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Scientific Results
Since its launch, several projects have run in the World Community Grid. Some of the results
include:

In February 2014 the Help Fight Childhood Cancer project scientists announced the
discovery of 7 compounds that destroy neuroblastoma cancer cells without any apparent side
effects.[28] This discovery, made with the support of the WCG volunteers, is a positive step
towards a new treatment. The project has announced that it is seeking a collaboration with a
pharmaceutical company in order to develop the compounds into treatments. Given the
success of the project, the scientists have stated that are already planning a follow-up project
that will focus in other pediatric cancer, possibly in collaboration with a newly formed PanAsian oncology group, of which they are a founding member.[29]

The GO Fight Against Malaria project reported the discovery of several molecules that
are effective against Malaria and Drug-Resistant Tuberculosis (including TDR-TB, for which
there is no treatment available). The project also tested for new molecules
against MRSA, Filariasis and Bubonic Plague. Laboratory testing continues in order to turn
those molecules into possible treatments. GFAM was also the first project to ever perform a
billion different docking calculations.[30]

The Discovering Dengue Drugs - Together project scientists reported the discovery of
several new Dengue protease inhibitors, most of which also inhibit theWest Nile
Virus protease. A handful of these have already entered "crucial pre-clinical pharmacokinetic
and efficacy studies". In November 2014, an update reported that the scientists have a drug
lead that disables a key enzyme that allows the Dengue virus to replicate. It has also shown
the same behaviour in other flaviviruses, such as the West Nile Virus. No negative side
effects such as toxicity, carcenogenicity or mutagenicity have been observed, making this
drug lead a very strong antiviral drug candidate for these viruses. The scientists are now
working to synthesize variants of the molecule to improve its activity and enter planned preclinical and clinical trials.[31]

In June 2013 the Clean Energy Project published a database of over 2.3 million organic
molecules which have had their properties characterized. Of these, 35,000 molecules have
shown the potential to double the efficiency over organic solar cells being produced
nowadays. Before this initiative, scientists knew of just a handful of carbon-based materials
that were able to convert sunlight into electricity efficiently.[32][33][34]

In February 2010 the FightAIDS@Home project scientists announced that they found
two compounds that make a completely new class of AIDS-fighting drugs possible: "two
compounds that act on novel binding sites for an enzyme used by the human
immunodeficiency virus (HIV), the virus that causes AIDS. The discovery lays the foundation
for the development of a new class of anti-HIV drugs to enhance existing therapies, treat
drug-resistant strains of the disease, and slow the evolution of drug resistance in the
virus".[35][36]