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Running head: ATTENTION-DEFICIT/HYPERACTIVITY DISORDER IN CLINICAL PRACTICE Attention-Deficit/Hyperactivity Disorder in Clinical Practice Cheryl S. Davis-Triplett Methodist University Research for Professional Nursing Practice, Professor Barry 1 ATTENTION-DEFICIT/HYPERACTIVITY DISORDER IN CLINICAL PRACTICE 2 Attention-Deficit/Hyperactivity Disorder in Clinical Practice Attention-Deficit/Hyperactivity Disorder or ADHD is a chronic mental health condition characterized by inattention, hyperactivity, and impulsivity. This condition can affect children as well as adults and is often misdiagnosed, prematurely diagnosed, or altogether misinterpreted in the clinical setting. These inconsistencies in care may be due to the fact that the signs and symptoms of this condition are usually manifested in the academic setting. This is an expected finding as the child or adolescent spends the majority of their time in school. In this paper, this author is going to discuss recommended clinical guidelines in the assessment, diagnosis, and treatment and/or management of ADHD in the child and adolescent population from age 4 to 18. Definition of Terms The following terms may appear throughout this author’s literature reviews. Behavior therapy is a form of psychotherapy that uses basic learning techniques to modify maladaptive behavior patterns by substituting new responses to given stimuli for undesirable ones. Treatment modality are methods used to treat a patient for a particular condition (Baily & Simpson, 2008). School truancy is defined as a child who made an attempt to go to school but strayed elsewhere. Oppositional defiant disorder (ODD) is defined by the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV), as a recurring pattern of negative, hostile, disobedient, and defiant behavior in a child or adolescent, lasting for at least six months without serious violation of the basic rights of others. (LaMuhammad et al, 2011). Risk-taking behavior includes alcohol and drug use, delinquency, acts of aggression, sexual activity, and so on. Delinquency refers to the participation in any of a number of antisocial acts such as truancy, vandalism, sexual promiscuity, shoplifting, homicide; delinquency most often occurs during adolescence. Comorbidities refer to two or more coexisting medical ATTENTION-DEFICIT/HYPERACTIVITY DISORDER IN CLINICAL PRACTICE 3 conditions or disease processes that are additional to an initial diagnosis. Learning Disabilities (LD) are disorders in the basic cognitive and psychological processes involved in using language or performing mathematical calculations, affecting persons of normal intelligence, and not the result of emotional disturbance or impairment of sight or hearing (McNamara, Vervaeke, & Willoughby, 2008). Substance abuse refers to excessive use of a potentially addictive substance, especially one that may modify body functions, such as alcohol and drugs. Prescription stimulant refers to a substance that temporarily increases the physiologic activity of an organ or organ system (Nelson & Galon, 2012). Adverse drug reactions are un-intended and harmful effects of drug therapy, neither intended nor expected in normal therapeutic use. Pharmacologic therapy any oral, parenteral, or topical substance used to alleviate symptoms and treat or control a disease process or aid recovery from an injury (Roma, 2010). Problem, Intervention, Comparison, Outcomes (PICO) The symptoms of Attention-Deficit/Hyperactivity Disorder can vary from patient to patient which may require more than one treatment modality. In order to discover the best current evidence regarding this mental health process, this author used the PICO model. The patient/problem identified in this paper are children and adolescents with symptoms of ADHD. The intervention of interest includes early diagnoses combined with evidence-based parent, physician, and teacher therapy. This author did not have a comparison of interest regarding this topic. The outcome of interest involves a decreased incidence of academic and behavioral problems due to ADHD symptoms. Therefore the question generated is as follows: For a patient with Attention-Deficit/Hyperactivity Disorder, will early diagnosis combined with evidence- ATTENTION-DEFICIT/HYPERACTIVITY DISORDER IN CLINICAL PRACTICE 4 based parent, physician, and teacher administered therapy decrease the incidence of associated academic and behavioral problems? In order to answer this question, this author reviewed and analyzed the guideline titled ADHD: clinical practice guideline for the diagnosis, evaluation, and treatment of attention-deficit/hyperactivity disorder in children and adolescents by the subcommittee on attention-deficit/hyperactivity disorder, steering committee on quality improvement management (ADHD, 2011). Literature Review The guideline reviewed proposes recommendations for the assessment, diagnosis, and treatment of ADHD in children and adolescents age 4 – 18. The guideline lists recommendations in the form of six action statements. The guideline strongly advocates early diagnosis in order to ensure appropriate individualized treatment to prevent escalating symptoms of ADHD. This author conducted a systematic search of relevant peer-reviewed articles