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OBJECTIVES OF TUTORIALS (& some clinical reasoning sessions) CARDIOLOGY 1.CHEST PAIN: 1. Ability to assess patient with acute chest pain in emergency room 2. Classification and treatment strategies for acute coronary syndrome 3. Diagnosis of ST-segment elevation myopcardial infarction and choice between primary PCI vs. thrombolysis 4. Highlights on the Diagnosis and treatment of aortic dissection 5. Highlights on the diagnosis and treatment of pulmonary embolism 2. PALPITATION: 1. Ability to assess patient with palpitation in outpatient setting 2. Identify the common and the serious causes of palpitation clinically and by ECG 3. Diagnosis and treatment of atrial fibrillation and flutter 4. ECG findings in premature beats (Atrial and ventricular) Supraventricular tachycardia (sinus tachycardia, atrial tachycardia, AVRT, AVNRT) and Ventricular tachycardia 3.CARDIAC MURMURS: 1. Pathogenesis of murmur 2. Approach to a patient with cardiac murmur. Approach to clinical diagnosis type of murmur (systolic, diastolic , continuous) sites (apical, basal, lt.parasternal) causes (congenital, rheumatic or ischemic). Investigations X-Ray chest Echo Doppler study ECG. Discussion about MITRAL VALVE LESIONS AORTIC VALVE LESIONS REGARDS 1. Pathogenesis 2. Features 3. Investigations 4. Complications 5. Management Medical Interventional Surgical 6. Prophylaxi for infective endocarditis and rheumatic fever 4.HYPERTENSION: 1. Diagnosis of systemic hypertension, Burden in Saudi Arabia 2. Treatment of systemic hypertension 3. Causes and treatment of secondary hypertension 4. Rule of ambulatory BP monitoring 5. Impact of treatment of systemic hypertension on stroke and myocardial infaction 5. HEART FAILURE : Define Heart failure Types: a. According to out put…… High; Low b. According to chamber….. LVF; RVF; CCF c. According to cycle….. Systolic; Diastolic Etiology in young: Brief about…… Congenital causes Valvular lesions Myocarditis Hypertension Arrhythmias Cardiomyopathy In old: IHD , HTN & Cardiomyopathy Approach to a patient with suspected cardiac failure History Physical examination Investigations CARDIOMYOPATHY Define Etio Types and clinical features Criteria for diagnosis of CMP Management 6. Fever in Cardiac Patients : Approach to a patient with suspected cardiac fever History (IE,Rh.F.,post MI) Physical examination Investigations Infective Endocarditis Define Etio clinical features Criteria for diagnosis of IE Management - Rheumatic fever: Link of rheumatic fever to streptococcal infection and its prevention. Elaborate on the major manifestation of rheumatic fever and how to recognize them. How to investigate and the manage a patient with possible rheumatic fever GASTROENTEROLOGY 7. JAUNDICE: 1. Definition of jaundice. 2. Bilirubin metabolism and mechanisms producing jaundice (Haemolysis,hepatocellular damage or cholestasis). 3. Approach to a patient presenting with jaundice : History: To differentiate between types of jaundice. Clinical examination for detection of each pathognomic signs e.g. o Pallor, Splenomegaly (hemolytic J.) o Hepatocellular failure manifest. (Hepatocellular J.) o Scratching marks &abdominal mass (obstructive J.) Investigation LFTs, Urine analysis for bilirubin &urobilinogen, Abdominal U/S, Viral markers Discussion about: Hepatitis Discussion about: Acute hepatitis - Etio A,B,C,D,E - Clinical Stages - Features - Diagnosis , Complications - Management Chronic hepatitis - Definition - Types Post hepatitic B,C - clinical picture - Diagnosis - Therapy Autoimmune Hepatitis Drug Induced Hepatitis 8. Liver Cirrhosis Definition & Etiology and types Features Diagnosis, Complications (e.g. hepatocellular failure –HCC) & Assess the Severity of Liver Disease Outline the Prognosis, and Management Brief about causes of Cirrhosis - Alcoholic Cirrhosis, Post hepatitis Cirrhosis, Cardiac Cirrhosis, Biliary Cirrhosis, Hemochromatosis, Hepatolenticular Degeneration "Wilson dis" 9. CHRONIC DIARRHEA Define diarrhea: Classify: Acute Chronic Chronic diarrhea: Subclassify: According to