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How do Vitamin E and Selenium work? Vitamin E and Selenium work in synergy to protect cells from free radical damage. Selenium exerts its anti-oxidant effect within the cell itself, while Vitamin E works in the cell membranes which enclose the cell. An excess of one of these nutrients will help to counteract a deficiency of the other. However, optimum amounts of both are necessary to minimise oxidation-induced tissue damage. A regular daily supply is needed, as these nutrients are used-up in the process of de-toxifying free radicals. Vitamin E and Selenium protect cells in many parts of the body – depending on the tissues affected. Muscles Performance horses require a large amount of energy to fuel muscle activity. Therefore muscle cells have a very high requirement for anti-oxidants. The more exercise undertaken by the horse, the higher the anti-oxidant requirement. If Vitamin E or Selenium are deficient, muscle cells (including the heart muscle) may be damaged by free radicals leading to muscle pain – and stiffness, loss of muscle strength, stamina and flexibility and in severe cases “tying-up”. A deficiency of anti-oxidants may also delay muscle recovery and rebuilding after strenuous exercise. Immunity Cells involved in providing immunity against infectious diseases also rely on anti-oxidants to function to their full potential. A high level of immunity is important for all horses but particularly newborn foals and young horses in race training, shows or sales where they may be exposed to many infectious diseases. The stress of hard training and competition is known to lower immunity so any horse exposed to these factors could benefit from an anti-oxidant supplement. Reproduction Deficiencies of Selenium and Vitamin E have been shown to lead to reproductive problems in many species of animals. Once again, the most likely cause of reproductive problems due to anti-oxidant deficiency is free radical damage to reproductive hormones, sperm and egg cells and the cells lining the uterus. Anecdotally, breeders have had success getting low fertility mares in foal, once they began supplementation with Vitamin E and Selenium. Foals born to mares which have received inadequate Vitamin E or Selenium during pregnancy may suffer from a condition known as “White Muscle Disease”. These foals may be stillborn, weak at birth, or may appear normal at birth but develop signs of the disease within the first few weeks of life. Red blood cells Free radicals can damage the membranes of red blood cells as they circulate in the bloodstream, making them more fragile and decreasing their lifespan. This is of particular importance to racing and high performance horses that have a very high level of free radical production but also require a high red blood cell count to perform to their full potential. Adequate Vitamin E to act as an anti-oxidant in red cell membranes is therefore very important in equine athletes. Free radicals can damage the membranes of red blood cells, decreasing their lifespan. Adequate anti-oxidants are essential to maintain general health, vitality and performance of humans and animals and to minimise the risk of a wide range of debilitating diseases. As more and more information becomes available on the benefits of anti-oxidants, they are becoming widely recommended by human health professionals and increasingly by animal nutritionists and veterinarians. Routine use of anti-oxidants in working, showing and breeding horses should provide significant health and performance advantages. Injury and infection Increased levels of free radicals can prolong the disease process. Supplementing with Vitamin E and Selenium will help boost the immune system and hasten recovery. High fat diets Feeding high fat diets is an excellent way of providing horses with energy without the need to feed large amounts of grain. This is useful for horses that tie-up and for those that become “fizzy” on grain. However, high fat diets require additional anti-oxidants to mop up the free radicals produced by oxidation of the extra fats and lipids. Why choose White-E or White-E with Selenium? White-E (powder or liquid) White-E with Selenium Muscle strength and stamina Horses susceptible to ‘tying-up’ Strengthening immune system Reproductive function in mares and stallions Nervous disorders Selenium deficient areas Muscular disorders in foals Recommended daily dose rate (refer to pack for directions for use) Stress, nervousness and anxious behaviour Stress and nervousness increase the rate of body metabolism – therefore nervy horses have a higher requirement for anti-oxidant nutrients. Both emotional and physical stress is known to increase the production of free radicals. White-E powder White-E liquid White-E with Selenium Horses 1 dose 1 dose 16g 450-500kg 16g =1000IU 60mL =1000 IU Vitamin E =1000IU, Selenium =500µg Ponies ½ dose ½ dose ½ dose 250-300kg 500 IU 30mL = 500 IU Vitamin E =500IU, Selenium =250µg Pack Size 500g = 31 doses 1.5kg = 93 doses 8kg = 500 doses 5Lcask = 83 doses 500g = 31 doses 20L = 333 doses 1.5kg = 93 doses Standard doses