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Indian Journal of Research in Homoeopathy Vol. 3, No. 4, October-December 2009 CLINICAL VERIFICATION TARENTULA HISPANICA - A Multicentric Clinical Verification Study conducted by CCRH 1,7 8 1 1 7 2 1 P.S.Chakraborty, Anil Khurana , J.P.Singh , M.K.Rai , Pramodji Singh , A.K.Vichitra , A.K.N.Singh , Deepa Chakraborty1, D.K.Singh6, Hari Singh2, Mohan Singh5, M.N.Sinha6, Rajpal1, R.K.Rai5, S.Prakash5, S.D.Pathak6, 4 7 2 6 1,5 1 S.R.Bhagat , Vikram Singh , Vijay K. Paul , V.K.Singh , Yogendar Rai & V.A. Siddiqui 1. Homoeopathic Drug Research Institute, Lucknow (U.P.) 2. Regional Research Institute (H), New Delhi 3. Homoeopathic Research Institute, Jaipur (Rajasthan) 4. Clinical Research Unit, Jammu (J & K) 5. Clinical Verification Unit, Ghaziabad (U.P.) 6. Clinical Verification Unit, Patna (Bihar) 7. Clinical Verification Unit, Vrindaban (U.P.) 8. Central Council for Research in Homoeopathy. New Delhi Tarentula hispanica is a known drug in Homoeopathy but it has not been used extensively. Its use has been reported in homoeopathic literature for various clinical conditions like depression, headache, hiccough, quinsy, cystitis, vertigo, otorrhoea, pyrosis, constipation, seminal emission, neuralgia of legs, cough, dyspnoea and fever. Most of these symptoms have been reconfirmed in the study conducted by Central Council for Research in Homoeopathy (CCRH). Besides these, in conditions like conjunctivitis, dyspepsia, flatulence, loose stool, pain in deltoid region, pain in shoulder joints and in pimple-like eruptions it is also found useful. A total of 2794 patients were studied in this multicentric clinical verification trial under CCRH to confirm the symptoms of Tarentula hispanica, as mentioned in the homoeopathic materia medica. Keywords: homoeopathy; clinical verification; tarentula hispanica; dyspepsia; constipation; intermittent fever; tonsillitis; depression; dry cough INTRODUCTION royal residence of Pardo, Spain, in the month of 3 July, during which time the poison is stronger . The medicine was prepared from the live spider, all its parts triturated in sugar of milk to complete dryness 1 and from this the alcoholic dilution was prepared . Tarentula covers a number of poisonous spiders, but in homoeopathy, unless otherwise distinguished, it refers to Tarentula hispanica. Nunez is the chief authority of this drug. He conducted the proving and collected much outside information bearing on the action of the poison. Provings conducted by Monge, del Rio, Tejero, Fejedor, Cuesta, Dubost, Perry, Ros, Ituttalde, Gonzales and Chategnier, were reported by Nunez, translated by Terry and were 1 published in American Journal of Homeopathy. “Tarantella” is a dance named from the city of Tarento in Southern Italy. “Tarantism” is a dancing mania, set up in persons bitten by the Tarentula spider, or in those who imagine themselves bitten. 2 The cure is through music and dancing. Clarke has illustrated some cases where it has been mentioned that the toxicological symptoms developed after the bite of Tarentula were completely recovered by hearing music and it also can alleviate the periodical recurrence of complaints.2 Many stalwarts in Homoeopathy like C.M. Boger, Hering, Farrington, Kent and P. C. Majumdar have mentioned their experiences with Tarentula for different clinical conditions. These include suffocative feeling, constant jerking of limbs, rolling of head in night gowns, tonsillitis and cystitis. Its prominent sensations are tickling, burning, scorching and numbness and it is suited to nervous, hysterical 2 patients subject to choreic affections and tickling . It is also suited to the persons of foxy, mischievous 4 nature with destructive tendency . The male and female Tarentula used in the provings were collected by Dr. Mariano de la Paz Graells, at the * Address for Correspondence: Director General Central Council for Research in Homeopathy 61-65, Institutional Area, Janakpuri, New Delhi- 110 058 Email: [email protected] 25 TARENTULA HISPANICA - A Multicentric Clinical Verification Study conducted by