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Sex Determination in humans
Chromosomes
Chromosomal sex
Regulator Genes
Genetic sex
Prenatal Hormones
Genital sex
External &
internal
genitalia
Phenotypic sex
Gonads
Brain
structures
Gonadal sex
Brain sex
Gonads and internal genitalia
SRYgene
Development of testes
Mullerian Inhibiting
Factor & others
Testosterone
Müllerian Duct degenerates
Wollfian duct develops
Epididymis
Vas Deferens
Seminal Vesicles
Prostate Gland
Male Differentiation
Testosterone (from testes)
Wolffian Duct develops
Epididymis
Vas Deferens
Seminal Vesicles
Prostate Gland
Male Differentiation
SRY gene
Mullerian Inhibiting Factor & other factors
Müllerian Duct degenerates
Wnt-4 Gene
• Essential for female development
• Prevents production of testosterone
• Initiates development of Mullerian
duct
• Necessary for proper oocyte
development
• Suppresses Wolffian duct
Female Differentiation
No Y, No
SRY, No MIF
Wnt-4 Gene
Activates Müllerian Duct
Fallopian Tubes
Uterus
Cervix
Inner vagina
Development
of ovaries
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