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Universitatea de Medicină şi Farmacie „Grigore T. Popa” Iaşi Comisia pentru asigurarea calităţii DISCIPLINE RECORD/ COURSE / SEMINAR DESCRIPTION 1. Information about the program 1.1. 1.2. 1.3. 1.4. 1.5. 1.6. UNIVERSITY: “GRIGORE T. POPA” UNIVERSITY OF MEDICINE AND PHARMACY OF IAŞI FACULTY: PHARMACY SCHOOL / DEPARTMENT: PHARMACEUTICAL SCIENCES I SUBJECT: PHARMACEUTICAL PHYSICS STUDY FIELD: MEDICINE STUDY CYCLE: UNDERGRADUATE STUDY PROGRAMME: IN ENGLISH 2. Subject data 2.1. SUBJECT: PHARMACEUTICAL PHYSICS 2.2. Module leader: Prof. Mihaela Baican, PhD, Lecturer Florina Crivoi, PhD 2.3. Seminar leader: Prof. Mihaela Baican, PhD, Lecturer Florina Crivoi, PhD 2.4. Year of I 2.5. Semester in I/II 2.6. Evaluation E1/E2 2.7. Subject Obligatory study: which is taught type status 3. Duration of the course (hours per semester) 3.1. Number of hours / week 4 (1st sem.) 4 (2nd sem.) 3.2. Number of hours / week 1 (1st sem.) 2 (2nd sem.) 3.3.Seminar / lab 3 (1st sem.) 2 (2nd sem.) 3.4.Total number of learning hours 112 3.5.Total number of learning hours 14 (1st sem.) 28 (2nd sem.) 42 3.6.seminar / lab 42 (1st sem.) 28 (2nd sem.) 70 hours 35/ 38 20/10 20/14 5/ 5 4/2 10/80/67 150/125 6/5 3.7.Distribution of activities in the course (1st sem./ 2nd sem.) Study based on the manual, printed course, bibliography and notes Additional research in the library, on specialized e-platforms and field study Preparation for seminars, practical courses, portfolios and essays Tutoring Assessment Other activities 3.8. Number of hours of individual study 3.9. Number of hours per semester 3.10. Number of ECTS 4. Previous Knowledge (if applicable) 4.1. course related 4.2. skill related It is not the case Mathematics and physics elementary notions 5. Requirements (if applicable) 5.1. course conditions 5.2. seminar / laboratory conditions 6. Specific Skills Acquired Videoprojector, course support Specific laboratory devices Professional skills displayed by knowledge and skills Transversal skills (role skills, professional and personal skills) Evaluation of some physical factors that influence the pharmaceutical products preservation (temperature, humidity, atmospheric pressure); Appreciation of purity degree and quality of the substances in different aggregation forms, using the studied methods; Determination of some physical parameters having an important part in conditioning and storing of a pharmaceutical substance or a pharmaceutical product Team work skills; Use of known concepts in new contexts; Use of theoretical and practical knowledge in solving specific problems of the professional qualification; Oral and written communication skills specific to the profession, problem solving and decision making; Opening for lifelong learning, autonomy and responsibility, respect for professional ethics. 7. Course Objectives (confirmed by the grid of specific skills acquired) 7.1. General Objective 7.2. Specific Objectives Acquiring knowledge about physics concepts applied in qualitative and quantitative characterization of different substances that are used in pharmaceutical preparations. Acquisition of knowledge on physics concepts with applications in biomedical domain; Acquisition of skills on working with laboratory equipment, in order to characterize substances in solid and liquid state, as well as assessing their purity degree. 8. Contents 8.1. Course Fundamental and derivative physical quantities. Dimensional equation. Motion types Dynamics principles; centripetal and centrifugal forces. Statics notions. General conditions of equilibrium of bodies Oscillations and waves. Oscillatory motion; elastic waves; plane wave equation; waves interference Sound waves; Doppler effect; ultrasounds Fluids. Fluids statics. Fundamental principle of hydrostatics; Archimedes’s principle. Fluids dynamics. Bernoulli’s equation Dynamic of real fluids; Blood viscosity. Sedimentation and centrifugation. Blood viscosity Surface phenomena in liquids. Pressure created by a curved liquid surface; contact phenomena; capillarity Surface phenomena at the contact between three media; superficial tension of solutions; thermal expansion; appreciation of drugs stability Transport phenomena (osmosis and diffusion) Gaze perfecte; gaze reale; izotermele Andrews Coulomb’s law; Electrostatic field Electric dipole; polarization of atoms and molecules; electric current; Ohm’s law; applications of superconductors Joule’s effect; electric networks in permanent regime; motion of Teaching methods videoprojector Observations videoprojector 2 hours videoprojector 2 hours videoprojector videoprojector 2 hours 2 hours videoprojector 2 hours videoprojector 2 hours videoprojector 2 hours videoprojector videoprojector videoprojector videoprojector 2 hours 2 hours 2 hours 2 hours videoprojector 2 hours 2 hours charged particles in electric and magnetic fields Photometry; principles of geometric optics; light refraction and videoprojector 2 hours reflection Thin lenses; characteristics of optical instruments videoprojector 2 hours Polarization of light (polarization types, rotatory polarization) videoprojector 2 hours Light absorption; light dispersion videoprojector 2 hours X-Ray (production and scattering, characteristic spectra, videoprojector 2 hours properties, attenuation law, applications); photoelectric effect Atomic nucleus (properties, Mass spectrograph, mass defect, videoprojector 2 hours nuclear binding energy, internuclear forces) Natural radioactivity; radiations emitted by the nuclei; decay videoprojector 2 hours nuclear laws Radiopharmaceuticals (properties, classification, radioisotopes videoprojector 2 hours preparation, administration ways) Bibliography 1. Young DH, Freedman RA. University Physics. San Francisco : Pearson Education, Inc., 2008. 