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Lecture Plan By Dr. Fouzia Rafat Department of Chemistry, V.B.U, Hazaribag Organic Chemistry M.Sc. Semester IV, Paper- XIIIB Unit Unit 1. Selectivity Topic Regio, Stereo & Chemo selectivity. Reagents for reduction of alkenes, alkynes and arenes Reagents for reduction of carbonyl compound Removal of functional group Protection of aldehydes and ketones Protection of alcohols and amines Chemo selective oxidation of C=C double bond Chemo selective oxidation of alcohols and carbonyl compound Peptide synthesis Unit 2. Making new C-C bond Alkylation of nitroalkanes and alkyl nitriles Alkylation of aldehydes and ketones Specific enol equivalents Thermodynamic and kinetic enolates Alkylation of beta dicarbonyl compounds Formation of enolates regiospecifically Acylation of enols and enolates Conjugate addition of enolates C-C bond formation using radicals Tributyltin hydride Nucleophilic and electrophilic radical Comparison between intermolecular and intramolecular radical reaction Comparison of reactivity pattern of radical and polar reagent No. of Lect ures 1 2 1 1 1 1 2 2 2_ 13 1 1 1 1 1 1 1 2 1 1 1 1 1 1 Barton reaction Hoffmann Loffler Freytzag Reaction 1 1 17 Unit 3. Aldol reaction Unit 5. Synthesis using reagents containing P,S and B Acid and Base catalyzed aldol condensation Crossed aldol condensation Conditions of successful crossed aldol Controlling aldol with specific enol equivalents Use of lithium enolates, silylenolethers, zinc enolates in aldol reaction Use of zinc enolates, aza enolates and enamines in aldol reaction Intramolecular aldol reaction Reaction of phosphorous ylides Reductive cyclization of nitro compounds Synthesis of alkenes from 1,2-diols Conversion of alcohols into aldehydes Reaction of Sulfur ylides Sulfoxide elimination Use of dithioacetals Reversal polarity of carbonyl compounds Julia reaction Reaction of organoboranes from alkenes Oxidation to alcohols Conversion into primary amines Carbonylation Synthesis of ketones and aldehydes Cyanidation and synthesis of esters Reactions of organoboranes from alkynes Synthesis of ketones and aldehydes Synthesis of E and Z alkenes Synthesis of conjugated dienes Synthesis of bromoalkenes 1 1 1 1 1 1 1 1 08 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 20 Reference Books:1. Organic Chemistry By, Clayden, Greeves, Warren and Wothers Oxford publisher 2. Principles of Organic Synthesis By, Norman and Coxan ELBS Publisher
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