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company profile
Med-Pharmex, Inc. was incorporated in 1983, with the purpose
of manufacturing quality generic human and veterinary drug products.
The main strength of the company is its technical expertise in the
areas of pharmaceutical manufacturing, formulation and research and
development. With this expertise, it is possible to develop specialized
products for the pharmaceutical market and get them approved
by the U.S. Food and Drug Administration.
To date, Med-Pharmex has specialized in the veterinary market.
This includes products for companion animals, such as dogs, cats and
horses, and food-producing animals such as cattle, swine and poultry.
Med-Pharmex, Inc. is represented by some of the largest veterinary
distributors in the U.S. and has a complete national (U.S.) coverage in its
distribution. Internationally, Med-Pharmex, Inc. has a presence
in several foreign countries.
The company is committed to continued development of newer products
and to serve the veterinary community with a complete line of quality
generic products at a reasonable cost.
table of contents
Betagen® Topical Spray..........................2-3
Derma-Vet® Ointment....................... 4-5
Tri-Otic® Ointment.............................. 6-7
Miconosol® Lotion/Spray 1%.............. 8-9
Vet Beta•gen® Otic Solution............. 10-11
CEFTIFLEX ®. ................................... 12-13
Iver•On®............................................ 14-15
IVERSOL.......................................... 16-17
Ivermectin Paste 1.87%.................. 18
Buta-Vet™ Paste............................... 19
Euthanasia-III Solution..................... 20
Atropine Sulfate............................. 21
Dexpanthenol................................. 21
Dexamethasone Solution................ 22
Lidocaine......................................... 22
Thiamine.......................................... 23
Vitamin C......................................... 23
Vitamin B-12.................................... 24
Lincosol Soluble Powder................... 25
Neosol•Oral..................................... 26
Neosol Soluble Powder..................... 27
Sulfasol Soluble Powder.................... 28
Sulforal............................................. 29
Tetrasol Soluble Powder................... 30-31
Udder Balm..................................... 32
C-M-P-K .......................................... 33
Pect Plus......................................... 33
CONVEY®. ........................................ 34
Vet-o-lyte®. ...................................... 35
Nutri Lyte Powder +...................... 35
Med-Pharmex’s Calf Energy........ 36
Med-Pharmex’s Red Ribbon........ 37
KAO-PECTIN.................................... 38
Bismuth Suspension..................... 38
1
COMPANION
antibiotic
Broad-spectrum antibiotic for effective treatment
of canine bacterial skin disorders
Betagen Topical Spray
®
Gentamicin Sulfate with Betamethasone Valerate
Betagen® Topical Spray delivers a solid one-two punch
with the unparalleled combination of two active ingredients.
1
2
Gentamicin a broad spectrum
antibiotic with not less than 500 mcg
of gentamicin base per milligram.
Betamethasone­a potent
corticosteriod which provides
strong anti-inflammatory
and antipruritic activity.
Betagen®
Topical Spray—
clearly the product
of choice for
treating infected
superficial lesions
in dogs.
ANADA #200-188, Approved by FDA.
®
Betagen Topical Spray
TOXICITY: Gentamicin sulfate with betamethasone valerate topical
spray was well tolerated in an abraded skin study in dogs. No
treatment-related toxicological changes in the skin were observed.
(GENTAMICIN SULFATE WITH BETAMETHASONE VALERATE)
Veterinary
For Topical Use in Dogs Only
CAUTION: Federal law restricts this drug to use by or on the order
of a licensed veterinarian.
Systemic effects directly related to treatment were confined to
histological changes in the adrenals, liver, and kidney and to
organ-to-body weight ratios of adrenals. All were dose related,
were typical for or not unexpected with corticosteroid therapy, and
were considered reversible with cessation of treatment.
DESCRIPTION: Each mL contains: gentamicin sulfate equivalent
to 0.57 mg gentamicin base, betamethasone valerate equivalent
to 0.284 mg betamethasone, 163 mg isopropyl alcohol, propylene
glycol, methylparaben and propylparaben as preservatives, purified
water q.s. Hydrochloric acid may be added to adjust pH.
SIDE EFFECTS: Side effects such as SAP and SGPT enzyme
elevations, weight loss, anorexia, polydipsia, and polyuria have
occurred following parenteral or systemic use of synthetic
corticosteroids in dogs. Vomiting and diarrhea (occasionally
bloody) have been observed in dogs.
CHEMISTRY: Gentamicin is a mixture of aminoglycoside
antibiotics derived from the fermentation of Micromonospora
purpurea. Gentamicin sulfate is a mixture of sulfate salts of the
antibiotics produced in this fermentation. The salts are weakly
acidic and freely soluble in water.
Cushings syndrome in dogs has been reported in association with
prolonged or repeated steroid therapy.
PRECAUTIONS: Antibiotic susceptibility of the pathogenic
organism(s) should be determined prior to the use of this
preparation. Use of topical antibiotics may permit overgrowth of
non-susceptible bacteria, fungi, or yeasts. If this occurs, treatment
should be instituted with other appropriate agents as indicated.
Gentamicin sulfate contains not less than 500 micrograms of
gentamicin base per milligram.
Betamethasone valerate is a synthetic glucocorticoid.
PHARMACOLOGY: Gentamicin, a broad-spectrum antibiotic, is
a highly effective topical treatment for bacterial infections of the
skin. In vitro, gentamicin is bactericidal against a wide variety of
gram-positive and gram-negative bacteria isolated from domestic
animals.1,2 Specifically, gentamicin is active against the following
organisms isolated from canine skin: Alcaligenes sp., Citrobacter
sp., Klebsiella sp., Pseudomonas aeruginosa, indole-positive
and negative Proteus sp., Escherichia coli, Enterobacter sp.,
Staphylococcus sp., and Streptococcus sp.
Betamethasone valerate emerged from intensive research as the
most promising of some 50 newly synthesized corticosteroids in
the experimental model described by McKenzie3, et al. This human
bioassay technique has been found reliable for evaluating the
vasoconstrictor properties of new topical corticosteroids and is
useful in predicting clinical efficacy.
Betamethasone valerate in veterinary medicine has been shown
to provide anti-inflammatory and antipruritic activity in the topical
management of corticosteroid-responsive infected superficial
lesions in dogs.
WARNING: Clinical and experimental data have demonstrated
that corticosteroids administered orally or parenterally to animals
may induce the first stage of parturition when administered during
the last trimester of pregnancy and may precipitate premature
parturition followed by dystocia, fetal death, retained placenta,
and metritis.
Additionally, corticosteroids administered to dogs, rabbits and
rodents during pregnancy have produced cleft palate. Other
congenital anomalies including deformed forelegs, phocomelia,
and anasarca have been reported in offspring of dogs which
received corticosteroids during pregnancy.
CONTRAINDICATIONS: If hypersensitivity to any of the
components occurs, treatment with this product should be
discontinued and appropriate therapy instituted.
2
Administration of recommended dose beyond 7 days may result in
delayed wound healing. Animals treated longer than 7 days should
be monitored closely.
Avoid ingestion. Oral or parenteral use of corticosteroids,
depending on dose, duration, and specific steroid may result
in inhibition of endogenous steroid production following drug
withdrawal.
In patients presently receiving or recently withdrawn from
systemic corticosteroid treatments, therapy with a rapidly acting
corticosteroid should be considered in especially stressful
situations.
If ingestion should occur, patients should be closely observed
for the usual signs of adrenocorticoid overdosage which include
sodium retention, potassium loss, fluid retention, weight gains,
polydipsia, and/or polyuria. Prolonged use or overdosage may
produce adverse immunosuppressive effects.
HOW SUPPLIED: Plastic spray bottle containing 60 mL, 120 mL
or 240 mL of Betagen® Topical Spray.
Store upright between 2°C and 30°C (36°F and 86°F).
REFERENCES:
1. Hennessey, PW, et al. In vitro activity of gentamicin against
bacteria isolated from domestic animals. Veterinary Medicine/
Small Animal Clinician. November 1971; 1118-1122.
2. Bachmann, HJ, et al: Comparative in vitro activity of gentamicin
and other antibiotics against bacteria isolated from clinical
samples from dogs, cats, horses, and cattle. Veterinary
Medicine/Small Animal Clinician. October 1975; 1218-1222.
3. McKenzie, HW and Atkinson, RM: Topical activities of
betamethasone esters in man. Arch Derm. 1964; 19:741-746.
Med-Pharmex, Inc., Pomona, CA 91767
April 1999
INDICATIONS: For the treatment of infected superficial lesions in
dogs caused by bacteria sensitive to gentamicin.
Available in 60 mL, 120 mL, and
240 mL plastic spray bottle.
ANIMALS
DOSAGE AND ADMINISTRATION: Prior to treatment, remove
excessive hair and clean the lesion and adjacent area. Hold bottle
upright 3 to 6 inches from the lesion and depress the sprayer
head twice. Administer 2 to 4 times daily for 7 days.
Each depression of the sprayer head delivers 0.7 mL of Betagen®
Topical Spray.
NET CONTENTS:
60 mL
120 mL
240 mL
3
NDC
54925-028-60
54925-028-12
54925-028-24
COMPANION
By virtue of its 4 active ingredients, the ointment provides 4 basic therapeutic
effects: anti-inflammatory, antipruritic, antifungal and antibacterial
antibiotic
Derma-Vet Ointment
®
Nystatin
Neomycin Sulfate
Thiostrepton
Triamcinolone
Acetonide
4
Combining four active ingredients to treat:
• acute and chronic ear infection
• interdigital cysts in cats and dogs
• anal gland infections in dogs
• moist or dry dermatologic disorders
characterized by inflammation from bacterial,
and candidal infections, as well as from
contact, eczematous, seborrheic
and parasitic (ear mites)
dermatitis.
Through its four
active ingredients,
Derma-Vet®
Ointment
provides four basic
therapeutic effects:
anti-inflammatory,
antipruritic, antifungal
and antibacterial.
Dema-Vet Ointment
®
NYSTATIN, NEOMYCIN SULFATE, THIOSTREPTON AND TRIAMCINOLONE
ACETONIDE OINTMENT
For Use Only in Dogs and Cats
CAUTION: Federal law restricts this drug to use by or on the order of a
licensed veterinarian.
DESCRIPTION: Nystatin, neomycin sulfate, thiostrepton and triamcinolone
acetonide ointment in a non-irritating vehicle, a polyethylene and mineral
oil gel base.
Shake well before using.
Each mL contains:
Nystatin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 100,000 Units
Neomycin Sulfate (equivalent to neomycin base) . . . . . 2.5 mg.
Thiostrepton . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2,500 Units
Triamcinolone Acetonide . . . . . . . . . . . . . . . . . . . . . . . . 1.0 mg.
In a polyethylene and mineral oil gel base.
Nystatin, neomycin sulfate, thiostrepton and triamcinolone acetonide
ointment is supplied in tubes of 1/4 fl. oz. (7.5 mL.), 1/2 fl. oz. (15 mL.),
and 1 fl. oz. (30 mL.), each with an elongated tip for easy application and
in dispensing bottles of 8 fl. oz. (240 mL.). The preparation is intended
for local therapy in a variety of cutaneous disorders of cats and dogs; it
is especially useful in disorders caused, complicated or threatened by
bacterial and/or candidal (monilial) infections.
Sensitivity to neomycin may occur. If redness, irritation or swelling persists
or increases, discontinue use. Do not use if pus is present since the drug
may allow the infection to spread. Keep this and all medications out of the
reach of children.
Avoid ingestion. Oral or parenteral use of corticosteroids (depending on
dose, duration of use, and specific steroid) may result in inhibition of
endogenous steroid production following drug withdrawal.
SIDE EFFECTS: SAP and SGPT (ALT) enzyme elevations, polydypsia/
polyuria, vomiting, and diarrhea (occasionally bloody) have been observed
following parenteral or systemic use of synthetic corticosteroids in dogs.
Cushing’s syndrome has been reported in association with prolonged or
repeated steroid therapy in dogs.
Temporary hearing loss has been reported in conjunction with treatment
of otitis with products containing corticosteroids. However, regression
usually occurred following withdrawal of the drug. If hearing dysfunction
is noted during the course of treatment with nystatin, neomycin sulfate,
thiostrepton and triamcinolone acetonide ointment, discontinue its use.
ACTIONS: By virtue of its four active ingredients, the ointment provides
four basic therapeutic effects: anti-inflammatory, antipruritic, antifungal
and antibacterial. Triamcinolone acetonide is a potent synthetic
corticosteroid providing rapid and prolonged symptomatic relief on topical
administration. Inflammation, edema and pruritus promptly subside and
lesions are permitted to heal. Nystatin is the first well tolerated antifungal antibiotic of dependable efficacy for the treatment of cutaneous
infections caused by Candida albicans (monilia). Nystatin is fungistatic
in vitro against a variety of yeast and yeast-like fungi including many
fungi pathogenic to animals. No appreciable activity is exhibited against
bacteria. Thiostrepton has a high order of activity against gram-positive
organisms, including many which are resistant to other antibiotics;
neomycin exerts antimicrobial action against a wide range of grampositive and gram-negative bacteria. Together they provide comprehensive
therapy against those organisms responsible for most superficial bacterial
infections.
CAUTION: Before instilling any medication into the ear, examine the
external ear canal thoroughly to be certain the tympanic membrane is not
ruptured in order to avoid the possibility of transmitting infection to the
middle ear as well as damaging the cochlea or vestibular apparatus from
prolonged contact. If hearing or vestibular dysfunction is noted during the
course of treatment, discontinue the use of nystatin, neomycin sulfate,
thiostrepton and triamcinolone acetonide ointment.
DOSAGE AND ADMINISTRATION: Frequency of administration is
dependent on the severity of the condition. For mild inflammations,
application may range from once daily to once a week; for severe
conditions nystatin, neomycin sulfate, thiostrepton and triamcinolone
acetonide ointment may be applied as often as two to three times daily,
if necessary. Frequency of treatment may be decreased as improvement
occurs.
Wear gloves during the administration of the ointment or wash hands
immediately after application.
INDICATIONS: Nystatin, neomycin sulfate, thiostrepton and triamcinolone
acetonide ointment is particularly useful in the treatment of acute and
chronic otitis of varied etiologies, in interdigital cysts in cats and dogs,
and in anal gland infections in dogs. The preparation is also indicated in
the management of dermatologic disorders characterized by inflammation
and dry or exudative dermatitis, particularly those caused, complicated,
or threatened by bacterial or candidal (Candida albicans) infections. It is
also of value in eczematous dermatitis; contact dermatitis and seborrheic
dermatitis; and as an adjunct in the treatment of dermatitis due to
parasitic infestation.
OTITIS: Clean ear canal of impacted cerumen. Inspect canal and remove
any foreign bodies such as grass awns, ticks, etc. Instill three to five drops
of nystatin, neomycin sulfate, thiostrepton and triamcinolone acetonide
ointment.
WARNING: Clinical and experimental data have demonstrated that
corticosteroids administered orally or by injection to animals may induce
the first stage of parturition if used during the last trimester of pregnancy
and may precipitate premature parturition followed by dystocia, fetal
death, retained placenta and metritis.
OTHER DERMATOLOGIC DISORDERS: Clean affected areas, removing
any encrusted discharge or exudate. Apply nystatin, neomycin sulfate,
thiostrepton and triamcinolone acetonide ointment sparingly in a thin film.
Additionally, corticosteroids administered to dogs, rabbits, and rodents
during pregnancy have resulted in cleft palate in the offspring. In dogs,
other congenital anomalies have resulted; deformed forelegs, phocomelia,
and anasarca.
4
ANIMALS
There is some evidence that corticosteroids can be absorbed after
topical application and cause systemic effects. Therefore, an animal
receiving nystatin, neomycin sulfate, thiostrepton and triamcinolone
acetonide ointment therapy should be observed closely for signs such
as polydipsia, polyuria, and increased weight gain. Nystatin, neomycin
sulfate, thiostrepton and triamcinolone acetonide ointment is not generally
recommended for the treatment of deep or puncture wounds or serious
burns.
NADA #140-810, Approved by FDA.
PRECAUTIONS: Nystatin, neomycin sulfate, thiostrepton and triamcinolone acetonide ointment is not intended for the treatment of deep abscesses or deep-seated infections such as inflammation of the lymphatic
vessels. Parenteral antibiotic therapy is indicated in these infections.
Nystatin, neomycin sulfate, thiostrepton and triamcinolone acetonide
ointment has been extremely well tolerated. Cutaneous reactions
attributable to its use have been extremely rare. The occurrence of
systemic reactions is rarely a problem with topical administration.
