu Liu, Jeffrey Rathmell, Donald P McDonnell.
B25 Novel hepatic phenotypes caused by conditional c-Myc deletion. Lia R Edmunds, Lokendra
Sharma, Peter Anthony Otero, Sonia D'Souza, James M Dolezal, Xuemei Zeng, Ying Ding, Fei Ding, Megan E
Beck, Lisa E Kratz, Jerry Vockley, Eric Goetzman, Donald Scott, Nathan Yates, Andrew W Duncan, Edward V
Prochownik.
B26 Substrate trapping proteomics reveals that targets of the betaTrCP2/FBXW11 ubiquitin ligase
are important for cell metabolism. Tai Young Kim, Priscila F. Siesser, Michael B. Major.
B27 Kras alters expression of asparagine synthetase (Asns) in non-small cell lung cancer (NSCLC)
and protects tumors during nutrient stress. Dana M Gwinn, Alejandro Sweet-Cordero.
B28 The Interplay between Met-HGF/SF-Glucose-Glutamine signaling dictates spatiotemporal
mitochondrial activity, cell morphology and wave of directional group cell motility. Elena Mocan, Sari
Natan, Ohad Doron, Eshel Ben Jacob, Ilan Tsarfaty.
B29 LRP16 is an essential mediator for DNA double-strand breaks induced NF-kappaB
activation. Zhiqiang Wu, Chunmeng Wang, Miaomiao Bai, Xiaolei Li, Qian Mei, Xiang Li, Yao Wang,
Xiaobing Fu, Guangbin Luo, Weidong Han.
B30 Identification of new YAP/TAZ kinases regulated by metabolism. Giovanni Sorrentino, Giannino
Del Sal.
B31 Disruption of Folliculin interacting protein-1 modulates Myc-driven metabolism, increasing cell
death following metabolic stress. Julita A Ramirez, Mark Tsang, Heon Park, Daciana Margineantu, Haiwei
Gu, Daniel Raftery, David M Hockenbery, Brian M Iritani.
B32 FOXOs support the metabolic requirements of normal and tumor cells by regulating IDH1
expression. Paraskevi Charitou, Maria Rodriguez-Colman, Johan Gerrits, Nanda Verhoeven-Duif, Boudewijn
Burgering.
An AACR Special Conference
Metabolism and Cancer
June 7-10, 2015 | Hyatt Regency Bellevue | Bellevue, WA
Poster Presentations
B33 Assessing the role of DGAT activity on lipid homeostasis and cancer cell survival . Daniel
Ackerman, Bo Qiu, Hong Xie, Jurre Kamphorst, M. Celeste Simon.
B34 Transcriptional regulation of glutaminase expression downstream of oncogenic Rho GTPase
signaling. Michael J Lukey, Kai Su Greene, Jon W Erickson, Kristin F Wilson, Richard A Cerione.
B35 Association between acute leukemia’s and levels of leptin in blood: A Meta-analysis. Vijaya
SenaReddy Dendi, Sivakanth Aloor, Rahul Gadde, Kranthi Kunkalla, Roopesh Reddy Sadashiva Reddy,
Jeffrey Gryn.
B36 Serum Adiponectin Levels Association with Acute Leukemia’s: A Meta-analysis. Vijaya
SenaReddy Dendi, Sivakanth Aloor, Dinesh Keerty, Jeffrey Gryn, Jeffrey Gryn.
B37 Concomitant blockade of glucose uptake and paracrine HGF signaling uncovers the metabolic
vulnerability of KRAS-mutant colorectal tumors. Alessia Mira, Paolo Michieli.
Alterations of Nutrient/Fuel Sensing in Cancer
B38 Melatonin efficacy in breast cancer microenvironment under acidosis. Nathália Martins Sonehara,
Bruna Victorasso Jardim-Perassi, André de Lima Mota, Marina Gobbe Moschetta, Debora Aparecida Pires de
Campos Zuccari, Rubens de Paula.