CCRH P.S.Chakraborty et al depression, choreic phenomena of a marked character, being more severe and terrible in their manifestations than are those produced by any other poison. It is said that the patients will cause their bodies to move to the measure of the music and are often led to execute a kind of a dance. The chief characteristic is that the paroxysms are quieted, sometimes entirely removed, through the influence of music, a cure sometimes resulting there from. The attacks are often accompanied by great sexual 6 excitement . Central Council for Research in Homoeopathy reproved the drug Tarentula hispanica between 1985-1987 and more than 40 symptoms were found to have reappeared when compared with original 7 proving . This demonstrated the validity of earlier provings. Many new symptoms were also proved in this proving and which required clinical verification for their professional use. Tarentula hispanica P. C. Majumdar reports a case of a girl of 18 years, diagnosed as hystero-epilepsy and Ignatia 30 as a first prescription did nothing to the patient but Tarentula in high potency brought her out of the fit and restored her completely in a few minutes. C. M. Boger cured a male patient complaining of irritative cough with soreness all over the body and with dryness of throat, cough aggravation by lying down, at night and in morning after rising and amelioration from smoking. There was tearing pain in chest with shortness of breath for at least an hour after each attack of cough. Three doses of Tarentula cured the case.2 Materials and Methods Participants for the study were drawn from the OPDs of the respective Institutes / Units of the Council. Patients who presented with the indications of the drug were enrolled in the study. Details of the presenting symptoms and signs were recorded in the predefined case recording proforma and the patient was prescribed Tarentula hispanica (if indicated) in 6c potency. If there was no change in symptoms and signs for a significant period, next higher potencies like 30c and 200c were prescribed and in case no change was observed, even after change of potencies, the case was dropped from the study and those cases were treated in the O.P.D. of the concerned Institute/ Unit with other indicated medicine(s). It has been reported in literature that Tarentula hispanica is capable of relieving a number of clinical conditions when indicated homoeopathically and these include Angina pectoris, Callosities, Chorea, Coccygodynia, Corneal opacity, Cystitis, Depression of spirits, Insanity, Dysmenorrhoea, Epistaxis, Fibroma, Headache, Hiccough, Hysteria, Intermittent fever, Kleptomania, Nymphomania, Levitation, Locomotor ataxia, Mania, Migraine, Pruritus pudenda, Gonorrhoea, Weakness in sphincter ani, Quinsy, Diphtheria, Septic diseases, Spinal irritation, Spinal sclerosis, Tumours, Cancer, neuralgia of 1,2,4, 5 Uterus, & Tumours of vertebrae. In this multicentric trial of Tarentula hispanica, 2794 patients (1348 males and 1446 females) were prescribed trial drug during the period. The medicine was procured from the licensed pharmacy in various potencies viz. 6c, 30c and 200c. Caution has been given not to prescribe this medicine below 3x potency.3 The scientific name of this spider is Tarentula 6 hispanica and its natural order is Araneideae . Study settings The study was carried out at Regional Research Institute (H), New Delhi, Homoeopathic Drug Research Institute, Lucknow (U.P.), Homoeopathic Research Institute, Jaipur (Rajasthan), Clinical Research Unit, Jammu (J & K), Clinical Verification Unit, Ghaziabad (U.P.), Clinical Verification Unit, Patna (Bihar) and Clinical Verification Unit, Vrindaban (U.P.), from April 1982 to March 2004. It is distributed over South America and South of Europe especially Spain 3. This spider venom contains an active principle known as Arachnolysin3 which is haemolytic. The action of this poison differs only from other spider poisons in that it is more persistent. The cerebro-spinal system being the seat of its primary effects, through which it causes, together with restlessness, and