Preliminary use of a local anesthetic such as Proparacaine Hydrochloride
Ophthalmic Solution may be advisable.
INFECTED ANAL GLANDS, CYSTIC AREAS, ETC: Drain gland or cyst
and then fill with nystatin, neomycin sulfate, thiostrepton and triamcinolone
acetonide ointment.
STORAGE:
240 mL. bottle. Do not store above 86°F. 7.5 mL, 15 mL, 30 mL
tubes: Store at room temperature; avoid excessive heat (104°F).
Manufactured by Med-Pharmex, Inc., Pomona, CA 91767
Revised October 1998
NET CONTENTS:
7.5 mL (1/4 fl. oz.)
15 mL (1/2 fl. oz.)
30 mL (1 fl. oz.)
240 mL (8 fl. oz.)
5
NDC
54925-003-75
54925-003-15
54925-003-30
54925-003-40
COMPANION
antibiotic
Antibacterial, anti-inflammatory and antifungal combine
to combat canine ear infections.
Tri-Otic Ointment
®
3
Three active ingredients for antibacterial,
anti-inflammatory and antifungal protection.
betamethasone valerate
gentamicin sulfate
clotrimazole
Tri-Otic® Ointment is
an effective triple
combination steroid,
antibacterial and
antifungal treatment
that works together to
combat painful canine
ear infections. Indicated
for the treatment of acute and
chronic infections associated with
yeast (Malassezia pachydermatis,
formerly Pityrosporum canis) and/or
bacteria susceptible to gentamicin.
Available in 7.5 g and
15 g Tubes, and 10 g, 15 g,
25 g and 215 g Bottles
ANADA #200-229, Approved by FDA
Tri-Otic Ointment
®
GENTAMICIN SULFATE, USP BETAMETHASONE VALERATE, USP AND
CLOTRIMAZOLE, USP OINTMENT
Veterinary
For Otic Use in Dogs Only
CAUTION: Federal law restricts this drug to use by or on the order
of a licensed veterinarian.
Keep this and all drugs out of the reach of children.
DESCRIPTION: Each gram of Tri-Otic® Ointment contains gentamicin sulfate,
USP equivalent to 3 mg gentamicin base; betamethasone valerate, USP
equivalent to 1 mg betamethasone; and 10 mg clotrimazole, USP in a mineral
oil-based system containing a plasticized hydrocarbon gel.
PHARMACOLOGY:
Gentamicin: Gentamicin sulfate is an aminoglycoside antibiotic active
against a wide variety of pathogenic gram-negative and gram-positive
bacteria. In vitro tests have determined that gentamicin is bactericidal and
acts by inhibiting normal protein synthesis in susceptible microorganisms.
Specifically, gentamicin is active against the following organisms commonly
isolated from canine ears: Staphylococcus aureus, other Staphylococcus spp.,
Pseudomonas aeruginosa, Proteus spp., and Escherichia coli.
Betamethasone: Betamethasone valerate is a synthetic adrenocorticoid
for dermatologic use. Betamethasone, an analog of prednisolone, has a high
degree of corticosteroid activity and a slight degree of mineralocorticosteroid
activity. Betamethasone valerate, the 17-valerate ester of betamethasone,
has been shown to provide anti-inflammatory and anti-pruritic activity in
the topical management of corticosteroid-responsive otitis externa. Topical
corticosteroids can be absorbed from normal, intact skin. Inflammation can
increase percutaneous absorption. Once absorbed through the skin, topical
corticosteroids are handled through pharmacokinetic pathways similar to
systemically administered corticosteroids.
Clotrimazole: Clotrimazole is a broad-spectrum antifungal agent that is
used for the treatment of dermal infections caused by various species of
pathogenic dermatophytes and yeasts. The primary action of clotrimazole
is against dividing and growing organisms. In vitro, clotrimazole exhibits
fungistatic and fungicidal activity against isolates of Trichophyton rubrum,
Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum
canis, Candida spp. and Malassezia pachydermatis (Pityrosporum canis).
Resistance to clotrimazole is very rare among the fungi that cause
superficial mycoses. In an induced otitis externa infected with Malassezia
pachydermatis, 1% clotrimazole in the Tri-Otic® Ointment vehicle was
effective both microbiologically and clinically in terms of reduction of exudate
odor and swelling. In studies of the mechanism of action, the minimum
fungicidal concentration of clotrimazole caused leakage of intracellular
phosphorus compounds into the ambient medium with concomitant
breakdown of cellular nucleic acids and accelerated potassium efflux. These
events began rapidly and extensively after addition of the drug. Clotrimazole is
very poorly absorbed following dermal application.
Tri-Otic® Ointment: By virtue of its three active ingredients, gentamicinbetamethasone-clotrimazole ointment has antibacterial, anti-inflammatory,
and antifungal activity. In component efficacy studies, the compatibility and
additive effect of each of the components were demonstrated. In clinical field
trials, gentamicin-betamethasone-clotrimazole was effective in the treatment
of otitis externa associated with bacteria and Malassezia pachydermatis.
Gentamicin sulfate, USP Betamethasone valerate, USP and Clotrimazole,
USP ointment reduced discomfort, redness, swelling, exudate, and odor, and
exerted a strong antimicrobial effect.
INDICATIONS: Tri-Otic® Ointment is indicated for the treatment of
canine acute and chronic otitis externa associated with yeast (Malassezia
pachydermatis, formerly Pityrosporum canis) and/or bacteria susceptible to
gentamicin.
CONTRAINDICATIONS: If hypersensitivity to any of the components occurs,
treatment should be discontinued and appropriate therapy instituted.
Concomitant use of drugs known to induce ototoxicity should be avoided. Do
not use in dogs with known perforation of eardrums.
6
WARNINGS: The use of Tri-Otic® Ointment has been associated with
deafness or partial hearing loss in a small number of sensitive dogs (eg.
geriatric). The hearing deficit is usually temporary. If hearing or vestibular
dysfunction is noted during the course of treatment, discontinue use of
gentamicin-betamethasone-clotrimazole ointment immediately and flush
the ear canal thoroughly with a non-ototoxic solution. Corticosteroids
administered to dogs, rabbits, and rodents during pregnancy have resulted
in cleft palate in offspring. Other congenital anomalies including deformed
ANIMALS
forelegs, phocomelia, and anasarca have been reported in offspring of dogs
which received corticosteroids during pregnancy.
Clinical and experimental data have demonstrated that corticosteroids
administered orally or parenterally to animals may induce the first stage of
parturition if used during the last trimester of pregnancy and may precipitate
premature parturition followed by dystocia, fetal death, retained placenta
and metritis.
PRECAUTIONS: Identification of infecting organisms should be made either
by microscopic roll smear evaluation or by culture as appropriate. Antibiotic
susceptibility of the pathogenic organism(s) should be determined prior to use
of this preparation.
If overgrowth of nonsusceptible bacteria, fungi or yeasts occur, or if
hypersensitivity develops, treatment should be discontinued and appropriate
therapy instituted. Administration of recommended doses of Tri-Otic®
Ointment beyond 7 days may result in delayed wound healing. Avoid
ingestion. Adverse systemic reactions have been observed following the
oral ingestion of some topical corticosteroid preparations. Patients should
be closely observed for the usual signs of adrenocorticoid overdosage
which include sodium retention, potassium loss, fluid retention, weight
gain, polydipsia and/or polyuria. Prolonged use or overdosage may produce
adverse immunosuppressive effects. Use of corticosteroids, depending
on dose, duration, and specific steroid, may result in endogenous steroid
production inhibition following drug withdrawal. In patients presently receiving
or recently withdrawn from corticosteroid treatments, therapy with a rapidly
acting corticosteroid should be considered in especially stressful situations.
Before instilling any medication into the ear, examine the external ear canal
thoroughly to be certain the tympanic membrane is not ruptured in order
to avoid the possibility of transmitting infection to the middle ear as well as
damaging the cochlea or vestibular apparatus from prolonged contact.
TOXICOLOGY: Clinical and safety studies with Gentamicin sulfate, USP
Betamethasone valerate, USP and Clotrimazole, USP ointment have
shown a wide safety margin at the recommended dose level in dogs (see
PRECAUTIONS/SIDE EFFECTS).
SIDE EFFECTS:
Gentamicin: While aminoglycosides are absorbed poorly from skin,
intoxication may occur when aminoglycosides are applied topically for
prolonged periods of time to large wounds, burns, or any denuded skin,
particularly if there is renal insufficiency. All aminoglycosides have the
potential to produce reversible and irreversible vestibular, cochlear and renal
toxicity.
Betamethasone: Side effects such as SAP and SGPT enzyme elevations,
weight loss, anorexia, polydipsia, and polyuria have occurred following the
use of parenteral or systemic synthetic corticosteroids in dogs. Vomiting
and diarrhea (occasionally bloody) have been observed in dogs and cats.
Cushing’s syndrome in dogs has been reported in association with prolonged
or repeated steroid therapy.
Clotrimazole: The following have been reported occasionally in humans
in connection with the use of clotrimazole: erythema, stinging, blistering,
peeling, edema, pruritus, urticaria, and general irritation of the skin not
present before therapy.
DOSAGE AND ADMINISTRATION: The external ear should be thoroughly
cleaned and dried before treatment. Remove foreign material, debris, crusted
exudates, etc., with suitable non-irritating solutions. Excessive hair should
be clipped from the treatment area. After verifying that the eardrum is intact,
instill 4 drops (2 drops from the 215 g bottle) of gentamicin-betamethasoneclotrimazole ointment twice daily into the ear canal of dogs weighing less
than 30 lbs. Instill 8 drops (4 drops from the 215 g bottle) twice daily into
the ear canal of dogs weighing 30 lbs or more. Therapy should continue for
7 consecutive days.
HOW SUPPLIED: Tri-Otic® Ointment is available in 7.5 gram and 15 gram
tubes as well as in 10 gram, 15 gram, 25 gram and 215 gram plastic bottles.
Store between 2° and 25°C (36° and 77°F).
Shake well before use when using the 215 gram bottle.
Med-Pharmex, Inc., Pomona, CA 91767
January 2001
NET CONTENTS:
7.5 g Tube
15 g Tube
10 g Bottle
15 g Bottle
25 g Bottle
215 g Bottle
7
NDC
54925-032-75
54925-032-15
54925-032-10
54925-032-45
54925-032-25
54925-032-40
COMPANION
antifungal
Effective treatment of fungal infections in dogs and cats
caused by the three major dermatophytes
Miconosol
®
Lotion/Spray 1%
Miconazole Nitrate
Safe and soothing treatment
for fungal skin and ear infections
as well as ringworm
in dogs and cats.
ANADA #200-196, Approved by FDA
ANADA #200-196, Approved by FDA
(MICONAZOLE NITRATE)
(MICONAZOLE NITRATE)
Miconosol® Lotion 1%
Topical antifungal agent for dogs and cats
DESCRIPTION: MICONOSOL (miconazole nitrate) Lotion
is a synthetic antifungal agent for use in dogs and cats.
It contains: 1.15% miconazole nitrate (equivalent to 1%
miconazole base by weight), polyethylene glycol 400 and ethyl
alcohol 55%.
DESCRIPTION: MICONOSOL (miconazole nitrate) Spray
is a synthetic antifungal agent for use in dogs and cats.
It contains: 1.15% miconazole nitrate (equivalent to 1%
miconazole base by weight), polyethylene glycol 400 and ethyl
alcohol 55%.
INDICATIONS: MICONOSOL (miconazole nitrate) Lotion is
indicated for the treatment of fungal infections in dogs and
cats caused by Microsporum canis, Microsporum gypseum
and Trichophyton mentagrophytes.
INDICATIONS: MICONOSOL (miconazole nitrate) Spray is
indicated for the treatment of fungal infections in dogs and
cats caused by Microsporum canis, Microsporum gypseum
and Trichophyton mentagrophytes.
PRECAUTIONS: In the event of sensitization or irritation due
to MICONOSOL Lotion, treatment should be discontinued.
Avoid contact with eyes, since irritation may result. Wash
hands thoroughly after administration to avoid spread of
fungal infection.
PRECAUTIONS: In the event of sensitization or irritation due
to MICONOSOL Spray, treatment should be discontinued.
Avoid contact with eyes, since irritation may result. Wash
hands thoroughly after administration to avoid spread of
fungal infection.
DOSAGE AND ADMINISTRATION: Accurate diagnosis of
the infecting organism is essential. Identification should be
made either by direct microscopic examination of a mounting
of infected tissue in a solution of potassium hydroxide, or by
culture on an appropriate medium.
DOSAGE AND ADMINISTRATION: Accurate diagnosis of
the infecting organism is essential. Identification should be
made either by direct microscopic examination of a mounting
of infected tissue in a solution of potassium hydroxide, or by
culture on an appropriate medium.
Apply a light covering of MICONOSOL (miconazole nitrate)
Lotion to affected areas, once daily, for 2 to 4 weeks.
Application is best accomplished using a gauze pad or cotton
swab. Medication must be continued until the infecting
organism is completely eradicated as indicated by appropriate
clinical or laboratory examination. If no improvement is
noticed within 2 weeks, diagnosis should be re-evaluated.
Difficult cases may require treatment for 6 weeks.
Spray affected areas from a distance of 2 to 4 inches to
apply a light covering, once daily for 2 to 4 weeks. Medication
must be continued until the infecting organism is completely
eradicated as indicated by appropriate clinical or laboratory
examination. If no improvement is noticed within 2 weeks,
diagnosis should be re-evaluated. Difficult cases may require
treatment for 6 weeks.
HOW SUPPLIED: MICONOSOL (miconazole nitrate) Lotion in
60 mL containers.
CAUTION: Federal law restricts this drug to use by or on the
order of a licensed veterinarian.
August 1997
NET CONTENTS:
60 mL
8
animals
General measures in regard to hygiene should be observed
to control sources of infection or reinfection. Clipping of hair
around and over the sites of infection should be done at the
start of treatment and again as necessary.
HOW SUPPLIED: MICONOSOL (miconazole nitrate) Spray in
120 mL and 240 mL containers.
CAUTION: Federal law restricts this drug to use by or on the
order of a licensed veterinarian.
August 1997
Med-Pharmex Inc., Pomona, CA 91767
Med-Pharmex, Inc., Pomona, CA 91767
small
Miconosol® Spray 1%
Topical antifungal agent for dogs and cats
General measures in regard to hygiene should be observed
to control sources of infection or reinfection. Clipping of hair
around and over the sites of infection should be done at the
start of treatment and again as necessary.
Available in 60 mL lotion
dropper bottle and 120 mL and
240 mL spray bottles
ANIMALS
NDC
54925-031-06
NET CONTENTS:
120 mL
240 mL
9
NDC
54925-031-12
54925-031-24
COMPANION
antibiotic
Broad-spectrum antibiotic for effective treatment of canine
otitis externa and canine and feline superficial infected lesions
caused by bacteria sensitive to gentamicin.
Vet Beta•gen® Otic Solution
Gentamicin Sulfate with Betamethasone Valerate
the vasoconstrictor properties of new topical corticosteroids and is
useful in predicting clinical efficacy.
ANADA #200-183, Approved by FDA.
For Use in Dogs and Cats Only.
CAUTION: Federal law restricts this drug to use by or on the order
of a licensed veterinarian.
DESCRIPTION: Vet Beta•gen® Otic Solution is packaged in a
convenient plastic squeeze bottle for easy application. Each mL
of Vet Beta•gen® Otic Solution contains gentamicin sulfate
equivalent to 3 mg gentamicin base, betamethasone valerate
equivalent to 1 mg betamethasone, 1.0 mg hydroxyethylcellulose,
2.5 mg glacial acetic acid, 200 mg purified water, 19% ethanol,
9.4 mg benzyl alcohol as preservative, 300 mg glycerin and propylene glycol q.s.
CHEMISTRY: Gentamicin is a bactericidal antibiotic of the aminoglycoside group derived from Micromonospora purpurea of the
Actinomyces group. It is a powder, white to buff in color, basic in
nature, readily soluble in water and highly stable in solution.
Betamethasone valerate is a synthetic corticosteroid derivative of
prednisolone.
ACTION: Vet Beta•gen® Otic Solution combines the broadspectrum activity of gentamicin sulfate with the anti-inflammatory
and antipruritic activity of betamethasone valerate. In vitro
antibacterial activity1 has shown that gentamicin is active against
most gram-negative bacteria including Pseudomonas aeruginosa,
indole-positive and negative proteus sp., Escherichia coli, Klebsiella pneumoniae, Aerobacter aerogenes, and Neisseria. Gentamicin
is also active against strains of gram-positive bacteria including
Staphylococcus species and some Streptococcus species.
