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Unit A: Maintaining Health Chapter and Unit Review Suggested Answers Science 30 © 2007 Alberta Education (www.education.gov.ab.ca). Third-party copyright credits are listed on the attached copyright credit page. Science 30 Science 30 © 2007 Alberta Education (www.education.gov.ab.ca). Third-party copyright credits are listed on the attached copyright credit page. Science 30 Unit A: Maintaining Health Chapter and Unit Review Suggested Answers This document is intended for You may find the following Internet sites useful: Students ✓ Teachers ✓ • Alberta Education, http://www.education.gov.ab.ca • Learning Resources Centre, http://www.lrc.education.gov.ab.ca • Tools4Teachers, http://www.tools4teachers.ca Administrators Home Instructors General Public Other Exploring the electronic information superhighway can be educational and entertaining. However, be aware that these computer networks are not censored. Students may unintentionally or purposely find articles on the Internet that may be offensive or inappropriate. As well, the sources of information are not always cited and the content may not be accurate. Therefore, students may wish to confirm facts with a second source. Copyright © 2007, Alberta Education. This resource is owned by the Crown in Right of Alberta, as represented by the Minister of Education, Alberta Education, 10155 – 102 Street, Edmonton, Alberta, Canada T5J 4L5. All rights reserved. This resource was developed by or for Alberta Education. It may be reproduced in any form, including photocopying, without written permission from Alberta Education provided that associated copyright notices are also reproduced. THIS RESOURCE IS NOT SUBJECT TO THE TERMS OF A LICENCE FROM A COLLECTIVE OR LICENSING BODY, SUCH AS ACCESS COPYRIGHT. Knowledge 1. The four main jobs of the human circulatory system are to replace carbon dioxide and wastes within the body’s cells with oxygen and nutrients to send chemical messengers throughout the body, to distribute body heat, and to defend against disease. 2. This table compares the chambers of the mammalian heart. Heart Chamber Location Type of Blood Found in Chamber right atrium top right deoxygenated receives blood from body from vena cava right ventricle bottom right deoxygenated receives blood from right atrium and delivers blood to lungs left atrium top left oxygenated receives blood from lungs left ventricle bottom left oxygenated receives blood from left atrium and delivers blood to body via aorta Function 3. Arteries and veins differ in the following ways: • Arteries carry blood away from the heart, they usually carry oxygenated blood, and they have thicker walls and are more elastic than veins. • Veins carry blood toward the heart, they usually carry deoxygenated blood, they have thinner walls than arteries, and they have one-way valves. 4. Plasma, red blood cells, white blood cells, and platelets is the order of blood components ranked by their relative proportions in a sample. 5. The blood component responsible for initiating the clotting process is platelets. 6. Cardiovascular disease is one of many disorders that affect the heart and/or circulatory system. Examples include coronary heart disease, strokes, and varicose veins. 7. Both a heart attack and a stroke are caused by thrombosis or clots. However, in a heart attack the coronary arteries that supply the heart are blocked. This causes cell death in the heart. In the case of a stroke, a blockage in the arteries that supply the brain causes the death of brain cells. 8. Disease-causing pathogens can enter the body through vectors, inhaled droplets from an infected person, cuts or breaks in the skin barrier, and via food or water contaminated by pathogens. Science 30: Unit A Chapter and Unit Review Suggested Answers Science 30 © 2007 Alberta Education (www.education.gov.ab.ca). Third-party copyright credits are listed on the attached copyright credit page. Chapter 1 Review Questions Science 30 © 2007 Alberta Education (www.education.gov.ab.ca). Third-party copyright credits are listed on the attached copyright credit page. 9. A vaccination involves the injection of dead or weakened disease-causing pathogens into body tissues by using a hollow needle. With few adverse effects, the body produces an immune response to the weakened or dead pathogens. This production of memory cells and antibodies helps the body respond quickly to future exposure from live pathogens. 10. The answers to these questions can be checked by referring to “Overview of Immune Response” on page 65 of the textbook. Applying Concepts 11. a. The greater the organism’s size, the lower the resting heart rate. b. Since this is an estimate, answers may vary. A reasonable estimate for the resting heart rate of a 3-kg cat should be about 175 beats per minute. c. Since this is an estimate, answers may vary. A reasonable estimate for the resting heart rate of a 7000-kg T. rex should be about 28 beats per minute. d. Since this is an estimate that is not bounded by two data points, answers may vary considerably to this question. One possible answer is 20 beats per minute. This question demonstrates the limitations of using data that goes beyond the end points of the data set. e. The data provided is for mammals only. Extinct dinosaurs could have had different physiological adaptations for their circulatory systems and, therefore, cannot be directly compared. 