cause Osmotic Secretory Motility Chronic infection Inflammatory According to site Small bowel Large bowel Approach to chronic diarrhea: History…. Age; Diarrhea pattern; Diurnal variation Relation to meal; Weight Loss; Stool consistency Examination …. GPE; Abdomen Investigations….. CBC Stool analysis: especially Stool Osmolal gap Stool culture UCE Ca, Po4, ALP Albumin TFT Sigmoido and colonoscopy Barium studies Tests for malabsorption Fecal fat D-xylose Pancreatic function Jejunal biopsy H breath test Discussion: Celiac disease Inflammatory bowel disease Irritable bowel syndrome 10.GASTROINTESTINAL BLEEDING Epidemiology. Brief description of sources of GI bleeding and mortality. Prognostic factors including clinical(details ) and endoscopic factors (brief ) Time of rebleed Overview of Causes of GI bleeding. Role of acidity in gastrointestinal bleeding Goal of therapy and management lines in details for both acute cases and stable cases Incidence of peptic ulcer disease ,common sites ,differences between erosion and ulceration ,hospitalization rate ,physiological explanation of ulceration, smoking effect on Peptic ulcer disease H pylori bacteriology ,pathology ,incidence of infectivity ,method of detection with sensitivity and specificity ,line of management and therapy Causes of lower gastrointestinal bleeding and diagnostic modality with advantages and disadvantages 11.HEART BURN & DYSPHAGIA HEART BURN: Definition of Gastro esophageal reflux disease , Prevalence ,reason for diagnosis ,physiological mechanism of GERD , Hiatus hernia and GERD , Clinical presentation with extra esophageal complication , Diagnostic modality ,timing and differences of outcome of each modality Treatment goals including both non- pharmacological and pharmacological therapy Safety of therapy Treatment of persistent symptoms and chronic relapsing condition Complications of GERD Principles of surgical therapy and endoscopic therapy Differential diagnosis DYSPHAGIA: Definition Etiology: (a) Mechanical (b) Motor Approach to a patient with Dysphagia 1. History 2. Examination 3. Investigations Esophagoscopy; Barium Swallow and meal; Manometry 4. Brief about a) Achalasia b) Ca esophagus NEPHROLOGY 12 .RENAL FAILURE Introduction to structure and function of kidneys Definition of Renal failure Types: Acute ARF Chronic CRF Define ARF Define Oliguria; Anuria; Azotemia & Uremia Stages of ARF……………….RIFLE D/D: Prerenal/Renal/Postrenal ARF Practical approach to a case of ARF History Examination Investigations: How to differentiate Pre-renal/Renal/Post-renal? Latest markers of ARF Management of ARF Indications for Hemodialysis Management of some specific causes of ARF Acute tubular necrosis Radio-contrast ARF Acute interstitial nephritis Definition of CRF and Chronic kidney disease Stages of renal dysfunction Etiology: with more stress on common causes of CRF Manifestations of CRF Investigations in a case of CRF Complications of CRF with mechanisms of osteodystrophy Management of the CRF and its Complications Renal Replacement therapy Peritoneal dialysis Hemodialysis: especially access for Hemodialysis Renal transplant Advantages and disadvantages of each method Causes of death in ESRD with poor prognostic factors Differentiation of ARF from CRF 13. NEPHROTIC/NEPHRITIC SYNDROME (glomerulonephritis) Introduction to the Glomerular structure and mechanisms of injury Define GN Classification of glomerulonephritides How the patient may present? Nephritic Nephrotic Nephrotic+Nephritic Nephritic syndrome components Sequence of events Investigations to confirm Nephritic syndrome An approach to etiology of the nephritic syndrome by investigations General management Specific disorders: Post infectious GN IgA nephropathy Brief introduction to HS purpura Anti-GBM GN Nephrotic Syndrome components Etiology Complications Investigations General management Specific disorders Minimal change disease Membranous GN Diabetic Nephropathy Nephrotic+Nephritic presentation Lupus nephritis 14. Electrolytes imbalance 1. Organize an algorithm on how to diagnose the cause of