B39 PTP1B deficiency potentiate prostate cancer invasiveness by sensitizing Pten-null tumors to
high fat diet. David P Labbé, Noriko Uetani, Valérie Vinette, Isabelle Aubry, Eva Migon, Jacinthe Sirois, Jody
J Haigh, Laurent Lessard, Louis R Bégin, Lloyd C Trotman, Marilène Paquet, Michel L Tremblay.
B40 AKT-ACLY signaling preferentially maintains histone acetylation over lipid synthesis during
nutrient limitation. Joyce V Lee, Zuo-Fei Yuan, Shichong Liu, Benjamin A Garcia, Kathryn E Wellen.
B41 Post-transcriptional regulation of IDH1 by the RNA-binding protein HuR is important for
pancreatic cancer cell survival under nutrient deprivation. Mahsa Zarei, Fernando F Blanco, Laszlo G
Boros, Charles J Yeo, Jonathan R Brody , Jordan M Winter.
B42 Metabolic pathway changes induced by a PIK3 mutation and reverted by drugs. Xiang-He Lei,
Shawn Noble, Barry R. Bochner.
B43 The utilization of extracellular proteins as nutrients is suppressed by mTORC1. Wilhelm Palm,
Youngkyu Park, Kevin Wright, Natalya N Pavlova, David A Tuveson, Craig B Thompson.
B44, PR07 Functional identification of a mitochondrial glutamine carrier using isotope
tracers. Christian Metallo.
Emerging Analytical Approaches
B45 Optical spectroscopy of tumor oxygenation and metabolism in pre-clinical head and neck
tumors that fail radiation therapy. Narasimhan Rajaram, Helen A Murphy, Nimmi Ramanujam.
B46 The use of quantitative proteomics to increase the knowledge about metabolic symbiosis in a
tumor microenvironment. Evelyne Maes, Mathias Wenes, Dirk Valkenborg, Inge Mertens, Hans Prenen,
Massimiliano Mazzone, Geert Baggerman.
An AACR Special Conference
Metabolism and Cancer
June 7-10, 2015 | Hyatt Regency Bellevue | Bellevue, WA
Poster Presentations
B47 Unraveling tumor metabolism with “in silico” IHC multiplexing supported by automated imaging
analysis. Suzana Vega Harring, Marta Canamero, Konstanty Korski, Georges Marchal, Oliver Grimm, Claudia
Ferreira, Joerg Bredno, Christophe Chefd`hotel, Fabien Gaire.
B48 Optical toolbox for in vivo analysis of glucose uptake, vascular oxygenation, and mitochondrial
membrane potential in breast cancer. Amy Frees Martinez, Samuel S. McCachren, Narasimhan Rajaram,
Mark W. Dewhirst, Nimmi Ramanujam.
B49 Bioluminescent assays for measuring glycolytic rate and glucose homeostasis. Jolanta
Vidugiriene, Donna Leippe, Mary Sobol, Mike Valley, Natasha Karassina, Sarah Duellman, James Cali.
B50 Detecting colorectal cancer and polyps using nuclear magnetic resonance spectroscopy and
mass spectrometry based metabolomics. Lingli Deng, Haiwei Gu, Jiangjiang Zhu, Nagana Gowda, Danijel
Djukovic, Daniel Raftery.
B51 Metabolic imaging with hyperpolarized [1-13C]-pyruvate and DCE-MRI. James A Bankson,
Christopher M Walker, Yunyun Chen, Stephen Y Lai, John D Hazle.
B52 Targeted LC-MS/MS metabolic profiling for colon cancer progression monitoring. Jiangjiang
Zhu, Danijel Djukovic, Lingli Deng, Lingli Deng, Haiwei Gu, Farhan Himmati, Mohammad Abu Zaid, E. Gabriela
Chiorean, E. Gabriela Chiorean, Daniel Raftery, Daniel Raftery.
Autophagy and Metabolic Stress in Cancer
B53 The role of RPL39 induced autophagy in resistance of breast cancer stem cells. Bhuvanesh Dave,
Dong Soon Choi, Helen Wong, Yi Liu, Prem Siddharth Gunamalai, Jenny C. Chang.