Betamethasone valerate has emerged from intensive research as
the most promising of some 50 newly synthesized corticosteroids
in the experimental model described by McKenzie2 et al. This
human bioassay technique has been found reliable for evaluating
Betamethasone valerate in human medicine has been shown to
provide anti-inflammatory and antipruritic activity in the topical
management of corticosteroid-responsive dermatoses. In the
responsive cases, the local anti-inflammatory activity is sustained
by the vasoconstrictor properties of the steroid.
TOXICITY STUDIES: Parenterally, no toxic effects were observed
in rats given gentamicin sulfate 20 mg/kg/day for twenty-four
days; in cats given 10 mg/kg/day for forty days. Gentamicin
sulfate given to dogs at 6 mg/lb/day, 6 days weekly for three
weeks, caused no detectable kidney damage. At higher doses,
impairment of equilibrium and of renal function were observed in
these species.
Subacute otic toxicity study in dogs showed Vet Beta•gen® Otic
Solution to be well tolerated locally with no adverse systemic
effects when administered 5 drops twice a day for 21 consecutive days.
Gentamicin sulfate solution in a 21-day subacute dermal toxicity
study in dogs was shown to be well tolerated when applied topically to abraded skin. There were no meaningful findings except
a reduction in eosinophil count attributable to absorption of the
corticosteroid component.
INDICATIONS: Vet Beta•gen® Otic Solution is indicated for the
treatment of acute and chronic canine otitis externa and canine
and feline superficial infected lesions caused by bacteria sensitive
to gentamicin.
DOSAGE AND ADMINISTRATION: Duration of treatment will
depend upon the severity of the condition and the response
obtained. The duration of treatment and/or frequency of the dosage may be reduced, but care should be taken not to discontinue
therapy prematurely.
Otitis externa – The external ear and ear canal should be properly cleaned and dried before treatment. Remove foreign material,
debris, crusted exudates, etc., with suitable nonirritating solutions.
Excessive hair should be clipped from the treatment area of the
external ear. Instill 3 to 8 drops of Vet Beta•gen™ Otic Solution
(approximately room temperature) into the ear canal twice daily for
seven to fourteen days.
Superficial infected lesions – The lesion and adjacent area
should be properly cleaned before treatment. Excessive hair
should be removed. Apply a sufficient amount of Vet Beta•gen®
Otic Solution to cover the treatment area twice daily for seven to
fourteen days.
CONTRAINDICATIONS: If hypersensitivity to any of the components occurs, treatment with this product should be discontinued
and appropriate therapy instituted.
Concomitant use of drugs known to induce ototoxicity should be
avoided.
This preparation should not be used in conditions where corticosteroids are contraindicated.
Do not administer parenteral corticosteroids during treatment with
Vet Beta•gen® Otic Solution.
PRECAUTIONS: The antibiotic sensitivity of the pathogenic organism should be determined prior to the use of this preparation.
Use of topical antibiotics occasionally allows overgrowth of nonsusceptible bacteria, fungi, or yeasts. In these cases, treatment
should be instituted with other appropriate agents as indicated.
Adverse systemic reactions have been observed following the oral
ingestion of some topical corticosteroid preparations. Patients
should be closely observed for the usual signs of adrenocorticosteroid overdosage which include sodium retention, potassium
loss, fluid retention, weight gains, polydipsia and/or polyuria.
Prolonged use or overdosage may produce adverse immunosuppressive effects.
ANIMALS
and anasarca have been reported in offspring of dogs which
received corticosteroids during pregnancy.
Avoid ingestion.
SIDE EFFECTS: Side effects such as SAP and SGPT enzyme
elevations, weight loss, anorexia, polydipsia, and polyuria have
occurred following the use of parenteral or systemic synthetic
corticosteroids in dogs. Vomiting and diarrhea (occasionally
bloody) have been observed in dogs and cats.
Cushing’s Syndrome in dogs has been reported in association
with prolonged or repeated steroid therapy.
HOW SUPPLIED: Vet Beta•gen® Otic Solution, squeeze
bottles of 7.5 mL, 15 mL, and 240 mL (8 fl oz.).
Store between 2°C and 25°C (36°F and 77°F).
REFERENCES:
1. Weinstein, M.J., Leudemann, G.M., Oden, E.M., and
Wagman, G.H.: Gentamicin, a new broad-spectrum antibiotic
complex. Antimicrobial Agents and Chemotherapy, 1963, pp. 1-7.
2. McKenzie, A.W., and Atkinson, R.M.: Topical activities of
betamethasone esters in man. Arch Derm. 1964; 19:741-746.
Manufactured by Med-Pharmex, Inc. Pomona, CA 91767
May 1996
NET CONTENTS:
7.5 mL
15 mL
240 mL
Experimentally it has been demonstrated that corticosteroids,
especially at high dosage levels, may result in delayed wound
healing. An increase in the incidence of osteoporosis may be
noted, mainly in the elderly, with prolonged use of these compounds. Their use in older dogs during the healing stages of
bone fracture is not indicated for the reason listed above. Use of
corticosteroids, depending on dose, duration, and specific steroid,
may result in inhibition of endogenous steroid production following drug withdrawal. In patients presently receiving or recently
withdrawn from systemic corticosteroid treatments, therapy with
a rapidly acting corticosteroid should be considered in unusually
stressful situations.
CAUTION: Before instilling any medication into the ear, examine the external ear canal thoroughly to be certain the tympanic
membrane is not ruptured in order to avoid the possibility of
transmitting infection to the middle ear as well as damaging
the cochlea or vestibular apparatus from prolonged contact. If
hearing or vestibular dysfunction is noted during the course of
treatment, discontinue use of Vet Beta•gen® Otic Solution.
Available in 7.5 mL, 15 mL
and 240 mL sizes.
WARNING: Clinical and experimental data have demonstrated
that corticosteroids administered orally or parenterally to
animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death,
retained placenta, and metritis. Additionally, corticosteroids can
induce cleft palates in offspring when given to pregnant animals during the period of palate closure of the embryos. Other
congenital anomalies including deformed forelegs, phocomelia,
10
11
NDC
54925-026-75
54925-026-15
54925-026-40
ANADA #200-420, Approved by FDA
antibiotic
Proven Formulation. Trusted Brand.
Ceftiflex
®
(ceftiofur sodium sterile powder)
Available in 1 gram
and 4 gram vials.
Ceftiflex® contains the sodium salt of ceftiofur which is a broad spectrum cephalosporin antibiotic active against
gram-positive and gram-negative bacteria including β-lactamase-producing strains. Like other cephalosporins, ceftiofur is bactericidal in vitro, resulting from inhibition of cell wall synthesis.
Each mL of the reconstituted drug contains ceftiofur sodium equivalent to 50 mg ceftiofur. The pH was adjusted with
sodium hydroxide and monobasic potassium phosphate.
Ceftiflex® Indications:
• Cattle Ceftiflex® is indicated for treatment of bovine respiratory disease (shipping fever, pneumonia)
associated with Mannheimia haemolytica, Pasteurella
multocida and Histophilus somni. Ceftiofur Sodium
Sterile Powder is also indicated for treatment of acute
bovine interdigital necrobacillosis (foot rot, pododermatitis) associated with Fusobacterium necrophorum
and Bacteroides melaninogenicus.
• Swine Ceftiflex® is indicated for treatment/control
of swine bacterial respiratory disease (swine bacterial pneumonia) associated with Actinobacillus (Haemophilus) pleuropneumoniae, Pasteurella multocida,
Salmonella choleraesuis and Streptococcus suis.
• Sheep Ceftiflex® is indicated for treatment of sheep
respiratory disease (sheep pneumonia) associated with
Mannheimia haemolytica and Pasteurella multocida.
• Goat Ceftiflex® is indicated for treatment of caprine
respiratory disease (goat pneumonia) associated with
Mannheimia haemolytica and Pasteurella multocida.
• Horses Ceftiflex® is indicated for treatment of respiratory infections in horses associated with Streptococcus zooepidemicus.
• Dogs Ceftiflex® is indicated for the treatment of
canine urinary tract infections associated with Escherichia coli and Proteus mirabilis.
12
small
animals
CEFTIFLEX
®
(ceftiofur sodium sterile powder)
For intramuscular and subcutaneous injection in cattle only. For
intramuscular injection in swine, sheep, goats, and horses. For
subcutaneous injection only in dogs. This product may be used in
lactating dairy cattle, sheep, and goats.
CAUTION: Federal USA law restricts this drug to use by or on the order of a licensed
veterinarian.
DescriptioN
Ceftiflex® contains the sodium salt of ceftiofur which is a broad spectrum
cephalosporin antibiotic active against gram-positive and gram-negative bacteria including β-lactamase-producing strains. Like other cephalosporins, ceftiofur
is bactericidal in vitro, resulting from inhibition of cell wall synthesis.
Each mL of the reconstituted drug contains ceftiofur sodium equivalent to
50 mg ceftiofur. The pH was adjusted with sodium hydroxide and monobasic
potassium phosphate.
Shake thoroughly prior to use.
Reconstitution of the sterile powder: Ceftiflex® should be reconstituted
as follows:
1 gram vial- Reconstitute with 20 mL Sterile Water for Injection. Each mL of
the resulting solution contains ceftiofur sodium equivalent to 50 mg ceftiofur.
4 gram vial- Reconstitute with 80 mL Sterile Water for Injection. Each mL of
the resulting solution contains ceftiofur sodium equivalent to 50 mg ceftiofur.
INDICATIONS
Cattle Ceftiflex® is indicated for treatment of bovine respiratory disease (shipping fever, pneumonia) associated with Mannheimia haemolytica, Pasteurella
multocida and Histophilus somni. Ceftiofur Sodium Sterile Powder is also
indicated for treatment of acute bovine interdigital necrobacillosis (foot rot,
pododermatitis) associated with Fusobacterium necrophorum and Bacteroides
melaninogenicus.
Swine Ceftiflex® is indicated for treatment/control of swine bacterial respiratory disease (swine bacterial pneumonia) associated with Actinobacillus (Haemophilus) pleuropneumoniae, Pasteurella multocida, Salmonella choleraesuis
and Streptococcus suis.
Sheep Ceftiflex® is indicated for treatment of sheep respiratory disease (sheep
pneumonia) associated with Mannheimia haemolytica and Pasteurella multocida.
Goat Ceftiflex® is indicated for treatment of caprine respiratory disease (goat
pneumonia) associated with Mannheimia haemolytica and Pasteurella multocida.
Horses Ceftiflex® is indicated for treatment of respiratory infections in horses
associated with Streptococcus zooepidemicus.
Dogs Ceftiflex® is indicated for the treatment of canine urinary tract infections
associated with Escherichia coli and Proteus mirabilis.
DOSAGE AND ADMINSTRATION
Cattle Administer to cattle by intramuscular or subcutaneous injection at the
dosage of 0.5 to 1.0 mg ceftiofur per pound (1.1 to 2.2 mg/kg) of body weight
(1-2 mL reconstituted sterile solution per 100 lbs body weight). Treatment should
be repeated at 24-hour intervals for a total of three consecutive days. Additional
treatments may be given on days four and five for animals which do not show a
satisfactory response (not recovered) after the initial three treatments. Selection of
dosage (0.5 to 1.0 mg/lb) should be based on the practitioner’s judgement of severity of disease (i.e., for respiratory disease, extent of elevated body temperature,
depressed physical appearance, increased respiratory rate, coughing and /or loss
of appetite; and for foot rot, extent of swelling, lesion and severity of lameness).
Swine Administer to swine by intramuscular injection at the dosage of 1.36 to
2.27 mg ceftiofur per pound (3.0 to 5.0 mg/kg) of body weight (1 mL of reconstituted sterile solution per 22 to 37 lbs body weight). Treatment should be repeated
at 24-hour intervals for a total of three consecutive days.
Sheep Administer to sheep by intramuscular injection at the dosage of 0.5 to 1.0
mg ceftiofur per pound (1.1 to 2.2 mg/kg) of body weight (1-2 mL reconstituted
sterile solution per 100 lbs body weight). Treatment should be repeated at 24-hour
intervals for a total of three consecutive days. Additional treatments may be given
on days four and five for animals which do not show a satisfactory response (not
recovered) after the initial three treatments. Selection of dosage (0.5 to 1.0 mg/lb)
should be based on the practitioner’s judgment of severity of disease (i.e., extent
of elevated body temperature, depressed physical appearance, increased respiratory rate, coughing and/or loss of appetite).
Goat Administer to goats by intramuscular injection at the dosage of 0.5 to 1.0
mg ceftiofur per pound (1.1 to 2.2 mg/kg) of body weight (1-2 mL reconstituted
sterile solution per 100 lbs body weight). Treatment should be repeated at 24-hour
intervals for a total of three consecutive days. Additional treatments may be given
on days four and five for animals which do not show a satisfactory response (not
recovered) after the initial three treatments. Selection of dosage (0.5 to 1.0 mg/
lb) should be based on the practitioner’s judgment of severity of disease (i.e.,
extent of elevated body temperature, depressed physical appearance, increased
respiratory rate, coughing and/or loss of appetite). Pharmacokinetic data indicate
that elimination of the drug is more rapid in lactating does. For lactating does, the
high end of the dose range is recommended.
Horses Administer to horses by intramuscular injection at the dosage of
1.0 to 2.0 mg ceftiofur per pound (2.2 to 4.4 mg/kg) of body weight (2-4 mL
reconstituted sterile solution per 100 lbs body weight). A maximum of 10 mL
may be administered per injection site. Treatment should be repeated at 24-hour
intervals, continued for 48 hours after clinical signs have disappeared and should
not exceed 10 days.
Dogs Administer to dogs by subcutaneous injection at the dosage of 1.0 mg
ceftiofur per pound (2.2 mg/kg) of body weight (0.1 mL reconstituted sterile
solution per 5 lbs body weight). Treatment should be repeated at 24-hour intervals
for 5-14 days.
Reconstituted CEFTIFLEX® is to be administered to dogs by subcutaneous injection. No vial closure should be entered more than 20 times. Therefore, only the 1
gram vial is approved for use in dogs.
CONTRAINDICATIONS
As with all drugs, the use of Ceftiflex® is contraindicated in animals previously
found to be hypersensitive to the drug.
WARNINGS
NOT FOR HUMAN USE. KEEP OUT OF REACH OF CHILDREN.
Penicillins and cephalosporins can cause allergic reactions in sensitized
individuals. Topical exposures to such antimicrobials, including ceftiofur,
may elicit mild to severe allergic reactions in some individuals. Repeated
or prolonged exposure may lead to sensitization. Avoid direct contact of the
product with the skin, eyes, mouth, and clothing.
Persons with a known hypersensitivity to penicillin or cephalosporins
should avoid exposure to this product.
In case of accidental eye exposure, flush with water for 15 minutes. In
case of accidental skin exposure, wash with soap and water. Remove
contaminated clothing. If allergic reaction occurs (e.g., skin rash, hives,
difficult breathing), seek medical attention.
The material safety data sheet contains more detailed occupational safety
information. To obtain a material safety data sheet (MSDS) please call
1-909-392-8900. To report any adverse event please call 1-909-392-8900.
RESIDUE WARNINGS:
Cattle: When used according to label indications, dosage and routes of
administration, treated cattle must not be slaughtered for 4 days following the
last treatment. When used according to label indications, dosage and routes of
administration, a milk discard time is not required. Use of dosages in excess
of those indicated or by unapproved routes of administration, such as
intramammary, may result in illegal residues in edible tissues and/
or in milk.
Swine: When used according to label indications, dosage and route of
administration, treated pigs must not be slaughtered for 4 days following
the last treatment. Use of dosages in excess of those indicated or by
unapproved routes of administration may result in illegal residues in
edible tissues.
Sheep: Neither a pre-slaughter drug withdrawal interval nor a mild discard time
is required when this product is used according to label indications, dosage,
and route of administration. Use of dosages in excess of those indicated
or by unapproved routes of administration, such as intramammary,
may result in illegal residues in edible tissues and/or in milk.
Goats: Neither a pre-slaughter drug withdrawal interval nor a milk discard time
is required when this product is used according to label indications, dosage,
and route of administration. Use of dosages in excess of those indicated
or by unapproved routes of administration, such as intramammary,
may result in illegal residues in edible tissues and/or in milk.
Horses: Do not use in horses intended for human consumption.
PRECAUTIONS The effects of Ceftiflex® on the reproductive performance,
pregnancy, and lactation of cattle, swine, sheep, and goats have not been
determined.
