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Delaney Sullivan [email protected] Undergraduate Student, Stanford University April 12, 2015 Photo 51 Photo 51 Rosalind Franklin X-ray crystallography Nobel Prize in Physiology or Medicine, 1962 James Watson Francis Crick Maurice Wilkins Review: What is the function of DNA? DNA is our genetic material The Central Dogma of Molecular Biology The Central Dogma of Molecular Biology “DNA makes RNA makes protein” The structure of DNA Left-handed vs. Right-handed Helix Forms of DNA: A, B, Z A B Z (Image source: http://commons.wikimedia.org/wiki/File%3AA-B-Z-DNA_Side_View_Transparent.png) B-DNA (Image source: http://www.pbs.org/wgbh/nova/body/DNA-photograph.html) Base Pairs Base Pairs What’s wrong with these figures? Chromatin Chromatin Packing Epigenetic Regulation: Lysine (De)acetylation (Image source: Fundamentals of Chromatin) Epigenetic Regulation: The Histone Code (Image source: Molecular Biology of the Cell, 4th ed.) Epigenetic Regulation: The Histone Code (Image source: Molecular Biology of the Cell, 4th ed.) Epigenetic Regulation: The Histone Code (Image source: Molecular Biology of the Cell, 4th ed.) Epigenetic Regulation: The Histone Code (Image source: Molecular Biology of the Cell, 4th ed.) Stanford SPLASH All of you