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Donald Allen Thompson III (Trey) Volunteer Research Experience Academic Honors & Awards Education [email protected] CV last updated 7/31/2014 University of North Carolina at Chapel Hill, PhD student 2013-Present University of North Carolina at Chapel Hill, PharmD 2009-2013 North Carolina State University, Raleigh, NC, B.S. in Biochemistry 2005-2009 North Carolina School of Science and Mathematics, Durham, NC, Diploma 2003-2005 Pharmacy Network Foundation Scholarship Fred Lockwood Scholarship PharmD curriculum cumulative GPA 3.543 Degree honors: Distinction 3rd place essay: Integration of Pharmacokinetics into Community Practice Jeffry M. Jordan Scholarship Bachelors of Science in Biochemistry cumulative GPA 3.471 Degree honors: Cum Laude Dean’s list – five semesters 2012-2013 2011-2012 2009-2013 2011 2010-2011 2005-2009 Coinvestigator – Systematic Review University of North Carolina at Chapel Hill Primary Investigator Dr. Susan J. Blalock Employing techniques of a systematic review, five co-authors investigated correlations present in community pharmacy intervention publications. This is the first systematic review of exclusively community pharmacy-based interventions. August 2011-July 2012 Research Consultant Hamner Institute for Health Sciences Principle Investigator Dr. Tom O’Connell Utilizing 1D NMR analytic software to determine serum and urine metabolite variances in primate dams and offspring exposed to tobacco smoke. Metabolite variance was compared to existing histological evidence in the grey literature. Metabolomics analysis discontinued early in the project citing poor quality and validity in provided samples. January-March 2011 Student Researcher Hamner Institute for Health Sciences Principle Investigator Dr. Tom O’Connell Data mining metabolomics data from 72 human patients dosed with atorvastatin. Compared metabolites identified in serum samples to verify gene expression changes and clinical data. August 2010-December 2010 Donald Allen Thompson III (Trey) Publications Clinical Authorship Volunteer Research Experience [email protected] Research Consultant Hamner Institute for Health Sciences Principle Investigator Dr. Tom O’Connell Assessment of urine concentration variances from wild type control mice compared to knock out mutation of renal organic anion transporter 1. Comparative analysis of in vitro and ex vivo data to known metabolic pathways in conjunction with existing studies to postulate causal links to metabolic shifts. Undergraduate Research Assistant North Carolina State University Advisement of Dr. Scott Witherow Identification of an expressed chimera of M1 muscarinic receptor DNA leading to translation into a protein that interacts specifically with RGS7- β5. Alternatively, creation of an M3 receptor chimera, which would not interact with RGS7- β5 would verify region specificity. Successfully created a M1/M3 chimera using a novel overlap PCR approach. Manipulation of Recombinant DNA North Carolina State University Instruction of Dr. Sue Carson Introduction to recombinant DNA. Transfection of E. coli using egfp inserted into pET-41a(+) expression vectors. Confirmation of clone production by antibody probe, DNA probe, restriction analysis, PCR, and IPTG plating. Book Chapter: Status Epilepticus and Epilepsy Disorder Management A clinical handbook for informed formulary decisions Authors: Trey Thompson and Dr. Laura Enman Federal Medical Center Formulary March 2010-August 2010 May 2008-July 2008 January 2008-May 2008 November 2012 Remeron® for Sleep: The Relationship Between Mirtazapine Dose and Sedation Authors: Trey Thompson and Dr. J. Cameron Mitchell Central Regional Hospital Pharmacy Newsletter August 2012 The Effects of Community Pharmacy-Based Interventions on Patient Health Outcomes: A Systematic Review Authors: Susan J. Blalock, Andrew W. Roberts, Julie C. Lauffenburger, Trey Thompson, Shanna K. O’Connor Medical Care Research and Review 2012 Oct 21 [Epub] October 2012 Donald Allen Thompson III (Trey) Poster Presentations Papers in Preparation [email