12. Evaluate your model according to the specific design criteria provided. All key structures on the heart diagram are to be included in the model. Even though the model will not include labels, if someone points to a heart structure on the model, you should be able to answer the following focusing questions: • What is the name of this structure? • Where would blood in this part of the heart go next? • Does this part contain oxygen-rich blood or oxygen-poor blood? 13. Evaluate the models of other students according to the same design criteria used to evaluate your model. 14. a. Determine the strong points of your model by using the feedback from other students and teachers. b. A great source of ideas for how to improve each model is evident in the work of the other students. Science 30: Unit A Chapter and Unit Review Suggested Answers Hi, I’m Robbie the Red Blood Cell. My friend Tina Toe Cell asked me to bring her some oxygen and dispose of some waste. Here is my ADVENTURE The blood re-enters the heart from the lungs through the pulmonary veins. It then enters the left atrium. The blood is then pumped into the left ventricle. From the left ventricle it goes into the aorta where it starts travelling to the brain and the entire body. The blood first enters into the heart by the vena cavae and enters the right atrium. The blood is then pumped into the right ventricle. From the right ventricle the blood enters the lungs through the pulmonary artery. The blood then starts travelling throughout your body down the main artery. It branches off into small capillaries that carry oxygen-rich blood to your entire body while picking up wastes and carbon dioxide and bringing it to disposable organs. The blood continues down the leg, still with the capillaries to feed the muscles in your leg. But it’s not so difficult for your body. It is doing it constantly. Finally, the blood reaches you. It seems like a long process, but it actually only takes the body a matter of seconds for it to be pumped so far away from the heart. Without the heart, the blood would not circulate the body. This could result in limbs that do not function properly. Science 30: Unit A So that’s how it all works. Who could know that it could be such a complicated process? Chapter and Unit Review Suggested Answers Science 30 © 2007 Alberta Education (www.education.gov.ab.ca). Third-party copyright credits are listed on the attached copyright credit page. 15. Although answers will vary, a sample comic strip is shown. Science 30 © 2007 Alberta Education (www.education.gov.ab.ca). Third-party copyright credits are listed on the attached copyright credit page. 16. a. Injecting more red blood cells creates an advantage for athletes because more red blood cells means they have a greater oxygen carrying capacity. This would give the athletes a cardiovascular advantage. b. It is more difficult to prove that an athlete has engaged in blood doping because drugs can be detected in the blood, whereas blood itself is natural and it’s difficult to prove that extra blood cells are a result of doping rather than high-altitude training. c. Blood doping will most likely cause an increased density to the blood and, therefore, an increased blood pressure. d. Possible negative health effects of the practice of blood doping include an increased chance of infection due to the injection and an increased blood pressure during exercise. Also, the removed blood may not be stored properly in these illegal circumstances, resulting in dead or clotted blood being injected back into the body. e. Responses will vary for this question. You may argue that high-altitude training relies upon the efforts of the athlete, while blood doping relies upon the expertise of technicians and medical staff. From this point of view, blood doping may appear to be unethical. 17. Responses will vary somewhat. The activity can be scored using the scoring guide for skills shown in the Science Data Booklet. A sample experimental write-up follows. Your response should be similar. Problem Does the use of the manufacturer’s weight-loss drug cause an increased heart rate? Hypothesis If people take the drug, there is a greater incidence of increased heart rates. Manipulated Variable use of drug Responding Variable heart rate Controlled Variables Control the test groups for age, gender, amount of exercise, diet during the study, and heart rate prior to the drug trial. Science 30: Unit A Chapter and Unit Review Suggested Answers Measure and record the cardiac health of your test subjects by recording their heartbeats both at rest and during exercise with a heart-rate monitor. Split your test subjects into two approximately equal groups. Administer the drug to one group and give a placebo to the other group. The study should be done as a double-blind test so that neither the researchers nor the subjects are aware of who is taking the placebo and who is using the actual drug. At regular intervals over a period of six months, record the resting and exercising heart rates of all participants. Participants should keep a log of any adverse effects. At the end of the study, compare the reported and recorded effects from each of the two groups to determine if the group administered the drug actually reports significantly more adverse effects than the placebo group. 