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Pick Disease This is an uncommon cause for dementia, but it appears similar to Alzheimer disease. The cerebral atrophy with Pick disease is lobar and typically involves the frontal and temporal lobes. This atrophy is so striking that it is "knife-like" in appearance. This atrophy may be asymmetrical. Microscopically, there is marked loss of cortical neurons with gliosis. Pick bodies, cytoplasmic inclusions that are highlighted by silver stain, are seen in the cortex. Mutations in the tau gene which codes for tau, a protein that is associated with microtubules, can be found in Pick disease. The abnormal tau may be present in the microscopically apparent Pick bodies, which have partially degraded (called ubiquitinated, since they are positive with immunohistochemical staining for ubiquitin) tau fibrils. (Perl, 2000)