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th May 10 , 2016. Auditorium. School of Informatics. 13.00 - 15.00 JBI2016 Registration. 14.00 - 14.15 JBI2016 Student Symposium. Welcome by Carles Hernandez (Symposium Chair) and Salvador Capella Gutierrez (JBI2016 Organizing committee). 14.15 - 15.45 JBI2016 Student Symposium Workshop. Disseminating Science: from traditional media to social networks. José Miguel Mulet (UPV). 15.45 - 16.00 JBI2016 Student Symposium Talk. Blast2GO Hackathon: A Bioinformatics Coding Challenge. Robert Nica (BioBam Bioinformatics). 16.00 - 16.30 Coffee break. 16.30 - 17.30 Special Session #1: Student Symposium (I). Carles Hernandez (ISGlobal-CREAL) & Carla GinerDelgado (Universitat Autònoma de Barcelona). • cICB: a modular high-throughput computational pipeline for the annotation of proteins of unknown function by Integrative Cell Biology. Nicola Bordin (Centro Andaluz de Biología del Desarollo). • Integration of multiomics data to describe link between developmental exposure to pesticides and impaired neurodevelopment. Elena Bernabeu (CIPF). • New applications for computational docking: modeling of protein-peptide complexes and oligomeric structures. Chiara Pallara (Life Sciences Department, Barcelona Supercomputing Center). • When in development? Estimating natural selection through Drosophila life cycle using population genomics data. Marta Coronado-Zamora (Universitat Autònoma de Barcelona). 17.30 JBI2016 Student Symposium. Closing words by Carla Giner-Delgado (Symposium Co-chair). 17.45 - 18.00 Break. 18.00 - 19.00 Undergraduate & Graduate programs on Bioinformatics. An overview about current situation and future proposals. • BIB: taking action on bioinformatics education and training. Eva Alloza. BIB - Bioinformatics Barcelona. • The ELIXIR-EXCELERATE Training Programme. Alex Upton. University of Malaga. • Bioinformatics in Madrid: Master in Bioinformatics and Computational Biology. Miguel Ponce de León. Universidad Complutense de Madrid. • Undergraduate & Graduate programs on Bioinformatics: The case of the Universitat Politècnica de València. José M. Sempere. (UPV). 19.00 - 20.00 Round table about training and educational programs on Bioinformatics. Moderated by Eduardo Vendrell Vidal. Director of School of Informatics – iSchool (UPV). 20.00 - 20.30 Walk around the campus to get to the Social event venue. 20.30 - 23.00 Social event & networking at Bocalinda (includes light dinner). th May 11 , 2016. Auditorium. Cubo Azul Building. 09.00 - 10.30 JBI2016 Registration. 10.30 - 10.45 JBI2016 Official reception. Welcome by Alfonso Valencia (Director - Spanish National Institute of Bioinformatics), Francisco José Mora Mas (Rector - Universitat Politècnica de València), and Javier F. Urchueguía Schölzel (JBI2016 Organizing Committee). 10.45 - 12.15 Scientific Session #1: Structural Bioinformatics & Function. Marc Marti-Renom (CNAG-CRG). • Structural diseasomes and hot-spot prediction enable detection of network-attacking mutations. Didier Barradas-Bautista (Barcelona Supercomputing Center). • Rationally designed drug blending as a mechanism to overcome drug resistance in cancer. Francisco Martinez-Jimenez (CNAG-CRG). • Machine learning-based method for residue-residue contact prediction. Ruben Sanchez-Garcia (CNB-CSIC). • Characterization and quantification of the global transcriptome in the Oligodendrocyte differentiation by means of PacBio and Illumina sequencing. Manuel Tardaguila (University of Florida). • Nucleosome Dynamics portal. Ricard Illa (IRB). • Transcriptional atlas of Drosophila melanogaster imaginal discs. Cecilia Coimbra Klein (CRG). 12.15 - 12.30 Break. 12.30 - 13.30 Keynote #1: The Evolution of Enzyme Function. Janet Thornton (EMBL-EBI). Introduced by Alfonso Valencia (CNIO). 13.30 - 15.00 Lunch, poster viewing & networking. 15.00 - 16.00 Special Session #2: Highligths (H). Ana Rojas (Institute of Biomedicine in Seville). • A single three-dimensional chromatin compartment in amphioxus indicates a stepwise evolution of vertebrate Hox bimodal regulation. Ibai Irastorza (Universidad Pablo de Olavide). • Epigenomic Co-localization and Co-evolution Reveal a Key Role for 5hmC as a Communication Hub in the Chromatin Network of ESCs. David Juan (CNIO). • Beyond the Whole-Genome Duplication: Phylogenetic Evidence for an Ancient Interspecies Hybridization in the Baker's Yeast Lineage. Marina Marcet-Houben (CRG). 16.00 - 16.30 Coffee break & poster viewing. 16.30 - 18.00 Scientific Session #2: NGS Technologies: Genomics & Transcriptomics (D). Metagenomics (B). Mar Alba (IMIM). • Designing a sensitive software tool for methylation analysis on long-reads datasets. Juan M. Orduña (Universitat de València). • Health and disease imprinted in the time variability of the human microbiome. Andrés Moya (FISABIO). • Integrated solution to metagenomics, from taxonomy to functional analysis. David Pérez-Villarroya (FISABIO). • Searching for the chromatin determinants of hematopoiesis.Enrique Carrillo-De Santa Pau (CNIO) • FAIR, Functional Analysis at Isoform Resolution by using long reads technologies. Lorena de La Fuente Lorente (CIPF). • A cheap and simple method for sample tracking for illumina TruSightOne clinical Exomes. Cristian Perez-Garcia (Instituto de Medicina Genómica). May 12th, 2016. Auditorium. Cubo Azul Building. 