protected] Prototypical Anxiolytic Chlordiazepoxide Does Not Reduce Anxiety-like Behavior in C57BL/6J Mice Authors: Trey Thompson, Laura Grabowski-Boase, Lisa M. Tarantino In Preparation Cocaine Disposition and Behavior in Forty Five Inbred Mice Strains – A Pharmacokinetic and Pharmacodynamic Study Authors: Trey Thompson In Preparation Paradoxical Anxiogenic-like Effects of Chlordiazepoxide in Anxiety Tests in Inbred Mice UNC Chapel Hill – Psychiatry Research Day Authors: Trey Thompson, Laura Grabowski-Boase, Joseph Farrington, Lisa M. Tarantino Chapel Hill, NC November 2013 Paradoxical Anxiogenic-like Effects of Chlordiazepoxide in Anxiety Tests in Inbred Mice UNC Chapel Hill – 2013 Department of Genetics Retreat Authors: Trey Thompson, Laura Grabowski-Boase, Joseph Farrington, Lisa M. Tarantino Myrtle Beach, SC September 2013 Sleep Hygiene and Substances to Aid in Temporary Relief of Insomnia North Carolina State University – Healthy State Fair Authors: Trey Thompson Raleigh, NC April 2013 Teaching Neurocognitive Profile of Chronic Cannabis Users The International Society for CNS Clinical Trials and Methodology Authors: Trey Thompson, Alan Boyd, Dexter Morgan, Kevin Gray Poster Presentation – 9th Annual Scientific Meeting Washington, DC Diagnosis and Treatment of Psychiatric Disorders Case UNC Eshelman School of Pharmacy Class of 2015 Problems in Pharmacotherapy group case designed to elucidate considerations for diagnosis, initiation and continuation of treatments February 2013 April 2014 Donald Allen Thompson III (Trey) [email protected] Teaching Insomnia Diagnosis and Treatment SOAP note Recitation UNC Eshelman School of Pharmacy Class of 2016 Small group case discussion, nonpharmacotherapy and pharmacotherapeutic options for insomnia Hypertension Diagnosis and Treatment UNC Eshelman School of Pharmacy Class of 2015 Suggested solutions to a Problems in Pharmacotherapy course case, and review of relevant JNC8, and JACC guideline updates January 2014 Central Nervous System Physiology UNC Eshelman School of Pharmacy Class of 2017 Five lecture series to prepare and aquiant students with nervous system pathophysiology, therapeutic remedies, and side effects. October 2013 Software Infectious Disease SOAP note recitation UNC Eshelman School of Pharmacy Class of 2015 Small group recitation session Pharmacy Experience April 2014 August 2013 Phoenix WinNonlin (Intermediate) NONMEM (Begginner) Microsoft Excel (Intermediate-Advanced) SPSS (Intermediate) JMP (Intermediate) SAS (Intermediate) Clinical Pharmacist – Adult Diagnostic and Treatment Center University of North Carolina Chapel Hill Neurosciences Hospital Attending: Dr. James Jenson Advanced Community, Advanced Professional Pharmacy Experience (Honors) North Carolina State University Student Health Preceptor Ms. Myra Brickell Raleigh, NC Adult Acute Care, Advanced Professional Pharmacy Experience WakeMed Raleigh Campus Preceptor Dr. Jenna Minton Raleigh, NC June 2013-present April 2013 March 2013 Donald Allen Thompson III (Trey) [email protected] Pharmacy Experience Elective Research, Advanced Professional Pharmacy Experience (Honors) CNS Vital Signs LLC Preceptor Mr. Alan Boyd Cary, NC Advanced Hospital, Advanced Professional Pharmacy Experience (Honors) Federal Medical Center Preceptor LCDR Randy Seys Butner, NC Academic Teaching Elective, Advanced Professional Pharmacy Experience (Honors) UNC Eshelman School of Pharmacy Preceptor Dr. Adam Persky Chapel Hill, NC Community Ambulatory Care, Advanced Professional Pharmacy Experience (Honors) Wake County Human Services Preceptor Dr. Robert Dodge Raleigh, NC January 2013 November 2012 October 2012 September 2012 Clinical Specialty, Psychiatry I, Advanced Professional Pharmacy Experience (Honors) Central Regional Hospital Preceptor Dr. J Cameron Mitchell Butner, NC July 2012 Advanced Community, Advanced Professional Pharmacy Experience Johnson’s Family Pharmacy Preceptor Dr. Mary Margaret Johnson Raleigh, NC June 2012 Compounding, Advanced Professional Pharmacy Experience (Honors) Triangle Compounding Pharmacy Preceptor Dr. Wendy Hagwood