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Mapping Science and Technology with Heterogeneous Data Analysis Tools for strategic management of innovation – Biotech.Obs Andrei Mogoutov | AGUIDEL Paris - Montreal www.aguidel.com Tools for strategic management of innovation • Data collection and management « Biotech » actors using online questionnaires, publications, patents, existing databases, institutional contacts, company websites, news and press releases • Services/applications – – – – – – – – – – – – Positioning of companies, projects, products, patents, publications, research fields Startup support Early warning Partnership network building Advice on local promotion Advice on foundation and management of « clusters » Evaluation of projects Market and technological studies Benchmarking, competitiveness Consultancy for valorization actors Communication strategy development Academic research • Software solutions: On-line applications, off-line applications, customized solutions, integration of customers data, analytical tools • Data analysis: Custom methods for the analysis of complex & heterogeneous datasets, text and data mining, relational analysis, GIS, scientometrics Projects & partners • CEA (French Nuclear Energy Commission): Nano/Bio - clusters Dynamics of Nano-bio-technology field. • Biotech Clusters - Genopole Evry – research labs, startups & big pharma • Public Health Canada: Clusters of Nanotechnologies in Canada, Obesity issues and research, • Regional innovation agencies – “Technopole” Angers • INSERM: Evaluation of research laboratories, strategic analysis of neurosciences research, • INRA/CNRS: Mapping of controversies and research fields in genetically modified food safety • McGill University: Anticancer drugs clinical trials, Microarray R&D, Cancer research worldwide, Cancer and genetics, Standardisation and Migraine research, • University of Vienna: Scientometrics of Social Studies of Science Field • Big International Foundations: Open Society Institute, WWF Ford foundation, McArthur's foundation, Govcom.org foundation various political, ecological and technological issues • Private companies: industry, big pharma, telecoms, medical imaging • Investors, business angels ../ANALYTICAL DIMENSIONS SPACE TIME Client side Apps News RSS Feeds Client side Apps News Client/Server Apps RSS Feeds archives Client/Server Apps News RSS Feeds archives Client/Server Client/Server side CONTENT Client side Apps News, Web search, Blogs Client/Server Apps Client side Apps News archives, Web search, Blogs Client/Server ACTORS & NETWORKS Client/Server side Apps RSS Feeds archives + Scientometrix Client/Server Apps + ANALYTICAL DIMENSIONS/DATA/METHODS/TOOLS side Apps + Apps + offline apps side Apps + side Information « Spaces » • • • • • • • • • • • News Streams Blog Sphere Web Sites E-Communication (Mailing Lists, Forums) Scientific Information Data Bases (Publications, Patents) Offline “Literature” Press archives Surveys/ Interviews Traditional Media (TV, Radio) archives Specific Data Bases Etc ? Traditions/Methods/Solutions • • • • • • • • Statistics / Data Mining Textual Analysis Tools / Text Mining Web Cartography Scientometrics Tools for Qualitative Data Analysis Social / Socio-Technical Networks GIS Etc. Heterogeneous Data Sets: Back Office Press archives Online Data Collection Tools Parsing & Matching System “Offline” Questionnaires Actor Location Existing Databases Contents Classification Schema Actor Identity Sci publications Patents Web Crawler NETWORK ORIENTED DATABASE Design of Analytical Solution OFF-LINE DATA UPDATE ON-LINE Front Office - graphical/analytical interfaces (GIS, Relational Mappings, Statistical Charts) - statistical tables, indicators and textual synthesis - integrated querying tools Middle Office - a layer of analytical queries - pre-defined queries for multilevel data aggregation and synthetic analysis and indicators FEED-BACK Back Office - data tables - web crawler - matching tools - tools for textual analysis - tools for data update and control “Online” Data Collection Tool Front Office “Desktop” 350 300 250 200 150 100 50 0 cancer family history risk factors hormonalcontraception personal medical history family relatives environment- cancer genes tobacco Scientometrix – Publications and Patents PubMed (Medline) ISI Derwent /Scientometrics/results (ReseauLu Sci_Metrix) 10 00 sugar crops public opinion phosphinothricin acetyltransferase 1 Weed management -0 0 oilseed plants geneflow