to determine if the use of this guideline in clinical practice will yield positive outcomes. The following articles provided information addressed by the guideline. Bailey & Simpson (2008) on the attitudes of health care professionals regarding ADHD it was revealed that “in the discussions that took place in the interviews, participants expressed doubts, cynicism, and a lack of acceptance of the existence of the condition” (p. 30, Appendix A). The guideline reviewed addresses this issue in action statement number four which states that “the primary care clinician should recognize ADHD as a chronic condition and, therefore, consider children and adolescents with ADHD as children and youth with special health care needs” (ADHD, 2011, p. 1014). LaMuhammad, et al (2011) provided information on truancy and the associated behavioral issues that may arise from the delayed diagnosis and treatment of ADHD. The case ATTENTION-DEFICIT/HYPERACTIVITY DISORDER IN CLINICAL PRACTICE 5 report presented by this researcher describes a 14 year old adolescent who’s violent and impulsive behaviors were first diagnosed as resulting from major depressive disorder rather than the proper subsequent diagnosis of oppositional defiant disorder (ODD) combined with ADHD (p. 250-251, Appendix I). This misdiagnosing issue is addressed in the guideline in action statement 3 “in the evaluation of a child for ADHD, the primary care clinician should include assessment for other conditions that might coexist with ADHD…” (ADHD, 2011, p. 1013). McNamara, Vervaeke, & Willoughby (2008) also found a correlation between ADHD and risk taking behaviors seen in individuals who have a comorbid condition of a learning disability (p. 561, Appendix A). Action statements 5b and 5c of the guideline describe recommendations for medication administration in children and adolescents. One researcher provides information on the efficacy of stimulant versus non-stimulant pharmacologic therapy in the treatment of ADHD. This researcher proposes that non-stimulant drug therapy may be more beneficial in the ADHD population due to the decreased potential for uncomfortable side effects compared to stimulant drugs (Roman, 2010, p. 548, Appendix A). The proper administration of these drugs in such a sensitive patient population is addressed by Nelson & Galon (2012) in their research on the correlation between the adolescent ADHD population and substance abuse in which they advocate for combined behavioral therapy to decrease the risk of dependency to stimulants (p. 116, Appendix A). The research reviewed in conjunction with the guideline analyzed has provided this author to conclude that the recommendations put forth by the board members of the subcommittee on attention-deficit/hyperactivity disorder is a valid and relevant tool to utilize in the clinical setting to provide accurate and efficient assessment, diagnosis, and treatment of ADHD. ATTENTION-DEFICIT/HYPERACTIVITY DISORDER IN CLINICAL PRACTICE 6 Action Plan Physicians, parents, teachers, and the ADHD patient population have a direct influence on the treatment related to this condition. All of these individuals must be educated in the signs, symptoms, treatment, and outcome goals of ADHD. This can be achieved by using the plan, do study, act (PDSA) evidence based practice model of measuring change (Appendix C). In order to properly measure the recommendations outlined in the guideline, this author proposes using behavioral assessment tools in the clinical and academic setting every two years for the ADHD population beginning at age 4 and analyzing the occurrence of new diagnosis annually to see if a correlation exists between early detection and truancy behaviors related to ADHD. This author proposes that an increase in ADHD diagnosis will exist as well as a decrease in the behavioral symptoms and academic issues related to this condition as a result of eliminated delayed diagnosis. Special Considerations Complementary and alternative therapies for the treatment of ADHD such as increase in physical activity and dietary changes such as implementing a gluten free diet were not considered as having enough research to validate such claims. ATTENTION-DEFICIT/HYPERACTIVITY DISORDER IN CLINICAL PRACTICE APPENDIX A Author & Year Bailey, S., & Simpson, A. (2008) Attitudes towards attention deficit hyperactivity disorder in child Title and adolescent mental health services teams. The study set out to explore the attitudes of child and adolescent mental health workers towards the identification, conceptualization, Question/Purpose assessment and treatment of ADHD and the use of the NICE clinical guidelines in practice. A semi-structured interview survey of multi-disciplinary members Design of three CAMHS teams was used. Ten multidisciplinary staff members were purposively sampled to provide representatives from three different CAMHS teams, several Sample different professions and to reflect the gender and age balance of the teams. Responses from the interviews were transcribed and analyzed using interpretative phenomenological analysis. This method of analysis is used to identify specific themes in the acquired data systematically and objectively. The procedure involved selecting one interview and reading the transcript several times. Sub-themes Data