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TITLE Required imaging at osteosarcoma BACKGROUND Osteosarcoma is the most common bone tissue sarcoma, which mainly occurs in childhood and adolescents. There are no specific patterns of complaints. Swelling and pain are the only complaints where patients suffer from. At diagnosis, an osteosarcoma is often only localized. Metastases at diagnosis are there in 15-20 % of the cases. The current therapy exists of neo-adjuvant chemotherapy and surgery. With this therapy 60-70% of all patient will cured. Imaging is essential to create an optimal treatment. Both orthopedic surgery and pediatric oncologist need imaging to obtain specific information that will influence therapeutic decision making. Especially local staging is very important. There is a European and American treatment protocol. However in this protocol there is hardly information about imaging. This results in different guidelines in Europe. The guidelines between Europe and USA are not alike. A uniform imaging guideline is necessary for providing the essential information considering planning the optimal treatment. PURPOSE Create an literature (evidence ) based guideline for the imaging strategy in patients with an osteosarcoma. DESIGN Clinical interviews to explore what the pediatric oncologist and the orthopedic surgery need to know from imaging. Literature search to explore evidence based guidelines in this perspective . We used as a guideline ‘Evidence-based richtlijnontwikkeling’ from the CBO. TIME SCHEDULE March 2011 – July 2011 RESEARCH TEAM SCIENTIFIC STAGE STUDENT MEREL BIRNIE DAILY COACH DR. J.H.M. MERKS DEPARTMENT OF PEDIATRIC ONCOLOGY, ACADEMIC MEDICAL CENTER TELEPHONE: 63050 (SECRETORY0 EMAIL: J.H.M.MERKS@@AMC.NL SENIOR TUTOR DR. M. MAAS DEPARTMENT OF RADIOLOGY, ACADEMIC MEDICAL CENTER TELEPHONE: 63629 PAGER: 81-63629 EMAIL: [email protected]