Cattle Following subcutaneous administration of ceftiofur sodium in the neck,
small areas of discoloration at the site may persist beyond five days, potentially
resulting in trim loss of edible tissues at slaughter.
As with any parenteral injection, localized post-injection bacterial infections may
result in abscess formation. Attention to hygienic procedures can minimize their
occurrence.
Swine The safety of Ceftiflex® has not been determined for swine intended for
breeding.
Horses The safety of Ceftiflex® has not been determined for horses intended for
breeding. The administration of antimicrobials to horses under conditions of stress
may be associated with acute diarrhea that could be fatal. If acute diarrhea is
observed, discontinue use of this antimicrobial and initiate appropriate therapy.
Dogs The safety of Ceftiflex® has not been determined for dogs intended for
breeding, or pregnant dogs.
ADVERSE REACTIONS The use of CEFTIFLEX® may result in some sign of
immediate and transient local pain to the animal.
STORAGE CONDITIONS Store unreconstituted product at controlled room
temperature 20˚ to 25˚ C (68˚ to 77˚ F) [see USP].
Store reconstituted product either in a refrigerator 2˚ to 8˚ C (36˚ to 46˚ F) for up
to 7 days or at controlled room temperature 20˚ to 25˚ C (68˚ to 77˚ F) [see USP]
for up to 12 hours. Protect from light. Color may vary from off-white to a tan color.
Color does not affect potency.
one-time salvage procedure for reconstituted product
At the end of the 7-day refrigeration or 12-hour room temperature storage period
following reconstitution, any remaining reconstituted product may be frozen for up
to 8 weeks without loss in potency or other chemical properties. This is a one-time
only salvage procedure for the remaining product. To use this salvaged product
at any time during the 8-week storage period, hold the vial under warm running
water, gently swirling the container to accelerate thawing, or allow the frozen
material to thaw at room temperature. Rapid freezing or thawing may result in vial
breakage. Any product not used immediately upon thawing should be discarded.
NET CONTENTS:
1 gram vial
4 gram vial
Revised May 2009
13
NDC
54925-082-01
54925-082-04
I V E R M E C T I N
parasiticide
Broad Spectum Coverage–Kills Internal
and External Parasites (inhibited Ostertagia)
®
Ivermectin Pour-On for Cattle
ANADA #200-299, Approved by FDA.
Contains 5 mg ivermectin/mL
Parasiticide
Consult your veterinarian for assistance in the
diagnosis, treatment and control of parasitism.
INTRODUCTION
Ivermectin Pour-On® delivers internal and external parasite
control in one convenient low-volume application. Ivermectin
Pour-On contains ivermectin, a unique chemical entity.
INDICATIONS
Ivermectin Pour-On applied at the recommended dose level
of 500 mcg/kg is indicated for the effective treatment and
control of these parasites:
Gastrointestinal Roundworms: Ostertagia ostertagi (including inhibited stage) (adults and L4), Haemonchus placei (adults
and L4), Trichostrongylus axei (adults and L4), T. colubrifomis
(adults and L4), Cooperia oncophora (adults and L4), Cooperia
punctata (adults and L4), Cooperia surnabada (adults and L4),
Strongyloides papillosus (adult), Oesophagostomum radiatum
(adults and L4), and Trichuris spp. (adult)
Lungworms: Dictyocaulus viviparus (adults and L4)
Cattle Grubs: Hypoderma bovis, H. lineatum (parasitic
stages)
Mites: Sarcoptes scabiei var. bovis
Available in 250 mL bottle,
1 Liter bottle with a squeeze-measure-pour system,
2.5 Liter and 5 Liter collapsible pack container intended
for use with appropriate automatic dosing equipment.
Lice: Linognathus vituli, Haematopinus eurysternus,
Damalinia bovis, Solenopotes capillatus
Horn Flies: Haematobia irritans
PERSISTENT ACTIVITY
Ivermectin Pour-On has been proved to effectively control
infections and to protect cattle from re-infection with:
Oesophagostomum radiatum and Dictyocaulus viviparus for 28
days after treatment; Cooperia punctata and Trichostrongylus
axei for 21 days after treatment; Ostertagia ostertagi, Haemonchus placei, Cooperia oncophora and Cooperia surnabada
for 14 days after treatment; Damalinia bovis for 56 days after
treatment.
Treatment of Cattle for Horn Flies
Ivermectin Pour-On controls horn flies (Haematobia irritans) for
up to 28 days after dosing. For best results Ivermectin Pour-On
should be part of a parasite control program for both internal
14
and external parasites based on the epidemiology of these
parasites. Consult your veterinarian or an entomologist for the
most effective timing of applications.
DOSAGE
The dose rate is 1 mL for each 22 lb of body weight. The
formulation should be applied along the topline in a narrow
strip extending from the withers to the tailhead.
ADMINISTRATION
Squeeze-Measure-Pour System
(8.5 fl. oz/250 mL Bottle with 25 mL Measuring Cup)
Measure the amount of solution to be used, at the dose of 1
mL for each 22 lb of body weight into a measuring cup. When
body weight is between markings use the higher setting. Tilt
the measuring cup to deliver the dose.
Squeeze-Measure-Pour System
(33.8 fl. oz/1 L Bottle with 25 mL Measuring Cup)
Measure the amount of solution to be used, at the dose of 1
mL for each 22 lb of body weight into a measuring cup. When
body weight is between markings use the higher setting. Tilt
the measuring cup to deliver the dose.
Collapsible Pack
(84.5 fl. oz/2.5 L Pack and 169 fl oz/5 L Pack)
Connect the applicator gun to the collapsible pack as follows:
Attach the open end of the draw-off tubing to dosing equipment. Replace the shipping cap with the draw-off cap and
tighten down. Attach draw-off tubing to the draw-off cap.
Gently prime the applicator gun, checking for leaks.
Follow the manufacturer’s directions for adjusting the dose.
When the interval between uses of the applicator gun is
expected to exceed 12 hours, disconnect the gun and draw-off
tubing from the product container and empty the product from
the gun and tubing back into the product container. To prevent
removal of special lubricants from the applicator gun, the gun
and tubing must not be washed.
MODE OF ACTION
Ivermectin as a member of the macrocylic lactone class of
endectocides which have a unique mode of action. Compounds
of the class bind selectively and with high affinity to glutamategated chloride ion channels which occur in invertebrate nerve
and muscle cells. This leads to an increase in the permeability
of the cell membrane to chloride ions with hyperpolarization of
the nerve or muscle cell, resulting in paralysis and death of the
parasite. Compounds in this class may also interact with other
ligand-gated chloride channels such as those gated by the
neurotransmitter gamma-aminobutyric acid (GABA).
The margin of safety for compounds of this class is attributable
to the fact that mammals do not have glutamate-gated chloride
channels, the macrocyclic lactones have a low affinity for other
mammalian ligand-gated chloride channels and they do not
readily cross the blood-brain barrier.
ANIMAL SAFETY
Studies conducted in the USA have demonstrated the safety
margin for ivermectin. Based on plasma levels, the topically
applied formulation is expected to be at least as well tolerated
by breeding animals as is the subcutaneous formulation which
had no effect on breeding performance.
RESIDUE INFORMATION
Cattle must not be treated within 48 days of slaughter for human consumption. Because a withdrawal
time in milk has not been established, do not use
in female dairy cattle of breeding age. A withdrawal
period has not been established for this product in
pre-ruminating calves. Do not use in calves to be
processed for veal.
WARNING! DO NOT USE IN HUMANS.
This product should not be applied to self or others because
it may be irritating to human skin and eyes and absorbed
through the skin. To minimize accidental skin contact, the user
should wear a long-sleeved shirt and rubber gloves. If accidental skin contact occurs, wash immediately with soap and water.
If accidental eye exposure occurs, flush eyes immediately with
water and seek medical attention.
Keep this and all drugs out of the reach of children.
WARNING! FLAMMABLE! KEEP AWAY FROM HEAT,
SPARKS, OPEN FLAME, AND OTHER SOURCES
OF IGNITION.
PRECAUTIONS
Store away from excessive heat (104°F/40°C) and
protect from light.
Use only in well-ventilated areas or outdoors.
Close container tightly when not in use.
Cattle should not be treated when hair or hide is wet
since reduced efficacy may be experienced.
Do not use when rain is expected to wet cattle within
six hours after treatment.
This product is for application to skin surface only.
Do not give orally or parenterally.
See website for full label information.
NET CONTENTS:
250 mL 1 Liter 2.5 Liter 5 Liter 15
NDC
54925-042-20
54927-042-10
54925-044-25
54925-044-51
I V E R M E C T I N
All horses should be included in a regular parasite control program
with particular attention being paid to mares, foals and yearlings.
ivermectin
IVERSOL
Liquid for Horses 10 mg/mL
ANADA #200-292, Approved by FDA.
CAUTION: Federal (U.S.A.) law restricts this drug to use by or on
the order of a licensed veterinarian.
INTRODUCTION
IVERSOL (ivermectin) Liquid for Horses has been formulated for
professional administration by stomach tube or oral drench. One
low-volume dose is effective against important internal parasites,
including the arterial stages of Strongylus vulgaris, and bots.
FEATURES & BENEFITS
• Broad-spectrum: Effectively controls a wide range of equine parasites, including immature stages.
• Flexible dosing: Iversol can be administered as a drench or by stomach tube, either diluted or undiluted.
• Convenience: 1mL will treat 100 pounds of body weight (10mL will treat an 1100 pound horse).
• Multiple Presentations: Available in 50mL, 100mL and 250mL containers.
• Safe: Iversol can be used in mares at any stage of ]pregnancy, and in stallions without affecting fertility.
DESCRIPTION
Ivermectin is derived from the avermectins, a family of potent,
broad-spectrum antiparasitic agents, which are isolated from
fermentation of Streptomyces avermitilis.
IVERSOL (ivermectin) Liquid is a clear, ready-to-use solution with
each mL containing 1% ivermectin (10 mg), 0.2 mL propylene
glycol, 80 mg polysorbate 80, 9 mg sodium phosphate monobasic
monohydrate, 1.3 mg sodium phosphate dibasic anhydrous, 1 mg
butylated hydroxytoluene, 0.1 mg disodium edetate, 3% benzyl
alcohol and purified water q.s. ad 100%.
INDICATIONS
IVERSOL (ivermectin) Liquid is indicated for the effective treatment
and control of the following parasites or parasitic conditions in
horses:
Large Strongyles:
Strongylus vulgaris (adults and arterial larval stages)
S. edentatus (adults and tissue stages)
S. equinus (adults) Triodontophorus spp (adults)
Small Strongyles – including those resistant to some benzimidazole class compounds (adults and fourth-stage larvae)
Cyathostomum spp
Cylicocyclus spp
Cylicostephanus spp
Cylicodontophorus spp
Pinworms (adults and fourth-stage larvae): Oxyuris equi
Ascarids (adults and third- and fourth-stage larvae):
Parascaris equorum
Hairworms (adults): Trichostrongylus axei
Large-mouth Stomach Worms (adults): Habronema muscae
Bots (oral and gastric stages): Gastrophilus spp
Lungworms (adults and fourth-stage larvae): Dictyocaulus arnfieldi
Intestinal Threadworms (adults): Strongyloides westeri
Available in 3 convenient sizes
50 mL, 100 mL and 250 mL containers
12 bottles per case for each size.
Summer Sores caused by Habronema and Draschia spp cutaneous
third-stage larvae.
Dermatitis caused by neck threadworm microfilariae, Onchocerca sp.
DOSAGE
IVERSOL (ivermectin) Liquid for Horses is formulated for administration by stomach tube (nasogastric intubation) or as an oral drench.
The recommended dose is 200 mcg of ivermectin per kilogram (91
mcg/lb) of body weight. Each mL contains sufficient ivermectin to
treat 110 lb (50 kg) of body weight: 10 mL will treat an 1100 lb (500
kg) horse.
ADMINISTRATION
Use a calibrated dosing syringe inserted into the bottle to measure
the appropriate dose, or pour the IVERSOL (ivermectin) Liquid into
a graduated cylinder for dose measurement. Use a clean syringe if
accessing the bottle to avoid contaminating the remaining product.
Administration by stomach tube (gravity or positive flow): The
recommended dose can be used undiluted or diluted up to 40 times
with clean tepid water (see Notes to Veterinarian). Use tepid water to
flush any drug remaining in the tube into the horse’s stomach.
Administration by drench: For administration by this method,
an undiluted dose is usually preferred. Clear the horse’s mouth of
any food material, elevate the horse’s head, and using a syringe,
deposit the appropriate dose in the back of the mouth. In order to
avoid unnecessary coughing or the potential for material to enter
the trachea and lungs, do not use excessive pressure (squirting), do
not use a large (diluted) dose volume, and do not deposit the dose in
the laryngeal area. Increased dose rejection may occur if the dose is
deposited in the buccal space. Keep the horse’s head elevated and
observe the horse to insure the dose is retained.
16
small
animals
SUGGESTED PARASITE CONTROL PROGRAM
All horses should be included in a regular parasite control program
with particular attention being paid to mares, foals and yearlings.
Foals should be treated initially at 6 to 8 weeks of age, and routine
treatment repeated as appropriate. IVERSOL (ivermectin) Liquid
effectively controls gastrointestinal nematodes and bots in horses.
Regular treatment will reduce the chances of verminous arteritis
and colic caused by S. vulgaris. With its broad spectrum, IVERSOL
(ivermectin) Liquid is well suited to be the major product in a
parasite control program.
MODE OF ACTION
Ivermectin, one of the avermectins, kills certain parasitic roundworms and ectoparasites such as mites and lice. The avermectins
are different in their action from other antiparasitic agents. This
action involves a chemical that serves as a signal from one nerve
cell to another, or from a nerve cell to a muscle cell. This chemical, a
neurotransmitter, is called gamma-aminobutyric acid or GABA.
In roundworms, ivermectin stimulates the release of GABA from
nerve endings and enhances binding of GABA to special receptors at
nerve junctions, thus interrupting nerve impulses-thereby paralyzing
and killing the parasite.
The enhancement of the GABA effect in arthropods such as mites
and lice resembles that in roundworms except that nerve impulses
are interrupted between the nerve ending and the muscle cell.
Again, this leads to paralysis and death.
The principal peripheral neurotransmitter in mammals, acetylcholine, is unaffected by ivermectin. Ivermectin does not readily
penetrate the central nervous system of mammals where GABA
functions as a neurotransmitter.
SAFETY
IVERSOL (ivermectin) Liquid may be used in horses of all ages
including mares at any stage of pregnancy. Stallions may be treated
without adversely affecting their fertility. These horses have been
treated with no adverse effects other than those noted under Notes
to Veterinarian.
Healing of summer sores involving extensive tissue changes may
require other therapy in conjunction with IVERSOL (ivermectin)
Liquid. Reinfection, and measures for its prevention, should also be
considered.
Special consideration should be given to the effects or potential for
injury from handling, restraint, and placement of the tube during
administration by stomach tube. IVERSOL (ivermectin) Liquid should
be administered by drench if the risks associated with tubing are of
concern. Due to the consequences of improper administration (also
see Dosage and Administration), IVERSOL (ivermectin) Liquid is
intended for use by a veterinarian only and is not recommended for
dispensing.
IVERSOL (ivermectin) Liquid in 1 to 20 and 1 to 40 dilutions with
tap water has been shown to be stable for 72 hours under the
conditions recommended for the product (i.e., at room temperature, in a tightly closed container, protected from light). The diluted
product does not promote the growth of common organisms. However, prolonged storage of the diluted product cannot be recommended, as the effects of possible contaminants and interactions
with untested materials are unknown.
PACKAGING INFORMATION
IVERSOL (ivermectin) Liquid for Horses is available in 50 mL,
100 mL or 250 mL plastic bottle. Each 100 mL bottle contains
sufficient ivermectin to treat 10-500 kg (1100 lb) horses. Contents
may be poured into a graduated cylinder for dose measurement.
Alternatively, a clean syringe may be inserted directly into the
bottle to draw off the appropriate dose.
Do not store above 30°C (86°F).
NET CONTENTS:
50 mL 100 mL 250 mL RESIDUE WARNING:
Do not use in horses intended for human consumption.
PRECAUTIONS
• Caution: IVERSOL (ivermectin) Liquid has been formulated specifically for use in horses only. This product should not be used in
other animal species as severe adverse reactions, including fatalities in dogs, may result.
• Refrain from smoking and eating when handling. Wash hands after use. Avoid contact with eyes. Keep this and all drugs out of the
reach of children.
• Store in a tightly closed container at room temperature.
• Protect IVERSOL (ivermectin) Liquid (undiluted or diluted) from
light.
