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Media Contacts: Pharmavite News Bureau (877) 866-2539 toll free [email protected] NATURE MADE® TRIPLEFLEX® FACT SHEET WHAT IS NATURE MADE TRIPLEFLEX? Nature Made TripleFlex is a line of non-prescription joint health products that may help the 46 million Americans who suffer from joint discomfort, nourish, cushion and strengthen their joints without any significant side effects. TRIPLEFLEX TRIPLE STRENGTH: ■ TripleFlex Triple Strength: Combines glucosamine, chondroitin and MSM in SCIENTIFIC SUPPORT FOR TRIPLEFLEX INGREDIENTS: Years of science support the ingredients used in TripleFlex products. Some key research includes: ■ A 202 patient, 3-year, randomized, placebo-controlled, double-blind study demonstrated that glucosamine retards the progression of cartilage damage. 1 ■ Glucosamine and chondroitin have been shown to enhance the protective response of chondrocytes, the cells that form cartilage, and may improve cartilage health. 2 ■ Key findings from the 2002 U.S. Department of Health and Human Services agency for Healthcare Research and Quality (AHRQ) titled “Evidence Report on S- Adenosylmethionine for Treatment in Depression, Osteoarthritis and Liver Diseases,” which reviewed more than 100 studies, concluded that SAM-e effectively provides joint comfort. 3 This report is available online at www.ahrq.gov. one convenient, triple strength formula. Triple Strength contains: ¾ Glucosamine, a naturally occurring compound found mainly in cartilage, stimulates the formation of cartilage, promoting joint comfort and flexibility ¾ Chondroitin cushions cartilage tissue to help relieve joint stress ¾ Methylsulfonylmethane (MSM) is a natural source of dietary sulfur. It plays an important role in maintaining elasticity and flexibility of the connective tissue that make up the joints. -more- DOSAGE: The Nature Made recommended daily dose of TripleFlex is two or three tablets daily Pavelka, K., Gatterova, J., Olejarova, M., et al. (2002) Glucosamine Sulfate Use and Delay of Progression of Knee Osteoarthritis. Arch Intern Med 162, 21132123. 2 Lippiello, L. (2003) Glucosamine and Chondroitin Sulfate: Biological Response Modifiers of Chondrocytes under Simulated Conditions of Joint Stress. Osteoarthritis and Cartilage 11, 335-342 3 Hardy, M, et al. (2002) S-Adenosyl-L-Methionine for Treatment of Depression, Osteoarthritis, and Liver Disease. AHRQ Publication 02-E034. 1 TripleFlex Fact Sheet Page 2 of 2 (depending on which product is used) with a meal. The tablets can be taken together or separately throughout the day. CONTRAINDICATIONS AND SIDE EFFECTS: Nature Made recommends individuals allergic to shellfish consult with a health care professional prior to taking TripleFlex. TripleFlex ingredients have no significant side effects. 4 5 They may safely be used in combination with over-the-counter and prescription NSAIDS and anti-inflammatories. WHERE TO BUY NATURE MADE TRIPLEFLEX: All TripleFlex products can be found at club, discount, drug and grocery retailers nationwide, including Costco, Sav-On, Target and Walgreens. ■ TripleFlex Triple Strength is available in 60-count tablets, for a suggested retail price of $18.99. WHY NATURE MADE TRIPLEFLEX? ■ TripleFlex is committed to supporting the Arthritis Foundation in helping people with arthritis enjoy active, mobile lives through education and research. That’s why TripleFlex is a proud sponsor of The Arthritis Walk of the Arthritis Foundation. To learn more and get involved in the Arthritis Walk, call 1-800283-7800 or visit www.arthritis.org. ■ Dr. Theodosakis recommends Nature Made TripleFlex in his book The Arthritis Cure – Revised Edition. CONSUMER QUESTIONS Consumers, pharmacists or other health professionals can learn more about Nature Made TripleFlex by calling the Nature Made information hotline, 1-800-276-2878, Monday through Friday from 7 a.m. to 4 p.m. PT or by visiting NatureMade.com. REGULATION OF TRIPLEFLEX The dietary supplement industry is regulated by the U.S. Food and Drug Administration and the Federal Trade Commission, as well as by government agencies in each of the 50 states. As a distributor/marketer of TripleFlex, Pharmavite (Nature Made) was required by the Dietary Safety, Health and Education Act (DSHEA) to submit safety data to the Food and Drug Administration before introducing the product. Nature Made would not have been allowed to market TripleFlex had FDA found it to be unsafe. ### 4 5 McAlindon, T., LaValley, M., Gulin, J., and Felson, D. (2000) Glucosamine and Chondroitin for Treatment of Osteoarthritis. JAMA 283:11, 1469-1475. Hardy, M, et al. (2002) S-Adenosyl-L-Methionine for Treatment of Depression, Osteoarthritis, and Liver Disease. AHRQ Publication 02-E034.