09.00 - 10.00 Keynote #2: Function and Evolution of Post-Translational Modifications. Vera van Noort (KU Leuven). Introduced by Javier F. Urchueguía Schölzel (UPV). 10.00 - 11.30 Scientific Session #3: Systems and Synthetic Biology (G). Chair Javier Urchueguía (UPV). • Learning the genome. Davide Bau (CNAG-CRG). • Computational RNA models guide the engineering of novel gene regulatory systems from sequence to function. Guillermo Rodrigo (IBMCP UPV). • Functional Meta-Analysis for Genomic Studies. Francisco García-García (CIPF) • Prediction of bacterial optimal growth rates in insect-endosymbiont systems at exponential growth. Jorge Calle Espinosa (Universidad Complutense de Madrid). • Integration of proteomic and metabolomic data in genome-scale metabolic models and its application to the cyanobacteria Synechocystis sp. PCC 6803. Marina Pérez-Naveira (ITACA). • Modelling non-steady state metabolic fluxes using dynamic elementary modes. Abel Folch-Fortuny (UPV). 11.30 - 12.00 Coffee break & poster viewing. 12.00 - 13.00 Special Session #3: Highligths (H). Joaquin Dopazo (CIPF). • Late acquisition of mitochondria by a host with chimaeric prokaryotic ancestry. Toni Gabaldón (CRG). • Bacterial antisense RNAs are mainly the product of transcriptional noise. Verónica Lloréns-Rico (CRG) • The potential clinical impact of the release of two drafts of the human proteome. Michael Tress (CNIO) 13.00 - 13.30 ELIXIR solutions around human data management. Alfonso Valencia (CNIO-INB). Jordi Rambla (CRG). 13.30 - 13.50 Bioinformatics and Populational Health: The future of the Electronic Health Record. Juan Carlos Muria (Business Developer Manager for Healthcare of Fujitsu Spain), Víctor de la Torre (Senior Research Fellow at Fujitsu Laboratories of Europe). 13.50 - 15.00 Lunch, poster viewing & networking. 15.00 - 16.30 Scientific Session #4: Biomedical Informatics: from Biomedical Bioinformatics to Mining Electronic Health Records (A). Fatima Al-Shahrour (CNIO). • Inferring significant pathway regulators from the integration of multi-omic NGS data in Generalized Linear Models. Sonia Tarazona (CIPF). • RD-Connect and identification of rare disease patients with similar genotype and phenotype combinations in other platforms through GA4GH Matchmaker Exchange. J. Protasio (CNAG-CRG). • Higher gene expression variability in the more aggressive subtype of chronic lymphocytic leukemia. Daniel Rico (CNIO). • • • Spanish Population-Specific Differences in Disease-Related Genetic Variation. Alicia Amadoz (CIPF). Leveraging text mining, expert curation and data integration to develop a database on psychiatric diseases and their genes. Alba Gutiérrez Sacristán (GRIB). The pan-cancer pathological regulatory landscape. Matias M. Falco (CIPF). 16.30 - 17.00 Presentación del Borrador sobre “Bionformática en la Clínica”. Resultado del 1er Encuentro Nacional de Bioinformáticos Clínicos. Angela del Pozo (Hospital Universitario La Paz). 17.00 - 17.30 Coffee break & poster viewing. 17.30 - 19.00 Round table “How to bring discoveries and ideas to the market” moderated by Marc Ramis Castelltort (Manager at TBI). Kunio Suzuki (Board Member, Advisory Board & Head of Innovation at Fujitsu Technology Solutions), Ana Conesa (BioBam’s Co-founder and Bioinformatics Professor at Univ. of Florida), Manuel Pérez Alonso (Instituto de Medicina Genómica’s CEO), Carlos Esteban (Investment Director at Caixa Capital Risc), & Ángel Alberich-Bayarri (QUIBIM’s CEO & Co-founder). 21.00 Gala dinner at “Restaurante de Ana”. th May 13 , 2016. Auditorium. Cubo Azul Building. 10.00 - 11.00 JBI2016 Keynote #3: Towards a pan-eukaryotic kinome. Berend Snel (Utrecht Bioinformatics Center). Introduced by Toni Gabaldón (CRG). 11.00 - 11.30 Coffee break 11.30 - 13.15 Scientific Session #5: Phylogeny & Evolutionary Bioinformatics (E). Methods matter & Reproducible Science(C). Toni Gabaldón (CRG). • Breaking-Cas – Interactive design of guide RNAs for CRISPR-Cas experiments for ENSEMBL genomes. Mònica Franch (CNB-CSIC). • Interplatform consistency using estimations of signaling pathway activity from transcriptomic data. Daniel Crespo (CIPF). • RECONSTRUCTOR: a new tool that mixes reference guided and de novo assembly strategies to create a private genome sequence. Irantzu Anzar (Sequentia Biotech). • Evolution of nested endosymbiosis in Tremblaya: bulls in a China shop. Rosario Gil (Universitat de València). • Understanding the frequency distribution of human polymorphic inversions. Isaac Noguera (Universitat Autònoma de Barcelona). • Prokaryote Protein Co-evolution points to Cell Response to Environment. David Juan (CNIO). • DOMINO: Development of informative molecular markers IN non-model organisms using NGS data or pre-computed alignments. José F. Sánchez-Herrero (Universitat de Barcelona). 13.15 - 13.30 Wrap-up and JBI2016 Closing (including best talk and best poster prizes delivery). 13.30 - 15.00 Lunch.