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Indian Journal of Advances in Plant Research (IJAPR) www.ijapronline.com Vol. ( ): - ; ISSN: - Review Article Properties of traditional ayurvedic herbo-mineral formulation bhasma Acharya , P., Ranjan , R., Kirar , P., Srivastva , S. and Singh , P. * Samhita Siddhant Deptt. Govt.Ayurvedic College, Rewa M.P. Samhita Siddhanta Deptt. Sri Sai Ayurvedic Medical College, Aligarh U.P. Rog Nidan & Vikriti Vigyan Deptt. Sri Sai Ayurvedic Medical college, Aligarh U.P. Ayurvedic Medical Officer, C.H., Aligarh, U.P. *Corresponding Author: Dr. Pravanjan Acharya [email protected] Received: Accepted: Published: ABSTRACT In the Ayurvedic description, several metallic preparations are in clinical use since 12th century AD. They have specific methods for their detoxification and utilization in the form of bhasma which becomes suitable for clinical use in therapeutic doses. The uses of metal in ayurveda practicing from ancient time. There is strong faith in the fact that metal are very essential for maintaining physiological function of body. These metals can be administered as bhasma in nanonized form with other minerals and herbs. As per traditional ayurveda text bhasma are suggested to uses in various diseases like: heart problem, skin disease, as aphrodisiac agent and as rejuvenating agent. Recent research also established bhasma as potent antioxidant agent. The preparation and intake of bhasma is need to be special emphasize since overdose or excess quantity of any metal may cause lethal effect, thus they should prescribed with in therapeutic dose and prepared as per traditional authenticated text of ayurveda. Therefore this article involve a detailed discussion on various bhasma used for the treatment of different abnormal physiology of human body. Key Words: Herbo-mineral formulations, bhasma, marana, shodhana. INTRODUCTION In Ayurvedic system of medicine, there are three major classes of drugs belonging to plant, animal and mineral origin. Herbo-mineral formulations of ayurveda, constituting bhasma as an ingredient, are the superior forms of administration of nanomedicine. Rasashastra is a branch of Ayurveda known as the Ayurvedic metallurgy. These formulations take on different valence states and have different crystal structure and physical properties. It involves preparations of bhasma which prepared by process of Sodhana, Bhavana and Marana. Bhasmas are tiny enough, having nano size, to work into blood circulation imparting pharmacological efficacy to the Bhasma. Reduction in particle size facilitates absorption and assimilation of the Bhasma in the system (Sarkar and Chaudhary, 2010). Recent studies have claimed that the herbo-mineral formulations of Ayurveda constituting Bhasmas to be equivalent and in tune with nanotechnology (Virupaksha et al., 2011). The present study proved this. This physico-chemical characterization study will help in a reappraisal of Bhasma preparations (preparations, where herbs, minerals and metals are incinerated to ash under supervised conditions) as novel nano-technological applications giving a new thrust to Ayurvedic pharmaceutics. Utilization of metals and minerals of aquatic and soil Origin in ayurveda is the basis of bhasma. These metals and minerals after several process of purification and calcination forms nanosized fine powders as bhasma. Bhasmas are also referred as herbo-metallic preparations as they contain both metallic and herbal ingredients (Reddy, 2010). Swarna makshika Swarna makshika is a mineral having various therapeutic uses, has been used since long in Ayurveda. Swarna makshika used for the treatment of anemia, insomnia, convulsions, and for skin diseases (Sharma, 2004). It is also used as a single constituent formulation or in multi-ingredient formulation. Swarna makshika contains iron (Fe), Copper (Cu) and sulfur. Preparation: It is prepared in two steps- Indian J. Adv. Plant Res., Vol. ( ): www.ijapronline.com I) Shodhana: Involves different techniques like fomentation, heating and quenching and roasting. II) Marana: Application of puta system of heating in different types of putas, like varahaputa, kukkutaputa, gajaputa, it also involves utilization of lemon juice, kulottha decoction, eranda taila, snuhi ksheera (Chaudhary et al., 1998). Firstly Swarna makshika powdered in an iron mortar with an iron pestle. Then this powdered material poured into the heated iron pan and subjected to intense heat with frequent addition of lemon juice till it turned red. The process was completed in few days. For the Marana of Swarna makshika shuddha gandhaka and lemon juice used. Equal amounts of shuddha Swarna makshika and shuddha gandhaka triturated with lemon juice till a