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Dr. Eric M. Tippmann Indiana University-Purdue University Fort Wayne 2101 E. Coliseum Blvd. Fort Wayne, IN 46805 [email protected] EDUCATION The Ohio State University Ph.D. (Advisor: Prof. Matthew S. Platz) 2003 IPFW and Purdue University Bsc 1998 EXPERIENCE • Postdoctoral Fellowship, The Scripps Research Institute (Peter G. Schultz) • Senior Lecturer Cardiff University 2007 – • Bristol Synthetic Components Network 2011 Research Board member Cardiff Institute of Tissue Engineering and Repair (CITER) 2011 – Expert reviewer Programme Blanc, de l’Agence Nationale de la Recherche, France (French National Science Foundation) 2011 – • • • Welsh Crucible outreach programme. http://www.welshcrucible.org.uk/ • Editorial Board Springer, Associate Editor at Amino Acids 2004-06 2011 – 2011 – PUBLICATIONS AND PROFESSIONAL REVIEWING 1. Linn, D. E. Jr.; Skidd, G. M.; Tippmann, E. M. . (1999); 291(1-2); 142-147. 2. Likhotvorik, I. R.; Tippmann, E.; Platz, M. S. . Tett Lett (2001); 42(17); 3049-3051. 3. Likhotvorik, I.; Zhu, Z.; Tae, E. L.; Tippmann, E.; Hill, B. T.; Platz, M. S. . Journal of the American Chemical Society (2001); 123(25); 6061-6068. 4. Tae, E. L.; Ventre, C.; Zhu, Z.; Likhotvorik, I.; Ford, F.; Tippmann, E.; Platz, M. S. . Journal of Physical Chemistry A (2001); 105(44); 10146-10154. 5. Sun, Y.; Tippmann, E. M.; Platz, M. S. Organic Letters (2003); 5(8); 1305-1307. 6. Tippmann, E.M. ;Platz, M. S. Journal of Physical Chemistry A (2003); 107(41); 8547-8551. 7. Tippmann, E. M.; Holinga, G.; Platz, M. S. Organic Letters (2003); 5(26); 4919-4922. 1 8. Buron, C.; Tippmann, E. M.; Platz, M. S. Journal of Physical Chemistry A (2004); 108(6); 1033-1041. 9. Presolski, S. I.; Zorba, A.; Thamattoor, D. M.; Tippmann, E. M.; Platz, M. S. Tetrahedron Letters (2004); 45(3); 485-486. 10. Tippmann, E. M.; Platz, M. S.; Svir, I. B.; Klymenko, O.V. Journal of the American Chemical Society (2004); 126(18); 5750-5762. 11. Condon, S. E.; Buron, C.; Tippmann, E. M.; Tinner, C.; and Platz, M. S. Organic Letters (2004); 6(5); 815-818. Post-PhD: 12 Tippmann, E. M.; Liu, W.; Summerer, D.; Schultz, P. G. Site-Specific Incorporation of a Photo- affinity Probe into Proteins in Escherichia coli. CHEMBIOCHEM (2007) 8, 2210-2214.14. 13. Tippmann, E. M.; Schultz, P. G. A Genetically Encoded Metallocene Containing Amino Acid, Tetrahedron (2007) 63, 6182-6184. (Invited submission as part of a 50th anniversary issue). 14. Amy J. Baldwin, James A. J. Arpino, Wayne R. Edwards, Eric M. Tippmann*, D. Dafydd Jones Mol. BioSyst., 2009, 5, 764-766. 15. Alicja K. Antonczak, Zuzana Simova, Eric M. Tippmann* A Critical Examination of Escherichia coli Esterase Activity J. Biol. Chem. 2009 284: 28795-28800. 16. Michael J. Yurkovich, Michael A. Watkins, Sarah M. Mandell, Eric M. Tippmann, Matthew S. Platz and Hilkka I. Kenttämaa International Journal of Mass Spectrometry 2009, 287, 16-20. 17. Yonemoto, I. and Tippmann*, E. M. The Juggernauts of Biology, BioEssays, 2010, 32, 314321; (Invited submission) 18. Morgan, Sundaram, and Tippmann*. Synthesis of bioorthogonal and crosslinking amino acids for use in peptide synthesis, Amino Acids, 2010. .doi/10.1007/s00726-010-0594-3. 19. Evans, Sundaram, Toscano, Tippmann* Weinreb amides in carbene chemistry: A TimeResolved IR investigation into a potential intramolecular stabilization mechanism Organic Letters; (2010) DOI: 10.1021/ol101946u. 20. Antonczak, Morris, Tippmann*. Advances in the mechanism and understanding of siteselective non-canonical amino acid incorporation. Current Opinion in Structural Biology. 10.1016/j.sbi.2011.04.004. 21. Richter, Gerald; Ladebeck, Oliver; Cummings, Stephanie J.; Tippmann, Eric; Ballare, Carlos L. Stapleton, Ann E. Perceiving UV-B: Identification of an ultraviolet-B photoreceptor in Arabidopsis thaliana. Science; accepted for full review. 22. Alicja K. Antonczak, Zuzana Simova, Isaac T. Yonemoto, Matthias Bochtler, Anna Piasecka, Honorata Czapińska, Andrea Brancale, and Eric M. Tippmann*. Importance of single molecular determinants in the fidelity of expanded genetic codes. 2011 Proceedings of the National Academy of Sciences 2011, 108, 1341-1345. 