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IMAGE REGISTRATION AND DYNAMIC IMAGING IN PACS Igor Vujović, Ivica Kuzmanić, Maja Krčum INTRODUCTION PACS systems are increasingly developing every day. They are not invented to be useful aid to medical experts, but to serve in reducing space for archive purposes, and in transmitting medical images to the distance, they are, in combination with HIS, becoming a basic part of expert systems in development. The problem in processing the images and the possible cause of misdiagnosis in the future expert systems could be SNR Is the SNR the right criteria for the quality of the image? IMAGE RECONSTRUCTION Nevertheless every day’s improvements, some questions still remain: 1) can we use a prior knowledge about image structure or function to design better systems of computer-aided diagnostics and PACS (if we are looking for a fibrosis in X-ray, or anomaly in bones, there is a prior knowledge of what are we looking for, where it could be found), 2) how can be clear image be reconstructed from nonuniformly sampled data, 3) can the resulting image be qualitatively and quantitatively characterized (can we find a measure of the quality of the reconstruction). DYNAMIC IMAGING AND IMAGE REGISTRATION In the dynamic imaging, a lot of images in series are acquisited from the same anatomical site. Dynamic imaging is useful for functional MRI, mammography and interventional MRI. Conventional Fourier imaging methods require a tradeoff between spatial and temporal resolutions (the Heisenberg's equation of uncertainty). Spatial and temporal resolutions are (if N encodings are collected for each image): x 1 / N x and T a cq = NT R . For the dynamic imaging (we need high speed), if a large N is used to obtain high spatial resolution, temporal resolution will be compromised. The key issue of the image reconstruction is how can we effectively use the reference data for reconstruction of the dynamic images so that data truncation due to encoding can be minimized. EXAMPLE FROM PRACTICE Figure 1 - Example of sharpening pulmonary X-ray: a) analyzed image, b) highly sharpen image, c) normally sharpen image, d) enlarged detail of the histogram differences. CONCLUSIONS Whatever we do with matrix, the goal issue should not be SNR 3, 4 or saving memory and time, but to find ways of not changing the medical information contained in the medical image 6, 8. It is the simple question that should be answered: whether the result of processing is the truth – or lie. Even a simple matrix operation (A = A + B) leads to the possible loss of the real medical information, because the original is changed. And it is possible, in that simple operation, to lose the truth of the patient's health.