Cary, NC May 2012 Donald Allen Thompson III (Trey) Pharmacy Experience [email protected] Community Introductory Professional Pharmacy Experience (Honors) Dee’s Drug Store Preceptor Dr. James Wilson Burgaw, NC May 2011 Hospital Introductory Professional Pharmacy Experience (Honors) Columbus Regional Healthcare System Preceptor Dr. Brian Jenkins Whiteville, NC May 2010 Select Presentations Time Management for Pharmacy Students Alumni speaker for Phi Delta Chi Alpha Gamma chapter High-Attenuating Anti-Retroviral Therapy Illicit street use of ritonivir leads to extreme, sometimes lethal levels of recreational drugs Betablockers in Hypertension Use of cocaine recreationally can conflict with goals of betablocker therapy November 2013 April 2013 March 2013 Once a Day or More Monitoring – Aminoglycosides Federal Medical Center pharmacists. Exploring Once Daily Aminoglycoside pharmacokinetics and toxicity. November 2012 Hyperexcitability – Targets for AntiEpileptic Drugs Federal Medical Center pharmacy and practitioner audience to discuss formulary options to optimize safe patient care in epilepsy and status epilepticus November 2012 Truvada Prophylaxis PK reveals adherence Wake County Health Department staff and practitioners reviewed pivotal trials for tenofovir/emtricitabine approval for prophylaxis revealing <4 days/week adherence September 2012 Clinical Pearl – Mirtazapine Dosing for Insomnia CRH Pharmacy, focus differentiating inverse dose-dependency to elicit sleep. Supported by primary literature review. July 2012 Donald Allen Thompson III (Trey) Select Presentations Select Presentations [email protected] Drug-Induced Pancreatitis, a Patient Case Presentation Schizophrenia, epilepsy, and bipolar topic and pharmacotherapy. Specific case etiology and course of therapy presented to an interdisciplinary audience at Central Regional Hospital. July 2012 Topic Presentation: Schizophrenia Introduction to psychiatric patient treatment highlighting schizophrenia DSM-IV diagnostic traits, presentation and course of therapy guidance. July 2012 Journal Club: The BALANCE trial Small group presentation of a landmark bipolar therapy choice differentiation. July 2012 Porter’s Liniment – A Natural Product Independent pharmacy staff and students reviewing key components contributing to the perceived efficacy for a multitude of uses of an older natural product. June 2012 Elelyso™ (Taliglucerase Alfa) New drug update and brief review of Gaucher’s Disease, the kinetics of enzyme supplementation, and trials for approval. June 2012 Journal Club: Intramuscular versus Intravenous Therapy for Prehospital Status Epilepticus Presentation of emergent treatment standard of care compared to midazolam intramuscular autoinjector. June 2012 Antipsychotics and Neuroleptic Malignant Syndrome – Does Potency Matter? Primary literature review supplemented by prior associated theories presentation to a psychiatry elective audience. Chemistry of Metabolic Transformations Differential analysis of clinical relevance derived from identified and putative metabolites of omeprazole, gefitinib, diltiazem, laterperdin. Presented to the Metabolism 810 class. March 2012 September 2011 Donald Allen Thompson III (Trey) Select Presentations Select Presentations [email protected] “Dee’s Drug” Planogram and Remodeling Item selection and suggestions were individualized to specific retail traffic at the practice site. Approximately 1/3 of the interior storefront was repurposed. May 2011 Silenor® (doxepin hydrochloride) New drug update, transition of a tricyclic antidepressant to be used as a sedating histamine H1 antagonist for hypnotic qualities. March 2011 Diabetic Nephropathy Continuing Education on pharmaceutical applications to identify, slow, and slow progression of end stage renal disease. May 2010 Lyrica® (pregabalin) Innovative drug continuing education for Pharmacy staff and interns at Columbus Regional Healthcare System. May 2010 Inhalants – Aerodynamic Parameter and Particle Deposition A two-part presentation to serve as a refresher and inject new vitality into the Pulmonary staff