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EMBARGO: August 30, 2016, 11am Pacific / 2pm Eastern Time
Road Map for Addressing Ethical Concerns Tied to Research on Human-Animal Embryos
Recommendations Come as NIH Poised to Lift Funding Moratorium
A new bioethical framework for addressing concerns surrounding potentially revolutionary research on
human-animal embryos is publishing on August 30, 2016 in the open-access journal PLOS Biology.
Human-animal embryos, called chimeras, can be produced when human stem cells are transplanted into
animal embryos. By creating these types of embryos scientists could potentially grow human organs in large
animals, such as pigs and sheep, to help ease the chronic shortage of human organs available for
transplantation. This research could also be used to study the causes of many human diseases. But the use of
the human cells in this work is controversial and last September, the National Institutes of Health imposed a
moratorium on funding the research in response to ethical concerns (private funding was unaffected). Then,
in early August, the NIH announced plans to lift the moratorium after a 30-day comment period on proposed
regulations that require heightened review of the research under certain conditions.
In the PLOS Biology opinion piece, Insoo Hyun, PhD, associate professor of bioethics at the School of
Medicine of Case Western Reserve University, argues that most, if not all, concerns tied to such research can
be reasonably addressed in a way that prioritizes animal welfare while enabling scientific progress to help
patients who need organ transplants.
While some researchers and bioethicists worry that a developing animal with a human organ could attain
something like human moral status, especially if the central nervous system is involved, Hyun argues that
these concerns - while understandable - are overstated. The appearance of human-like self-consciousness is
needed to elevate the moral status of a research animal, but this distinctive psychological characteristic is not
likely to emerge in a chimeric animal’s brain, Hyun says. Instead, the much more likely outcome of
neurological chimerism is an increased chance of animal suffering and biological dysfunction and
disequilibrium, if past experience with transgenic animals can serve as a guide. “This is why,” says Hyun,
“focusing on animal welfare principles is crucial.”
Hyun’s arguments reflect the ethical standards for chimera research established by the Ethics and Public
Policy Committee of the International Society for Stem Cell Research, which he helped develop.
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In your coverage please use this URL to provide access to the freely available article in PLOS Biology:
http://dx.doi.org/10.1371/journal.pbio.1002535
Press-only preview: http://blogs.plos.org/everyone/files/2016/08/pbio-8-30-Hyun.pdf
Contact: Marc Kaplan, [email protected]
Citation: Hyun I (2016) What’s Wrong with Human/Nonhuman Chimera Research? PLoS Biol 14(8): e1002535.
doi:10.1371/journal.pbio.1002535
Funding: The author received no specific funding for this work.
Competing Interests: The authors have declared that no competing interests exist.
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