B54 The role of Fatty Acid Synthase in regulation of autophagy in colorectal cancer. Yekaterina
Zaytseva, Jennifer Harris, Ji Tae Kim, Eun Lee, Heidi Weiss, Tianyan Gao, Mark Evers.
B55 Role of HSF1 in Chemotherapy –Induced Autophagy and Endoplasmic Reticulum Stress
Response in Breast Cancer. Shruti Desai, Ming Tan.
B56 Treatment-induced autophagy increases amino acid uptake and switches glucose addiction to
amino acid catabolism in cancer. Gigin Lin, Helen Troy, Gabriela Andrejeva, Anne-Christine LF Wong Te
Fong, Dow-Mu Koh, Simon P Robinson, Ian R Judson, John R Griffiths, Martin O Leach, Yuen-Li Chung.
B57 Autophagy promotes Kras-driven lung cancer cell survival by maintaining glutamine
metabolism and nucleotide salvage. Jessie Yanxiang Guo, Xin Teng, Sinan Khor, Gizem Karsli Uzunbas,
Yang Yang, Ling Liu, Josh Rabinowitz, Eileen White.
B58, PR04 HIF-2α dependent lipid storage promotes endoplasmic reticulum homeostasis in clear
cell renal cell carcinoma. Bo Qiu, Daniel Ackerman, Danielle J Sanchez, Bo Li, Joshua D Ochocki, Alison
Grazioli, Ekaterina Bobrovnikova-Marjon, J. Alan Diehl, Brian Keith, M. Celeste Simon.
B59 Autophagy mediates senescence and supports survival upon treatment with anti-mitotic
drugs. Bing Cheng, Alex Wong, Karen Crasta.
B60 Autophagy mediates senescence and support post-slippage survival upon treatment with
antimitotic drugs. Bing Cheng, Alex Wong, Karen Crasta.
An AACR Special Conference
Metabolism and Cancer
June 7-10, 2015 | Hyatt Regency Bellevue | Bellevue, WA
Poster Presentations
B61 Effects of metformin on papillary thyroid cancer apoptosis and autophagy. Young Shin Song,
Eun Young Kim, Hyun Jin Sun, Young Joo Park, Do Joon Park, Sun Wook Cho.
B63 Lung cancer-associated PIK3C3 mutations reveal critical dose-dependent effects of hVPS34 in
the acceleration of lung tumorigenesis. Robert S Banh, Richard Marcotte, Benjamin G Neel.
B64 Targeting the autophagy kinase ULK1 in non-small cell lung cancer. Karen L Burger, Anders E
Berglund, Derek R Duckett, John L Cleveland.
B65, PR06 Identification of metabolic dependencies in tuberous sclerosis and
lymphangioleiomyomatosis. Harilaos Filippakis, Damir Khabibullin, Carmen Priolo, Elizabeth P. Henske.
Metabolic Effects on Epigenetics and Gene Expression
B66 Development of RNA drugs to defeat metabolic disorders. Jui-Wen Huang, Yen-Ju Lin, ChunMing Liu, Wei-Chen Hsieh, Ching-Han Tsao, Szu-Hsiu Liu, Huan-Yuan Chen, Fu-Tong Liu.
B67 Identifying obesity-linked gene expression changes in prostate cancer. Ericka M Ebot, Travis
Gerke, Svitlana Tyekucheva, David P Labbé, Giorgia Zadra, Rachel S Kelly, Michaela Bowden, Jennifer R
Rider, M Kathryn Wilson, Neil E Martin, Myles Brown, Matthew G Vander Heiden, Edward L Giovannucci,
Massimo Loda, Lorelei A Mucci.
B68 Calorie restriction normalizes global microRNA expression by preventing the loss of Dicer
expression during mammary tumorigenesis. Kaylyn L Devlin, Tiffany Sanford, Elizabeth Mambo, Stephen
D Hursting.
B69 Mechanisms underlying Nkx3.1-driven maintenance of prostate identity involve a metabolic
transcriptional program. Aditya Dutta, Clémentine Le Magnen, Cory Abate-Shen.