of Columbus Regional Healthcare System. May 2010 Pulmozyme® (dornase alfa) Biochemical derivation and physiologic mechanism of action presented to an audience of Advanced Biochemistry students. April 2010 Soy Isoflavones Complementary and alternative medicine opportunities presented to pharmacy students enrolled in Pharmaceutical Care lab. November 2009 DNA Replication Mechanism Lecture and demonstration given to students taking the course Biochemistry of Gene Expression. November 2008 Photoreceptors to Interpret the Energy Expenditure of the NCSU Nuclear Reactor Model and findings presented to introduction to engineering students and faculty. November 2005 Donald Allen Thompson III (Trey) Select Presentations [email protected] Investment Strategies for Successful Short-Course Profitability Summary presentation from Financial Investment and Money Management mini-term. Presented as validation of methods used to recover more than invested over a two-week investment period using only $1000 as a start-up. March 2005 Lego or Reprogram Mini-term robotics topic discussion presented to NCSSM students and faculty. Project to extend introductory robotics course material to more complex tasks performed by programmable Legos™. March 2004 Meetings UNC Genetics Department Annual Retreat International Society for CNS Clinical Trials and Methodology (ISCTM) Annual Scientific Meeting American Society of Health-System Pharmacists (ASHP) Midyear Meeting Work Experience September 2013 Property Manager Smart Properties of Minnesota; previously independently operated Durham, NC Student Technology Assistance Resource Univ. North Carolina at Chapel Hill Chapel Hill, NC Contract Editor American Journal Experts Durham, NC Travelling Tutor Independently owned and operated Raleigh/Durham/Cary/Wake Forest, NC Travelling Tutor Educational Enrichment Raleigh, NC February 2013 December 2012 August 2009-Present August 2009-May 2012 November 2010-December 2011 December 2011-May 2012; December 2008-March 2010 May 2008-December 2008 Donald Allen Thompson III (Trey) Work Experience [email protected] Administrative Coordinator North Carolina State University Housing Raleigh, NC August 2007-May 2008 Technology Product Specialist Circuit City Burnsville, MN June 2007-August 2007 Resident Advisor North Carolina State University Housing Raleigh, NC February 2006-May 2007 Independent Sales Contractor Southwestern Company Seaford, DE Awards & Achievements Volunteer Consultant Smart Properties of Minnesota, LLC Burnsville, MN Chadsford Homeowner’s Association – Vice President Chadsford Homeowner’s Association – compliance officer Durham, NC Therapeutic visitation companion Compassionate Options for Progressive Eldercare Raleigh/Durham/Cary, NC February 2006-August 2006 December 2011-Present March 2014-Present July 2013-Present August 2009-May 2012 Emergency Preparedness Evaluator Emergency Preparedness Competition Loris, SC June 2010 Exemplary Brother Award (Phi Delta Chi) East Campus Programmer of the Year (NCSU) Southwestern Co. Top 15 first-year sales x5 weeks Southwestern Co. Success Coin April 2010 2006/2007 2006 2006 Donald Allen Thompson III (Trey) Tests Tests Organizations [email protected] Phi Delta Chi Webmaster Re-founder Alpha Gamma chapter American Society of Health-System Pharmacists UNC Pharmacy Honor Court member AHEC Placement Overview Committee Biochemistry Club Resident Advisor Liaison to the Quad Area Hall Council Quad Area Hall Council Administrative Coordinator Advisor Biochemistry Seminar Series Participant Quad Area Hall Council November 2009-Present November 2009-May 2012 January 14th 2010 July 2012-July 2014 August 2009-May 2012 August 2011-May 2012 August 2006-May 2009 August 2007-May 2008 August 2007-May 2008 August 2006-May 2007 February 2006-May 2007 General Record Exam (GRE) Verbal Reasoning Quantitative Reasoning Analytical Writing Score 162 160 5.0 Percentile 89 81 92 Pharmacy College Admission Test (PCAT) Verbal ability Biology Reading Comprehension Quantitative Ability Chemistry Composite Score 445 460 414 437 431 437 Percentile 96 98 71 93 89 96