2. Sanny J, Moebs W. University Physics. WCB Publishers, 1996. 3. Crivoi F, Baican M. Physical methods applied in pharmacy. Iasi: Ed. “Gr. T. Popa“, 2012. 4. Sampson B. Textbook of radiopharmacy, Theory and Practice, 3-rd edition; Gordon and Breach Publishers, 1999. 5. Courrière Ph. Physique et biophysique pharmaceutiques. Paris : Masson, 1990. 8.2. Seminar / Practical lessons Teaching Observations Methods Work protection. Physical quantities. Measurement of the 3 hours physical quantities. Errors. Presentation of the results Measurement of density for solid state 3 hours Measurement of density for liquids by pycnometer method 3 hours Determination of liquids density using the densimeter and the 3 hours Mohr-Westphal balance Evaluation of some physical factors which influence the 3 hours conservation of the pharmaceutical products Tracing of the calibration curve for a thermocouple 3 hours Determination of the superficial tension coefficient 3 hours Modification of the superficial tension coefficient by the surface 3 hours active substances Determination of crioscopic point of a solution 3 hours Measurement of the specific heat for the solid substances 3 hours Determination of melting specific latent heat of ice 3 hours Determination of the viscosity coefficient using Ostwaldt 3 hours viscometer 3 hours Variation of the viscosity coefficient with temperature 3 hours Measurement of the viscosity coefficient of glycerin by Stokes method Determination of surface free energy for solids. Contact angle 2 hours method 2 hours Measurement of the electric resistance using Wheatstone bridge 2 hours Study of the dialyse phenomenon using Kohlrausch bridge 2 hours Determination of the mechanical equivalent of the calory. Joule 2 hours effect 2 hours Determination of osmotic pressure with Dutrochet device 2 hours Determination of the focal distance of a lens 2 hours Measurement of the refractive index of liquids using Abbé refractometer 2 hours Determination of the optical microscope qualities: magnification and diameter of the visual field 2 hours Application of the microscope for measuring the dimensions of the penicillin crystals 2 hours Determination of the refractive index of a glass blade using the microscope 2 hours Tracing of the calibration curve of the prism spectroscope. Subtance identification using spectra in visible domain 2 hours Determination of the concentration of a solution using Spekol photocolorimeter 2 hours Using of the polarimeter for measurment the concentration of a glucose solution Atomic absorbtion spectrophotometry. IR -spectrometry (demonstrative work) Bibliography 1. Crivoi F, Baican M. Physical Methods Applied in Pharmacy.Iasi: Grigore T. Popa Publishing House U.M.F. Iaşi, 2012. 2. Young DH, Freedman RA. University Physics 12-th edition, Pearson International 2008. 3. Breithaupt J. Understanding physics for advanced level. 2-nd edition, Stanley Thornes Publisher Ltd. 1990. 4. Sanny J, Moebs W. University Physics, Johnson M Eds. Brown Wm C Publishers 1996. 9. The agreement between the course contents and the expectations of the representatives of the epistemic communities, professional associations and employers in the field related to the program Physics course provides to the first year students a number of notions very useful in their training as future pharmacists, putting them on hand a multitude of techniques that enable them - with the chemical methods - a comprehensive characterization of pure substances that are part of pharmaceutical products. These skills acquired after attending Pharmaceutics Physics Course will be of a real use to the future graduate, whether will choose to work in industry, in pharmacy, or will choose a career in academia. 10.Assessment Activity 10.4. Course 10.5. Seminar Practical lessons 10.1. Assessment criteria Acquiring of the notions reached at the course / Learning the theoretical notions met in practical works and acquiring skills in the use the laboratory equipment 10.2. Assessment methods Written exam from course content Oral evaluation during the semester and written tests from laboratory notions 10.3. Percentage of the final grade 50 % 50 % (- 15% represent the continuous testing during the semester and 35% - represent the final testing by the practical works examination) Minimal standard of proficiency: Minimum mark to pass: 5 Date: 16.12.2014 Date of indorsement in the Council of the Department Signature of Coordinator for Teaching Activities Lecturer Florina Crivoi, PhD Prof. Mihaela Baican, PhD Signature of The Department Director Assoc. Prof. Gladiola Țântaru, PhD