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Open Studies
Evaluation of Multi-Parametric Magnetic Resonance Imaging in the Diagnosis and
Characterisation of Prostate Cancer PROMIS
Principal Investigators
Prof Mark Emberton
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Health Category: Cancer
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Study Type: Other Trials
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Primary Intervention / Area: Drug
An Open-label, Non-randomised, Multicentre, Comparative, Phase I Study to Determine
the Pharmacokinetics, Safety and Tolerability of Olaparib following a Single Oral 300 mg
Dose to Patients with Advanced Solid Tumours and Normal Hepatic Function or Mild or
Moderate Hepatic Impairment D0816C00005
Dr Rebecca Kristeleit
Study of oral PQR309 in Patients with Advanced Solid Tumours PQR309-001/SAKK 67/13
Dr Rebecca Kristeleit
A Phase I/IIa, Dose-Escalation, Study of CHR-3996 in Combination with Tosedostat in
Participants with Relapsed, Refractory Multiple Myeloma MUK Three
An Open-Label, Dose-Escalation, Phase 1/2 Study of the Oral Form of MLN9708, a NextGeneration Proteasome Inhibitor, Administered in Combination With a Standard Care
Regimen of Melphalan and Prednisone in Patients With Newly Diagnosed Multiple
Myeloma Requiring Systemic Treatment C16006 / MLN9708
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Health Category: Cancer
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Study Type: Phase 1
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Primary Intervention / Area: Drug

Health Category: Cancer
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Study Type: Phase 1
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Primary Intervention / Area: Drug
Dr Rakesh Popat
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Health Category: Cancer
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Study Type: Phase 1
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Primary Intervention / Area: Drug
Dr Kwee Yong
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Health Category: Cancer

Study Type: Phase 1
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Primary Intervention / Area: Drug
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Open Studies
An Open-Label, Multicentre, Phase 2 Study of Oral MLN9708 in Adult Patients with
Relapsed and/or Refractory Follicular Lymphoma C16017 / MLN9708
An Open-Label Phase I/IIa Study of Intravenous BAL101553 in Adult Patients with
Advanced Solid Tumours CDI-CS-001 / BAL101553
Principal Investigators
Dr Rakesh Popat
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Health Category: Cancer
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Study Type: Phase 1
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Primary Intervention / Area: Drug
Dr Rebecca Kristeleit
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Health Category: Cancer

Study Type: Phase 1
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Primary Intervention / Area: Drug
An Open-label, Multicentre, Multiple Dose, Phase 1 Study to Establish the Maximum
Dr Rebecca Kristeleit
Tolerated Dose of E7389 Liposomal Formulation in Patients with Solid Tumours E7389-112
 Health Category: Cancer
-001/Esai Bold
 Study Type: Phase 1
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A Phase 1b/2 Double-Blind Randomized Trial of the Hedgehog/SMO Antagonist
LY2940680 in Combination with Carboplatin and Etoposide Followed by LY2940680 versus
Carboplatin and Etoposide Plus Placebo Followed by Placebo in Patients with ExtensiveStage Small Cell Lung Cancer 14J-MC-HHBE/LY2940680
A phase Ib, open-label, multi-centre, two-arm, dose-finding study to assess the safety and
efficacy of the oral combination of Ruxolitinib (INC424) and BKM120 in patients with
primary myelofibrosis (PMF), postpolycythemia vera-myelofibrosis (PPV-MF), or post
essential thrombocythemia-myelofibrosis (PET-MF).INC424A2104 (Harmony)
Primary Intervention / Area: Drug
Dr Martin Forster
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Health Category: Cancer
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Study Type: Phase 1
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Primary Intervention / Area: Drug
Dr Rakesh Popat
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Health Category: Cancer
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Study Type: Phase 1
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Primary Intervention / Area: Drug
2
Open Studies
MAGnetic NAnoparticle thermoaBLATion – Retention and Maintenance in prostatE:
A Phase 0 Study in Men (MAGNABLATE I Trial)
Principal Investigators
Dr Hashim Ahmed