great mental and physical Indian Journal of Research in Homoeopathy Vol. 3, No. 4, October-December 2009 26 TARENTULA HISPANICA - A Multicentric Clinical Verification Study conducted by CCRH P.S.Chakraborty et al Results (character, modalities, concomitants etc.) have also been found to be relieved in patients which are not mentioned in the literature and have been kept along with the main symptom in italics. In the column 'Improvement observed' the first figure denotes the number of patients who had the symptom and to whom the medicine was prescribed and the second figure denotes the number of patients who got relief of the same symptom; this is followed by the percentage of improvement given in parenthesis. The data of all the cases were collected, compiled and analyzed. The clinically verified symptoms are given in Table-1 along with the number of patients prescribed on the basis of symptoms available in literature and also the number of patients who got relieved after application of medicine. Numericals super scribed along with the symptoms denote the literature cited. Moreover during the study, part of the main symptom Table 1: Symptoms verified clinically during the study Location Symptom(s) Mind Aversion for company but wants someone to be present Depression Improvement observed 1,5 with aversion to talk Mental depression Irritability Vertigo ? 7 worse on talking, better after sleep 2/2 (100%) 49/35 (71.42%) worse on changing position 4/4 (100%) 5, 7 Vertigo with giddiness 1, 2, 4, 5 Vertigo 1, 2, 4, 5 ? Head 22/18 (81.81%) with heaviness in head 7 8/2 (25%) with sensation of falling down worse on standing Headache 7 36/27(75%) 7 14/9 (64.28%) 1,2, 4,7 2/1 (50%) 1,2 Intense headache better by rubbing Headache better by rubbing 1,2 6/4 (66.66%) and motion 4/4 (100%) 1 Frontal headache worse from noise 1, 5 Frontal headache with nausea Heaviness of head 2/2 (100%) and heaviness of eyes 5, 7 Throbbing pain in head worse from warmth better in open air Headache, dull aching Dull aching headache 2/2 (100%) 8/7 (87.5%) 7 7 7 worse in sun Conjunctivitis with redness of eyes 7 7 and whitish mucopurulent discharge 7 7 Conjunctivitis with itching in eyes 27/14 (51.85%) 73/48 (65.75%) 5/5 (100%) 7 Swelling of lower eyelid, worse on reading, better by cold application Redness of conjunctiva 42/23 (54.76%) 8/1 (12.5%) Conjunctivitis with redness of eyes, itching and lachrymation 5 10/7 (70%) 39/26 (66.66%) worse from sun , better by pressure Headache better by cold application Eye 9/5 (55.55%) 6/4(66.6%) 5, 7 1, 2, 4,5,7 Vertigo 20/17 (85%) 9/4 (44.44%) 7 1, 2, 5, 7 Forgetfulness Vertigo 1 4 with swelling of lids 27 7 and itching 3/3 (100%) 67/48 (71.64%) (Cont. ......) Indian Journal of Research in Homoeopathy Vol. 3, No. 4, October-December 2009 TARENTULA HISPANICA - A Multicentric Clinical Verification Study conducted by CCRH P.S.Chakraborty et al Ear Otorrhoea Nose Coryza 2,5 thin, sticky, offensive , thin, watery nasal discharge ? worse in closed room, better in open air 49/31 (63.26%) ? copious discharge 7 with sneezing 66/49 (74.24%) 2, 7 61/42 (68.85%) 7 29/22(75.86%) ? with dry cough ? with heaviness in head Aphthae, tongue painful Pain and swelling 7 1/1 (100%) 1 4/3 (75%) 1, 7 1/1 (100%) of tonsils 2,7 Soreness in throat, ? 1,2 7 2/2 (100%) 7 with rawness in throat 1/1 (100%) 7 rawness and worse on swallowing 7 better by hot fomentation Tonsils inflamed 2 11/10 (90.90%) 7/7 (100%) 1,2,7 23/17(73.91%) 7 ? with rawness ? worse at night ? worse on swallowing 1/1 (100%) ? painful 3/2 (66.66%) 3/3 (100%) 7 3/2 (66.66%) 2, 7 Hoarseness of voice ? with soreness, worse in morning Pain in throat, worse on swallowing Tonsils swollen, inflamed Hiccough 1 Heartburn Dyspepsia 7/5 (71.42%) 7 with acidity 155/125 (80.64%) with anorexia Pain in epigastrium 1, 7 and sour eructation and heaviness 2, 5, 7 12/9 (75%) 7 6/5(83.33% ) with flatulence with pain in abdomen, 5, 7 with rumbling in abdomen worse after eating 7 7 32/28 (87.5%) better by passing flatus 2, 5, 7 1/1(100%) worse after breakfast Flatulence with dyspepsia 3/3 (100%) 5/5 (100%) 7 Abdomen distended with heaviness, worse after eating ? 