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Markey Cancer Center Nurses’ Guide: Intravenous Push (IVP) Drug List – Approved for RN Administration Updated: 2/25/05 University of Kentucky Chandler Medical Center Bumetanide (Bumex) Butorphanol Tartrate (Stadol) Cosyntropin (Cortrosyn) Dexamethasone Sodium Phosphate (Decadron) Dextrose 50% Diazepam (Valium) Diphenhydramine HCL (Benadryl) Dolasetron Mesylate (Anzemet) Droperidol (Inapsine) Epinephrine (Adrenaline Chloride) Famotidine (Pepcid) Flumazenil (Romazicon, Mazicon) Furosemide (Lasix) Glucagon (Glua Gen) Glycopyrrolate (Robinul) Granisitron HCL (Kytril) Haldoperidol (Haldol) Heparin (Heparin, Hep-Lock) Hydralazine HCL (Apresoline) Hydrocortisone Sodium Succinate (Solu-Cortef) Hydromorphone (Dilaudid) Insulin – Regular Only Ketorolac (Toradol) Labetalol (Normodyne, Trandate) Leucovorin Calcium (Wellcovorin) Levothyroxine (Synthroid) Lorazepam (Ativan) Meperidine (Demerol) Methylprednisolone Sodium Succinate (Solu-Medrol) Metoclopramide (Reglan) Morphine (MSO4) Muromonab-CD3 (Orthoclone, OKT3) *BMT Unit ONLY Naloxone (Narcan) Pantoprazole (Protonix) Promethazine (Phenergan) *Via Central or PICC Line Only Sodium Bicarbonate (NaHCO3, Bicarb) Torsemide (Demadex) If medication is not approved for the IV push administration and alternative routes of administration are not available, approval for this individual situation must be obtained through collaboration with pharmacy and the patient care manager Markey Cancer Center Nurses’ Guide: Intravenous Push (IVP) Drug List – Approved for RN Administration Updated: 2/25/05 University of Kentucky Chandler Medical Center GENERIC NAME (BRAND NAME(S)) Atropine Bumetanide (Bumex) Butorphanol Tartrate (Stadol) Cosyntropin (Cortrosyn) Dexamethasone Sodium Phosphate (Decadron) THERAPEUTIC CATEGORY/ INDICATIONS TYPICAL ADULT DOSE MAXIM UM ADULT DOSE MAXIMUM CONCENTR ATION MAXIMUM RATE OF ADMINISTRATION Antiarrhythmic/ Anticholinergic/ Treat symptomatic bradycardia, Pre-op antidote for certain insecticide poisoning Diuretic/ Acute pulmonary edema, CHF, renal disease Pre-op: 0.40.6mg 2 mg 1mg/ml 1 mg or less over 1 minute Narcotic-Opioid analgesic/ Relief of modsevere pain Diagnostic Agent 0.5-2 mg q 3-4 hours 4mg/do se 0.25mg 1mg Antiemetic esp. for high dose chemo & radiation; Antiinflammatory, Cerebral edema 4mg Highly variable based on disease/ pt. respons e (20100 mg) Bradycardia: 0.4-1 mg q 3-5 min to max of 2 mg 0.5-2mg 10mg/d ay 2mg/ml ADMINISTRATION CONSIDERATIONS Dry mouth, dizziness, palpitations, urinary retention, nervousness, weakness. 2mg over 2 minutes Pain at injection site 2mg over 3-5 minutes Also supplied as nasal spray 10mg.ml 2 minutes 4mg/ml Over 1 minute maximum, slower if itching Over 3-5 min is better. ADVERSE EFFECTS/COMMENTS MONITORING PARAMETERS Contraindicated in pts. with psychosis, AIDS, TB, VRE, fungal infections Risk of ototoxicity if concurrent use with aminoglycoside antibiotics. Multiple drug interactions. Dizziness, weakness, N&V, orthostatic hypotension, hypokalemia, polyuria N&V, sedation, diplopia, palpitations, respiratory depression, caution with ambulation Peak cortisol concentration occurs 4560 min after administration Insomnia, nervousness, increased appetite, thrombocytopenia, fluid retention, Watch for GI bleeding, epistaxis If medication is not approved for the IV push administration and alternative routes of administration are not available, approval for this individual situation must be