18. You should be able to list some general adaptations to increase the ability of diving mammals to stay underwater for prolonged periods. These include an increased lung capacity, a greater amount of blood or a greater ability of blood to carry oxygen, more efficient lungs, and a slower use of oxygen while underwater. The Weddell seal is able to remain underwater for more than an hour without surfacing to breathe because of the following adaptations of the seal’s circulatory and respiratory systems: • The seal has twice the volume of blood per kilogram as compared to a human, so it can store twice as much oxygen. • The seals have a diving reflex that, while underwater, slows the pulse and reduces oxygen consumption. • Their muscles have a protein called myoglobin—similar to hemoglobin in blood—that stores oxygen in muscles. 19. a. Patient 2 has high cholesterol, high blood pressure, and a high resting heart rate. These are all risk factors for developing heart disease and its associated problems like a heart attack or a stroke. The doctor would probably recommend that this patient stop smoking, exercise more, and follow a diet low in cholesterol and saturated fats. b. Patient 1 has a very high white blood cell count compared to the other two patients. This elevation can indicate an infection. c. Patient 3 does regular intensive exercise. This person’s heart is working very hard during this exercise, which increases the heart’s capacity to stretch and expand. This means that to circulate the blood, the more efficient heart of an athlete has to work much less when it’s at rest. 20. Students who have been actively focusing on questions 21 to 24 will have evidence of their active reading strategies. This evidence can take the form of point-form notes or of highlighted passages on the print copy. 21. a. The first test done was simply the resting heart-rate value. The second test was the heart-rate increase, which was measured by subtracting the resting heart rate from the peak exercise heart rate. The final test was heart-rate recovery, which was the difference in heart rate between the peak value during exercise and the value one minute after the exercise had stopped. b. The test that appears to have the best ability to predict sudden death from a heart attack is heart-rate increase. Participants with a heart-rate increase of less than 89 beats per minute had four times the risk of sudden death due to heart attack compared to those with heart-rate increase values in excess of 113 beats per minute. Science 30: Unit A Chapter and Unit Review Suggested Answers Science 30 © 2007 Alberta Education (www.education.gov.ab.ca). Third-party copyright credits are listed on the attached copyright credit page. Experimental Design Science 30 © 2007 Alberta Education (www.education.gov.ab.ca). Third-party copyright credits are listed on the attached copyright credit page. 22. The subjects in the study had to meet the following criteria. They had to • be men employed in the French civil service • be between 42 and 53 years old • be free of any known or suspected cardiovascular disease • have a resting systolic blood pressure less than 180 mmHg • complete the exercise testing This screening procedure was used to determine if there was a test that could determine the likelihood of sudden death from a heart attack in a population of men who seemed quite healthy and who had no symptoms of cardiovascular disease. These screening procedures were also important for the health of the participants—if they suffered from cardiovascular illness or high blood pressure, the exercise test could have been dangerous for them. 23. a. The control group consisted of 5503 men. These subjects, during follow-up, were either alive or had died from causes other than heart attacks. b. There were 81 men from the original group who died suddenly due to heart attacks. 24. This research did not test a representative sample of the whole population. Only men who worked in the French civil service were tested, so it would be difficult to extend the research results to the entire population or to women since they were not part of this research. Chapter 2 Review Questions Knowledge 1. A chromosome is a coiled section of DNA visible using a microscope. DNA is the molecule that a chromosome is made from. A gene is a region of DNA that provides instructions for making a protein. Different genes are found in different locations on particular chromosomes. Note that chromosomes are only visible with a light microscope during meiosis and mitosis. 