• For customer service contact: Med-Pharmex, Inc.
2727 Thompson Creek Rd., Pomona, CA 91767
ENVIRONMENTAL SAFETY
Studies indicate that when ivermectin comes in contact with the
soil, it readily and tightly binds to the soil and becomes inactive
over time. Free ivermectin may adversely affect fish and certain
water-borne organisms on which they feed. Do not contaminate
lakes, streams, or ground water by direct application or by improper
disposal of drug containers. Dispose of drug container in an approved landfill or by incineration.
NOTES TO VETERINARIAN
Swelling and itching reactions after treatment with IVERSOL (ivermectin) Liquid have occurred in horses carrying heavy infections of neck
threadworm microfilariae, Onchocerca sp. These reactions were most
likely the result of microfilariae dying in large numbers. Symptomatic
treatment may be advisable.
17
NDC
54925-041-05
54925-041-10
54925-041-25
ivermectin
anti-flammatory
Contents will treat up to 1250 lb body weight.
ButaVet
Ivermectin Paste 1.87%
Phenylbutazone Paste
for Horses
Anthelmintic and Boticide
Removes worms and bots with a single dose.
ANADA #200-390, Approved by FDA.
®
your veterinarian for a control program to meet your specific needs. Ivermectin Paste effectively controls gastrointestinal nematodes and bots of
horses. Regular treatment will reduce the chances of verminous arteritis
caused by Strongylus vulgaris.
For Oral Use in Horses Only.
Each Syringe Contains 0.21 oz (6.08 g) IVERMECTIN PASTE
Net Wt. 0.21 oz (6.08 g)
INDICATIONS: Consult your veterinarian for assistance in the diagnosis,
treatment, and control of parasitism. Ivermectin Paste 1.87% provides
effective treatment and control of the following parasites in horses.
Large Strongyles (adults) – Strongylus vulgaris (also early forms
in blood vessels), S. edentatus (also tissue stages), S. equinus,
Triodontophorus spp., including T. brevicauda and T. serratus, and
Craterostomum acuticaudatum; Small Strongyles (adults, including
those resistant to some benzimidazole class compounds) – Coronocyclus
spp. including C. coronatus; C. labiatus and C. labratus; Cyathostomum
spp., including C. catinatum and C. pateratum; Cylicocyclus spp. including C. insigne, C. leptostomum, C. nassatus and C. brevicapsulatus;
Cylicodontophorus spp.; Cylicostephanus spp. including C. calicatus, C.
goldi, C. longibursatus, and C. minutus; Petrovinema poculatum; Small
Strongyles – Fourth-stage larvae; Pinworms (adults and fourth-stage
larvae) – Oxyuris equi; Ascarids (adults and third- and fourth-stage larvae) – Parascaris equorum; Hairworms (adults) –Trichostrongylus axei;
Large-mouth Stomach Worms (adults) – Habronema muscae;
Bots (oral and gastric stages) – Gasterophilus spp. including G. intestinalis and G. nasalis; Lungworms (adults and fourth-stage larvae) –
Dictyocaulus arnfieldi; Intestinal Threadworms (adults) – Strongyloides
westeri; Summer Sores caused by Habronema and Draschia spp.
cutaneous third-stage larvae; Dermatitis caused by neck threadworm
microfilariae, Onchocerca sp.
PRODUCT ADVANTAGES: Broad-spectrum Control– Ivermectin Paste
kills important internal parasites, including bots and the arterial stages of
S. vulgaris, with a single dose. Ivermectin Paste is a potent antiparasitic
agent that is neither a benzimidazole nor an organophosphate.
ANIMAL SAFETY: Ivermectin Paste may be used in horses of all ages,
including mares at any stage of pregnancy. Stallions may be treated
without adversely affecting their fertility.
WARNING: Do not use in horses intended for human consumption.
Not for use in humans. Keep this and all drugs out of reach of
children.
Refrain from smoking and eating when handling. Wash hands after use.
Avoid contact with eyes. The Material Safety Data Sheet (MSDS) contains
more detailed occupational safety information. To report adverse reactions in users, to obtain more information, or to obtain a MSDS, contact
Med-Pharmex Incorporated at 909-593-7875
PRECAUTIONS: Ivermectin Paste has been formulated specifically for
use in horses only. This product should not be used in other animal species as severe adverse reactions, including fatalities in dogs, may result.
Environmental Safety: Ivermectin and excreted ivermectin residues
may adversely affect aquatic organisms. Do not contaminate ground
or surface water. Dispose of the syringe in an approved landfill or by
incineration.
DOSAGE AND ADMINISTRATION: This syringe contains sufficient
paste to treat one 1250 lb horse at the recommended dose rate of 91
mcg ivermectin per lb (200 mcg/kg) body weight. Each weight marking
on the syringe plunger delivers enough paste to treat 250 lb body weight.
(1) While holding plunger, turn the knurled ring on the plunger 1/4 turn
to the left and slide it so the side nearest the barrel is at the prescribed
weight marking. (2) Lock the ring in place by making a 1/4 turn to the
right. (3) Make sure that the horse’s mouth contains no feed. (4) Remove
the cover from the tip of the syringe. (5) Insert the syringe tip into the
horse’s mouth at the space between the teeth. (6) Depress the plunger as
far as it will go, depositing paste on the back of the tongue. (7) Immediately raise the horse’s head for a few seconds after dosing.
INFORMATION FOR HORSE OWNERS: Swelling and itching reactions
after treatment with Ivermectin Paste have occurred in horses carrying
heavy infections of neck threadworm (Onchocerca sp.) microfilariae.
These reactions were most likely the result of microfilariae dying in
large numbers. Symptomatic treatment may be advisable. Consult your
veterinarian should any such reactions occur. Healing of summer sores
involving extensive tissue changes may require other appropriate therapy
in conjunction with treatment with Ivermectin Paste. Reinfection, and
measures for its prevention, should also be considered. Consult your
veterinarian if the condition does not improve.
PARASITE CONTROL PROGRAM: All horses should be included in
a regular parasite control program with particular attention being paid
to mares, foals and yearlings. Foals should be treated initially at 6 to 8
weeks of age, and routine treatment repeated as appropriate. Consult
NET CONTENTS: 6.08g
Store at 20°C to 25°C (68°F to 77°F), excursions permitted
between 15°C and 30°C (between 59°F and 86°F).
November 2012
NDC 54925-048-06
ANADA #200-266, Approved by FDA.
For Veterinary Use Only
For Oral Use in Horses Only.
Each syringe contains 20 g phenylbutazone.
Each 3 mL marking on the plunger contains
Phenylbutazone: 1 g.
DESCRIPTION: ButaVet® Phenylbutazone Paste is a synthetic,
non-hormonal anti-inflammatory, antipyretic compound useful
in the management of inflammatory conditions. The apparent
analgesic effect is probably related mainly to the compounds’s
anti-inflammatory properties. Chemically, Phenylbutazone
Paste is 4-butyl-1, 2-diphenyl-3, 5-pyrazolidinedione. It is
pyrazolone derivative, entirely unrelated to steroid hormones.
INDICATIONS: For the relief of inflammatory conditions
associated with the musculosketal systems in horses.
CONTRAINDICATIONS: Use with caution in patients who have
a history of drug allergy.
WARNING: Not for use in horses intended for food.
PRECAUTIONS: Stop medication at the first sign of
gastrointestinal upset, jaundice, or blood dyscrasia.
Authenticated cases of agranulocytosis associated with the
drug have occurred in man; fatal reactions, though rare,
have been reported in dogs after long-term therapy. To guard
against this possibility, conduct routine blood counts at weekly
intervals during the early phase therapy and at intervals of two
weeks thereafter. Any significant fall in the total white blood
cell count, relative decreases in granulocytes, or black or tarry
stools should be regarded as a signal for immediate cessation
of therapy and institution of appropriate counter-measures.
In the treatment of inflammatory conditions associated with
infections, specific anti-infective therapy is required.
maintenance dose. Maintain lowest dose capable of producing
desired clinical response. Response to ButaVet® Phenylbutazone Paste therapy is prompt, usually occurring within 24
hours. If no significant clinical effect is evident after five days,
re-evaluate diagnosis and therapeutic approach.
Many chronic conditions will respond to ButaVet® Phenylbutazone Paste therapy, but discontinuance of treatment may result
in recurrence of symptoms.
STORAGE: Store at 15°-30°C (59°-86°F)
HOW SUPPLIED: Syringes containing 20 g Phenylbutazone.
KEEP OUT OF REACH OF CHILDREN
CAUTION: Federal (U.S.A.) law restricts this drug to use by or
on the order of a licensed veterinarian.
Manufactured by: Med-Pharmex, Inc.
Pomona, CA 91767-1861
Revised June 2012
NET CONTENTS:
Net Volume 60 mL
ADMINISTRATION AND DOSAGE: Orally – 1 to 2 g of
phenylbutazone per 500 lb. of body weight daily. Do not exceed
4 g daily.
When administering ButaVet® Phenylbutazone Paste, the oral
cavity should be empty. Deposit paste on the back of tongue
by depressing plunger that has been previously set to deliver
the correct dose.
Guidelines to Successful Therapy: Use a relatively
high dose for the first 48 hours, then reduce gradually to a
18
small
animals
19
NDC
54925-088-60
injectables
injectables
Euthanasia-III Solution
ANADA #200-280
For Dogs Only.
CAUTION: Federal law restricts this drug to use by or on the order
of a licensed veterinarian.
Description
A non-sterile solution containing pentobarbital sodium and phenytoin sodium as the active ingredients. Rhodamine B, a bluish-red
fluorescent dye, is included in the formulation to help distinguish
it from parenteral drugs intended for therapeutic use. Although the
solution is not sterile, benzyl alcohol, a bacteriostat is included to
retard the growth of microorganisms.
EACH mL CONTAINS: Active ingredients: 390 mg pentobarbital sodium (barbituric acid derivative), 50 mg phenytoin
sodium; Inactive ingredients: 10% ethyl alcohol, 18%
propylene glycol, 0.003688 mg rhodamine B, 2% benzyl alcohol
(preservative), purified water qs. Sodium hydroxide and/or
hydrochloric acid may be added to adjust pH.
Actions
Euthanasia-III Solution contains two active ingredients which
are chemically compatible but pharmacologically different. Each
ingredient acts in such a manner so as to cause humane, painless and rapid euthanasia. Euthanasia is due to cerebral death
in conjunction with respiratory arrest and circulatory collapse.
Cerebral death occurs prior to cessation of cardiac activity.
When administered intravenously, pentobarbital sodium produces rapid anesthetic action. There is a smooth and rapid onset
of unconsciousness. At the lethal dose, there is depression of
vital medullary respiratory and vasomotor centers.
When administered intravenously, phenytoin sodium produces toxic
signs of cardiovascular collapse and/or central nervous system
depression. Hypotension occurs when the drug is administered
rapidly.
Pharmacodynamic Activity
The sequence of events leading to humane, painless and rapid
euthanasia following intravenous injection of Euthanasia-III
Solution is similar to that following intravenous injection of
pentobarbital sodium or other barbituric derivatives. Within
seconds, unconsciousness is induced with simultaneous collapse
of the dog. This stage rapidly progresses to deep anesthesia with
concomitant reduction in the blood pressure. A few seconds later,
breathing stops, due to depression of the medullary respiratory
center; encephalographic activity becomes isoelectric, indicating
cerebral death; and then cardiac activity ceases.
Phenytoin sodium exerts its effect during the deep anesthesia
stage caused by the pentobarbital sodium. This ingredient, due
to its cardiotoxic properties, hastens the stoppage of electrical
activity in the heart.
Enviromental Hazard
This product is toxic to wildlife. Birds and mammals feeding
on treated animals may be killed. Euthanized animals must
be properly disposed of by deep burial, incineration, or other
method in compliance with state and local laws, to prevent
consumption of carcass material by scavenging wildlife.
Human Warning
Caution should be exercised to avoid contact of the drug with
open wounds or accidental self-inflicted injections. Keep out of
reach of children. If eye contact, flush eyes with water and seek
medical attention.
Precautions
Euthanasia may sometimes be delayed in dogs with severe
cardiac or circulatory deficiencies. This may be explained by
the impaired movement of the drug to its site of action. An
occasional dog may elicit reflex responses manifested by motor
movement; however, an unconscious animal does not experience
pain, because the cerebral cortex is not functioning.
When restraint may cause the dog pain, injury or anxiety,
or danger to the person making the injection, prior use of
tranquilizing or immobilizing drugs may be necessary.
Dosage and Administration
Dosage: Dogs: 1 mL for each 10 pounds of body weight.
Administration: Intravenous injection is preferred. Intracardiac
injection may be made when intravenous injection is impractical,
as in a very small dog, or in a comatose dog with impaired
vascular functions. Good injection skill is necessary for
intracardiac injection.
The calculated dose should be given in a single bolus injection.
For intravenous injection, a needle of sufficient gauge to ensure
intravenous placement of the entire dose should be used.
The use of a Luer-Lok® syringe is recommended to prevent
accidental exposure to needle/syringe separation.
Atropine
Sulfate
Dexpanthenol
(Apropine Sulfate Injection 1/120 Grain)
(Dexpanthenol Injection)
CAUTION: Ferderal law restricts this drug to use by or on the
order of a licensed veterinarian.
CAUTION: Ferderal law restricts this drug to use by or on the
order of a licensed veterinarian.
For Intravenous, Intramuscular or Subcutaneous Use
COMPOSITION: Each mL contains:
Dexpanthenol . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 250 mg
Benzyl Alcohol . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1% w/v
Water for Injection . . . . . . . . . . . . . . . . . . . . . . . . . q.s.
Acetic Acid, Glacial, USP . . . . . . . . . . . . . . . . . . to adjust PH
COMPOSITION: Each mL contains:
Atropine Sulfate .................... . . . . . . 0.54 mg
Sodium Chloride ................... . . . . . . . 9 mg
Benzyl Alcohol (preservative) ...... . . . . . . . 1.5%
Water for Injection ................. . . . . . . . q.s.
pH adjusted with sulfuric acid when necessary.
INDICATIONS: For use as a nutritional source of
dexpanthenol.
DOSAGE AND ADMINISTRATION:
Dogs and Cats: Inject 1 mL for each 20 lbs. of body weight
as a pre-anesthetic adjuvant or to reduce salivation, bronchial
secretion or internal peristalsis associated with colic or diarrhea.
As an antidote for parasympathomimetic drugs, 1 mL for each
7.5 lbs. of body weight. It is suggested that 1/4 of the dosage
be injected intravenous and the remainder intramuscular or
subcutaneous.
WARNING: Poisonous alkaloid. Keep out of reach of children.
Antidotes: warmth, emetics, cholinergics.
FOR ANIMAL USE ONLY.
KEEP OUT OF REACH OF CHILDREN.
Store at room temperature between 15°- 30° C
(59°- 86° F).
Net Contents: 100 mL Seterile Multiple Dose Vial
NDC 54925-063-10
DOSAGE AND ADMINISTRATION:
Dogs and Cats: 25 mg per 5 lbs. body weight intramuscularly
Horses: Initial dose 10 cc intravenously or intramuscularly.
PRECAUTION: Following the administration of succinylcholine
chloride, a one-hour waiting period is advisable before initiation of dexpanthenol therapy.
CONTRAINDICATIONS: In therapy of colic resulting from
administration of cholinergic type anthelmintics.
FOR ANIMAL USE ONLY.
KEEP OUT OF REACH OF CHILDREN.
Store at room temperature between 15°- 30° C
(59°- 86° F).
Net Contents: 100 mL NDC 54925-064-10
Revised April 2008
Revised April 2008
HOW SUPPLIED: Euthanasia-III Solution is available in 100-mL
multiple-dose vials.
Manufactured by a non-sterilizing process.
STORAGE: Store between 15°
and 30°C (59° and 86°F).
Med-Pharmex Inc.,
Pomona, CA 91767
NDC 54925-045-10
October 2004
Indications
For use in dogs for humane, painless and rapid euthanasia.
Warning
For canine euthanasia only. Must not be used for therapeutic
purposes. Do not use in animals intended for food.
20
21
injectables
injectables
Dexamethasone
Solution
Sterile Multiple Dose Vial 2mg/mL
ANADA #200-456, Approved by FDA
For Intravenous or Intramuscular Injection.
CAUTION: Ferderal law restricts
this drug to use by or on the order
of a licensed veterinarian.
