Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Epilepsy Surgery American Epilepsy Society Epilepsy Care Seizure Epilepsy diagnosis Medication trials Imaging for pathology Medical intractability Surgical Consideration Surgical workup Surgery American Epilepsy Society 2008 S-Slide 2 Candidates for Epilepsy Surgery Persistent seizures despite appropriate pharmacological treatment Usually at least two drugs, appropriate to seizure type, at adequate doses, with adequate compliance Impairment of quality of life due to ongoing seizures Loss of driving privileges, employment opportunities, social/cultural stigma, dependence on others, side effects of medications, under achievement in school, memory deficit, attention deficit, injuries, accidents American Epilepsy Society 2008 S-Slide 3 Presurgical Evaluation History and Physical Exam Electroencephalography Imaging Presurgical Testing Neuropsychology Evaluation Comprehensive Patient Care Conference American Epilepsy Society 2008 S-Slide 4 Imaging for Surgical Candidates MRI- with epilepsy protocols • T1- inversion prepared, gradient-echo, echoplanar, true inversion recovery image • T-2- fast spin echo, FLAIR, 3D volume acquisition American Epilepsy Society 2008 S-Slide 5 Presurgical Evaluation- MRI Right hippocampal sclerosis (arrow) American Epilepsy Society 2008 S-Slide 6 Presurgical Evaluation- MRI Left mesial temporal sclerosis S-Slide 7 Presurgical Evaluation- PET/SPECT Functional Imaging • PET • hypometabolism interictally • SPECT • hypoperfusion interictally • hyperperfusion ictally • PET and/or SPECT may be coregistered with MRI American Epilepsy Society 2008 S-Slide 8 Presurgical EvaluationSISCOM SISCOM (SPECT with MRI coregistration) in a patient with extratemporal epilepsy American Epilepsy Society 2008 S-Slide 9 Presurgical evaluation - fMRI fMRI- language lateralization, hippocampus function, epileptogenic focus assessment Patient with left temporal lobe epilepsy. Left: Language mapping with verb generation task activation in Broca’s and Wernicke’s areas. Right: Memory localization with picture encoding task decreased activation in the left hippocampus. American Epilepsy Society 2008 S-Slide 10 Presurgical EvaluationMEG Magnetoencephalography (MEG) Magnetic source localization of interictal epileptiform discharges Functional mapping fMRI has a good spatial resolution but provides poor temporal correlation, while EEG provides timed waveforms with poor localization. MEG jointly records these two signals providing spatially and temporally correlated images. American Epilepsy Society 2008 S-Slide 11 Testing for Surgical Candidates Visual fields Formal testing if resection will endanger vision Intracarotid Amobarbital Procedure (Wada) Language dominance Verbal memory Prediction of postoperative decline Phase II monitoring with intracranial electrodes if necessary Subdural/depth electrodes Identification of ictal onset and epileptogenic zone Allows for cortical mapping if needed Cortical mapping Intraoperative (phase III) or during phase II monitoring Identification of eloquent areas of cortex American Epilepsy Society 2008 S-Slide 12 Neuropsychological Evaluation for Surgical Candidates Provides preoperative baseline Predicts risk of cognitive decline with surgery Testing includes: IQ battery of tests Language localization Memory- verbal and visual localization Visuospatial function Attention/Executive Motor- coordination and speed Psych- expectations of surgery, coping skills, social support, stability American Epilepsy Society 2008 S-Slide 13 Comprehensive Patient Care Conference for Surgical Candidates Epileptologist presents the patient Video-EEG studies are reviewed Semiology Interictal EEG morphology Ictal EEG morphology Neuroradiologist discusses imaging studies Neuropsychology results are examined Neurosurgeon delineates surgical options Discussion of risks/benefits/outcomes Group consensus American Epilepsy Society 2008 S-Slide 14 Epilepsy Surgery Phase II subdural electrodes for intracranial monitoring American Epilepsy Society 2008 S-Slide 15 Types of Surgical Procedures Resective Surgery: Lesionectomy Selective amygdalohippocampectomy Corticectomy Lobectomy (e.g. temporal lobectomy) Multilobar resection American Epilepsy Society 2008 S-Slide 16 Types of Surgical Procedures Disconnective/Palliative Surgery: Hemispherectomy Anatomic Functional Corpus Callosotomy Multiple Subpial Transections Vagus Nerve Stimulator American Epilepsy Society 2008 S-Slide 17 Surgical Treatment of Epilepsy MRI frameless stereotactic localization of focal cortical dysplasia at the base of the central sulcus (center of cross hairs) American Epilepsy Society 2008 S-Slide 18 Standard Temporal Lobectomy 4.5 cm Resection of the anterior temporal lobe (~4.5 cm on left side, ~5.5 cm on right side) followed by resection of mesial structures (amygdala, hippocampus, parahippocampal gyrus) American Epilepsy Society 2008 S-Slide 19 Selective Amygdalohippocampectomy Idea is to remove mesial structures (hippocampus, amygdala, parahippocampal gyrus) leaving lateral temporal cortex intact Distinct surgical approaches include: Transsylvian Transcortical Subtemporal American Epilepsy Society 2008 S-Slide 20 Transsylvian Selective Amygdalohippocampectomy American Epilepsy Society 2008 S-Slide 21 Functional hemispherectomy American Epilepsy Society 2008 S-Slide 22 Functional hemispherectomy Introduced by Rasmussen Extensive cortical resection in temporal and central cortex with disconnection of residual frontal and occipital cortex by transecting white matter fibers (not shown) Perisylvian Deafferentation Transsylvian Keyhole Classic (Rasmussen) American Epilepsy Society 2008 S-Slide 23 R hemimegalencephaly in a 7month-old boy Pre-op Post-op American Epilepsy Society 2008 S-Slide 24 Transsylvian functional hemispherotomy (Schramm) Transsylvian exposure and temporomesial resection (uncoamygdalohippocampectomy) Transventricular callosotomy and occipitoparietal mesial disconnection Frontobasal disconnection American Epilepsy Society 2008 S-Slide 25 Corpus Callosotomy Introduced by William P. Van Wagenen in 1940 For intractable generalized epilepsy Particularly effective against “drop attacks” corpus callosum pericallosal artery septum pellucidum Partial vs. complete Spares the anterior commissure, fornix American Epilepsy Society 2008 callosotomy (in progress) S-Slide 26 VNS Surgery Electrodes are placed around the left vagus nerve and connected to the pulse generator in the chest or abdomen American Epilepsy Society 2008 S-Slide 27 Clinical Trials Experimental Surgical Treatments Under Clinical Trials • Deep brain stimulation • Responsive neurostimulation • Gamma knife radiosurgery American Epilepsy Society 2008 S-Slide 28 Head Trauma and Epilepsy • Acute symptomatic seizures • Usually within few days after head trauma • Incidence is proportional to the severity of trauma • Remote symptomatic seizures • Seizure prevention in patients with traumatic brain injury American Epilepsy Society 2008 S-Slide 29 M ar y h Ci ead Ci vili in vil an ju r ia n HI y ( HI (s HI (m eve ) od re Em er ) b at LV oli H c r S e) w isk tro *L itho fa ke VH ut ct o w the rs ith r Ba th apy ct En er e a As ria cep py ce l m ha Al pti en liti zh c in s m ei m en gitis M er' in ul s gi tip di tis l e se sc ase le ro Al sis co ho H *M e l ar roin iju a No na ris k ilit Risk ratio Risk Factors for Epilepsy 1000 580 100 10 1 0.1 29 20 4 16 7.3 2.3 0.7 10 4 2 4 3 3 1 0.4 LVH = left ventricular hypertrophy. *Protective. Hesdorffer DC, Verity CM. In: Engel J Jr, Pedley TA, eds. Epilepsy: A Comprehensive Textbook; vol 1. Philadelphia, Pa: Lippincott-Raven Publishers; 1997:59-67. Head Trauma and Epilepsy 404 pts, severe head injury with cortical damage randomized in < 24 hr: phenytoin vs. placebo. Seizures in one week: placebo 14%, phenytoin 4% Once late seizure occurs, 86% recurrence. Recommend: Use prophylactic AED for 1-2 weeks after severe head trauma, then stop. If late seizures occur, treat with AED. Temkin, NEJM 1990. American Epilepsy Society 2008 S-Slide 31 Conclusion Many patients with medically-intractable epilepsy are surgical candidates All patients with epilepsy should undergo epilepsy protocol imaging Many modern epilepsy surgery options exist, including resection, disconnection and palliation American Epilepsy Society 2008 S-Slide 32