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Lab # 6 Digestive System-1 Digestive tract - Oral cavity - Pharynx - Esophagus - Stomach - Small intestine - Large intestine Accessory organs - Teeth - Tongue - Salivary glands - Liver - Gallbladder - Pancreas Digestive System Pharynx Tongue and teeth Salivary glands Oral cavity Esophagus Liver Gallbladder Stomach Pancreas Large intestine Small intestine Most of the digestive tract follows the basis structural plan with digestive tract wall consisting of the following tissue layers, in order from the inner to the outer surface: Cross section of the esophagus 1- Mucosa: Stratified squamous epithelium Lamina propria Muscularis mucosae Stratified squamous epithelium 2- Submucosa 3- Muscularis externa: Inner circular layer Outer longitudinal layer Simple columnar epithelium 4- Serosa Stratified squamous epithelium Diaphragm Stomach Esophagus Simple columnar epithelium (it contains gastric pits and gastric glands) Stratified squamous epithelium (also in oral cavity, pharynx and esophagus). Three layers of smooth muscle in the muscularis externa: outer longitudinal, middle circular, and inner oblique. Two layers of smooth muscle in the muscularis externa: outer longitudinal and inner circular. Folds of the mucosa called rugae. Longitudinal folds of the mucosa that allow for expansion Taeniae coli Small Intestine Simple columnar epithelium with microvilli (it contains crypts of Lieberkuhn and intestinal glands) Two layers of smooth muscle in the muscularis externa: outer longitudinal and inner circular. Transverse folds of the mucosa called plicae circulares, and fingerlike projections called villi. Large Intestine Transverse folds of the wall called haustra. Simple columnar epithelium without villi (it is dominated by mucous cells) Two layers of smooth muscle in the muscularis externa: outer longitudinal reduced to the taeniae coli, and inner circular. The Oral Cavity 1- The Lips and the Cheeks, 2- The Palate Functions: 1- Ingestion takes place, 2- Mechanical and chemical digestion start Soft palate Hard palate Uvula Upper lip Cheek Vestibule Lingual frenulum Lower lip Tongue Functions: The Tongue 1- Mechanical digestion, 2- Keeping the food against the teeth during chewing and swallowing, 3- Analysis of food (touch, temperature, and taste receptors), 4- Secretion of mucus and lingual lipase, 5Helping in speech (taste buds) (friction) (taste buds) The Salivary Glands Functions: They secret saliva which 1- Cleanses the mouth, 2- Dissolves and moistens food, and 3- Contains enzymes that starts the break down of the carbohydrates Parotid ducts Parotid glands Sublingual glands Submandibular glands Mucous cells (Mucins) Serous cells (Enzymes) Duct The Teeth Functions: Mechanical break down of food (chewing or mastication) Enamel Dentin Crown Neck Pulp cavity Gingiva or gum Periodontal ligament Root Cementum Root canal Blood vessels and nerve The Teeth Central incisor Lateral incisor Cuspid or canine (Blade-shape teeth: Clipping and cutting) (Conical with a sharp ridgeline and a pointed tip: Tearing or slashing) Upper dental arch Molars Bicuspids or premolars (Flattened crown with prominent ridges: Crushing, smashing and grinding) (Very large flattened crowns with prominent ridges: Crushing and grinding) Total: 32 permanent or secondary teeth Lower dental arch Total: 20 primary, temporary or deciduous teeth The Pharynx Function: It propels the food to the esophagus. Nasopharynx Pharyngeal tonsil (air passageway) Eustachian or auditory tube Oropharynx (food and air passageway) Laryngopharynx (food and air passageway) Soft palate Palatine tonsil Lingual tonsil Epiglottis Glottis The Esophagus Function: It carries food and liquids to the stomach Mucosa The Stomach Fundus Cardia Serose Muscularis Externa: Pyloric region: Longitudinal layer Lesser curvature Pyloric Antrum Circular layer Pyloric canal Pyloric sphincter Oblique layer Mucosa Greater curvature Duodenum Rugae Simple columnar epithelium Histology of the Stomach It secrets alkaline protective mucus Mucosa Gastric pit Lamina propria Muscularis mucosae Submucosa Oblique muscle Circular muscle Longitudinal muscle Serosa (visceral peritoneum) Mucous cells They produce alkaline protective mucus Gastric pit Parietal cells They produce HCl and Intrinsic Factor Chief cells They produce Pepsinogen Gastric gland (In new born and infants produce rennin and gastric lipase) G cells They are enteroendocrine cells that produce Gastrin, Somatostatin, Histamine and Serotonin The Small Intestine Macroscopic anatomy It is the major digestive and absorptive organ of the body. It extends from the pyloric sphincter to the ileocecal valve (19.7 ft ) Functions: 1- To complete digestion 2- To absorb 99% of the digested nutrients Duodenum (10 inches) It receives the pancreas and liver secretions that mix with the chyme Jejunum (8.2 ft ) It is where most chemical digestion and absorption take place Ileum (11.48 ft ) It is where digestion is completed. It ends at the ileocecal valve, which control the passage of undigestive materials to the large intestine Microscopic anatomy Plicae Circularis They increase the surface area for absorption They make chyme spiral through the lumen to mix with intestinal juice They slow movement to allow time for absorption Microscopic anatomy Mucosa General Structure of the Small Intestine Highly folded lining where absorption occurs Submucosa Connective tissue containing blood vessels and nerves Plicae Muscularis externa Peristalsis: The contraction of the smooth muscle that produces waves, which push materials along the length of the digestive tract Serosa Connective tissue Circular and longitudinal muscle layers used for peristalsis Absorption of nutrients Microvilli Epithelium (Simple columnar) Lacteal Villus Plica Capillary network Nerve Arteriole Lymphatic vessel Venule F- The Large Intestine Functions Large colon 1- Reabsorb water 2- Compact undigested food stuff into feces 3- Eliminate faces 4- Absorb bacterial vitamins 5- Store fecal matter until defecation Cecum Ileocecal valve Rectum Anus