45/36(80%) 26/23 (88.46%) 5, 7 worse after breakfast Bloated abdomen ? 12/11 (91.66%) 1, 7 ? ? 17/13(76.47) 34/24 (70.58%) with heartburn ? 4/3 (75%) 1/1 (100%) 1, 2, 7 2 ? ? 5, 7 2, 4 Pain in stomach Abdomen 154/106 (68.83%) 54/35(64.81%) Lips dry and red, worse in morning Stomach 7 worse in evening Bleeding from gums Throat 39/31 (79.48%) ? ? Mouth 5 7 14/11 (78.57%) 6/5 (83.33%) 7 9/7 (77.77%) (Cont. ......) Indian Journal of Research in Homoeopathy Vol. 3, No. 4, October-December 2009 28 TARENTULA HISPANICA - A Multicentric Clinical Verification Study conducted by CCRH P.S.Chakraborty et al with rumbling Rectum 7 3/2 (66.66%) 2, 7 Constipation 109/75 (68.80%) 2 Burning in anus, worse after stool 2 Constipation with difficult, Stool-hard, constipated Stool 1 7 2/2 (100%) hard, scanty and insufficient stool 7 34/26 (76.47%) 1,7 53/35 (66.03%) ? with difficulty in passing stool ? unsatisfactory stool 1, 7 10/5 (50%) 3/2 (66.66%) Burning in anus after passing stool Stool-scanty, mixed with mucus 1,2, 7 with pain in abdomen 1 1, 2, 7 3/2 (66.66%) 7 Stool loose watery ? 12/10 (83.33%) with pain in lower abdomen 7 10/8 (80%) Urinary organs Dribbling of urine1 2/1(50%) Frequent urination at night Retention of urine 1,2, 7 13/11 (84.61%) 1 1/1 (100%) 1, 5 Urine scanty, frequent, yellowish ? 7 with burning in urethra 7 21/17 (80.95%) 8/5 (62.5%) 7 Urine yellowish with burning Male sexual organs Seminal emission 15/11 (73.33%) 1,2,4, 7 Seminal emission 18/13 (72.22%) 1,2,4, 7 worse after urination Swelling of spermatic cord with pain on pressure Pain and swelling of spermatic cord ? Female sexual organs worse on walking Leucorrhoea 2 Back 7 2/2 (100%) Extremities 2, 7 with pain 5 2/1 (50%) 2/2 (100%) with inability to move 7 Pain in deltoid region 7 Pain in knee joints, Numbness of legs 1/1 (100%) with stiffness of shoulder joint 4/4 (100%) with loss of power to write and to hold anything 4/4 (100%) worse on movement 2/2 (100%) worse after motion, better on sitting 1/1 (100%) 5, 7 5, 7 7 5, 7 Pain in knee joints, Pain in knees, 3/2 (66.66%) 1/1 (100%) 2, 5, 7 5, 7 Cramps in hands Larynx 1 16/12 (75%) Stiffness in nape of neck ? 8/5 (62.5%) 3/3 (100%) 1,2, 4 Stiffness of neck Backache 1/1 (100%) 2, 7 2, 7 profuse, worse on walking Itching of vulvae 7/6 (85.71%) with stiffness 2/2 (100%) 1,2, 4 25/25 (100%) 2, 7 Hoarseness of voice 24/14 (58.33%) (Cont. ......) 29 Indian Journal of Research in Homoeopathy Vol. 3, No. 4, October-December 2009 TARENTULA HISPANICA - A Multicentric Clinical Verification Study conducted by CCRH P.S.Chakraborty et al Cough Cough with thick, whitish expectoration ? 5,7 5 with dyspnoea 9/9(100%) Cough with whitish mucoid expectoration, 7 morning and at night Dry cough 5, 7 worse in early 42/25 (59.52%) 2, 5, 7 89/61 (68.53%) 2, 5 ? with dyspnoea ? paroxysmal 4/4 (100%) 6/6 (100%) ? with tingling in throat ? worse in morning 7 17/11 (64.70%) 5,7 63/41 (65.07%) 2,5 ? with hoarseness of voice ? worse in morning and evening 14/13 (92.85%) 5, 7 Cough worse in morning and evening Skin 16/12 (75%) Vesicular eruptions with itching 8/7 (87.5%) 7 15/9 (60%) 4,7 7/4 (57.14%) 1, 5 Pustular eruptions ? 7/6 (85.71%) 1 with itching 5/4 (80%) 5, 7 Pimples with itching 4/2 (50%) 5 Pimples on face 9/7 (77.77%) Small, dry, reddish eruptions with itching, 7 worse from cold 24/17 (70.83%) 7 Small, reddish eruptions with itching, worse from heat of sun , better from cold application Fever 7 3/3 (100%) Fever with heaviness of whole body 17/14 (82.35%) ? worse by 5 p.m. 3/2 (66.66%) ? with restlessness Fever with chill 1,2,5 7 Fever with chill 1,2,5, 7 7 6/4 (66.66%) , worse in evening 16/9 (56.25%) and restlessness Intermittent fever with chill 6/2 (33.33%) 1,2,5 75/64 (85.33%) ? with headache and bodyache 29/28 (96.55%) ? with profuse thirst 27/26 (96.29%) ? with restlessness 14/12 (85.71%) ? worse at night 6/6(100%) ? worse 5-8 p.m. with bodyache 1/1 (100%) Fever with chill 5, 7 Fever with cough Indian Journal of Research in Homoeopathy Vol. 3, No. 4, October-December 2009 7 and heaviness in head, worse in