rape release GM Food safety glyphosate sugarbeet risk regulations biosafety maize DNA cereals cultivars Detection contamination backcrossing seed production intergeneric hybridization volunteer dispersal interspecific hybridization plant genetic resources pollen plants population dynamics safety gene flow hybridization Herbicide resistant weeds population genetics crop plants as weeds 1 ecology Biology evolution tomatoes Oil plants models reviews food legislation transgenics methodology foods proteins selectable markers analytical methods labelling detection food products fruits polymerase chain reaction vegetables soyabeans 1 0 pollination 2 2 0 2 0 2 0 3 1 0 2 1 9 0 1 1 9 0 1 9 9 1 9 8 1 9 7 1 9 6 1 9 5 1 9 4 1 9 3 1 9 2 1 9 1 1 9 8 0 1 9 8 9 1 9 8 1 9 8 7 9 8 6 8 5 4 European Union allergens legislation food allergies consumer attitudes food safety glufosinate swede herbicides rape weed control genetic chemical markers herbicide resistance control weeds flowering invasion wild relatives introgression tolerance plant breeding environmental impact risk assessment nontarget organisms potatoes lectins pesticides insecticides entomopathogenic bacteria entomopathogens Pathogens biological agricultural entomology beta-glucuronidase nontarget effects control toxins nucleotide sequences control bacterial insecticides agglutinins marker genes effects natural enemies gene transfer root Pest control gene expression crops microbial pesticides pest resistance promoters parasitoids genes leaves trypsin inhibitors Insect pests genetics reporter genes insect control genomes tobacco rice enzymes biological control agents lines proteinase inhibitors plant pests molecular genetics growth larvae resistance Potyvirus plant parasitic nematodes survival plant diseases Mol. Biol. and Virol. stimulant plants plant pathogens plant pathology coat proteinsdisease resistance plant pathogenic bacteria plant pathogenic fungi toxicity Agr. entomology Top Journals N. Art. Journal of Economic Entomology 98 Theoretical and Applied Genetics 41 Biotechnology and Development Monitor 37 Nature 33 Molecular Ecology 33 Transgenic Research 32 Nature Biotechnology 32 OCL - Oleagineux, Corps Gras, Lipides 30 Molecular Breeding 28 Science 27 Euphytica 26 Current Science 23 Biofutur 23 Environmental Entomology 22 Proceedings of the National Academy of Sciences of the United States of America 20 /tools (ReseauLu X2 SciMetrix) /tools (ReseauLu X2 SciMetrix) ../Stem Cells - Counts 6000 5000 4000 3000 2000 1000 0 1960 1965 1970 1975 1980 1985 1990 1995 2000 2005 2010 STEM CELLS - AUTHORS Name Nb Pub WEISSMAN, IL 45 ZSEBO, KM 26 ORKIN, SH 26 OGAWA, M 25 GAGE, FH 24 JAENISCH, R 22 BRADLEY, A 22 ROSSANT, J 22 MOORE, MAS 21 EAVES, CJ 21 WILLIAMS, DA 19 LANSDORP, PM 19 NISHIKAWA, S 18 MULLIGAN, RC 18 SMITHIES, O 18 HUMPHRIES, RK 16 ALT, FW 16 DICK, JE 16 MAK, TW 15 DEXTER, TM 15 ARMITAGE, JO 15 RAJEWSKY, K 14 MORRISON, SJ 14 MoyenneDePosition Name 0,87 WEISSMAN, IL 0,83 BRADLEY, A 0,76 ROSSANT, J 0,86 MULLIGAN, RC 0,62 ZSEBO, KM 0,82 MAK, TW 0,95 JAENISCH, R 0,71 RAJEWSKY, K 0,84 ORKIN, SH 0,83 OGAWA, M 0,94 GAGE, FH 0,54 LANSDORP, PM 0,27 WAKEHAM, A 0,86 SMITHIES, O 0,38 GERTSENSTEIN, M 1 CAPECCHI, MR 0,65 REYNOLDS, BA 0,84 WILLIAMS, DA 0,7 MOORE, MAS 0,88 DEXTER, TM 0,91 WEISS, S 0,81 LI, E 0,47 LANGLEY, KE 0,3 BRONSON, RT 0,44 NISHIKAWA, S 0,78 SORIANO, P NbCit 10455 8217 7859 7029 7016 6275 5798 5729 5471 5368 5244 5197 4889 4850 4611 4519 4487 4429 4301 4025 3985 3957 3893 3850 3831 3766 NbCitPos 8971 7435 5398 6451 5119,75 5666 5588,5 3963,5 4472 4483,75 4905,5 2774,25 1277,5 4074 1503,75 4519 3149 3444,5 2947,75 3806 3598,5 3335,5 1782,25 1298,5 1669 3296,5 Stem Cells Co-Citation STEM CELLS – Collaboration networks STEM CELLS – International Collaboration STEM CELLS – Emerging themes Scientometrix: Early Warning: Strategic Diagrams of Research Community Evolution: biosafety research 0,1 0,001 0,01 0,1 2000-2003 0,0001 TABASHNIK BE - 250 GOULD F - 258 HILBECK A - 92 ELLSTRAND NC - 114 DANIELL H - 89 SCHULER TH - 64 LOSEY JE - 59 SAXENA D - 47 SCHUBBERT R - 41 MALONE LA - 35 GATEHOUSE AMR - 71 ROUSH RT - 96 PILCHER CD - 49 SIMS SR - 59 PERLAK FJ - 98 NIELSEN KM - 50 MCGAUGHEY WH - 98 CHEVRE AM - 48 CRAWLEY MJ - 76 ANDOW DA - 44 SHELTON AM - 43 LIU YB - 49 KOZIEL MG - 72 TANG JD - 47SCHEFFLER JA - 50 PADGETTE SR - 43 DALE PJ - 85 TAYLOR SL - 45 ALSTAD DN - 44 STEWART CN - 49 SNOW AA - 41 JORGENSEN RB - 49 ONSTAD DW - 41 JOHNSON MT - 45 RAYBOULD AF - 57 CAPRIO MA - 37 