Collection that were similar were grouped together and those that were different were placed in a separate group. Clusters of themes were then formulated where similar topics or issues were identified and a master list of themes was produced, each containing a number of categories. These major themes captured most strongly the participants concerns on the topic. In general there was a consensus of knowledge base in all the responses suggestive of participants' understanding of classifications and clinical presentations of ADHD. However, views concerning the etiology of ADHD varied. Medical staff were more likely to proffer biological explanations, whereas non-medical staff referred to factors such as social construction theory, family Findings dynamics and psychoanalytic theories, which appeared to reflect professional background and training. The relationship between the role of participants and their professional background caused conflict for a number of non-medical participants. The findings demonstrated that ADHD was predominantly defined as a medical condition that needed diagnosis and treatment. Study of only ten professionals across just three CAMHS teams, so Limitations caution is required when considering the wider relevance of the findings. Level of Level III, Quality B (Johns Hopkins Hospital Strength of Evidence Evidence located in Appendix B) 7 ATTENTION-DEFICIT/HYPERACTIVITY DISORDER IN CLINICAL PRACTICE La Muhammad, N., Ismail, W., Chai Eng, T., Jaffar, A., Sharip, S., & Omar, K. (2011) Attention-deficit hyperactive disorder presenting with Title school truancy in an adolescent: a case report. To increase public awareness of ADHD, especially among Question/Purpose parents and teachers so that early intervention can be instituted in these children. Case Study Case Report Sample A 14 year old adolescent male Physical, Mental, Psychosocial Examination. Family and Data Collection Past Medical History Age at presentation is an important point to consider. In pre-school-aged children, hyperactivity and inattentive symptoms are common. In adolescents, symptoms of hyperactivity are diminished, but there are more symptoms of inattention and impulsivity. In this case, the comorbid depressive features masked symptoms of Findings ADHD and obscured the diagnosis of ADHD in the patient. In order for ADHD to be managed comprehensively at the primary care level, high levels of awareness and early detection are necessary. Adequate time should be allowed to make an accurate diagnosis. Once ADHD is diagnosed, physicians need to look for common comorbid conditions. Current DSM-IV-TR criteria reflect the clinical features of ADHD in children and do not focus on Limitations adolescents. This is a case study of one individual adolescent. Level of Level III, Quality C (Johns Hopkins Hospital Strength of Evidence Evidence located in Appendix B) Author & Year 8 ATTENTION-DEFICIT/HYPERACTIVITY DISORDER IN CLINICAL PRACTICE Author & Year Nelson, A., & Galon, P. (2012) Exploring the relationship among ADHD, stimulants, and Title substance abuse. This literature review explores the current state of prescriptive stimulant use for ADHD and the possible links to SA. Developmental, genetic, and neurochemical theories of the disorder that may contribute to SA as well Question/Purpose as the burden of comorbidity are considered. The impact of gender, cultural, legal, and ethical influences on diagnostic and treatment recommendations is also included. A cross-sectional review was used to analyze previously Design written articles that examined the most commonly prescribed ADHD medications. Of the drug prescriptions analyzed, 33.3% were written Sample for ages 10-14, 23% were for 5-9 year olds, 16% were for 15-19 year olds, and 2% were under the age of 5. U.S. and other English language articles were identified through PubMed and the Cumulated Index of Nursing and Allied Health Literature. These sources were used to Data Collection determine the current practice of stimulant prescription and the prevalence of SA as a comorbidity to other child psychiatric disorders including ADHD. The authors conclude that the use of stimulants is appropriate for children and adolescents with ADHD Findings when opportunities for screening, family and child education, and counseling concerning SA are consistently integrated into the ongoing treatment regimen. There is limited research information on the current Limitations incidence and prevalence of co-occurring ADHD and SUD in both adults and adolescents. Level of Level III, Quality C (Johns Hopkins Hospital Strength of Evidence Evidence located in Appendix B) 9 ATTENTION-DEFICIT/HYPERACTIVITY DISORDER IN CLINICAL PRACTICE Author & Year Nelson, A., & Galon, P. (2012) Exploring the relationship among ADHD, stimulants, and Title substance abuse. This literature review explores the current state of prescriptive stimulant use for ADHD and the possible links to SA. Developmental, genetic, and neurochemical theories of the disorder that may contribute to SA as well Question/Purpose as the burden of comorbidity are considered. The impact of gender, cultural, legal, and ethical influences on diagnostic and treatment recommendations is also included. A cross-sectional review was used to analyze previously Design written