hyponatremia, hypernatremia, hypokalemia and hyperkalemia 2. Diagnosis and management of SIADH 3. Diagnosis and management of hypernatremia 4. Diagnosis and management of hyperkalemia 5. Diagnosis and management of hypokalemia 6. Diagnosis and management of hypocalcemia and hypomagnesemia 7. Diagnosis and management of hypercalcemia and hyperphosphatemia INFECTIOUIS DISEASE 15.PYREXIA OF UNKNOWN ORIGION Body Temperature Definition of PUO Temp Duration Investigations Categories Classical Nosocomial Neutropenic HIV assoc Etiology Infections e.g. T.B Malignancy Connective tissue disorders Miscellaneous Diagnostic Approach Management Discussion about few causes of PUO Enteric fever Etio Transmission Manifestations Typhoid Paratyphoid Diagnosis Blood and bone marrow culture Serology Treatment Preventive aspects Chemoprophylaxis Vaccination Brucellosis Etio Transmission Manifestations Diagnosis Treatment Duration of therapy and follow up Preventive aspect Malaria Etio Transmission Manifestations Diagnosis Treatment Prophylaxis In chloroquine sensitive and resistant areas Complications of falciparum malaria esp. cerebral malaria and its management. T.B -.Recognize pulmonary tuberculosis as one of the most important global public health problems specially in the era of HIV. - Define the causative agent, pathogenesis and clinical features of the disease. - Describe methods for the diagnosis of pulmonary tuberculosis. - Recognize the importance of appropriate treatment of cases and the prevention of drug resistance. 16. HIV/AIDS Case definition Routes of transmission Epidemiology Major risk groups Causative agent HIV 1 HIV 2 How virus interacts with body cells How injury occurs Incubation/latent period Clinical features Systemic Respiratory Neurologic Rheumatologic Cutaneous Intestinal Eye Suspected malignancies Laboratory Antibody detection Antigen detection CBC The suitable investigation to diagnose AIDS in a suspected case follow up the case; Treatment progress Investigations for suspected infections and malignancies D/D Prevention Primary Secondary Risk to health care people and what to do in case of needle stick injury? Sexual exposure/drug abuse exposure....what to do? How to prevent vertical transmission? Pregnancy with AIDS Management Principles When to start therapy Name the different groups of antiretroviral drugs but limit to most recommended therapy i.e ZIDO+LAMI+EFA Important toxic effects of this regimen ENDOCRINOLOGY 17. GOITER 1. Definition 2. Classification 3. Examples 4. Stages of goiter 5. Features of goiter 6. What a hard thyroid means 7. Approach to goiter TFT Scan Biopsy 8. Management of individual cases Grave's disease Multinodular goiter Hashimoto's thyroiditis 9. Solitary nodule Investigations Management 10. Brief about Thyroid malignancies….names; general principles of management. 18.CUSHING Syndrome..: Pathophysiology and causes Clinical features Diagnosis (investigations) &D.D Treatment 19.ADDISON’S Disease.: Pathophysiology and causes Clinical features Diagnosis (investigations) Treatment 20.Pituitary Disorders: Pathophysiology and causes Clinical features of different disorders Diagnosis (investigations) &D.D Treatment Especial discussion about acromegaly 21. HYPERGLYCEMIA Normal blood glucose and its regulation Causes of hyperglycemia Diabetes mellitus 1. Types 2. Pathophysiology 3. Clinical manifestation 4. Investigations for diagnosis for follow up 5. Treatment oral hypoglycemics insulin therapy recent advances in treatment 6. Complications DKA ……. Features, Investigations, Management. Hypoglycemia Hyperosmolar non ketotic coma Nephropathy Neuropathy Retinopathy Diabetic foot RHEUMATOLOGY 22.MONOARTHRITIS - How to recognize arthritis. - Importance of monoarthritis. How urgent it is. - Identify most important causes of monoarthritis. septic; gout; systemic presenting with mono e.g RA ; reactive - Approach to a case of monoarthritis History Examination Investigations joint aspiration and synovial fluid analysis xray Discussion Septic arthritis Gouty arthritis regards Etio Pathogenesis Features Management acute long term 23. ARTHRITIS & RASH Approach to a patient with arthritis and rash History Examiantion Investigations Brief about common underlying cause Rheumatic fever SLE SLE: - Identify major manifestations of SLE. - Major clinical features of SLE. - Discuss major impact of SLE upon pregnancy and lactation. - Important complications - How to investigate a patient of SLE with its major differential diagnosis. - Outline the major therapeutic options. 