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Physiology and function of the cranial nerves
1. Describe in basic detail, the origin and course of the cranial nerves.
2. Identify the component fibres, structures innervated and functions of each cranial nerve.
Like spinal nerves, cranial nerves are bundles of sensory or motor fibres that innervate muscles
or glands; carry impulses from sensory receptors, or show a combination of these fibre types.
They are called cranial nerves because they emerge through foramina or fissures in the cranium
and are covered by tubular sheaths derived from the cranial meninges. There are twelve pairs of
cranial nerves, which are numbered I to XII, from rostral to caudal, according to their
attachment to the brain and penetration of the cranial dura. Their names reflect their general
distribution or function.
Nerve
Component
s
Location of Nerve
Cell Bodies
Cranial Exit
Main Actions
I Olfactory
Special sensory
II Optic
III Oculomotor
Special sensory
Somatic motor
Olfactory epithelium
(olfactory cells)
Retina (ganglion cells)
Midbrain
Foramina in cribriform
plate of ethmoid bone
Optic canal
Superior orbital fissure
Smell from nasal mucosa of roof of each nasal cavity and superior
sides of nasal septum and superior concha
Vision from retina
Motor to superior rectus, inferior rectus, medial rectus, inferior
oblique, and levator palpebrae superioris muscles; raises superior
eyelid; turns eyeball superiorly, inferiorly and medially (Not
inferiorly or laterally)
Parasympathetic innervation to sphincter of pupil and ciliary
muscle; constricts pupil and accommodates lens of eye
Superior orbital fissure
Motor to superior oblique that assists in turning eye inferolaterally (or laterally when adducted)
Superior orbital fissure
Sensation from cornea, skin of forehead, scalp, eyelids, nose and
mucosa naval cavity and paranasal sinuses
Visceral motor
IV Trochlear
Somatic motor
Presynaptic: midbrain
Postsynaptic: ciliary
ganglion
Midbrain
V Trigeminal
V1 Opthalmic
General sensory
Trigeminal ganglion
V2 Maxillary
Foramen rotundum
V3 Mandibular
Foramen ovale
VI Abducent
VII Facial
VIII
Vestibulocochlear
Vestibular
Cochlear
IX
Glossopharyngeal
Brachial motor
Pons
Somatic motor
Brachial motor
Pons
Pons
Special sensory
Visceral motor
Geniculate ganglion
Presynaptic: pons
Postsynaptic:
pterygopalatine
ganglion;
submandibular ganglion
Special sensory
Vestibular ganglion
Special sensory
Brachial motor
Visceral motor
Spiral ganglion
Medulla
Presynaptic; medulla
Postsynaptic; otic
ganglion
Superior ganglion
Visceral
sensory
Special sensory
General sensory
Brachial motor
X Vagus
Visceral motor
Visceral
sensory
XI Spinal
Accessory
XII Hypoglossal
Inferior ganglion
Inferior ganglion
Medulla
Superior orbital fissure
Internal acoustic
meatus; facial canal;
stylomastoid foramen
Internal acoustic meatus
Jugular foramen
Jugular foramen
Presynaptic; medulla
Postsynaptic; neurons
in, on or near viscera
Superior ganglion
Special sensory
General sensory
Inferior ganglion
Superior ganglion
Somatic motor
Spinal cord
Jugular foramen
Somatic motor
Medulla
Hypoglossal canal
Sensation from skin of face over maxilla, including upper lip,
maxillary teeth, mucosa of nose, maxillary sinuses and palate
Sensation from skin and over side of head mandible including
lower lip, mandibular teeth, temporomandibular joint, mucosa of
mouth and anterior two thirds of tongue
Motor to muscles of mastication, mylohyoid, anterior belly of
digastric, tensor veli palatini, and tensor tympani
Motor to lateral rectus that turns eye laterally
Motor to muscles of facial expression and scalp; also supplies
stapedius of middle ear, stylohyoid, and posterior belly of
digastric
Taste from anterior two thirds of tongue and the palate
Parasympathetic innervation to submandibular and sublingual
salivary glands, lacrimal gland, and glands of nose and palate
Vestibular sensation from semicircular ducts, utricle, and saccule
related to position and movement of head
Hearing from spiral organ
Motor to stylopharyngeus to assist with swallowing
Parasympathetic innervation to parotid gland
Visceral sensation from parotid gland, carotid body and sinus,
pharynx, and middle ear
Taste from posterior third of tongue
Cutaneous sensation from external ear
Motor to constrictor muscles of pharynx (except stylopharyngeus), intrinsic muscles of larynx, muscles of palate (except
tensor veli palatini), and striated muscle in superior two thirds of
esophagus
Parasympathetic innervation to smooth muscle of trachea, bronchi,
digestive tract, and cardiac muscle of heart
Visceral sensation from base of tongue, pharynx, larynx, trachea,
bronchi, heart, esophagus, stomach, and intestine to left colic
flexure
Taste from epiglottis and palate
Sensation from auricle, external acoustic meatus, and dura mater
of posterior cranial fossa
Motor to sternocleidomastoid and trapezius
Motor to intrinsic and extrinsic muscles of tongue (except
palatoglossus)
3. Describe the anatomy of the skull with particular reference to the cranial nerves.
4. Identify the eye muscles and describe how they function to maintain binocular vision
(conjugate gaze).
Remember what Katie said “3, 4 and 6, think of them together”
CRANIAL NERVE
III Oculomotor
MUSCLE INNERVATED

Superior Rectus

Inferior Rectus

Medial Rectus

Inferior Oblique
IV Trochlear
VI Abducens



Levator Palpebrae Superioris
Superior Oblique
Lateral Rectus
The general modes of action of the six extraocular muscles have been described in
connection with their anatomy: rotation of the eye toward the nose is carried out by the
medial rectus; outward movement is by the lateral rectus. Upward movements are carried
out by the combined actions of the superior rectus and the inferior oblique muscles, and
downward movements by the inferior rectus and the superior oblique. Intermediate
directions of gaze are achieved by combined actions of several muscles. When the two
eyes act together, as they normally do, and change their direction of gaze to the left, for
example, the left eye rotates away from the nose by means of its lateral rectus, while the
right eye turns toward the nose by means of its medial rectus. These muscles may be
considered as a linked pair contributing to binocular vision.
The binocular movements (the movements of the two eyes) fall into two classes, the
conjugate movements, when both eyes move in the same direction, as in a change in the
direction of gaze, and disjunctive movements, when the eyes move in opposite
directions. Thus, during convergence onto a near object both eyes move toward the nose;
the movement is horizontal, but disjunctive, by contrast with the conjugate movement
when both eyes move, say, to the right. The disjunctive movement of convergence can be
carried out voluntarily, but the act is usually brought about reflexly in response to the
changed optical situation—i.e., the nearness of the object of gaze.
5. Present an elementary analysis of causes of diplopia.
When movements of the external muscles of the two eyes are not perfectly coordinated, a
person cannot properly focus the images of the same area of the visual field from each
eye and so sees two images instead of one. This condition is called diplopia, or double
vision. It can result from paralysis or weakness of certain extrinsic muscles. Diplopia on
lateral gaze is associated with VI Abducent nerve paralysis. Diplopia when looking down
is associated with IV Trochlear nerve paralysis.
However, often diplopia may present as a temporary consequence of acute alcohol
intoxication.