evening and cold 5 5/3 (60%) 21/20 (95.23%) 30 TARENTULA HISPANICA - A Multicentric Clinical Verification Study conducted by CCRH P.S.Chakraborty et al Table : 2 Clinical symptoms During the study, a group of symptoms were also found to be relieved which are new and not found in the referred literature, although they may be present in other text books of Materia Medica. These are the additional symptoms of the medicine that were relieved either fully or partially. These, therefore, emerged as clinical symptoms of Tarentula hispanica. Location Symptom(s) Improvement observed Nose Coryza with thick, yellowish discharge 3/2 (66.66%) Stomach Thirstlessness 7/7 (100%) Sour eructation 18/13 (72.22%) ? 5/4 (80%) Abdomen worse after eating Flatulence with heaviness in abdomen, worse sitting and on exertion 4/4 (100%) ? 2/2(100%) worse in morning and after eating and better after passing stool Urinary organs Retention of urine 1/1 (100%) Male sexual organs Sexual weakness 2/2 (100%) Extremities Pricking pain in hand, worse on motion, noise and amel. by rubbing 64/47 (73.43%) Pain in shoulder joint, worse on raising the arm 5/4 (80%) Pain in sacral region, worse on movement and on lying down and better on sitting 1/1 (100%) Pain in heels, worse on sitting and on movement 13/8 (61.53%) Aching pain in legs 18/14 (77.77%) Pain in calf muscles, better by tight bandage 11/7 (63.63%) Bruised pain in calf muscles better by tight bandage 2/1 (50%) ? pain from hips to heels 20/11 (55%) ? worse on movement, better by lying down 5/3 (60%) Skin Pain in deltoid region, worse on raising the hand 18/14 (77.77%) Small papular eruptions with itching of legs and knees, worse on scratching, better in open air 3/1 (33.33%) REPERTORY A concise repertory of the verified symptoms, according to the structure of Kent's Repertory of the Homoeopathic Materia Medica has been compiled for the purpose of quick reference. Rubrics / sub rubrics in italics are new rubrics, i.e., not mentioned in the above referred repertory while rubrics / sub rubrics in roman letters are the existing rubrics of the said repertory which were reconfirmed through verification in this study. The physicians may include these rubrics in their personal repertories for their day to day reference in practice. MIND COMPANY, aversion to but wants some one to be present FORGETFUL IRRITABILITY RESTLESSNESS 31 Indian Journal of Research in Homoeopathy Vol. 3, No. 4, October-December 2009 TARENTULA HISPANICA - A Multicentric Clinical Verification Study conducted by CCRH P.S.Chakraborty et al reading agg. chill during the 5 p.m. SADNESS, mental depression REDNESS SWOLLEN, lids sleep after amel. ITCHING TALK, indisposed to EAR VERTIGO DISCHARGES FALL, tendency to gluey, sticky GIDDINESS, with offensive HEAVINESS, in head with thin POSITION, change from NOSE STANDING, while CORYZA HEAD air, open, amel. HEAVINESS chill, during chill, during 4-8 p.m cough, dry with vertigo, with discharge, with (fluent) inside closed room agg. heaviness in head, with PAIN DISCHARGE cold applications amel. motion, amel. evening rubbing, amel. Forehead, in copious thick heaviness of eyes, thin with nausea, with watery noise yellow SNEEZING dull pain pressure amel. sun, from exposure to PULSATING, throbbing FACE DISCOLORATION, red air, in open, amel. morning warmth from lips DRYNESS EYE lips ERUPTIONS INFLAMMATION pimples conjunctiva DISCHARGES of mucus or pus MOUTH white ITCHING APHTHAE LACHRYMATION Tongue SWOLLEN sensitive lower lids BLEEDING cold amel. Indian Journal of Research in Homoeopathy Vol. 3, No. 4, October-December 2009 Gums 32 TARENTULA HISPANICA - A Multicentric Clinical Verification Study conducted by CCRH P.S.Chakraborty et al THROAT eating, after INFLAMMATION stool, after amel. indigestion in stomach, Tonsils with rumbling night HEAVINESS PAIN swallowing, eating, after on rawness exersion, on swallowing, when hot fomentation, amel. Tonsils sitting, while PAIN flatus, passing, amel. stool, after amel. sore Hypogastrium morning swallowing hot fomentation, amel. stool, during RUMBLING hoarseness of voice, with SWELLING Tonsils