24. CHRONIC ARTHRITIS - Approach to a patient with chronic arthritis. History Exam Investigations SEROLOGY RADIOLOGY Major causes of Chronic Arthritis RA SERONEGATIVE: REACTIVE PSORIATIC ANKYLOSING SPONDYLITIS Discussion about: RHEUMATOID ARTHRITIS - Major features - Introduce the concept of rheumatoid arthritis as a major cause of disabling chronic arthritis. Highlight the importance of early detection of rheumatoid arthritis and the impact on the outcome of the disease. Give an outline about how to investigate a patient with arthritis and possible differential diagnosis. Major therapeutic option of rheumatoid arthritis. NSAIDS……cox inhibitors..non-selective cox-2 DMARDS…..methotrexate; salazopyrines hydroxychloroquin Biological……infliximab; adalimumab etanercept Role of surgery . PULMONOLOGY 25. HEMOPTYSIS • • • • • • • Definition of hemoptysis Differentiate from Hematemesis Causes of hemoptysis Approach to a patient history examination asses the severity investigation Management Complications Discuss Bronchiectasis Bronchial cancer Regarding Etiology Features Types Specific investigations Therapy 26. FEVER, COUGH & CHEST PAIN (PNEUMONIA) Approach to a patient with suspected pneumonia History Examination Investigations Pneumonia Define Epidemiology Types Etiology Features Differential diagnosis Investigations How to assess the severity of CAP and its indications for Hospitalization Management treatment regimens of different types Complications 27. ACUTE DYPSNEA Causes of acute dyspnoea Clinical approach to the breathless patient History Physical investigations D/D between Cardiac and respiratory causes PULMONARY EMBOLISM Pathophysiology Risk factors Presentation Diagnostic Modalities Management Prognosis BRONCHIAL ASTHMA (Acute asthma) Cause Types Features Assesment of severity Investigations Management Acute severe Long term Pneumothorax (Def., Causes, Investigation and Treatment) Pulmonary oedema ( Cardiogenic Vs. non cardiogenic) 28. CHRONIC DYPSNEA Diagnostic approach to the patient with Chronic Dyspnea History Examination Investigations Causes of chronic dypsnea Interstitial Lung Diseases Definition Etiology and pathogenesis Clinical picture Causes of ILD Investigations Discuss Idiopathic Pulmonary Fibrosis COPD Definition Types Etiology Pathophysiology Features and staging Investigations Management 29. PLEURAL EFFUSION: 1. Definition 2. How to differentiate Transudative and Exudative Effusion Light's criteria 3. Causes of Transudative and Exudative Effusion What is Empyema? 4. Clinical Features 5. Investigations Esp. Pleural Aspiration and biopsy 6. Management 7. Indications of intercostal drainage HEMATOLOGY 30. ANEMIA/PALLOR • Define anemia • Types depending upon 1.RBC morphology 2.Underlying cause • Approach to a patient with anemia History Physical examination Investigations • Discuss: Iron deficiency Anemia Megaloblastic anemia Hemolytic anemias Thalassemia Sickle cell anemia G6PD deficiency Aplastic anemia List the signs and symptoms of anemia and distinguish between the symptoms of acute anemia with volume depletion and chronic anemia in the euvolemic state. Discuss possible eitiologies of the fore mentioned types of anaemias Recognize characteristics of the fore mentioned types of anaemias 31. CBC Normal values RBC, Hb and indices like MCV, MCH, MCHC, RDW TLC DLC Platelets Briefly discuss Anemia Approach to anemia Leucocytosis Neutrophilia Lymphocytosis Eosinophilia Monoytosis Leucopenia Thrombocytopenia Define Causes Risks at different counts Leukemias …. Blood picture in AML; CML; ALL; CLL 1. Students will define anemia and discuss how normal values vary with race and