B70 Decitabine, the DNA demethylating agent, works in solid tumor patients by promoting the
proliferation and lysis activity of T lymphocytes. Nie Jing.
Systemic Metabolic Alterations and Cancer
B72 Characteristic Features of Serum Bile Acids Profile in Patients with Non-Alcoholic
Steatohepatitis with Hepatocellular Carcinoma. Tadashi Ikegami, Akira Honda, Teruo Miyazaki, Shoichiro
Yara, Yasushi Matsuzaki.
B73 Increased serum fatty acyl carnitine levels may indicate development of advanced colorectal
adenoma. Thushanthi H Perera, Gwen Murphy, Matthew R Young, Nancy H Colburn, Elaine Lanza, Amanda J
Cross, Gerd Bobe.
B74 Dietary reprogramming of the metabolome of the laying hen: prevention and suppression of
ovarian cancer. Stephanie M Eastwood, Lacey Gibson, Dale Buchanan Hales.
B75 Circadian Homeostasis of Liver Metabolism Suppresses Tumorigenesis. Nicole M Kettner,
Chinenye A Katchy, Milton J Finegold, David D Moore, Loning Fu.
B76 Determining Mechanisms for the Association of Pancreatic Insufficiency, Diabetes and
Pancreatic Ductal Adenocarcinoma (PDA). Yalda Zolghadri, Ozhan Ocal, Galvin H Swift, Rolf A Brekken,
John Mansour, Tom M Wilkie.
An AACR Special Conference
Metabolism and Cancer
June 7-10, 2015 | Hyatt Regency Bellevue | Bellevue, WA
Poster Presentations
B77 Pre-diagnostic Insulin-like growth factors and pancreatic cancer survival. Adetunji T. Toriola,
Mark Ziegler, Yinjiao Ma, Rachael Stolzenberg-Solomon.
B78 The influence of breast cancer on the metabolic status of myeloid cells. Li-Rung Huang, ShiouLing Jian, Yi-Jyun Jhou.
B79 Novel protein glycan biomarker and future colorectal cancer. Paulette D Chandler, Akintunde
Akinkuolie, Deirdre Tobias, Lu Wang, M.V. Moorthy, Paul M Ridker, I-Min Lee, JoAnn E Manson, Julie E
Buring, James Otvos, Samia Mora.
B80 Beneficial regulation of metabolic profiles by black raspberries in human colorectal cancer
patients. Pan Pan, Chad W. Skaer, Steven M. Stirdivant, Matthew R. Young, Gary D. Stoner, John F. Lechner,
Yi-Wen Huang, Li-Shu Wang.
B81 Effects of black raspberry diet on the metabolomic profile of C57BL/6J mouse tissues. Chad W
Skaer, Pan Pan, Matthew R Young, Hsin Tzu Wang, Kiyoko Oshima, Yi-Wen Huang, Gary D Stoner, John
Lechner, Li-Shu Wang.
B82 PTH-related Protein and Adipose Tissue Browning in Cancer Cachexia. Serkan Kir, James White,
Sandra Kliener, Vickie Baracos, Bruce Spiegelman.
B83, PR11 Tissue-of-origin dictates the metabolic fate of branched chain amino acids in mutant Krasdriven cancers. Jared R Mayers, Margaret E Torrence, Shawn M Davidson, Thales Papagiannakopoulos,
Allison N Lau, Tyler Jacks, Matthew G Vander Heiden.
B84 Interplay between HGF/SF-Met-Ras-MAPK signaling, tumor metabolism and blood flow as a
potential target for breast cancer therapy. Sari Natan, Ilan Tsarfaty, Judith Horev, Roni Haklai, Yoel Kloog,
Galia Tsarfaty.
B85 HGF/SF-induced Ca+2 intake to breast tumor cells – a manganese enhanced MRI (MEMRI)
study. Galia Tsarfaty, Sari Natan, Gal Alperovich, Eli Konen, Tammar Kushnir, Ilan Tsarfaty.