LEFOL E - 35 KLINGER T - 54 MACINTOSH SC - 37 MIKKELSEN TR - 54 JEFFERSON RA - 36 LINDER CR - 40 HILDER VA - 37 DEBLOCK M - 43 RIESEBERG LH - 37 MEYER R - 42 BARTSCH D - 45 0,01 WILLIAMSON M - 37 MICHAUD D - 36 1984-1999 0,001 Scientometrix/ Adds Heterogeneous Networks Companies & Technologies Scientometrix / Adds: Actor/Networks R&D Collaboration Strategic Diagram 8% Centrality Glaxo SmithKline plc Pharma Group I Central, Star-like hierarchical networks Aventis 7% Johnson & Johnson Pfizer 6% Roche Bristol-Myers Squibb Co. Novartis Wyeth Pharma Group II Less central, Less hierarchical 5% Pharmacia Eli Lilly and Co. Applera Corporation Abbott Valentis Inc. National Institutes of Health Genzyme Corp. 4% AstraZeneca Amersham Pharmacia Biotech Merck & Co. Inc. Elan Corporation plc. Chiron Corp. Platform Tech. Companies Clique-like, complex networks Bayer AG 3% Incyte Genomics Schering AG Genentech Inc. Schering-Plough Corp. Millennium Pharmaceuticals Inc. Monsanto University of California Boehringer Ingelheim EI DuPont de Nemours & Co. Inc. 2% Amgen Celltech Group plc Medarex Inc. Pharmacopeia Inc. Novo Nordisk Perkin Affymetrix Inc. Baxter International inc.Elmer Shire Pharmaceuticals Group plc Vertex Pharmaceuticals Incorporated Corixa Corp. Merck KGaA Mitsubishi Group Harvard University ISIS Pharmaceuticals Inc. Johns Hopkins University Harvard Medical School Abgenix Inc. Akzo Nobel NV Lion Bioscience AG University of Texas Interneuron MedImmune Inc. ArQule Inc. Biogen Inc. Procter & Gamble Co. Acambis plc Lexicon Genetics Incorporated Sequenom Inc. Becton Dickinson BASF and Co. Yamanouchi Pharmaceutical Co. Ltd. Massachusetts Institute of Technology SkyePharma Xenova Group plc Mds Inc. Sanofi-Synthelabo Duke University Health System Cephalon Inc. Sankyo Fujisaw a Healthcare INC OSI Pharmaceuticals Inc. Allergan INC. Genome Therapeutics Corp. Takeda Chemical Industries Ltd Dyax Corporation Cell Pathw ays Inc. Applied Biosystems Group Ligand Pharmaceuticals Medtronic Inc. Chugai Biopharmaceuticals Inc. Cytogen Corp. Stanford University School of Medicine Bio-Technology General Corp. Xoma ltd. Biovail Corporation Aurora Biosciences Corp. Solvay Pharmaceuticals inc Schw arz Pharma AG Corning Inc Tyco International Ltd. Watson Pharmaceuticals Inc Nycomed Amersham plc. QUIDEL Corp. Teva Pharmaceutical Industries Ltd Degussa AG King Pharmaceuticals Inc IVAX Corporation Cardinal Health Inc. 1% ICN Pharmaceuticals Inc. 0% 0% 2% 4% 6% 8% 10% Density Scientometrix /GIS Spatial Network - Collaboration between NanoBiotech Clusters 01803 01730 01801 Scientometrix /GIS Space Biotech Clusters 02451 02139 02118 02210 Boston 02481 Boston Region 02132 01801 Scientometrix /GIS Space Nano-Biotech Clusters Scientometrix /GIS – Zooming In Canadian Nano-Bio publications by province and by discipline Scientometrix /GIS – Zooming In Number of publications by type, Montreal region Scientometrix /GIS – Zooming In Sub-clusters of the Montreal region, Note the Bio/medicine sub cluster in Laval. Web Cartography III IssueCrawler Project – GovCom.Org, Amsterdam (R Rogers et al) Technology transfer: Industrial Partners of INSERM 450 400 600 GROUPE PME 350 500 START-UP Total 300 400 250 300 200 150 200 100 100 50 0 0 1980 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 Industrial partners of INSERM: Emerging domains INSERM: international Collaboration Technologies & Companies Network in Time News The North Korean English News Space, Sept. 15 – Nov. 15, 2003. Findings: Whitehouse.gov (press release) couches North Korea in terms of regime change and human rights. The only other outlet that does so is Frontpagemag.org, a site which at the time of this map, extolled surfers to sign and e-petition and help “Stop the Left’s Anti-American Agenda… Help expose terrorists in our midst>” Connecting regime change to war is done by Fox News, Newsweek, and Asia Times online. Thus it is clear that these media outlets are framing regime change in terms of military conflict. Regime Change and Reunification are, basically, disconnected. Thus there is little talk of a German model achievement of Regime Change. The Financial Times subscription service, a strong example of the corporate angle on the issue, presented North Korea only in terms of regime change, notably isolating the issue from conflict, reunification, famine and other issues. Only CNN is able to connect famine and reunification, one of the more practical and meaningful associations between the issues of