gender 2. Students will interpret the common findings on a CBC; i.e., hemoglobin, hematocrit, white count, platelet count, MCV, and RDW 3. Students will describe indications for ordering and interpret the results of the following studies: A. Reticulocyte count B. Iron, Ferritin, Transferrin, and TIBC C. B12, folate, Methylmalonic Acid, Homocysteine D. LDH, Haptoglobin E. Hemoglobin Electrophoresis F. Blood Smear G. BM Biopsy 4. Students will recognize major findings on peripheral blood smear, including: A. Hemolysis (schistocytes) B. Hypersegmented polysegmented neutrophils C. Microcytosis D. Macrocytosis 32. BLEEDING DISORDERS Normal Hemostasis Approach to a patient with bleeding tendency History Examination Investigations CBC Bleeding/clotting time PT/APTT What is INR? Immune Thrombocytopenia Platelet function disorders DIC Hemophilia Purpura: Define Purpura Approach to purpuric rash VIRAL; BACTERIAL; IMMUNOLOGIC; ITP/TTP Vasculitis: Define - How to identify vasculitis (elicitic clues for its recognition). small vessel medium vessel large vessel - - Explain major clinical manifestations based on pathophysiology. local systemic Give an idea about major and most common clinical vascultidis giant cell arteritis takayasu arteritis polyarteritis nodosa wegener's granulomatosis henoch schonlein purpura Investigations in a case of vasculitis. Major management steps for vasculitis. A clinical approach for a patient suspected to have vasculitis. 33. LYMPHADENOPATHY What is Lymphadenopathy? Approach to a patient with generalized Lymphadenopathy? Causes: Infections Malignancies Autoimmune disorders Lipid storage disorders Drugs History Examination: Node characteristics Investigations Indications of LN biopsy Lymphoma Define Classification Some comments about the various classification systems of NHL like WHO, REAL. Epidemiology and etiology: brief How to differentiate Hodgkin and NHL? Features Investigations Staging Management Most common regimens according to the type Prognosis Leukemia Define Types ;- Acute, Chronic Features Investigations Management Prognosis 34. WEIGHT LOSS: Definition of unintentional weight loss Etiology: weight loss with adequate food intake Weight loss with inadequate (diminished) food intake Social Psychological Organic….. Malignancy Infections Endocrine GI causes Medications Evaluation Documentation History Examination Investigations NEUROLOGY 35 .SEIZURE What is a seizure Types of seizure….. motor; sensory; behavioral Approach to a patient with recurrent seizures Possible causes of seizures…. Metabolic; Vascular; exogenous Infectious; Inflammatory Definition of epilepsy Classification of epilepsy Features of each type Esp. the phases of a grand mal seizure Factors precipitating a seizure Differential diagnosis Investigations Special emphasis on the indications and yield of EEG; CT and MRI Management When to start the antiepileptic drugs How to manage a motor seizure in ER Among the antiepileptic drugs Valporate; carbamazepine; Phenobarbital Ethosuximide; Lamotrigine; Topiramate Adverse effects of these drugs Precautions in an epileptic e.g Regulations regarding driving; Choice of profession 36.HEMIPLEGIA/WEAKNESS :Approach to a patient with weakness of neuromuscular origion Upper motor neuron disease……chronic; acute Lower motor neuron disease Disease of peripheral nerves Disease of neuromuscular junction Disease of muscles Then discuss Hemiplegia:Definition Etiology Clinical picture of Hemiplegia at different levels. INVESTIGATIONS: Intracranial/spine…… CT, MRI Peripheral……. CBC; ESR; muscle enzymes; Protein electrophoresis ANA; TFT; HIV; Heavy metal screen NMJ…..Tensilon test EMG Muscle biopsy Discuss: STROKE Define Types Risk factors Etiology Also causes of a stroke in a young person TIA CEREBRAL INFARCT HAEMORRHAGE…… intracerebral; subarachnoid Localization of lesion Investigations CT why preferred? Other relevant investigations e.g CBC, ESR, RBS etc Management General Specific INFARCT Thrombolytic? Antiplatelet? ACE inhibitors? Target BP? Mannitol? HAEMORRHAGE Complications Aspiration SIADH DVT 37.FEVER