homogenous paste was formed. After triturating, small pellets of uniform size and thickness prepared and dried in sunlight. Pellets kept inside an earthen disc and another disc was inverted over it. The joint between the two discs was sealed with a rag and mud a ribbon of fine cloth uniformly smeared with fuller's earth and dried in sunlight. The properly sealed and dried samputa subjected to puta system of heating with cow dung cake. The process repeated using shuddha gandhaka in equal proportion to Swarna makshika for the first cycle and then in half the proportion for subsequent 8 cycles. Bhasma of the desired quality was obtained in 9 putas (Mohapatra and Jha, 2007). Tamra Bhasma It’s used for its rejuvenating and antioxidant property, it also having beneficial effect as aphrodiasic agent. It known to have properties of maintaining body circulation and tonicity. Preparation of Tamra bhasma Tamra bhasma prepared into 2 parts, purification of raw copper and bhasma preparation. For purification, copper turnings repeatedly heated to red hot condition and immediately quenched in different cold solvents in a sequence of Sessamum oil, butter milk, cow urine, sour gruel, decoction of Dolichos biflorus and juice of Oxalis orniculatum. This process repeated for 5 times in each solvent. For the bhasma preparation, equal quantity of purified copper, purified sulphur and purified mercury (Shodhit parad) were mixed. In the beginning, mercury and copper titrated with lemon juice to make the amalgam. Then equal ; ISSN: - quantity of sulphur added to it and again titrated till black fine powder formed. This powder heated in a glass bottle wrapped with seven layers of mud smeared cotton cloth by gradual rise in temperature in a thermostatic controlled muffle furnace. Next day bhasma collected from the bottom of the bottle and fine powder obtained and sieved (W.H.O., 1996). Fig. 2. Tamra Bhasma Abhraka Bhasma Abhraka Bhasma, a herbo-mineral product of Ayurveda acts as an tremendous antimicrobial agents. It acts as a synergistic agent, restoring the libido of men. Being a lifepromoting drug, it helps in procreation and synthesizes the sperms. It has a property of oleation. Abhraka Bhasma is called as a wonder drug due to its curative property in various ailments. Abhraka Bhasma is the Bhasma of the mineral, mica. It consist Fe as a major element and Ca, K and Si in low concentrations. Its synthesis involves repeated calcinations which transforms the metallic state into corresponding oxide form. Calcination involves repeated dasa puta (10 cycles), satha puta (100 cycles) and sahastra puta (1000 cycles), etc. This prompt calcinations provides fine scale particle sizes oof final product. Abhraka Bhasma is widely used for the treatment of hepatic dysfunction, leukemia, sex debility, azoospermia, cystic fibrosis, post encephalic dysfunction and cervical dysplasia (Mookerji, 2001). Fig. 3. Abhraka Bhasma Lauha Bhasma Lauha bhasma, an iron-based herbo-metallic preparation, is an Ayurvedic medicine prescribed for the treatment of anemia due to iron deficiency. It consisting of Fe2O3 and Fe3O4 the preparation of Lauha bhasma involves a Indian J. Adv. Plant Res., Vol. ( ): www.ijapronline.com rigorous procedure meant to convert the metal in to a fine, nontoxic and bio-available form. Preparation: The first stage in the preparation of Lauha bhasma involves a normal purification step by subjecting the raw material (iron) to heat treatments in various plant extracts and dairy products. This is followed by treating the purified material with herbal ingredients, in a special purification process, meant to detoxify the metal and incorporate specific therapeutic properties. Subsequently, calcination is performed to transform the material into the form of a fine powder that facilitates easy absorption (Anonymous, 2003). Fig. . Lauha Bhasma Hiraka Bhasma Hiraka bhasma synthesized from natural diamond is an important drug. It is an excellent remedy for heart troubles, heart pains, contraction of veins and blood clotting. It is also a powerful tonic and antitumor agent. It’s a carbon based drug. General Properties of Hiraka Bhasma Reddish in colour, partly soluble in water and sparingly soluble in organic solvents like chloroform and methanol. Its contains Carbon, Oxygen, Sodium, Magnesium, Aluminum, Silicon, Phosphorus, Sulfur Potassium, Calcium, Chromium and Iron. ; ISSN: - Preparation: Hiraka powder is heated in an iron ladle for a large number (approx. 108) of times. In this process diamond reacts with iron that after it triturated with plant juices (rose or aloe vera) and subjected to calcinations (Indian Meteria Medica K. M. Nadkarni, 1982). 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