obtained through collaboration with pharmacy and the patient care manager Markey Cancer Center Nurses’ Guide: Intravenous Push (IVP) Drug List – Approved for RN Administration Updated: 2/25/05 University of Kentucky Chandler Medical Center GENERIC NAME (BRAND NAME(S)) THERAPEUTIC CATEGORY/ INDICATIONS TYPICAL ADULT DOSE MAXIM UM ADULT DOSE MAXIMUM CONCENTR ATION MAXIMUM RATE OF ADMINISTRATION ADMINISTRATION CONSIDERATIONS Phlebitis risk, pain at injection site. Best per central line VAD -Phlebitis risk, pain at injection site-use large vein -Flumazenil (Romazicon) is the antagonist -Incompatible with most other drugs & solns. Push only in NS or D5NS very close to IV site Dilute to 25mg/ml in D5W or NS Dextrose 50% Symptomatic hypoglycemia 20 - 50ml of 50% solution - 20 - 50ml of 50% solution 10ml/minute Diazepam (Valium) Benzodiazipine; Seizure, Anxiety, Alcohol withdrawal Seizures: 5-10 mg initial, repeat at 10 min intervals to max 30 mg Anxiety: 2-5mg initial, repeat q3-4 hrs prn Alcohol Withdrawal: 10 mg initial, repeat 5-10 mg q 3-4 hrs prn. 30mg/8 hrs 5mg/ml 2- 5mg/minute Diphenhydramine HCL (Benadryl) Antihistamine; Histamine 1 Antagonist/ Alleviate allergic symptoms 5 HT3 Blocker – Antiemetic/ Prevent & treat chemo induced and post-op N&V 25-50mg Q24H 50mg/d ose400 mg/day 50mg/ml 25mg/minute 12.5mg/ 0.625 ml 100 mg/30 seconds Dolasetron Mesylate (Anzemet) 12.5 mg over 30 seconds ADVERSE EFFECTS/COMMENTS MONITORING PARAMETERS Hyperglycemia, confusion, tissue necrosis with extravasation of peripheral infusion. Bradycardia; tachycardia, drowsiness, hypotension, hypoventilation, urinary retention, caution in elderly, do not use with acute narrow angle glaucoma Hypotension, tachycardia, sedation, dizziness, insomnia, caution in asthma HTN, Headache, dizziness, tachycardia and urinary retention. Caution in patients at risk for prolonged QT interval If medication is not approved for the IV push administration and alternative routes of administration are not available, approval for this individual situation must be obtained through collaboration with pharmacy and the patient care manager Markey Cancer Center Nurses’ Guide: Intravenous Push (IVP) Drug List – Approved for RN Administration Updated: 2/25/05 University of Kentucky Chandler Medical Center GENERIC NAME (BRAND NAME(S)) THERAPEUTIC CATEGORY/ INDICATIONS TYPICAL ADULT DOSE MAXIM UM ADULT DOSE 10 mg MAXIMUM CONCENTR ATION MAXIMUM RATE OF ADMINISTRATION ADMINISTRATION CONSIDERATIONS 2.5- 10 mg/min *Drug Carries Black Box WarningReserve for pts who do not respond to alternatives Laryngospasm, hypotension especially orthostatic, hallucinations, sedation, prolonged QT interval. Check V/S at 30 min (peak effect) Usual conc. is 1mg/10ml 1 mg over 1-2 seconds Watch for injection site blanching/ extravasation -Tachycardia, hypertension, nervousness, restlessness, headache, dizziness HR, BP -Note: One mg = 1ml of 1:1000 soln OR 10ml of 1:10,000 soln -Do not mix with alkaline solutions Transient irritation at IV site Dosage adjusted in renal failure Use large vein & free flowing IV to minimize pain at injection site Headaches, dizziness, confusion, mental status changes Droperidol (Inapsine) Nausea & vomiting Premed for OR 2.5- 10 mg per min Epinephrine (Adrenaline Chloride) Sympathomimetic, Cardiac Arrest, Hypersensitivity reactions 1mg q 3-5 min. during cardiac arrest Famotidine (Pepcid) Gastrointestinal, Histamine 2 Antagonist 20mg Q12H 40mg 20mg/5 to 10ml 20mg/2 minutes Flumazenil (Romazicon, Mazicon) Benzodiazipine antagonist 0.2mg initial, them can repeat with 0.3mg Give no more than 1mg per dose or 3mg/ho ur 0.1mg/ml 0.2mg over 1530 seconds ADVERSE EFFECTS/COMMENTS MONITORING PARAMETERS Pt. may need additional doses in case of re-sedation. Caution in pts. at risk for or being treated for seizures If medication is not approved for the IV push administration and alternative routes of administration are not available, approval for this individual situation must be obtained through collaboration with pharmacy and the patient care manager Markey Cancer Center Nurses’ Guide: Intravenous Push (IVP) Drug List – Approved for RN Administration Updated: 2/25/05 University of Kentucky Chandler Medical Center GENERIC NAME (BRAND NAME(S)) THERAPEUTIC CATEGORY/ INDICATIONS TYPICAL ADULT DOSE MAXIM UM ADULT DOSE MAXIMUM CONCENTR ATION MAXIMUM RATE OF ADMINISTRATION ADMINISTRATION CONSIDERATIONS 80 mg but can vary widely 10mg/ml 1-2 minutes Rapid and high dose admin. can cause irreversible hearing loss Hypotension, headache, dizziness 1mg/minute May precipitate with NS, potassium & calcium. Unstable hypoglycemic diabetic may not respond & will need dextrose IV instead. N&V, hypokalemia in overdose, urticaria, respiratory distress, hypotension. Furosemide (Lasix) Loop Diuretic for pulmonary edema, fluid overload 40 mg Glucagon (Glua Gen) -Emergency treatment of symptomatic hypoglycemia -Diagnostic aid in some radiological exams Anticholinergic/ Preop: to diminish secretions & block cardiac vagal reflexes 0.5-1 mg. May be repeated 1-2 times. 5HT3 Blocker Prevention of N/V secondary to chemotherapy Antipsychotic/ Acute psychiatric episodes Nausea & vomiting 10 mcg/kg given 30 min prior to chemo dose 2-25 mg Glycopyrrolate (Robinul) Granisetron HCL (Kytril) Haldoperidol (Haldol) Compatible with D5W 0.0044 mg./kg 30 min prior to anesthesia 0.2mg.ml Varies with patient 100mg/ml ADVERSE EFFECTS/COMMENTS MONITORING PARAMETERS 0.2 mg over 1-2 minutes using free-flowing IV line Blurred vision, dry mouth, N&V, urinary hesitancy & retention Undiluted over 30 seconds Headache, diarrhea, constipation, hypertension, fever. 5mg/minute Start with lower doses in geriatric patients Drowsiness, extrapyramidal symptoms, hypotension, tachycardia, bradycardia, suppression of cough reflex, dry mouth, N&V If medication is not approved for the IV push administration and alternative routes of administration are not available, approval for this individual situation must be obtained through collaboration with pharmacy and the patient care manager Markey Cancer Center Nurses’ Guide: Intravenous Push (IVP) Drug List – Approved for RN Administration Updated: 2/25/05 University of Kentucky Chandler Medical Center GENERIC NAME (BRAND NAME(S)) Heparin (Heparin Hep-Lock) THERAPEUTIC CATEGORY/ INDICATIONS Anticoagulant/ DVT, Pulmonary Embolism, MI -Final flush for Groshong catheter in low dose Hydralazine HCL (Apresoline) Antihypertensive/ Severe essential hypertension, when need to lower BP is urgent Hydrocortisone Sodium Succinate (Solu-Cortef) Hydromorphone (Dilaudid) Narcotic Analgesic TYPICAL ADULT DOSE MAXIM UM ADULT DOSE MAXIMUM CONCENTR ATION MAXIMUM RATE OF ADMINISTRATION ADMINISTRATION CONSIDERATIONS 100-4000 units Initial bolus: 60-80 units/kg Infusion: 12-18 units/kg/hr 10-40 mg Repeated as necessary 10000 units/ml Over 1 minute Reversal agent: Protamine Takes 6 hours to see effects of dose change Bleeding, APTT, Hct, Hgb Thrombocytopenia (HIT - Heparin Induced Thrombocytopenia) 20 mg/ml Slow IVP Caution in CVA-may increase intercranial pressure. Headache, N&V, palpitations, angina, tachycardia, diarrhea. Elderly may be more sensitive to hypotensive effects. *Do not confuse with hydroxyzine. Succinate = 100-500mg Succinate= over at least 30 sec -Do not give with dextrose containing solutions -Undergoes color changes in most IV solutions. This does not indicate loss of potency -Succinate comes in “Mixo-vial, mix gently 1-4mg q 2-6 hrs prn 4mg/ml Each 2 mg over 2-5 minutes Nalxone (Narcan) is reversal agent ADVERSE EFFECTS/COMMENTS MONITORING PARAMETERS Insomnia, nervousness. May cause hyperglycemia in diabetics. Caution in TB & fungal infections & antibiotic resistant infections. Alert: salt formations are not interchangeable Alert: do not confuse Solu-Cortef with Solu-Medrol Palpitations, hypotension, constipation, dizziness, drowsiness, BP, RR If medication is not approved for the IV push administration and alternative routes of administration are not available, approval for this individual situation must be obtained through collaboration with pharmacy and the patient care manager Markey Cancer Center Nurses’ Guide: Intravenous Push (IVP) Drug List – Approved for RN Administration Updated: 2/25/05 University of Kentucky Chandler Medical Center GENERIC NAME (BRAND NAME(S)) THERAPEUTIC CATEGORY/ INDICATIONS TYPICAL ADULT DOSE Insulin (Regular Only) Pancreatic Hormone/ Hyperglycemia, DKA, Hyperkalemia 0.1-0.5 units/kg IV bolus Ketorolac (Toradol) NSAID/ Short term management of mod-severe pain 15 mg-30mg IV q 6 hours Labetalol (Normodyne) (Trandate) Antihypertensive Leucovorin Calcium (Wellcovorin) Folinic acid -High dose methotrexate rescue. 20 mg initial. Additional doses of 4080mg q 10 min. until max 300 mg Rescue: Based on methotrexate level but roughly 10mg/m2 -Advanced colorectal cancer (followed by 5FU as 2nd infusion) MAXIM UM ADULT DOSE 120 mg/day, max 5 days MAXIMUM CONCENTR ATION 30 mg/ml MAXIMUM RATE OF ADMINISTRATION ADMINISTRATION CONSIDERATIONS Over 10 seconds -ONLY Regular Insulin may be given IV -Hyperkalemia: 10 units in conjunction with dextrose and sodium bicarbonate Do not administer intrathecal or epidural routes Requires renal dose adjustment Over > 15 seconds 20 mg over 2 minutes 25mg/ml Over 3 minutes or longer. Do not exceed 160 mg/minute ADVERSE EFFECTS/COMMENTS MONITORING PARAMETERS Monitor Finger Stick Blood Sugars Edema, drowsiness, headache, renal toxicity. Do not administer to pts with active or recent bleeding. Do not use as pre-op analgesic. Avoid if already taking ASA or NSAIDS. Dizziness, orthostatic hypotension, vivid dreams, N&V, bronchospasm, dyspnea, arrhythmias, nasal stuffiness -Pain at injection site -Protect form heat & light Allergic reactions. Do not confuse leucovorin (folinic acid) with folic acid. Follow leucovorin rescue schedule/protocol VERY closely. Cancer: 20200mg/m2 If medication is not approved for the IV push administration and alternative routes of administration are not available, approval for this individual situation must be obtained through collaboration with pharmacy and the patient care manager Markey Cancer Center Nurses’ Guide: Intravenous Push (IVP) Drug List – Approved for RN Administration Updated: 2/25/05 University of Kentucky Chandler Medical Center GENERIC NAME (BRAND NAME(S)) THERAPEUTIC CATEGORY/ INDICATIONS Levothyroxine (Synthroid) Thyroid hormone/ Replacement therapy in hypothyroidism Lorazepam (Ativan) Benzodiazipine/ Anticonvulsant, sedation, anxiety, agitation Meperidine (Demerol) Narcotic Analgesic TYPICAL ADULT DOSE Initial dose: 200-500mcg, then100-300 on day two, then maint. 