23. Falrados, J.; Antonczak, A.; Tippmann,* E. M.; Allemann*, R. K. Cation-pi interactions in Aristolochene Synthase. J. Am Chem. Soc. 2011, 2011, 133, pp 13906–13909.. 24. Reddington, Watson, Jones,* Tippmann* Genetically encoded direct light control of protein activity using a photosensitive phenylazide non-natural amino acid. Angewandte Chemie, 2013, DOI: 10.1002/anie.201301490. 25. Reddington, Jones,* Tippmann* Residue choice defines efficiency and influence of bioorthogonal protein modification via genetically encoded strain promoted Click chemistry.. Chem Comm, 2012, 48, 8419. 2 Requested reviewer for: Journal of the American Chemical Society Angewandte Chemie Synlett Chemical Reviews (ACS) Plos ONE Molecular Biosystems Journal of Physical Organic Chemistry INVITED LECTURES & CONFERENCE PRESENTATIONS • Durham University, UK April 16-18, 2008. • 13TH International Biotechnology Symposium Daejon, Korea, May 15-18, 2008. • University of Leicester September 23, 2008. • Cardiff University, Dental School, Jan 9, 2009. • Cardiff University, School of Biosciences, March 30, 2009. • University of Edinburgh, Firbush conference, September 11, 2009. • University of Oxford, Synthetic Biology conference September 24, 2009. • University of Liverpool, Department of Chemistry February 16, 2010. • University of Oxford, Department of Chemical Biology, April 14, 2010. • University of Bristol, Physiology and Pharmacology, April 29, 2010. • 14th International Biotechnology Symposium, Rimini, Italy, Sept 15, 2010. • University of Wales Institute Cardiff, Lung Research Group, Sept 28, 2010. • World Congress on Biotechnology Hyderabad, India, 20 March 2011. • Centre for Cellular and Molecular Biology Hyderabad, India, 21 March 2011. • European Symposium Bioorganic Chemistry, Gregynog, Newtown Wales May 20-22, 2011. • University of Nottingham, Department of Chemistry, June 8, 2011. • 12th International Congress on Amino Acids, Peptides and Proteins, Beijing, China August 2, 2011. • University of Glamorgan, Department of Mathematics and Computational Biology, November 2, 2011. • University of Sussex, Biochemistry Department, November 23, 2011. • University of Freiburg, Institute of Biochemistry and Molecular Biology, Germany March 7, 2012. • University of Konstanz, Institute of Chemical Biology, Germany March 8, 2012. • Indian Institute of Sciences, Bangalore Department of Chemistry, May 17, 2012. • Queen’s University, Kingston Ontario, November 4, 2013. AWARDS AND GRANTS 2001-2003 GAANN Fellowship, Department of Education. 2003 International Young Chemistry Writer, Elsevier Science $2500. 3 CO-INVESTIGATOR: Engineering and Physical Sciences Research Council EPSRC/EP/H045848/1 (Area of Bioengineering and Stem Cell marker development) £1,513,355 PRINCIPAL INVESTIGATOR: Biotechnology and Biological Sciences Research Council BBSRC/H003746/1 (Novel methods of engineering bioactive molecules from enzymes) £314,170 PRINCIPAL INVESTIGATOR: BBSRC/G003572/1 (Improvement of protein properties using nonnatural amino acids) £586,384 PRINCIPAL INVESTIGATOR Medical Research Council SARTRE scheme £38,000 PRINCIPAL INVESTIGATOR Wellcome Trust VIP Award £38,500 PRINCIPAL INVESTIGATOR Higher Education Funding Council for Wales; £6,000 SUPERVISION EXPERIENCE: POSTDOCTORAL RESEARCHERS, PHD, MSC AND BSC PROJECT STUDENTS Cardiff University is a richly diverse university drawing students from all over the world: Alicja Antoczak (PhD 2008-11) Zuzana Simova (PhD 2008-11) Josie Morris (PhD 2009-121) Sam Reddington (PhD 2009) Dr. Mandeep Sidhu (Post-doctoral researcher 2008) Dr. Ian Morgan (postdoc 2008-09) Dr. Amy Baldwin (postdoc 2008-11) Dr. Rebecca Baker (postdoc 2008-10) Dr. Sundaram Guruswami (postdoc 2007-09) Dr. Sohie Shim (Postdoc 2008-11) Valerie Seymour (Msc 2008) Gregory Hopkins (Msc 2009) Anthony Ruston (Msc 2010) April Marquick (Msc 2011) Celine Shepard (Msc 2012) John Llewelyn Williams (Bsc 2009) Samuel Edwards (Bsc 20111) 4 Dr. Katrin Buerger (Postdoc 2010-11) Dr. James Arpino (Postdoc 2011-12) Dr. Oliver Ladebeck (Postdoc 2011-) Over Colleague and coworkers: Dr. Tatiana Tatarinova Mehedi Hassan Farzana Rahman Ram Kumar 5