Health Category: Cancer

Study Type: Phase 0
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Primary Intervention / Area: Drug
A Multi-Arm Safety and Tolerability Study of investigational medication in Combination with Dr Coziana Ciurtin
Other Anti-Tumour Agents B2151002
 Health Category: Musculoskeletal
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Study Type: Phase 1
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Primary Intervention / Area: Drug
Open Label, Adaptive Design, Ascending, Multiple-Dose Study to Evaluate Safety and
Efficacy of BMS-986004 (Anti-CD40L dAb) in Adult Subjects with Primary Immune
Thrombocytopenia (ITP) BMS - Study in Adult Subjects with Primary Immune
Thrombocytopenia (ITP)
Dr Marie Scully
NIHR BioResource- Adult Infectious Diseases -BioAID
Dr Mahdad Noursadeghi
An Open-Label Proof of Concept Phase IIa Trial of ALXN1007 for the Treatment of Noncriteria Manifestations of Antiphospholipid Syndrome Alexion (LEAD SITE)
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Health Category: Blood
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Study Type: Phase 1
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Primary Intervention / Area: Drug
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Health Category: Infection
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Study Type: Other Trials
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Primary Intervention / Area: N/A
Dr Hanna Cohen
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Health Category: Blood
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Study Type: Phase 2a
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Primary Intervention / Area: Drug
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Open Studies
A Phase 1 prospective, uncontrolled, open-label, multicentre, dose-escalation study
evaluating the safety and pharmacokinetics in hereditary TTP (Thrombotic
Thrombocytopenic Purpura) BAXTER
Golimumab: A Phase 4, UK Open Label, Single arm Study on its Utilization and Impact in
Ulcerative Colitis Go- Colitis
Principal Investigators
Dr Marie Scully
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Health Category: Blood
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Study Type: Phase 1
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Primary Intervention / Area: Drug
Dr Stuart Bloom
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Health Category: Oral and Gastrointestinal
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Study Type: Phase 4
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Primary Intervention / Area: Drug
A randomized ,Double-blind ,Placebo controlled study to evaluate the Safety ,tolerability
Dr Stuart Bloom
and efficacy of AMG 181 in subjects with moderate to severe Crohn's Disease Amgen-181
 Health Category: Oral and Gastrointestinal
Double-Blind, Randomised, Placebo-Controlled, Phase 2 Safety and Efficacy Trial of
MultiStem® in Adults With Ischemic Stroke-MultiStem
A 6 year prospective study to define the clinical and biological characteristics of
pregnancies affected by severe early onset Fetal Growth Restriction EVERREST
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Study Type: Phase 2a
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Primary Intervention / Area: Drug
Dr Richard Perry
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Health Category: Stroke
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Study Type: Phase 2a
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Primary Intervention / Area: Drug
Dr Anna David
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Health Category: Reproductive Health
and Childbirth
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Study Type: Other Trials
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Primary Intervention / Area: N/A
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Open Studies
A Study of Blood, Blood Vessels and Placenta from Pregnant Women with High Blood
Pressure and/or Small Babies and/or who smoke during pregnancy VAMPS2
Anti-Biopharmaceutical Immunisation: Predication and analysis of clinical relevance to
minimise the risk of immunisation in rheumatoid arthritis patients (ABIRISK).
Phase II trial VSN16R in MS related spasticity-Blood oxygen carrying capacity, iron, CPET
and POMS: a pilot study
An investigation into Lipid Metabolism in Pregnancy and its role in the pathogenesis of
Acute Fatty Liver of Pregnancy.AFLP study - Lipid Metabolism and Acute Fatty Liver in
Pregnancy
A Nationwide Register of First Degree Relatives of Patients with Rheumatoid Arthritis to
Evaluate Predictors of the Development of Rheumatoid Arthritis PREVENT RA
Principal Investigators
Dr David Williams
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Health Category: Reproductive Health
and Childbirth
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Study Type: Other Trials
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Primary Intervention / Area: N/A
Dr Claudia Mauri
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Health Category: Inflammatory and
Immune Systems

Study Type: Other Trials
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Primary Intervention / Area: Biomarker
Dr James Otto
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Health Category: Other
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Study Type: Pilot or Feasibility
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Primary Intervention / N/A
Dr David Williams
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Health Category: Reproductive Health
and Childbirth
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Study Type: Other Trials
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Primary Intervention / Area: N/A
Dr Coziana Ciurtin
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Health Category: Musculoskeletal
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Study Type: Other Trials
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Primary Intervention / Area: Biomarker
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Open Studies
A randomised double-blind controlled phase III study to compare the efficacy and safety of
intravenous ferric carboxymaltose (with placebo in patients with anaemia undergoing major
open abdominal surgery-PREVENTT
A Multicentre, Randomized, DoubleBlind, Study Comparing the Efficacy and Safety of
Continuing Versus Withdrawing Adalimumab Therapy in Maintaining Remission in Subjects
with Non Radiographic Axial Spondyloarthritis M13375, Adalimumab, nonradiographic axial
Spondyloarthritis study
The UCH Preterm Development Project: growing up after very preterm birth
Principal Investigators
Dr James Crosbie
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Health Category: Generic Health Relevance
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Study Type: Phase 3
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Primary Intervention / Area: Drug
Prof Derek Gilroy
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Health Category: Inflammatory and
Immune Systems
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Study Type: Other Trials
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Primary Intervention / Area: N/A
Prof Neil Marlow

Health Category: Reproductive Health
and Childbirth
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Study Type: Other Trials