RECTUM CONSTIPATION night difficult stool PAIN STOMACH burning in anus APPETITE stool, after wanting ERUCTATIONS sour eating, after HEARTBURN acidity, with HEAVINESS STOOL HARD INSUFFICIENT MUCOUS, slimy SCANTY WATERY breakfast, after pain in lower abdomen, with HICCOUGH INDIGESTION BLADDER NAUSEA RETENTION headache during URINATION, dribbling PAIN frequent THIRSTLESS night ABDOMEN DISTENSION eating, after URETHRA PAIN flatus passing amel. burning FLATULENCE morning URINE 33 Indian Journal of Research in Homoeopathy Vol. 3, No. 4, October-December 2009 TARENTULA HISPANICA - A Multicentric Clinical Verification Study conducted by CCRH P.S.Chakraborty et al BURNING tickling in larynx, from PAROXYSMAL COLOR, yellow SCANTY EXPECTORATION GENITALIA MORNING PAIN NIGHT MUCOUS Spermatic cords pressure, from THICK walking, while WHITE SEMINAL emissions night BACK urinating, after SEXUAL PASSION diminished PAIN SWELLING STIFFNESS Cervical region Spermatic cords Cervical region GENITALIA- FEMALE EXTREMITIES ITCHING CRAMPS LEUCORRHOEA Upper Limbs copious walking, while Upper Arm Hand loss of power to write and to hold anything, with LARYNX ANDTRACHEA ERUPTION VOICE papular hoarseness itching morning air open amel. evening scratching, from cough, during soreness in throat, with Lower Limbs Knee Leg RESPIRATION PAIN DIFFICULT stitching (pricking) cough, with Upper Limbs Upper Arm COUGH deltoid region raising MORNING arm agg. EVENING stiffness of shoulder, with Hand DRY motion, on noise, from morning evening rubbing amel. coryza, during Lower Limbs fever, during Indian Journal of Research in Homoeopathy Vol. 3, No. 4, October-December 2009 34 TARENTULA HISPANICA - A Multicentric Clinical Verification Study conducted by CCRH P.S.Chakraborty et al Nates red motion, on vesicular lying, on ITCHING sitting, amel. cold application, from motion, on heat of sun, from Hip amel. lying amel. extending to heel Knee GENERALITIES HEAVINESS, externally motion sitting, amel. stiffness, with Leg calf tight bandage, amel. heel sitting walking aching (bruised) STIFFNESS, joints Upper Limbs Shoulder raising arm agg. Lower Limbs Knee FEVER AFTERNOON 5 p.m. EVENING 5 p.m. to 8 p.m. bodyache, with CHILL, with extreme thirst, with INTERMITTENT Night SKIN ERUPTION dry papular pustules pimples chill, during Discussion The medicine was found useful to relieve depressive state of mind or sadness. Out of 20 patients, 17 were improved after intake of this medicine and which is the re-confirmation of symptoms mentioned 1 2 5 by Hering , Clarke & Allen in their Materia Medica. Tarentula hispanica was prescribed to 49 patients suffering from vertigo and 35 were improved after treatment. Out of these participants, 27 who were having the sensation of falling down were improved after taking the medicine. It is also found to be a very useful medicine to treat headache as mentioned in Homoeopathic Materia Medica but the modality verified in this trial was 'worse from sun and better by pressure' in 23 of such patients and they were relieved after taking medicine. In conjunctivitis its application was also found helpful to the participants with itching of eyes and lachrymation. Similarly in otorrhoea, the character of discharge was verified as thin, sticky and offensive. In coryza, Tarentula is found useful in thin, watery discharge, aggravation in closed room and better in open air. Dyspepsia (heart burn, sour eructation) and hiccough have also improved clinically by using Tarentula in a good number of patients(Table 1). Its action on gastro-intestinal tract is further verified through clinical improvement in bloating of abdomen and constipation especially in cases of hard, scanty and insufficient stool. Its urinary symptoms are marked with frequent scanty urination at night and is verified in lines with symptoms mentioned in the Materia Medica of Hering and Allen's Encyclopaedia. Pricking pain in hand agg. from motion, noise and amel. by rubbing emerged as a new symptom which was an associated symptom in 64 35 Indian Journal of Research in Homoeopathy Vol. 3, No. 4, October-December 2009 PDF to Word