50200mcg q day Maintenance = ½ of oral dose 1-2 mg 25-150 mg q 2-4 hrs prn MAXIM UM ADULT DOSE 8mg/12 hrs, or 4mg per dose MAXIMUM CONCENTR ATION 2mg/ml 100mg/ml MAXIMUM RATE OF ADMINISTRATION ADMINISTRATION CONSIDERATIONS ADVERSE EFFECTS/COMMENTS MONITORING PARAMETERS 100mcg/min -Do not mix with any other IV fluids -Do not further dilute drug Symptoms of hyperthyroidism (nervousness, tremor, headache tachycardia, heat intolerance, etc.) 2mg/minute -Flumazenil (Romazicon) is reversal agent used to treat respiratory depression. -Dilute with equal volume IVF Sedation, hypotension, dizziness, headache, amnesia, HR, BP, RR. -Dilute to < 10mg/ml -Contraindicated in pt. taking MAO inhibitor & with pt. in kidney failure -Naloxone (Narcan) is reversal agent Sedation, hypotension, dizziness, constipation, BR, RR Over 4-5 minutes Can increase digoxin levels. If medication is not approved for the IV push administration and alternative routes of administration are not available, approval for this individual situation must be obtained through collaboration with pharmacy and the patient care manager Markey Cancer Center Nurses’ Guide: Intravenous Push (IVP) Drug List – Approved for RN Administration Updated: 2/25/05 University of Kentucky Chandler Medical Center GENERIC NAME (BRAND NAME(S)) THERAPEUTIC CATEGORY/ INDICATIONS Methylprednisolone Sodium Succinate (Solu-Medrol) Metoclopramide (Reglan) Morphine Muromonab-CD3 (Orthoclone, OKT3) *BMT Unit ONLY TYPICAL ADULT DOSE MAXIM UM ADULT DOSE MAXIMUM CONCENTR ATION MAXIMUM RATE OF ADMINISTRATION ADMINISTRATION CONSIDERATIONS Anti-inflammatory agent Adrenal Corticosteroid/ Severe inflammation Immunosuppression Prevent infusion/allergic reactions Antiemetic/ Relief of symptomatic GE Reflux, facilitate small bowel intubation, N&V post-op and assoc. with chemo Narcotic Analgesic 10-125 mg -High dose regime ns will require IVPB route of admin 10 mg 62.5mg/ml Over 3-60 minutes 125mg / 3-5 min 250mg/15-30min 500mg/ 30min 1Gm/60min -Rapid admin of high doses can cause circulatory collapse. -* Only the succinate form can be given IV Insomnia, nervousness BP, monitor blood glucose levels in diabetic pts. Monitor Na+ and potassium levels 5mg/ml 1-2 minutes High doses >10mg require IVPB over 15 min. Admin over < 1 min. may cause intense anxiety & restlessness Caution with hypertension. Contraindicated in GI bleed. Mental depression, BP changes, restlessness, drowsiness, dizziness, dystonic reactions (extrapyramadal effects treated Benadryl). 10mg/ml 1 mg/min - Naloxone (Narcan) is reversal agent Sedation, dizziness, heart palpitation, hypotension, bradycardia, constipation BP, RR, Oxygen saturation Immunosuppressive Agent 5mg 1mg/ml <1minute Filter each dose through a low protein binding 0.22 micron filter Fever, chilling, dyspnea, wheezing, chest pain, tachycardia, dizziness, shortness of breath. Monitor all vital signs including temperature. 