Primary Intervention / Area: Screening
A multicentre, randomized, double-blind, placebo-controlled, parallel-group study of oral CP Dr Stuart Bloom
-690,550 as an induction therapy in subjects with moderate to severe ulcerative
 Health Category: Oral and Gastrointestinal
colitis.Octave Study Type: Other Trials
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Primary Intervention / Area: Drug
6
Open Studies
Trafficking and regulation of immune cells between the blood, skin and joint in autoimmune
rheumatic disease. Regulating inflammation in autoimmune rheumatic disease
Investigation of molecular mechanisms in obesity and weight loss-EMObesity
Effect of Tocilizumab on Ischaemia-Reperfusion Injury in Human Hand Veins TCZ study
The University College London (UCL) BioResource
Does the shingles vaccine Zostavax reverse the skin-specific T cell defect to varicella
zoster challenge? Reversing the effects of ageing on the cutaneous immune system
Principal Investigators
Prof Michael Ehrenstein
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Health Category: Musculoskeletal
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Study Type: Other Trials
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Primary Intervention / Area: Other
Dr Rachel Batterham

Health Category: Generic Health Relevance
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Study Type: Other Trials
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Primary Intervention / Area: Screening
Prof Raymond MacAlister
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Health Category: Cardiovascular
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Study Type: Other Trials
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Primary Intervention / Area: Other
Prof Nick Wood
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Health Category: Other
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Study Type: Other Trials
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Primary Intervention / Area: Screening
Prof Christopher Bunker
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Health Category: Inflammatory and
Immune Systems
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Study Type: Other Trials
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Primary Intervention / Area: Other
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Open Studies
The TACERA Study: a Longitudinal Observational Study of Patients with Early
Rheumatoid Arthritis
The effect of exercise on ischaemia reperfusion injury in humans-Ischemia-reperfusion
injury in human hand veins
A prospective randomised controlled phase II/III clinical trial of rivaroxaban versus warfarin
in patients with thrombotic antiphospholipid syndrome, with or without SLE.RAPS
The 2nd European Carotid Surgery Trial (ECST-2)
The Evaluation of blood pressure treatment stratified according to Central Aortic Systolic
Pressure (CASP) in Young Hypertensive Patients -TREAT CASP
Principal Investigators
Dr Coziana Ciurtin
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Health Category: Musculoskeletal
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Study Type: Other Trials
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Primary Intervention / Area: Screening
Prof Raymond MacAlister

Health Category: Cardiovascular
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Study Type: Phase 1
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Primary Intervention / Area: Other
Dr Hannah Cohen
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Health Category: Inflammatory and
Immune Systems
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Study Type: Phase 2a
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Primary Intervention / Area: Drug
Prof Mark Brown
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Health Category: Stroke
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Study Type: Other Trials
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Primary Intervention / Area: Surgical
Prof Bryan Williams

Health Category: Cardiovascular
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Study Type: Other Trials

Primary Intervention / Area: Screening
8
Open Studies
The EPICure Studies: EPICure@19 – the extremely preterm young adult
REVACEPT, An Inhibitor Of Platelet Adhesion In Symptomatic Carotid Stenosis: A PHASE
II, Multicentre; Randomised, Dose-finding, Double-blind and Placebo-controlled Superiority
Study with Parallel Groups
Inflammatory Bowel Disease and Fatigue: The effect of increasing physical activity and/or
omega 3 supplementation. Inflammatory Bowel Disease and Fatigue
Cortical pain response in human infants
Principal Investigators
Dr Neil Marlow

Health Category: Generic Health Relevance
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Study Type: Other Trials
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Primary Intervention / Area: N/A
Dr Toby Richards

Health Category: Neurological
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Study Type: Phase 2a
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Primary Intervention / Area: Drug
Pro Alistair Forbes
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Health Category: Gastroenterology
and Hepatology
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Study Type: Observational
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Primary Intervention / Area: N/A
Prof Maria Fitzgerald

Health Category: Neurological
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Study Type: Other Trials
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Primary Intervention / Area: N/A
9
Open Studies
Evaluation the impact of carrier status of obesity-linked genetic variants on the outcome of
medical weight loss and bariatric surgery The impact of genotype on the outcome of
obesity treatment
A Randomised, Double-blind, Placebo-controlled, Multiple Dose, Parallel, Multiple DoseLevel Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and
Clinical Effect of AMG 557 in Systemic Lupus Erythematosus (SLE) Subjects with Active
Lupus Arthritis AMG557
Principal Investigators
Dr Rachel Batterham
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Health Category: Metabolic and Endocrine
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Study Type: Other Trials
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Primary Intervention / Area: Genetic
Prof David Isenberg
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Health Category: Inflammatory and
Immune System
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Study Type: Phase 1
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Primary Intervention / Area: Drug
10
Open Studies
Principal Investigators
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