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Mini-Case Study 1-Contolled Drug Delivery: Due Sunday, February 29, 2004, 9:PM, by e-mail to
[email protected] (before class on March 1 )
(50 points possible)
Your group has been assigned to find a cure/treatment for cancer using a controlled drug delivery strategy.
You can choose from one of the following cancers: bladder, breast, eye, colon, lung, mouth, pancreas, prostate,
stomach, skin, blood, etc., EXCEPT BRAIN CANCER. You can pick the cancer that interests your group the
most. However, you cannot pick BRAIN CANCER and you cannot use gene therapy, or antisense as your
controlled drug delivery strategy.
In your report include:
1. A definition of controlled drug delivery. (5 points possible)
2. A description of the cancer, the organ system it affects, and what causes it. This should include, but is not
limited to, cancer symptoms, diagnosis, how the cancer is acquired (or is it inherited?), organs, tissues, and cells
affected, and complications of the cancer. Can the cancer be prevented? (10 points possible)
3. Previous and recent treatments now or in development (clinical trails, if any). Include a short description,
chemical structures and names, and discuss their efficacy. (10 points possible)
4. A description (including a diagram) of your controlled drug delivery strategy. In your description you must
explain your strategy (sustained, How Long?; biological, physical, or chemical targeting method, or a
combination of these methods and the purpose of each moiety). Please include the dosage form (IV,
subcutaneous, oral, liposomes, microparticles, polymers, linker, prodrug, a combination or cocktail, etc.). Please
note that you must discuss the rationale for your strategy. (15 points possible)
5. A prediction of any problems (biological, physiological, physiochemical) that your groups "new" controlled
drug delivery strategy might encounter. This can include, but is not limited to, side effects, problems with
formulation, effective dose and/or how it will be administered (oral, IV, etc.) and how frequently it will need to
be administered. (10 points)
The report is intended to be about 5-6 pages. (However you will NOT be penalized if you have more then 6).
Please make sure you put your GROUP NUMBER on the cover page, list all the names of your group members
and indicate the group leader (with e-mail address). Graphics, schematics, and figures may be drawn or
scanned. Also, (this is very important) please include references for any information taken from the
literature, Internet, books, etc. This includes figures, tables, etc. You should have at least 3 references
from journal articles.