Download RUCY®-XylBINAP

Takasago Fine Chemicals Division
RUCY®-XylBINAP
RUCY is a novel ruthenabicyclic complex. This complex with base shows excellent
catalytic activity in the asymmetric hydrogenation of ketones. In the case of
hydrogenation of acetophenone, the turnover frequency reaches about
35000min-1, affording 1-phenylethanol in >99% ee. Several base-labile and
bicyclic ketones, which are difficult substrates to hydrogenate with reported
catalyst system (RuCl2(diphosphine)(diamine)/t-BuOK), are smoothly converted
to the corresponding alcohols in high enantioselectivity.
“RUCY” is a registered trademark or a trademark of Takasago International
Corporation in Japan and other countries.
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(R)-RUCY-XylBINAP
(S)-RUCY-XylBINAP
RuCl[(R)-daipena][(R)-xylbinap]
RuCl[(S)-daipena][(S)-xylbinap]
CAS No.
1384974-38-2
CAS No.
1312713-89-5
Formula
C 71H 73ClN 2O 2P 2Ru
Formula
C 71H 73ClN 2O 2P 2Ru
M.W.
1184.91
M.W.
1184.91
OCH3
Ar2 Cl
P
Ru
P
Ar2
H2 H
N
H2
N
Ar2 Cl H2
N
P
Ru H
2
N
P
Ar2
Ar =
OCH 3
CH3 O
H
Ar =
CH3 O
Matsumura, K. J. Am. Chem. Soc. 2011, 133, 10696. doi: 10.1021/ja202296w
PCT Int. Appl. W O2011135753A, Takasago International C orp.(2010).
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Tech Note
1. Hydrogenation of Acetophenone
3. Hydrogenation of Bicyclic Ketones
2. Hydrogenation of Base-labile Substrates
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