5-10 mg 1-2mg/kg IV 30 min prior to chemo 2-10 mg q 2-4 hours prn 5mg ADVERSE EFFECTS/COMMENTS MONITORING PARAMETERS If medication is not approved for the IV push administration and alternative routes of administration are not available, approval for this individual situation must be obtained through collaboration with pharmacy and the patient care manager Markey Cancer Center Nurses’ Guide: Intravenous Push (IVP) Drug List – Approved for RN Administration Updated: 2/25/05 University of Kentucky Chandler Medical Center GENERIC NAME (BRAND NAME(S)) Naloxone (Narcan) Pantoprazole (Protonix) Promethazine (Phenergan) THERAPEUTIC CATEGORY/ INDICATIONS TYPICAL ADULT DOSE MAXIM UM ADULT DOSE MAXIMUM CONCENTR ATION MAXIMUM RATE OF ADMINISTRATION ADMINISTRATION CONSIDERATIONS ADVERSE EFFECTS/COMMENTS MONITORING PARAMETERS Pure Opiod Antagonist/ Treat respiratory depression from narcotic intake 0.4-2mg 24mg 1mg/ml Over 2 minutes -If pt. on chronic opioids, give <0.1 mg at a time to avoid reversal of pain relief Tachycardia, narcotic withdraw, hypertension, hypotension, anxiety, restlessness, HR, BP, RR Note: duration of narcotic may exceed that of Naloxone, monitor for return of respiratory depression Gastrointestinal; Proton pump inhibitor Antiemetic Antihistamine 40 mg 80 mg 4mg/ml 40mg/ 2 min Injection site reactions, headache, dyspepsia, and nausea 12.5-25mg 50mg 50mg/ml 25mg/min Reconstitute with 10ml, 0.9% NaCl. ALERT! Extravasation can lead to EXTENSIVE tissue damage. Give ONLY via Central or PICC Line -Push in cardiac arrests only -Tissue necrosis if extravasation. -inactivates catecholamines such as dopamine, epinephrine -Precipitates if given with calcium Edema, fluid overload, hypernatremia, metabolic alkalosis 0.1-0.2 mg q 23 min until desired reversal of post-op narcotic depression Via CENTRAL or PICC line only, or IVPB over 20 min. Sodium Bicarbonate (NaHCO3) (Bicarb) Alkalinization Agent/ -Metabolic acidosis (from cardiac arrest, renal failure, DKA, etc) -Maintain alkaline urine: tumor lysis syndrome, trauma, tricyclic antidepressant drug overdose 0.5-1 mEq/kg Dose for renal failure & DKA based n ABG 1mg/ml Rapid: 1-2 seconds ALERT – ONLY given via Central or PICC Line due to potential for tissue damage with extravasation. Hypotension, tachycardia, dizziness, drowsiness. If medication is not approved for the IV push administration and alternative routes of administration are not available, approval for this individual situation must be obtained through collaboration with pharmacy and the patient care manager Markey Cancer Center Nurses’ Guide: Intravenous Push (IVP) Drug List – Approved for RN Administration Updated: 2/25/05 University of Kentucky Chandler Medical Center GENERIC NAME (BRAND NAME(S)) Torsemide (Demadex) THERAPEUTIC CATEGORY/ INDICATIONS Diuretic/ HPT, CHF with fluid overload, renal & hepatic disease TYPICAL ADULT DOSE MAXIM UM ADULT DOSE 10-20 mg MAXIMUM CONCENTR ATION MAXIMUM RATE OF ADMINISTRATION 20mg over at least two min ADMINISTRATION CONSIDERATIONS ADVERSE EFFECTS/COMMENTS MONITORING PARAMETERS Contraindicated in anuria. Hypokalemia, hyperglycemia, N&V, headache, dizziness. If the medication is not approved for IV push administration and alternative routes of administration are not available, approval for this individual situation must be obtained through collaboration with pharmacy and the patient care manager Updated: 02/04/03 Developed by: Jeanne Bouvier, Staff Development and Kim Hopper, PharmD Approved by: Kimberley Hite, Tukea Talbot, Mary Lindsey Merrill Contact person for revisions: Kimberley Hite ([email protected]) If medication is not approved for the IV push administration and alternative routes of administration are not available, approval for this individual situation must be obtained through collaboration with pharmacy and the patient care manager