AND HEADACHE Meningitis Etiology Source and transmission Features with signs of meningeal irritation Investigations LP and CSF analysis with findings in viral; bacterial; Tuberculous meningitis Treatment Complications Encephalitis Etiology Source and transmission Features Investigations LP and CSF analysis and PCR CT Treatment Complications 38.COMA Glasgow Coma Scale Causes of coma…….Craniocerebral trauma Metabolic…….Exogenous Endogenous…Endocrine; renal; hepatic; Respiratory; Electrolyte and Acid base disorders CVA Infection…. CNS and sepsis SOL Psychiatric Seizure disorders How to differentiate Supratentorial lesions Infratentorial lesions Mid brain; pons; medulla;. Cerebellum Metabolic encephalopathy Psychogenic coma Approach ABC History Examination Labs ….. CBC; urine; PT; Toxicology screen; ABG; Urea; Creatinine; Electrolytes; LFT; ECG; CXR; LP; MRI General management 39.EXTRA-PYRAMIDAL DISORDERS Introduction to Motor system Pyramidal and extra-pyramidal system Basal ganglia Classification of extra-pyramidal disorders [Hypo-kinetic and Hyper-kinetic] Tremors Chorea Athetosis Hemiballismus An approach to movement disorders Discuss Parkinsonism in detail Briefly discuss: Essential tremors Huntington’s disease Sydenham chorea Wilson’s disease Acute Dystonia Tardive dyskinesia 40. PERIPHERAL NERVE DISORDERS Classification Etiology of Polyneuropathy Clinical features Approach to peripheral neuropathies Differential diagnosis Investigations Introduction to NCS and EMG Investigations to find cause General treatment Discuss: Guillian Barre syndrome Diabetic neuropathy Bell's palsy Carpal tunnel syndrome 41. Myopathies & Muscular dystrophies To understand major categories of muscle disease and the clinical differences between them. To be able to use appropriately the different diagnostic tools to diagnose muscle diseases. To recognize the major pathologic features of myopathic muscle. 42. Multiple sclerosis (MS) Epidemiology How to diagnose a case of MS (clinical picture, investigations) Treatment 43.HEADACHE Possible causes of Headache Intracranial Extracranial Neuralgias Approach to a patient with headache History….age; sex; duration: single episode of severe headache subacute recurrent chronic location; quality of ache; prodrome; Associated symptoms; ppt factors relieving factors; diurnal variation; family GPE Neurologic exam Investigations Visual acuity; field Fundus Paranasal sinus study CT or MRI LP Red flags in headache Discuss MIGRAINE…..Define; Types; Presentation; ppt factors; Management of acute attack Analgesic antiemetic Ergotamine Sumatriptan and zolmitiptan Prophylaxis Ca channel blocker esp. flunarazine Beta blocker Valproate CLUSTER HEADACHE SOME INVESTIGATIONAL SESSIONS TOPICS 44. ECG How to read ECG Rate Rhythm P wave QRS axis and voltage Evaluate chamber enlargement/ hypertrophy ST segment examination ECG2: 1. Approach of bradyarrhythmia 2. ECG findings on heart block ( 1st, second and third degree) 3. review on ECG finding on STEMI, VT and SVT 4. ECG findings on electrolytes imbalance, such as hyperkalemia 45. LFT Normal bilirubin metabolism Normal liver functions Interpretation Bilirubin ALT AST ALP GGT PT A/G ratio Identify: Patterns of Liver function abnormality Predominantly conjugated hyperbilirubinemia Predominantly unconjugated hyperbilirubinemia Mixed hyperbilirubinemia Pre-hepatic; hepatic; post-hepatic 46. ARTERIAL BLOOD GAS ANALYSIS Define pH, acid and base/alkali Physiology of the acid base regulation Normal acid base parameters Analysis of ABG report to identify the primary acid base disorders Meaning of compensation and hints to identify mixed acid base disorders Causes of primary acid base disorders: Metabolic acidosis Respiratory acidosis Metabolic alkalosis Respiratory alkalosis 47- PULMONARY FUNCTION TESTS : - Indications - Contraindications - PFT Procedures - Definitions of Tidal volume, Inspiratory and Expiratory reserve volumes, Vital capacity, Residual volume, Total lung capacity, FVC, FEV1, FEF 25%-75%, - Interpretation of Spirometry Obstructive or restrictive Assessment of severity