2. In an autosomal cell, humans possess 23 pairs or a total of 46 chromosomes (22 pairs of autosomal chromosomes and 1 pair of sex chromosomes). 3. Mitosis produces two genetically identical diploid daughter cells from one diploid body cell. Meiosis produces four genetically different haploid cells from diploid cells located in the ovaries or the testes. 4. Acquired characteristics are traits developed or present as a result of environmental influences. An example of an acquired characteristic is the ability to speak a particular language. Inherited characteristics include traits present in an individual as a result of the genes (genotype) that the organism possesses. An example of an inherited characteristic is a person’s eye colour. 5. a. Green pea pods are dominant since they appear to mask the yellow pea pod colour. b. Letters used may vary. The parent pea plant will be GG for the green pod pea plant and gg for the yellow pod pea plant. The offspring is heterozygous with a Gg genotype. Science 30: Unit A Chapter and Unit Review Suggested Answers 7. a. original strand: complementary strand: ATATACCAGCCGATA TATATGGTCGGCTAT ATA-TAC-CAG-CCG-ATA Isoleucine-Tyrosine-Glutamine-Proline-Isoleucine original strand: amino acid sequence: b. original strand: complementary strand: GCATGGTTCATAAGG CGTACCAAGTATTCC GCA-TGG-TTC-ATA-AGG Alanine-Tryptophan-Phenylanine-Isoleucine-Arginine original strand: amino acid sequence: c. original strand: complementary strand: CGTATGCCAGTTTAT GCATACGGTCAAATA CGT-ATG-CCA-GTT-TAT Arginine-Methionine-Proline-Valine-Tyrosine original strand: amino acid sequence: d. original strand: complementary strand: GGTTTATGCATTTCT CCAAATACGTAAAGA GGT-TTA-TGC-ATT-TCT Glycine-Leucine-Cysteine-Isoleucine-Phenylanine original strand: amino acid sequence: 8. a. amino acid sequence: Methionine-Threonine-Glutamine possible DNA triplets: ATG — b. amino acid sequence: possible DNA triplets: Science 30: Unit A ACT ACC ACA ACG CAA — CAG Arginine-Lysine-Tryptophan CGT CGC CGA CGG AGA AGG AAA — — TGG AAG Chapter and Unit Review Suggested Answers Science 30 © 2007 Alberta Education (www.education.gov.ab.ca). Third-party copyright credits are listed on the attached copyright credit page. 6. The term genotype refers to the alleles—the copies or forms of a particular gene—that an individual possesses. Genotypes can be represented using letters for the different alleles. The term phenotype refers to the physical characteristics or expression of the genotype. An example of a genotype is the listing of alleles for the eye colour genotype or describing alleles as being homozygous or heterozygous for a trait. An example of a phenotype is the eye colour of an individual. Science 30 © 2007 Alberta Education (www.education.gov.ab.ca). Third-party copyright credits are listed on the attached copyright credit page. c. amino acid sequence: possible DNA triplets: d. amino acid sequence: possible DNA triplets: Serine-Proline-Aspartate TCT TCC TCA TCG AGT AGC — CCT CCC CCA CCG — GAT GAC Leucine-Cysteine-Valine TTA TTG CTT CTC CTA CTG — TGT TGC — GTT GTC GTA GTG 9. Proteins are important and versatile molecules within a biological system. They form enzymes and hormones, as well as structural or transport components of the cell, and they can be used as an energy source for the body when carbohydrates and fats are unavailable. 10. Both types of mutations are changes in the DNA sequence, and they are often caused by the presence of environmental mutagens. A point mutation is the substitution of a nucleotide in the DNA sequence, while a frameshift mutation is an addition or deletion of a nucleotide. Both types of mutations change the sequence of amino acids in a gene. A significant difference in these types of mutations is that a point mutation alters one nucleotide base, which may cause a change in one amino acid in a sequence. Since a frameshift mutation literally shifts the frame or the grouping of all the nucleotides “downstream” from the substitution or deletion, this type tends to be a more damaging form of mutation. 11. The steps involved in creating recombinant DNA are as follows: (a) A gene is located on a chromosome. (b) Enzymes are used to cut the chromosome’s DNA into pieces, and the desired gene is isolated. (c) The segment of DNA containing the desired gene is inserted into a bacterial plasmid. The plasmid containing the genes from two or more organisms is called recombinant DNA. (d) A recombinant DNA plasmid can be inserted into a bacterium where it will be replicated during cell division. Copies will appear in subsequent daughter cells. Science 30: Unit A 10 Chapter and Unit Review Suggested Answers Comparing Mitosis and Meiosis—Labelled 12. Mitosis Meiosis DNA replicates DNA replicates pairing of homologous chromosomes alignment along centre separation of chromosomes chromosome exchange of genetic segments between homologous chromosomes (crossing over) separation of chromosomes cell division cell