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Company Profile
Vifor Pharma
The most effective partner for contract
development and manufacturing.
Contract development and
contract manufacturing offer
a challenging environment for
Vifor’s talented pharmaceutical
technologists, and enables the
company to use its diversified
equipment for the production of
medium-sized order volumes.
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To ensure speedy delivery times
and the development of innovative
products, Vifor Pharma can rely on
the following expertise:
A Customised Contract
Development Approach
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Fulfilment of high GMPquality standards (EU and FDA
requirement) certification through
a corporate quality management
system ; QA interaction based on
quality agreement
A development team, centrally
managed from Switzerland,
taking advantage of a multicultural background and
experience
Three manufacturing facilities
based in Switzerland and
Portugal for oral and topical
product ranges
Skilled employees, Swiss
precision, strong technical
capabilities and a high level
through commitment of
relatively small, yet efficient
teams at each individual site, for
a great flexibility and a strong,
customer service orientated
The formulation team ensures the
product development at laboratory
and pilot scale, based on a DoE
approach. They perform industrial
scale-up and process validation,
including manufacture of clinical
material.
Efficient containment solutions are
proposed, such as preservative-free
sprays, biphasic system, blisters
with inert gas and aluminium-/aluminium blisters.
The analytical team develops,
validates and transfers analytical
methods and manages ICH stability
studies.
The development team offers a
large spectrum of customised
services from preliminary
formulation to regulatory
submission. The scope of activities
is essentially pharmaceutical oral
and topical formulations with key
strengths in the following areas:
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Solid dosage forms with
sustained release, enhanced
control by use of micro-tabs, oneday delivery and gastro-resistance
Liquid formulations with
attractive flavours, enhanced
stability and paediatric
formulation
Micro-Tablet
Regulatory support is offered for
the preparation and submission of
product registration files. Specific
expertise includes development
of a complete CTD technical
documentation (modules 2.3
and 3). The company shows a
large knowledge in regulatory
requirements for: drug and
product (EU), medical devices,
nutraceuticals, cosmetics, and
can also provide support for
submission and notification to the
relevant authorities.
Key Niche Applications
Images: Vifor Pharma
Micro-Tablet
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This modern technology presents
many technical advantages (high
flexibility of drug load, immediate
or modified release, functional
coating) and clinical advantages
(gastro-intestinal tolerance) with a
comparable level of manufacturing
productivity equal to regular
tablets. This multi-particulate form
also enables a comfortable intake
for the patient.
Innovations in Pharmaceutical Technology Issue 42
Biphasic System
Biphasic System
Specific filling equipment fills
powder or granulate into cap
of bottle containing liquid
formulation as a single dose
container approach. Consumer
friendly designed, this device
brings the formulation some
of the essential benefits of
enhanced stability profile
of API and can prevent
incompatibility issues between
two APIs or components that are
physically segregated until the
reconstitution of the solution
for intake.
Dropper Tube
This innovative packaging for
liquid formulation is designed
for precise dose of intake or
a replacement for traditional
packaging for drops. The
solution is filled into tubes
equipped with a dropper
assembled on a speciallydesigned tube filling equipment,
enabling a switch from semisolid to liquid filling.
Dropper Tubes
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Well-Established Liquid
and Semi-Solid Forms
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Solid Dosage Form:
a Wide Range of Capabilities
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Wet and dry granulation is
available to prepare final
blends from pilot scale to
industrial batch size
Tablets, micro-tablets are
produced on automated presses
for regular and matrix tablets.
Sustained release profile are
obtained by film-coating on
various coating pans
Last generation fillers enable
the filling of capsules with
powder or two different
components (volumetric
dosage, 100 per cent weightcheck). A unique equipment
fills caps with a solid
component (powder or
granulate, pellets, microtablets) before closing the
bottles filled with liquid
Blistering operations are done
on lines equipped with the
most recent technologies
and enable individual cell
identification
Pot filling is done for capsules,
tablets and soft gel capsules
into plastic pots
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Innovations in Pharmaceutical Technology Issue 42
Solution and suspension
having high sugar alcohol
content are manufactured in
different equipment size and
under controlled conditions
Filling of solutions,
suspensions and emulsions
is carried out on flexible lines
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with full control of the
packaging operations (barcode
scanners, on-line weighing and
optical control)
Semi-solid: a wide range
of equipment enables the
manufacture and package
of gel, ointment cream,
suppositories, paste and
enema with the highest
level of control
Company History
Vifor Pharma is a Switzerland-based pharmaceutical
company belonging to the Galenica Group since 1977.
Mainly active in formulation development, the production
and commercialization of Rx and OTC pharmaceutical
products, Vifor Pharma covers the Swiss and a part of the
European market. Focused on expanding internationally
by establishing new relationships with selected partners,
Vifor Pharma accentuates the customized development
of new products of the highest pharmaceutical standard.
To find out more, please visit the company’s stand
at CPhI/ICSE, in Madrid from the 9th to 11th October,
Hall 10, Stand 10A02
Or contact:
Vifor Ltd
Route de Moncor 10, PO Box
CH-1752 Villar-sur-Glâne, Switzerland
Phone: +41 (0)58 851 6111
Fax: +41 (0)58 851 6050
Web: www.viforpharma.ch
Email: [email protected]
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