articles that examined the most commonly prescribed ADHD medications. Of the drug prescriptions analyzed, 33.3% were written Sample for ages 10-14, 23% were for 5-9 year olds, 16% were for 15-19 year olds, and 2% were under the age of 5. U.S. and other English language articles were identified through PubMed and the Cumulated Index of Nursing and Allied Health Literature. These sources were used to Data Collection determine the current practice of stimulant prescription and the prevalence of SA as a comorbidity to other child psychiatric disorders including ADHD. The authors conclude that the use of stimulants is appropriate for children and adolescents with ADHD Findings when opportunities for screening, family and child education, and counseling concerning SA are consistently integrated into the ongoing treatment regimen. There is limited research information on the current Limitations incidence and prevalence of co-occurring ADHD and SUD in both adults and adolescents. Level of Level III, Quality C (Johns Hopkins Hospital Strength of Evidence Evidence located in Appendix B) 10 ATTENTION-DEFICIT/HYPERACTIVITY DISORDER IN CLINICAL PRACTICE Author & Year Roman, M. (2010) Newly approved once-daily formulations of medications Title for the treatment of attention deficit (hyperactivity) disorder (ADHD) in children and adolescents. Advocate new formulations of ADHD medications that Question/Purpose produce fewer adverse effects. Reevaluation of statistics that review medication Design adherence rates versus adverse side effects reported between stimulant and non-stimulant treatments. Sample Children and adolescent population Efficacy and adherence rates reported by the National Health and Nutrition Examination Survey (NHANES) Data Collection regarding the use of stimulant pharmacologic therapy for the treatment of ADHD. The non-stimulant drug Guanfacine XR is the first alpha-2 agonist approved for the disorder, and appears to be more Findings specific to the anatomic areas that fine tune attention and distractibility. Costs and long-term effects are additional pertinent Limitations concerns that are not addressed here. Level of Level III, Quality C (Johns Hopkins Hospital Strength of Evidence Evidence located in Appendix B) 11 ATTENTION-DEFICIT/HYPERACTIVITY DISORDER IN CLINICAL PRACTICE Appendix B 12 ATTENTION-DEFICIT/HYPERACTIVITY DISORDER IN CLINICAL PRACTICE 13 Appendix C Aim: Decrease in the behavioral symptoms and academic problems associated with ADHD Every goal will require multiple smaller tests of change Describe your first (or next) test of change: Person responsible Assessment, Recognition, or Diagnosis of ADHD Physician Parent/Teacher Patient Plan List the tasks needed to set up this test of change Connors Parents Rating Scale, the Child Attention Problem Rating Scale, Strength and Weakness ADHD symptom and Normal Behavior Scale, Connors Teachers Rating Scale, and Child Behavior Checklist When to be done Screening every 2 yrs Person responsible Physician Parent/Teache r When to be done Every 2 yrs. Where to be done Clinic School Where to be done Clinic School Predict what will happen when the test is carried out Measures to determine if prediction succeeds If the ADHD screening tools are used to screen children and adolescents every two years beginning at age 4 until age 18, treatment can be initiated appropriately and truancy behaviors can be eliminated. Frequency of ADHD diagnosis being made yearly Percentage of truant behaviors decreased These measurements must be made within a specific time frame to gauge level of change. Do Describe what actually happened when you ran the test Study Describe the measured results and how they compared to the predictions Act Describe what modifications to the plan will be made for the next cycle from what you learned ATTENTION-DEFICIT/HYPERACTIVITY DISORDER IN CLINICAL PRACTICE 14 References ADHD: Clinical Practice Guideline for the Diagnosis, Evaluation, and Treatment of AttentionDeficit/ Hyperactivity Disorder in Children and Adolescents. (2011). Pediatrics, 128(5), 1007-1022. doi:10.1542/peds.2011.2654. Bailey, S., & Simpson, A. (2008). Attitudes towards attention deficit hyperactivity disorder in child and adolescent mental health services teams. Mental Health Practice, 11(10), 26-31. La Muhammad, N., Ismail, W., Chai Eng, T., Jaffar, A., Sharip, S., & Omar, K. (2011). Attentiondeficit hyperactive disorder presenting with school truancy in an adolescent: a case report. Mental Health In Family Medicine, 8(4), 249-254. McNamara, J., Vervaeke, S., & Willoughby, T. (2008). Learning disabilities and risk-taking behavior in adolescents: A comparison of those with and without comorbid attentiondeficit/hyperactivity disorder. Journal of Learning Disabilities, 41(6), 561-574. Nelson, A., & Galon, P. (2012). Exploring the relationship among ADHD, stimulants, and substance abuse. Journal Of Child & Adolescent Psychiatric Nursing, 25(3), 113-118. doi:10.1111/j.1744-6171.2012.00322.x. Roman, M. (2010). Newly approved once-daily formulations of medications for the treatment of attention deficit (hyperactivity) disorder (ADHD) in children and adolescents. Issues in Mental Health Nursing, 31(8), 548-549. doi:10.3109/01612840.2010.497241. ATTENTION-DEFICIT/HYPERACTIVITY DISORDER IN CLINICAL PRACTICE 15