Download Pharmacology Tutoring for Antidepressants

Antidepressants
Tutoring
BY ALAINA DARBY
Stella is feeling sad, hopeless, and guilty and has persistent
headaches, fatigue and insomnia. With no additional symptoms, which
of the following classes of depression would this fall into?

Reactive
b. Major depressive disorder
c. Bipolar disorder
d. Post-partum
a.
Which of the following is most responsive to antidepressant drugs
and ECT?

a.
b.
c.
d.
Reactive
Major depressive disorder
Bipolar disorder
Post-partum

What is the biogenic amine hypothesis for depression?
Deficit of norepinephrine and serotonin
b. Deficit of dopamine and serotonin
c. Excess of norepinephrine and serotonin
d. Excess of dopamine and serotonin
a.
Which of the following is not an adaptive change that could
underlie the therapeutic lag of antidepressive treatment?

a.
b.
c.
d.
Beta-receptors
cAMP and serotonergic neurotransmission
Norepinephrine receptor uncoupling
Neurogenesis
Which of the following is an issue with using St. John’s Wort to treat
depression?

a.
b.
c.
d.
It is much less effective than the placebo at treating depression
It interferes with various medications
It is not available in the US
It has similar efficacy to SSRI’s

Which of the following can cause resistance to antidepressants?
Downregulation in norepinephrine receptors
b. Downregulation in serotonin receptors
c. Single nucleotide polymorphisms in MDR1
d. Single nucleotide polymorphisms in norepinephrine receptors
a.
Which of the following is derived from amitriptyline through
metabolism?

a.
b.
c.
d.
Doxepin
Nortriptyline
Trimipramine
Desipramine
Sally has just started taking an antidepressant. She is experiencing
drowsiness, dysphoria, anxiety, and impaired cognition. Which of the
following is she most likely taking?

Duloxetine
b. Clomipramine
c. Paroxetine
d. Tranylcypromine
a.
Which of the following is not an adverse effect of tricyclic
antidepressants?

a.
b.
c.
d.
Hypertension
Sedation
Weight gain
Sexual disturbances

Which of the following should not be taken with clonidine?
Duloxetine
b. Clomipramine
c. Paroxetine
d. Tranylcypromine
a.
Which of the following is a norepinephrine transport inhibitor that
can also be used as an antipsychotic?

a.
b.
c.
d.
Trazodone
Vilazodone
Amoxapine
Maprotiline
Which of the following is most similar to vilazodone in its
mechanism of action?

a.
b.
c.
d.
Duloxetine
Venlafaxine
Bupropion
Vortioxetine
Molly needs to lose weight. Which of the following would be least
likely to be prescribed for her depression?

a.
b.
c.
d.
Bupropion
Duloxetine
Trazodone
Mirtazapine
Which of the following has a main MOA that does not block
neurotransmitter transporters?

a.
b.
c.
d.
Bupropion
Duloxetine
Trazodone
Mirtazapine
Which of the following can also be used to aid in smoking
cessation?

a.
b.
c.
d.
Bupropion
Duloxetine
Trazodone
Mirtazapine
Which of the following might be prescribed to someone who needs
to be alert in his job and has low blood pressure?

a.
b.
c.
d.
Venlafaxine
Duloxetine
Mirtazepine
Amitriptyline
Which of the following might be considered first line therapy in a
patient with major depression?

a.
b.
c.
d.
Amoxapine
Trazodone
Citalopram
Tranylcypromine
Which of the following would be least likely to be considered in a
patient with major depression?

a.
b.
c.
d.
Amoxapine
Trazodone
Citalopram
Tranylcypromine
Which of the following can be administered for weekly
administration?

a.
b.
c.
d.
Citalopram
Fluoxetine
Paroxetine
Fluvoxamine
Katie just switched from tranylcypromine to paroxetine for her
depression and has begun to exibit signs of hyperpyrexia,
hyperreflexia, tremor, shivering, and seizures. What is the reason for
these symptoms?

Understimulation of 5-HT1A receptors
b. Overstimulation of 5-HT1A receptors
c. Downregulation of 5-HT1A receptors
d. Upregulation of 5-HT1A receptors
a.

What action should immediately be taken to treat Katie?
Antiparkinson’s drug (benzamine) for her tremors
b. Discontinue paroxetine
c. Supportive therapy
d. Anticonvulsant (phenytoin) for her seizures
a.

Which of the following is primarily metabolized by MAO-B?
Norepinephrine
b. Serotonin
c. Tyramine
d. Dopamine
a.

Which of the following could be taken with MAOI’s?
Pseudoephedrine
b. Dextromethorphan
c. Fluoxetine
d. Lithium
a.

Which is not true of lithium?
a.
Its activity is thought to occur through inhibition of inositol
phosphate signaling
Its therapeutic window is very narrow
It is a potent blocker of the Na/K-ATPase pump
It is extensively metabolized
b.
c.
d.

Which of the following would be safe to take with lithium?
Aspirin
b. Furosemide
c. Carbemazepine
d. Hydrochlorithiazide
a.
Sandra has bipolar disorder and is taking birth control. Which of the
following drugs/drug combinations would be not be suitable for her?

a.
b.
c.
d.
Lithium
Valproic acid
Carbamazepine
Antipsychotic/antidepressant combination
Which would not be a reason to choose valproate or carbamazepine
over lithium to treat bipolar disorder?

a.
b.
c.
d.
Ability to increase the dose faster
Quicker response
Risk of pregnancy
Better therapeutic index