DOSAGE: Bovine – 5 to 20 mg
Equine – 2.5 to 5 mg
COMPOSITION:
Each mL contains:
2 mg dexamethasone, 500 mg
polyethylene glycol 400,
9 mg benzyl alcohol, 1.8 mg
methylparaben, 0.2 mg propylparaben (as preservatives); 4.75%
alcohol, hydrochloric acid and/or
sodium hydroxide used to adjust
pH to approximately 4.9, Water for
Injection q.s.
Lidocaine
(Lidocaine Hydrochloride Injectable 2%)
(Thiamine Hydrochloride 200 or 500 mg/mL)
CAUTION: Ferderal law restricts this drug to use by or on the
order of a licensed veterinarian.
COMPOSITION: Each mL of sterile aqueous solution contains:
Lidocaine Hydrochloride ………...…… 2.0%
Sodium Chloride …………...........… 0.2%
Potassium Phosphate Monobasic……… 0.2%
Potassium Phosphate Dibasic ………… 0.2%
Methylparaben …….............……… 0.1%
Water for Injection …….........……… q.s.
COMPOSITION: Each mL contains:
Thiamine Hydrochloride ………… . . . . . . . 200 mg / 500mg
Disodium Edetate …………..... . . . . . . … 0.01% w/v
Benzyl Alcohol …………......... . . . . … 1.5% w/v
Water for injection ………….... . . . . . . . … q.s.
ph is adjusted with Hydrochloric Acid or Sodium Hydroxide
COMPOSITION: Each mL of sterile aqueous solution contains:
Sodium Ascorbate … … … … . . . . . . . . . . . … 250 mg
Benzyl Alcohol (preservative) … … … … . . . 1.5% v/v
Sodium Metabisulfite … … … … . . . . . . . . . . . 0.2% w/v
PRECAUTIONS: Lidocaine is usually well tolerated. Nevertheless, as with all local anesthetics, untoward effects may occur
due to hypersensitivity, faulty technique, overdosage and
inadvertent intravascular or subarachnoid injection. In case
of respiratory arrest, immediate resuscitation with oxygen is
indicated.
DOSAGE AND ADMINISTRATION:
Epidural
Cattle and Horses – 5 to 15 mL.
Dogs and Cats – 1 mL per 10 pounds of body weight.
Nerve Block
Cattle and Horses – 5 to 20 mL.
INDICATIONS: For use as a supplemental source of thiamine
in dogs, cats, and horses.
DOSAGE AND ADMINISTRATION: For intramuscular use in
dogs, cats, and horses. For the 200 mg/mL dosage may be
repeated daily as needed.
Horses – 0.25 mL per 100 lb body weight
Dogs – 0.08 mL per 10 lb body weight up to 0.25 mL
maximum
Cats – 0.04 mL per 5 lb body weight up to 0.1 mL maximum.
For the 500mg/mL as determined by the veterinarian.
WARNINGS: Anaphylactogenesis to parenteral Thiamine HCI
has been reported. Administer slowly and with caution in
doses over 0.25 mL (50 mg) for the 200mg/mL and 0.1mL for
500mg/mL
FOR ANIMAL USE ONLY.
KEEP OUT OF REACH OF CHILDREN.
FOR ANIMAL USE ONLY.
Store at room temperature between 15°- 30° C
(59°- 86° F).
FOR ANIMAL USE ONLY.
KEEP OUT OF REACH OF CHILDREN.
Do not use if precipitated.
KEEP OUT OF REACH OF CHILDREN.
Store at room temperature between 15°- 30° C
(59°- 86° F).
Net Contents:
200 mg/mL 100 mL
200 mg/mL 250 mL
500 mg/mL 100 mL
500 mg/mL 250 mL
Net Contents: 100 mL
NDC 54925-067-10
(Injectable Solution)
CAUTION: Ferderal law restricts this drug to use by or on the
order of a licensed veterinarian.
CONTRAINDICATIONS: Lidocaine is contraindicated in
animals with known hypersensitivity to the drug.
RESIDUE WARNING:
A withdrawal period has not been established
for this product in preruminating calves.
Do not use in calves to be processed for veal.
Vitamin C
CAUTION: Ferderal law restricts this drug to use by or on the
order of a licensed veterinarian.
INDICATIONS: Lidocaine is a potent local anesthetic for
producing epidural and nerve conduction anesthesia.
Store between 20°C - 25°C (68°F - 77°F)
Before using this drug read package insert for complete
product information.
Thiamine
Net Contents:
100 mL
250 mL
Revised April 2008
22
NDC
54925-073-10
54925-073-25
INDICATIONS: For use as a nutritive supplemental vitamin
C in guinea pigs, primates, cattle, horses, sheep, swine, cats
and dogs.
PRECAUTIONS: Since pressure may develop on long storage,
precaution should be taken to release pressure before use.
Storage under refrigeration will reduce possibility of pressure
build-up.
DOSAGE AND ADMINISTRATION: Administer intramuscularly
1 to 10 mL, depending on condition, species, and body weight.
Repeat daily or as indicated by desired response.
FOR ANIMAL USE ONLY.
KEEP OUT OF REACH OF CHILDREN.
Store at room temperature between 15°- 30° C
(59°- 86° F).
Do not use if precipitated.
Avoid exposure to light.
Net Contents:
100 mL
250 mL
Revised March 2008
NDC
54925-058-10
54925-058-25
54925-059-10
54925-059-25
Revised October 2007
23
NDC
54925-062-10
54925-062-25
injectables
Oral Use in Swine and Broiler Chickens Only.
Lincosol Soluble Powder
Vitamin B-12
(Cyanocobalamin Injectable Solution)
CAUTION: Ferderal law restricts this drug to use by or on the
order of a licensed veterinarian.
B-12 1000 mcg/mL / B-12 3000 mcg/mL
and B-12 5000 mcg/mL
VITAMIN B-12 1000 mcg/mL
COMPOSITION: Each mL of sterile aqueous solution contains:
Cyanocobalamin (B-12) … … … … . . . ....1000 mcg
Sodium Chloride… … … … . . . . . . . . . . . .… 9 mg
Benzyl Alcohol … … … … . . . . . . . . . . . . . .…1.5 %
Water for injection … … … … . . . . . . . . .… q.s.
VITAMIN B-12 3000 mcg/mL
COMPOSITION: Each mL of sterile aqueous solution contains:
Cyanocobalamin (B-12) … … … … . . . ....3000 mcg
Sodium Chloride… … … … . . . . . . . . . . . .… 9 mg
Benzyl Alcohol … … … … . . . . . . . . . . . . . .…1.5 %
Water for injection … … … … . . . . . . . . .… q.s.
INDICATIONS: For use as a supplemental nutritive source of
Vitamin B12 in cattle, horses, sheep, swine, dogs and cats.
DOSAGE AND ADMINISTRATION: Inject subcutaneously or
intramuscularly.
Cattle, Horses, Sheep and Swine – 1 to 2 mL
Dogs and Cats – 0.25 to 0.5 mL
Suggested dosage may be repeated at 1 to 2 week intervals,
as indicated by condition and response.
INDICATIONS: For use in Vitamin B12 deficiency associated
with cobalt deficiency in cattle and sheep and for Vitamin B12
deficiency associated with inadequate Vitamin B12 intake or
intestinal malabsorption in swine.
DOSAGE AND ADMINISTRATION: Inject subcutaneously or
intramuscularly.
Cattle and Sheep – 0.2 to 0.4 mL
Swine – 0.1 to 0.4 mL
Suggested dosage may be repeated at weekly intervals if
necessary.
FOR ANIMAL USE ONLY.
KEEP OUT OF REACH OF CHILDREN.
Store at room temperature between 15°- 30° C
(59°- 86° F).
Do not use if precipitated.
Avoid exposure to light.
Net Contents:
NDC
B-12 1000 mcg/mL 100 mL
54925-053-10
B-12 3000 mcg/mL 100 mL
54925-054-10
B-12 5000 mcg/mL 100 mL
54925-055-10
B-12 1000 mcg/mL 250 mL
B-12 3000 mcg/mL 250 mL
Revised February 2008
B-12 5000 mcg/mL
COMPOSITION: Each mL of sterile aqueous solution contains:
Cyanocobalamin (B-12) … … … … . . . ....5000 mcg
Sodium Chloride… … … … . . . . . . . . . . . .… 9 mg
Benzyl Alcohol … … … … . . . . . . . . . . . . . .…1.5 %
Water for injection … … … … . . . . . . . . .… q.s.
54925-053-25
54925-054-25
(Brand of Lincomycin Hydrochloride
Soluble Powder)
ANADA #200-241, Approved by FDA.
AVAILABLE IN 3 SIZES:
32 oz. (0.907 Kg) Container, 1.41 oz (40 g) Packet, and
2.82 oz (80 g) Packet
SWINE: DIRECTIONS FOR USE
INDICATIONS: Lincomycin Soluble Powder is indicated for the
treatment of swine dysentery (bloody scours).
DOSAGE: Administer at a dose rate of 250 mg of lincomycin per
gallon of drinking water. In clinical studies, this dose rate provided
an average of 3.8 mg of lincomycin per pound of body weight per day.
TREATMENT PERIOD: The drug should be administered for
a minimum of 5 consecutive days beyond disappearance of
symptoms (bloody stools) up to maximum of 10 consecutive days.
If water treatment is discontinued prior to this time, a lincomycin
treatment program may be continued with lincomycin premix at
100 grams lincomycin per ton of complete feed as the sole ration
according to label directions.
ADMINISTRATION: One scoop (provided) of this powder will
medicate 64 gallons of drinking water providing 250 mg/gallon. The
1.41 oz (40 g) packet will medicate 64 gallons of drinking water
providing 250 mg/gallon. The 2.82 oz (80 g) packet will medicate
128 gallons of drinking water providing 250 mg/gallon. A dose of
3.8 mg lincomycin per pound of body weight may be maintained
by medicating the drinking water at a concentration of 250 mg per
gallon of drinking water when pigs are consuming 1.5 gallons per
100 lbs of body weight per day. Under these circumstances the
concentration of lincomycin required in medicated water may be
adjusted to compensate for variations in age and weight of animals,
the nature and severity of disease symptoms, environmental temperature and humidity, each of which affects water consumption.
For use in automatic water proportioners, prepare the stock solution by dissolving one packet in one gallon of water: then adjust
the proportioner to deliver 1 ounce of stock solution per gallon of
drinking water.
NOTE: After a treatment program is discontinued, a control program
for swine dysentery may be followed by feeding lincomycin premix
at 40 grams lincomycin per ton of complete feed as the sole ration.
BROILER CHICKENS: DIRECTIONS FOR USE
24
antibacterial
INDICATIONS: Lincosol Soluble Powder is indicated for the control
of necrotic enteritis caused by Clostridium perfringens susceptible
to lincomycin.
DOSAGE: Administer at a dose rate of 64 mg of lincomycin per
gallon of drinking water.
TREATMENT PERIOD: Start medication as soon as the diagnosis
of necrotic enteritis is determined. If improvement is not noted
within 24 to 48 hours, consult a licensed veterinarian or veterinary
diagnostic laboratory to determine diagnosis. The drug should be
administered for 7 consecutive days.
ADMINISTRATION: One scoop (provided) of this powder will
medicate 250 gallons of drinking water providing 64 mg/gallon. The
1.41 oz (40 g) packet will medicate 250 gallons of drinking water
providing 64 mg/gallon. The 2.82 oz (80 g)packet will medicate
500 gallons of drinking water providing 64 mg/gallon.
NOTE: After water medication is discontinued, a recommended
control program for necrotic enteritis consists of feeding lincomycin
premix at 2 grams lincomycin per ton of complete feed.
CAUTIONS:
1. Discard medicated drinking water if not used within 2 days.
Fresh stock solution should be prepared daily.
2. If clinical signs of bloody scours (watery, mucoid or bloody
stools) have not improved during the first 6 days of medication,
discontinue treatment and redetermine the diagnosis.
3. Occasionally, swine fed lincomycin may within the first two days
after the onset of treatment develop diarrhea and /or swelling
of the anus. On rare occasions, some pigs may show reddening
of the skin and irritable behavior. These conditions have been
self-correcting within five to eight days without discontinuing the
lincomycin treatment.
4. Not for use in swine weighing more than 250 pounds.
5. Do not allow rabbits, hamsters, guinea pigs, horses or ruminants
access to water containing lincomycin. Ingestion by these species may result in severe gastrointestinal effects.
6. Do not use the water treatment and the feed treatments
simultaneously.
7. Not for use in layer and breeder chickens.
WARNINGS:
1. Do not slaughter swine for human consumption for 6 days
following last treatment.
2. No drug withdrawal period is required before slaughter of
birds receiving Lincosol Soluble Powder at the approved
level of 64 mg per gallon of drinking water.
3. Not for human use.
Store at controlled room temperature 15˚ to 30˚C
(59˚ to 86˚F)
FOR ANIMAL USE ONLY.
Restricted Drug — Use only as Directed (California)
KEEP OUT OF REACH OF CHILDREN.
Net Contents: NDC
40 g Packet 54925-037-04
80 g Packet 54925-037-08
2 lb. Cantainer 54925-037-22
25
antibacterial
antibacterial
Neosol•Oral
Neosol Soluble Powder
(Neomycin Sulfate)
(Neomycin Oral Solution)
RESIDUE WARNINGS
Discontinue treatment prior to slaughter as follows:
Turkeys – 0 day
Cattle – 1 day
Sheep – 2 days
Swine and Goats – 3 days
A withdrawal period has not been established for this
product in pre-ruminating calves. Do not use in calves
to be processed for veal. A milk discard period has
not been established for this product in lactating dairy
cattle. Do not use in female dairy cattle 20 months
of age or older. Use of more than one product containg neomycin or failure to follow withdrawal times may
result in illegal drug residues.
ANADA #200-289, Approved by FDA.
AVAILABLE IN 2 SIZES:
1 Pint (473 mL) and 1 Gallon (3.785 L)
FOR ORAL USE ONLY.
INDICATIONS: For the treatment and control of colibacillosis (bacterial enteritis) caused by Escherichia coli susceptible to neomycin
sulfate in cattle (excluding veal calves), swine, sheep and goats.
For the control of mortality associated with Escherichia coli organisms susceptible to neomycin sulfate in growing turkeys.
DOSAGE AND ADMINISTRATION: Administer to cattle (excluding
veal calves), swine, sheep and goats at a dose of 10 mg neomycin
sulfate per pound of body weight in divided doses for a maximum
of 14 days. Administer to turkeys at a dose rate of 10 mg neomycin
sulfate per pound of body weight for 5 days.
DOSAGE SCHEDULE FOR TREATMENT OF COLIBACILLOSIS
Pounds
Amount of Neosol•Oral
of Body Weight
Solution Per Day in Divided Doses
25 lbs.
1.2 mL ( 1/4 teaspoonful)
50 lbs.
2.5 mL (1/2 teaspoonful)
100 lbs.
5.0 mL (1 teaspoonful)
300 lbs.
15 mL (1 tablespoonful)
591.5 lbs.
29.5 mL (1 fluid ounce)
INDICATIONS: For the treatment and control of colibacillosis (bacterial enteritis) caused by Escherichia coli susceptible to neomycin
sulfate in cattle (excluding veal calves), swine, sheep and goats.
Each 100 g packet contains: Neomycin Sulfate equivalent to
50 gm neomycin.
Contains per pound: Neomycin Sulfate equivalent to 227.5 gm
neomycin.
DOSAGE AND ADMINISTRATION: Administer to cattle (excluding
veal calves), swine, sheep and goats at a dose of 10 mg neomycin
sulfate per pound of body weight in divided doses for a maximum
of 14 days.
Drinking Water: Swine – Use the number of packets indicated
below in 256 gallons of water, or in two gallons of stock solution
used in proportioner set to one ounce per gallon.
Pigs Body Weight
25 to 50 lbs.
50 to 100 lbs.
Over 100 lbs.
Individual Animal Treatment: To provide 10 mg neomycin
sulfate per pound of body weight, mix 5 mL (1 tsp.) in water or
milk for each 100 lbs. of body weight. Administer daily either as a
drench in divided dosages or in the drinking water to be consumed
in 12-24 hours.
Number of Neosol Packets
2 packets
3 packets
4 packets
Caution: To administer the stated dosage, the concentration
of neomycin required in medicated water must be adjusted to
COMPOSITION: Each mL contains 200 mg of Neomycin Sulfate
equivalent to 140 mg of neomycin base.
Store at controlled room temperature 15˚ to 30˚C
(59˚ to 86˚F)
FOR ANIMAL USE ONLY.
Restricted Drug — Use only as Directed (California)
KEEP OUT OF REACH OF CHILDREN.
Net Contents: NDC
473 mL (pint) 54925-043-47
1 gallon 54925-043-11
26
small
For Oral Use in Animals Only.
Add to drinking water – Not for use in liquid supplements.
Individual Animal Treatment: To provide 10 mg neomycin sulfate
per pound of body weight, mix one (1) level teaspoon in water or
milk for each 160 pounds of body weight. Administer daily either
as a drench in divided doses or in drinking water to be consumed
in 12 - 24 hours.
Herd Treatment: Each 473 mL (1 Pint) will treat 9,464 pounds
of body weight. Each 3.785 L (1 Gallon) will treat 75,700 pounds
of body weight. Therefore estimate the total number of pounds of
body weight of animals to be treated and administer 29.5 mL (1 fl.
oz.) for each 591.5 lbs. The product should be added to the amount
of drinking water estimated to be consumed in 12-24 hours.
Provide medicated water as the sole source of water each day until
consumed, followed by non-medicated water as required. Fresh
medicated water should be prepared each day.
Important: Treatment should continue 24 to 48 hours beyond
remission of disease symptoms, but not to exceed a total of 14
consecutive days. Animals not drinking or eating should be treated
individually by drench.
AVAILABLE IN 2 SIZES:
3.5 oz. (100g) Packet and 50 lb. (22.5 kg) Container
Herd Treatment: Each packet will treat 7,150 pounds of body
weight. Therefore estimate the total number of pounds of body
weight of animals to be treated and administer one (1) packet (or
portion thereof) for each 7,150 pounds. The product should be
added to the amount of drinking water estimated to be consumed in
12-24 hours. Provide medicated water as the sole source of water
each day until consumed, followed by non-medicated water as
required. Fresh medicated water should be prepared each day.
Teaspoon = U.S. Standard Measure
Neosol•Oral Solution may be given undiluted or diluted with water.
Precautions: To administer the stated dosage, the concentration of neomycin required in medicated water must be adjusted to
compensate for variation in age and weight of animal, the nature
and severity of disease signs, and environmental temperature and
humidity, each of which affects water consumption.
If symptoms persist after using this preparation for 2 or 3 days,
consult a veterinarian. If symptoms such as fever, depression or
going off feed develop, oral neomycin is not indicated as the sole
treatment since systemic levels of neomycin are not obtained due to
poor absorption from the gastrointestinal tract.
ANADA #200-235, Approved by FDA.
animals
compensate for variation in age and weight of animal, the nature
and severity of disease signs, and environmental temperature and
humidity, each of which affects water consumption. If symptoms
persist after using this preparation for 2 or 3 days, consult a veterinarian. If symptoms such as fever, depression or going off feed
develop, oral neomycin is not indicated as the sole treatment since
systemic levels of neomycin are not obtained due to low absorption
from the gastrointestinal tract.
Important: Treatment should continue 24 to 48 hours beyond
remission of disease symptoms, but not to exceed a total of 14
consecutive days. Animals not drinking or eating should be treated
individually by drench.
WARNING:
Discontinue treatment prior to slaughter as follows:
Cattle and Goats – 30 days
Swine and Sheep – 20 days
(Not to be used in veal calves)
Daily Schedule for Drinking Water:
SWINE
One Tablespoon* of Neosol
Soluble Powder added to water
consumed in one day will treat Weight of
each pig
10 pounds
25 pounds
50 pounds
50 pigs
20 pigs
10 pigs
CATTLE (Not to be used in veal calves)
One Tablespoon* of Neosol
Soluble Powder added to water
or milk consumed in one day will treat
Weight of
each calf
50 pounds
75 pounds
125 pounds
10 calves
7 calves
4 calves
* Level Tablespoon = US Standard Measure
The product should be added to the amount of drinking water
estimated to be consumed in 12 - 24 hours. Provide medicated
water as a sole source of water used each day until consumed, followed by non-medicated water as required. Fresh medicated water
should be prepared each day. For a stock solution, add six level
tablespoonfuls to one gallon water. Each pint of this stock solution
will medicate 5 gallons of drinking water. For use in Automatic
Proportioners delivering 2 ounces of stock solution per gallon of
drinking water, dissolve 9 level tablespoonfuls in a gallon of water
to make the stock solution.
KEEP CONTAINER TIGHTLY CLOSED.
Store in a dry place with controlled room temperature of
15˚ to 30˚C (59˚ to 86˚F). When storing partially used containers,
securely close bags to prevent contents from caking.
Restricted Drug — Use only as Directed (California)
NOT FOR HUMAN USE.
KEEP OUT OF REACH OF CHILDREN.
Net Contents: NDC
3.5 oz. Packet 54925-036-35
50 lb. Container 54925-036-50
27
antibacterial
antibacterial
antibacterial
Sulforal
Sulfasol Soluble Powder
(Brand of Sulfadimethoxine)
FOR ORAL USE IN CHICKENS, TURKEYS, AND CATTLE
Broiler and Replacement Chickens – Use for the treatment
of disease outbreaks of coccidiosis, fowl cholera, and infectious
coryza.
Meat-producing Turkeys – Use for the treatment of disease
outbreaks of coccidiosis and fowl cholera.
Dairy Calves, Dairy Heifers, and Beef Cattle – Use for the treatment of shipping fever complex and bacterial pneumonia associated
with Pasteurella spp. sensitive to sulfadimethoxine; and calf
diphtheria and foot rot associated with Fusobacterium necrophorum
(Sphaerophorus necrophorus) sensitive to sulfadimethoxine.
For Broiler and Replacement Chickens Only – Use for the
treatment of disease outbreaks of coccidiosis, fowl cholera, and
infectious coryza.
For Meat-producing Turkeys Only – Use for the treatment
of disease outbreaks of coccidiosis and fowl cholera.
For Dairy Calves, Dairy Heifers, and Beef Cattle – Use for the
treatment of shipping fever complex and bacterial pneumonia associated with Pasteurella spp. sensitive to sulfadimethoxine; and calf
diphtheria and foot rot associated with Sphaerophorus necrophorus
sensitive to sulfadimethoxine.
DOSAGE AND ADMINISTRATION:
DAIRY CALVES, DAIRY HEIFERS, AND BEEF CATTLE
Dosage: 25 mg/lb first day followed by 12.5 mg/lb/day for 4 days
Sulfadimethoxine in Water
Water Consumption
Amount of
(Summer)*
(Winter)*
Stock Solution 1 gal/100 lb 1 gal/150 lb
for Cattle* body weight** body weight**
1 quart 10 gallons
7 gallons
First Day Add
2 quarts
20 gallons
14 gallons
1 gallon
40 gallons
28 gallons
1 quart
Next 4 Days Add 2 quarts
1 gallon
20 gallons
40 gallons
80 gallons
14 gallons
28 gallons
56 gallons
*Note: Make a cattle stock solution by adding one packet of
Sulfadimethoxine Soluble Powder to 1 gallon of water.
*Twenty fl. oz. of cattle stock solution will medicate 1-600 lb.
animal initially or 2-600 lb. animals on maintenance dose. Contents
of packet will medicate 6-600 lb. animals initially or 12-600 lb.
animals on maintenance dose.
**This dosage recommendation is based on a water consumption of 1 gallon per 100 lb. of body weight per day, the expected
water consumption rate for summer. Water consumption during
cold months (winter) may drop markedly (30%-40%). Accordingly,
adjustments must be made in the dilution rates to compensate for
this and insure proper drug intake.
For treatment of individual cattle, Sulfadimethoxine Soluble Powder
stock solution for cattle may be given as a drench.
Treatment Period: 5 consecutive days
(Sulfadimethoxine)
1 Gallon (3.8L) Sulforal Concentrated Solution 12.5%,
3.75 g. sulfadimethoxine/fl.oz.
Antibacterial for use in drinking water
ANADA #200-238, Approved by FDA.
Each packet contains: 3.34 oz. (94.6 g) sulfadimethoxine in the
form of the soluble sodium salt and disodium edetate.
Species Concentration Use Directions
Chickens 0.05%
Contents of packet to 50 gal. of water
Turkeys 0.025%
Contents of packet to 100 gal. of water
Automatic Proportioners: To make stock solution, add contents
of 5 packets to two gallons of water for chickens and to four gallons
of water for turkeys. Set proportioner to feed at a rate of 1 fl. oz.
stock solution per gallon of water.
Treatment Period: 6 consecutive days
ANADA #200-251, Approved by FDA.
CAUTION:
Chickens and Turkeys – If animals show no improvement within
5 days, discontinue treatment and reevaluate diagnosis. Prepare
a fresh stock solution daily. Handle the recommended dilutions
(chickens 0.05% and turkeys 0.025%) as regular drinking water.
Administer as sole source of drinking water and sulfonamide
medication. Chickens and turkeys that have survived fowl cholera
outbreaks should not be kept for replacements or breeders.
Cattle – During treatment period, make certain that animals
maintain adequate water intake. If animals show no improvement
within 2 or 3 days, reevaluate diagnosis. Treatment should not be
continued beyond 5 days.
WARNING
Chickens and Turkeys – Withdraw 5 days before
slaughter. Do not administer to chickens over 16 weeks
(112 days) of age or to turkeys over 24 weeks (168 days)
of age.
Cattle – Withdraw 7 days before slaughter. For dairy
calves, dairy heifers and beef cattle only. A withdrawal
period has not been established for this product in preruminating calves.
Do Not Use in Calves to be Processed for Veal.
Store at controlled room temperature 15˚ to 30˚C
(59˚ to 86˚F)
Restricted Drug — Use only as Directed (California)
NOT FOR HUMAN USE.
KEEP OUT OF REACH OF CHILDREN.
Net Contents: NDC
3.77 oz. Packet 54925-035-37
28
DOSAGE AND ADMINISTRATION:
Chickens and Turkeys
Treatment Period: 6 consecutive days
Recommended Concentration: Chickens – 0.05%;
Turkeys – 0.025%
Chickens Add 1 fl oz (30 mL) to 2 gallons of drinking water or
25 fl oz to 50 gallons of drinking water.
Turkeys Add 1 fl oz (30 mL) to 4 gallons of drinking water or
25 fl oz to 100 gallons of drinking water.
Automatic Proportioners* Stock Solution – To make 2 gallons of stock solution:
Chickens Add 1 gallon of Sulforal Concentrated Solution 12.5% to 1 gallon of water.
Turkeys Add 2 quarts of Sulforal Concentrated Solution 12.5% to 6 quarts of water.
*Set proportioner to a feed rate of 1 fl. oz. of stock solution per gallon
of water.
Dairy Calves, Dairy Heifers, and Beef Cattle
Treatment Period: 5 consecutive days
Dosage: Initial dose of 25 mg/lb followed by four maintenance
doses of 12.5 mg/lb/day.
Summer Administration Dosage recommendations for summer
are based on an estimated water intake of 1 gallon of water for
every 100 lb of body weight per day.
Daily Drinking Water Supply
25 gallons
50 gallons
200 gallons
Sulforal Concentrated Solution 12.5%
Initial Dose
Maintenance Dose
1 pt (16 fl oz)
1 qt (32 fl oz)
1 gal (128 fl oz)
1 cup (8 fl oz)
1 pt (16 fl oz)
2 qt (64 fl oz)
Winter Administration Dosage recommendations for winter are
based on an estimated water intake of 1 gallon of water for every
150 lb of body weight per day.
Daily Drinking Water Supply
16 gallons
33 gallons
127 gallons
Sulforal Concentrated Solution 12.5%
Initial Dose
Maintenance Dose
1 pt (16 fl oz)
1 qt (32 fl oz)
1 gal (128 fl oz)
1 cup (8 fl oz)
1 pt (16 fl oz)
2 qt (64 fl oz)
Individual Animal Treatment of Cattle: Sulforal Concentrated
Solution 12.5% may be given as a drench. Administer using an
initial dose of 25 mg/lb followed by 4 maintenance doses of 12.5
mg/lb/day. One fl oz will medicate one 150-lb initially and 1/2 fl oz
will medicate one 150-lb on maintenance dose.
CAUTION: Store at room temperature; if freezing occurs, thaw
before using. Protect from light; direct sunlight may cause discoloration. Freezing or discoloration does not affect potency. Prepare a
fresh stock solution daily.
Chickens and Turkeys – If animals show no improvement within
5 days, discontinue treatment and reevaluate diagnosis. Prepare
a fresh stock solution daily. Handle the recommended dilutions
(chickens 0.05% and turkeys 0.025%) as regular drinking water.
Administer as sole source of drinking water and sulfonamide
medication.
Chickens and turkeys that have survived fowl cholera outbreaks
should not be kept for replacements or breeders.
Cattle – During treatment period, make certain that animals
maintain adequate water intake. If animals show no improvement
within 2 or 3 days, reevaluate diagnosis. Treatment should not be
continued beyond 5 days.
WARNINGS
Chickens and Turkeys – Withdraw 5 days before
slaughter. Do not administer to chickens over 16 weeks
(112 days) of age or to turkeys over 24 weeks (168 days)
of age.
Cattle – Withdraw 7 days before slaughter. For dairy
calves, dairy heifers and beef cattle only. A withdrawal
period has not been established for this product in preruminating calves.
Do Not Use in Calves to be Processed for Veal.
PROTECT FROM LIGHT
Store at controlled room temperature 15˚ to 30˚C
(59˚ to 86˚F)
Restricted Drug — Use only as Directed (California)
NOT FOR HUMAN USE.
KEEP OUT OF REACH OF CHILDREN.
NDC 54925-034-11
29
T E T R A S O L ( C O N T. )
medicated water must be adequate to compensate for variations in
the age and class of animals, feed consumption, and environmental
temperature and humidity, each of which affects water consumption.
antibacterial
MIXING DIRECTIONS
Tetrasol Soluble Powder
(Tetracycline Hydrochloride
Soluble Powder)
ANADA #200-234, Approved by FDA.
AVAILABLE IN 3 SIZES:
5 oz (141.7 g) Packet – each packet containing 101.2 g of
tetracycline hydrochloride.
2 lbs. (907.2 g) and 5 lbs. (2.27 kg) Containers – each pound
containing 324 g of tetracycline hydrochloride.
INDICATIONS: For use in the control and treatment of the following
conditions in swine, calves and poultry.
SWINE AND CALVES
INDICATIONS: Control and treatment of bacterial enteritis (scours)
caused by Escherichia coli; bacterial pneumonia associated with
Actinobacillus pleuropneumoniae, Pasteurella spp. and Klebsiella
spp. sensitive to tetracycline hydrochloride.
RECOMMENDED DOSAGE LEVEL: Use soluble powder in the
drinking water at a drug level of tetracycline hydrochloride per gallon to provide 10 mg/lb of body weight per day in divided doses.
WARNING
SWINE – Do not slaughter animals for food purposes within
4 days of treatment.
CALVES – Do not slaughter animals for food purposes within
5 days of treatment. A withdrawal period has not been established for this product in pre-ruminating calves.
Do Not Use in Calves to be Processed for Veal.
CAUTION: Do Not Use for more than 5 consecutive days.
DIRECTIONS FOR USE: Administer for 3-5 days.
CHICKENS
INDICATIONS: Control of chronic respiratory disease (CRD) and air
sac disease caused by Mycoplasma gallisepticum and Escherichia
coli; infectious synovitis caused by Mycoplasma synoviae sensitive
to tetracycline hydrochloride.
WARNING
Do not slaughter birds for food within 4 days of treatment.
CAUTION: Not for use in turkeys or chickens producing eggs
for human consumption.
Do not use for more than 14 consecutive days.
DIRECTIONS FOR USE: Administer for 7-14 days. Medicate at first
clinical signs of disease or when experience indicates the disease
may be a problem.
GENERAL CAUTION: Prepare fresh solutions at least once a day.
Solutions are not stable for more than 24 hours. Use as a sole source
of tetracycline. Diagnosis should be reconsidered if improvement
is not noticed within 3 days. The concentration of drug required in
RECOMMENDED DOSAGE LEVEL: CRD and air sac disease: Use
soluble powder in the drinking water at a drug level of 400-800
mg tetracycline hydrochloride per gallon. Infectious synovitis: Use
soluble powder in the drinking water at a drug level of 200-400 mg
tetracycline hydrochloride per gallon.
TURKEYS
INDICATIONS: Control of infectious synovitis caused
by Mycoplasma synoviae; bluecomb (transmissible
enteritis, coronaviral enteritis) complicated by organisms sensitive to tetracycline hydrochloride.
FOR SWINE, CALVES AND TURKEYS:
Using 5 oz. Packet: 5 oz. dissolved in 1000 mL (approximately
34 fl. oz.) of warm water will provide a stock solution of 100 mg of
tetracycline hydrochloride activity per mL.
Using 2 lb. or 5 lb. Container: 2.52 oz. (two scoops) dissolved in
500 mL (approx. 17 fl. oz.) of warm water will provide a stock solution of 100 mg of tetracycline hydrochloride activity per mL.
FOR TURKEYS ONLY: This stock solution when metered at approximately 1 oz. per gallon, will provide drinking water containing 2,957
mg of tetracycline hydrochloride activity per gallon.
Using 5 oz. Packet: contents of packet are sufficient to deliver the
recommended daily dosage levels as follows:
At 25 mg/lb of body weight – 4,048 total lbs of turkeys to
be medicated.
At 10 mg/lb of body weight – 10,120 total lbs of swine or
calves to be medicated.
Individual calf treatment – 5 mL (1 measuring teaspoonful)
twice daily for each 100 lbs. of body weight administered as a
drench or by dose syringe.
Using 2 lb. or 5 lb. Container: The contents of two scoops
are sufficient to deliver the recommended daily dosage levels as
follows:
At 25 mg/lb of body weight – 2,040 total lbs. of turkeys to
be medicated.
At 10 mg/lb of body weight – 5,100 total lbs. of swine or
calves to be medicated.
Individual calf treatment – 5 mL (1 measuring teaspoonful)
twice daily for each 100 lbs. of body weight administered as a
drench or by dose syringe.
recommended dosage level of 10 mg/lb of body weight in divided
doses. Or the contents of this container will treat 25,920 lbs. of
turkeys when supplied at 25 mg/lb or at 200-800 mg/gallon will
provide 810 to 3,240 gallons of medicated drinking water for
chickens or turkeys.
The contents of 5 lb. container will provide sufficient drug to
treat 162,000 total pounds of swine or calves for a single day
at the recommended dosage level of 10 mg/lb of body weight in
divided doses. Or the contents of this container will treat 64,800
lbs. of turkeys when supplied at 25 mg/lb or at 200-800 mg/gallon
will provide 2,025 to 8,100 gallons of medicated drinking water for
chickens or turkeys.
Restricted Drug — Use only as Directed (California)
FOR USE IN ANIMALS ONLY.
KEEP OUT OF REACH OF CHILDREN.
Net Contents: NDC
5 oz. Packet 54925-033-05
2 lb. Container 54925-033-02
5 lb. Container 54925-033-50
FOR CHICKENS AND TURKEYS:
Using 5 oz. Packet: To arrive at the recommended dosages,
prepare stock solutions as follows:
200 mg/gallon – dissolve 1 packet (5 oz.) in 15,140 mL warm
water (4 gallons)
400 mg/gallon – dissolve 1 packet (5 oz.) in 7,570 mL warm
water (2 gallon)
800 mg/gallon – dissolve 1 packet (5 oz.) in 3,785 mL warm
water (1 gallon)
These stock solutions should then be metered into drinking water
at approximately 1 oz. per gallon. At 200-800 mg/gallon this packet
will provide 126.5 to 506 gallons of medicated drinking water.
Using 2 lb. or 5 lb. Container: To arrive at the recommended
dosages, use contents of two scoops to prepare stock solutions
as follows:
200 mg/gallon – dissolve 2 scoops (2.52 oz.) in 7,570 mL
warm water (2 gallons)
400 mg/gallon – dissolve 2 scoops (2.52 oz.) in 3,785 mL
warm water (1 gallon)
800 mg/gallon – dissolve 2 scoops (2.52 oz.) in 1,892 mL
warm water (0.5 gallon)
These stock solutions should then be metered into drinking water at
approximately 1 oz. per gallon. At 200-800 mg/gallon two scoops
will provide 63.8 to 255 gallons of medicated drinking water.
SPECIAL DIRECTIONS FOR BABY CALVES AND BABY PIGS:
Administer this product one hour before or two hours after feeding
milk or milk replacers. Provide clean (unmedicated) drinking water
at all times.
RECOMMENDED DOSAGE LEVEL: Infectious synovitis: Use soluble powder in the drinking water at
a drug level of 400 mg tetracycline hydrochloride per
gallon. Bluecomb: Use soluble powder in the drinking
water at a drug level of tetracycline hydrochloride per
gallon to provide 25 mg/lb of body weight per day in
divided doses.
30
NOTE: When using a watering trough, this product is to be administered twice a day in the drinking water of swine, calves and poultry.
One-half of the recommended daily dosage level of antibiotic is to
be consumed during each administration period, thus providing the
drug in divided doses.
The contents of 2 lb. container will provide sufficient drug to
treat 64,800 total pounds of swine or calves for a single day at the
31
antiseptic
nutritional supplements
Pect Plus
Udder Balm
C-M-P-K
Emollient, Antiseptic
Dextrose Oral Solution
Massage thoroughly and allow ointment to
remain for full antiseptic and softening
effect on the udder.
INDICATIONS: For use as a supplemental nutritive
source of calcium, phosphorus, magnesium, potassium and dextrose in cattle.
ACTIVE INGREDIENT: 8 Hydroxyquinoline sulfate
0.3% in a petroleum, lanolin base.
DOSAGE AND ADMINISTRATION: Administer
orally as a drench. The usual dose for adult cattle
is 500 mL.
INDICATIONS: For chapped teats, superficial
scratches, abrasions, wind burn and sunburn.
Each 500 mL contains:
Calcium chemically equivalent to
complex calcium borogluconate.................. 26%
Dextrose..................................................... 15%
Phosphorus................................................ 6.0 g.
(as sodium hypophosphite, H2O)
Magnesium...............................................2.76 g.
(as magnesium chloride hexahydrate)
Potassium...............................................0.525 g.
(as potassium chloride)
Benzyl alcohol............................................. 1.5%
In a suitable base.
DIRECTIONS: Apply Udder Balm thoroughly and
allow a coating to remain on the surface. Wash affected udder and teats thoroughly before and after
each milking to avoid contamination of milk. Dry
with a clean cloth.
WARNING: This protective ointment helps to keep
superficial tissue soft. If rash or irritation develops,
discontinue use and consult veterinarian.
KEEP OUT OF REACH OF CHILDREN.
VETERINARY USE ONLY.
NET WEIGHT:
12 oz.
4.5 lbs. (2.045 kg)
Dietary Supplement
for Calves
INGRDIENTS:
Psyllium
Dextrose Monohydrate
Dried Apple Pulp
Dried Potato Pulp
FEEDING DIRECTION:
Mix about 50 gram Pect Plus into 2 liters of calf
milk replacer or lukewarm water. Feed by teated
bucket or by open pail twice a day.
FOR ANIMAL USE ONLY.
USE ONLY AS DIRECTED.
Net Weight: 11 lbs.
NDC 54925-011-12
FOR VETERINARY USE ONLY.
NDC
54925-057-12
54925-057-45
USE ENTIRE CONTENTS.
Store at room temperature.
Revised October 2008
Net Contents: 500 mL
NDC 54925-066-50
32
small
animals
33
nutritional supplement
nutritional supplement
CONVEY ®
Nutritional Supplement for Young Calves
CONVEY ® provides supplemental electrolytes,
dextrose and fluids when mixed with water
and fed to calves.
CONTENTS: Psyllium Seed Husks, Dextrose Monohydrate, Sodium Bicarbonate, Sodium Chloride,
Sodium Citrate, Potassium Chloride, Citric Acid,
Magnesium Hydroxide, FD&C Red No. 40–Aluminum Lake.
FOR VETERINARY USE ONLY
DIRECTIONS: After mixing with water, feed
CONVEY to young calves requiring supplemental
electrolytes, dextrose and fluids. CONVEY is a
short term supplement in place of usual diet. Since
CONVEY™ is not a complete nutrition source, its
use should not exceed the recommended feeding
schedule.
GENERAL GUIDELINES: Feed CONVEY immediately after thorough mixing as the liquid may
become too thick to be ingested by calves. To avoid
absorption of moisture and caking, seal the CONVEY bag and replace the bucket lid immediately
after use. The 3rd feeding can be omitted if desired
and 4th feeding used in its place, followed in 12
hours by usual diet.
KEEP OUT OF REACH OF CHILDREN.
Vet-o-lyte
®
For Nutritional Supplement
in Calves
Contains: Dextrose anhydrous, sodium bicarbonate, sodium chloride, potassium chloride, magnesium sulfate anhydrous.
FOR VETERINARY USE ONLY
Each 80 grams of Vet-o-lyte provides: sodium,
134.0 mEq; potassium, 22.8 mEq; magnesium, 6.6
mEq; bicarbonate, 81.0 mEq; chloride, 75.8 mEq;
dextrose, 68 grams.
Directions For Use: Preparation of SolutionDissolve 80 grams (2 scoops) Vet-o-lyte in water
and dissolve 240 grams (6 scoops) of Vet-o-lyte in
water and dilute to a total volume of 3 quarts.
Dosage and Administration: Administer the
solution by feeding or drench at a rate of 1 quart
per 60 pounds of bodyweight 3-4 times daily for 2
days as the only source of oral fluids. The following
2 days the solution should be diluted 1:1 with milk
replacer and given at feeding time.
Nutri Lyte
Powder +
For Nutritional Supplement
in Calves
Ingredients: Dextrose, Salt, Potassium Chloride,
Glycine, Citric Acid, Sodium Bicarbonate, Ascorbic
Acid, Monosodium Phosphate, Magnesium Sulfate,
Manganese Sulfate, Zinc Sulfate, Copper Sulfate,
Vitamin A Acetate, Calcium Pantothenate, Xanthan
Gum, Artificial color and flavor.
Directions: Mix 2 oz. in 2 quarts of clean water or
1 lb. in 4 gallons.
Caution: To prevent lumping keep the lid tightly
closed. Store in cool place.
Net Contents: 25 lbs.
NDC 54925-008-25
Revised October 2008
Caution: Avoid exposure to excessive heat.
Keep container tightly closed. Store in a dry
place.
NOT FOR HUMAN USE.
KEEP OUT OF REACH OF CHILDREN.
Net Contents: 10 lbs.
Net Contents: 9.7 lbs. (4.4 kg)
NDC 54925-004-09
NDC 54925-005-19
34
35
nutritional supplement
medicated supplement
MED-PHARMEX’S
MED-PHARMEX’S
Calf Energy Formula
Medicated
Nutritional Supplement in Calves
Type C Medicated Feed
For oral treatment and prevention of Bacterial
Enteritis (Scours) in calves. Contains antibiotics, vitamins, and electrolytes with dextrose.
INGREDIENTS: Dextrose, Whey, Magnesium
Carbonate, Potassium Chloride, Salt, Choline Chloride, Calcium Lactate, Niacin, Riboflavin, Vitamin
B12 Supplement, Vitamin A Acetate, Vitamin D3,
Calcium Pentothenate, Psyllium.
ACTIVE DRUG INGREDIENTS:
Oxytetracycline
(from Quaternary Salt) equivalent to
Oxytetracycline HCI.................................. 3.0 g/lb
Neomycin Sulfate..................................... 6.0 g/lb
GUARANTEED ANALYSIS PER POUND:
Crude Protein (minimum)............................ 3.0 %
Crude Fat (minimum).................................. 0.1 %
Crude Fiber (minimum)............................... 1.0 %
Vitamin A.................................800,000 USP units
Vitamin D3...............................200,000 USP units
Choline Chloride....................................5,000 mg
Vitamin B12..............................................2.0 mg
Riboflavin.................................................200 mg
Niacin...................................................2,000 mg
Calcium Pentothenate.............................0.2174 g
Magnesium Carbonate................................. 5.0 g
Potassium Chloride...................................... 6.0 g
Calcium Lactate........................................... 5.0 g
Sodium Chloride........................................ 10.0 g
Restricted Drug: Use only as directed.
WARNING
Do not slaughter treated animals to be used
for food within 30 days following the last use
of this product. Exceeding the highest recommended dosage level may result in antibiotic
residues in edible portions of the animals beyond the withdrawal time as stated.
Net Contents: 40 lbs. (18.15 kg)
NDC 54925-039-40
FEEDING DIRECTIONS:
Prevention: As an aid in the prevention of bacterial enteritis (scours) 1/2 ounce (approximately
1 tablespoon) per gallon of reconstituted milk or
warm water.
Treatment: One (1) ounce (approximately 2
tablespoons) per gallon of reconstituted milk or
warm water.
36
RED RIBBON
INGREDIENTS: Glucose, sodium bicarbonate, glycine, potassium chloride, sodium chloride, calcium
hydroxide, magnesium sulfate, citric acid, ascorbic
acid, and artificial coloring (FD & C Red no. 40).
EACH OZ. CONTAINS:
Calcium, (Ca) maximum............................. 0.30%
Sodium, (Na) minimum.............................. 5.60%
Potassium, (K) minimum............................ 0.30%
Calcium, (Ca) minimum.............................. 0.10%
Magnesium, (Mg) minimum......................... 0.05%
MIX AND FEED INSTRUCTIONS:
Mix 2 scoops RED RIBBON with 2 qts. of 100°110° F. water. Withdraw all milk products and free
choice water. Discard any solution not consumed
in 12 hours. Use in conjunction with appropriate scours treatment. For large quantities, mix 4
scoops per each gallon of water.
Store in cool, dry place.
Net Contents: 25 lbs. (11.36 Kg)
NDC 54925-022-25
DAY 1
2 qts. RED RIBBON
2 X Daily
DAY 2
DAY 3
DAY 4
DAY 5
2 qts. RED RIBBON
1 qt. Milk Replacer
2 X Daily
Mix 2 oz.
into Milk Replacer
Milk Replacer
Mix Replacer
2 qts. RED RIBBON
+ 1 qt. Milk Replacer
2 X Daily
Milk Replacer
Milk Replacer
2 qts. RED RIBBON
3 X Daily
3rd Feeding
essential
2 qts. RED RIBBON
+ 1 qt. Milk Replacer
2 X Daily
Milk Replacer
2 qts. RED RIBBON
2 qts. RED RIBBON
3 X Daily
2 X Daily
3rd Feeding
2 qts. RED BIBBON
4 X Daily
4th Feeding
essential
2 qts. RED RIBBON
3 X Daily
3rd Feeding
essential
37
anti-diarrheal
notes
KAO-PECTIN
Bismuth
Suspension
Anti-Diarrheal Liquid
Anti-Diarrheal Liquid
COMPOSITION: Each fluid ounce contains:
Kaolin (Colloidal) ................... . . . . . . . 19.44%
Pectin (Citrus) ...................... . . . . . . . . 0.44%
in a palatable vehicle.
FOR VETERINARY USE ONLY
NOT FOR HUMAN USE
INDICATIONS: For oral administration as an aid in the
treatment of non-infectious diarrhea in horses, cattle,
dogs and cats.
SHAKE WELL BEFORE USE.
ADMINISTRATION: Oral
DOSAGE: May be repeated until condition improves.
Horses, Cattle: 6 to 10 ounces every 2 to 3 hours.
Colts, Calves: 3 to 4 ounces every 2 to 3 hours.
Dogs, Cats: 1 to 3 tablespoons every 1 to 3 hours.
WARNING: If symptoms persist after using this product
for 2 or 3 days, consult a veterinarian.
KEEP OUT OF REACH OF CHILDREN.
KEEP FROM FREEZING
Net Contents: One Gallon (3.785 L)
NDC 54925-006-11
FOR VETERINARY USE ONLY
A palatable oral solution for use as an aid in the control
of non-specific diarrhea.
USE ONLY AS DIRECTED
CONTAINS:
Bismuth Subsalicylate . . . . . . . . . . . . . . . . . . . . . . . 1 . 7 5 %
SHAKE WELL BEFORE USE.
ADMINISTRATION: Oral
DOSAGE: May be repeated until condition improves.
Horses, Cattle: 6 to 10 ounces every 2 to 3 hours.
Foals, Calves: 3 to 4 ounces every 2 to 3 hours.
Dogs, Cats: 1 to 3 tablespoons every 1 to 3 hours.
WARNING: If symptoms persist after using this product
for 2 or 3 days, consult a veterinarian.
KEEP OUT OF REACH OF CHILDREN.
KEEP FROM FREEZING
Store at room temperature between 15˚ to 30˚C
(59˚ to 86˚F)
Revised April 2008
Net Contents: One Gallon (3.785 L)
NDC 54925-014-11
Revised June 2008
38
39
2 7 2 7 T h o m p s o n C r e e k R o a d • P o m o n a , CA 91767
p h o n e 9 0 9 . 5 9 3 . 7 8 7 5 • 8 0 0 . 5 8 7 .4306
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