division daughter cells: 2n cell division to form gametes gametes: 1n Science 30: Unit A 11 Chapter and Unit Review Suggested Answers Science 30 © 2007 Alberta Education (www.education.gov.ab.ca). Third-party copyright credits are listed on the attached copyright credit page. Applying Concepts Science 30 © 2007 Alberta Education (www.education.gov.ab.ca). Third-party copyright credits are listed on the attached copyright credit page. 13. a. Since the gene for white colour is recessive, breeding a white tiger with a standard-coloured tiger would most likely produce offspring without the white phenotype. The standard-coloured tiger’s dominant allele masks the recessive white gene in the offspring. b. The inbreeding of any population often results in an increase in the frequency of certain traits. In white tigers, inbreeding could reduce the variety of alleles that could be inherited. Inbreeding could result in more offspring developing autosomal recessive genetic diseases if one of the parents possessed such an allele. 14. a. Since there was no family history of this trait, the red fur is most likely the result of a spontaneous mutation. b. It can be determined if the new colour trait is dominant or recessive by breeding the puppy with the red fur trait with another dog and observing the phenotypes of the offspring. If some or all of the offspring have red fur, then the trait is most likely dominant. If no offspring has the trait, then red fur is most likely recessive. A dog with red fur—the dominant trait of RR or Rr—is crossed with a dog with other-coloured fur (rr). R R r Rr Rr r Rr Rr R r r Rr r r r Rr r r Either all offspring would have the red-fur trait or half the offspring would have the trait. A dog with red fur—the recessive trait of rr—is crossed with a dog with other-coloured fur (RR). r r R Rr Rr R Rr Rr All offspring have the other-coloured fur phenotype. c. Ideally, the breeder should find another dog with a similar fur colour phenotype and breed them together. If offspring are only bred that have red colour fur (since they have at least one red fur-colour allele), there is a better chance of developing offspring that are homozygous for that red fur-colour trait. 15. Antibacterial soaps may kill most of the bacteria. The few bacteria with some natural resistance to these soaps are the ones that survive to reproduce. These somewhat resistant bacteria can transfer plasmids between other bacteria sharing the genes that cause antibacterial soap resistance. Eventually, a strain of antibacterial soap-resistant bacteria may develop. Science 30: Unit A 12 Chapter and Unit Review Suggested Answers Gene Therapy for Cystic Fibrosis tissue cell nucleus healthy person genetic material modification to viral DNA so it cannot cause disease modified adenovirus (cold virus) chromosome 7 “healthy” gene: codes for proper amino acid sequence—no cystic fibrosis symptoms healthy gene is spliced into adenovirus cells lining lung tissue of person with cystic fibrosis adenovirus with healthy gene goes to lung tissue adenovirus delivers healthy gene: now cell has code for proper amino acid sequence—if successful, symptoms of cystic fibrosis relieved person with cystic fibrosis Science 30: Unit A 13 Chapter and Unit Review Suggested Answers Science 30 © 2007 Alberta Education (www.education.gov.ab.ca). Third-party copyright credits are listed on the attached copyright credit page. 16. Science 30 © 2007 Alberta Education (www.education.gov.ab.ca). Third-party copyright credits are listed on the attached copyright credit page. 17. a. Agree. Since there are three phenotypes, this trait cannot be controlled by one gene with two alleles— this could indicate co-dominance. b. Disagree. If they all had homozygous genotypes, the greatest number of phenotypes of the offspring could be two—the homozygous recessive colour and the homozygous dominant colour. c. Disagree. One or both of the parent dogs are carriers for a different allele or possess one of each allele type to create a different phenotype. d. Agree. The phenotype provides some information about an organism’s genotype. 18. a. Only males are affected by a gene present on the Y chromosome. b. Since males get only one Y chromosome, they express all the alleles on that chromosome. There is no possibility of dominance masking another allele because there is no other allele to mask. c. The percentage probability of a hairy-eared man passing this trait onto his son is 100%. Sons always inherit the Y chromosome from their fathers, since the inheritance of the Y chromosome is what makes a child male. d. The percentage probability of a hairy-eared man passing this trait onto his daughter is 0%. Daughters never inherit the Y chromosome. The inheritance of the Y chromosome is what makes a child male. e. No. Carriers have two copies of a gene, and the dominant allele masks the expression of another recessive allele. If an individual inherits the Y chromosome, he will be male and express all the traits of that chromosome. 19. a. The pedigree indicates that the inheritance of the disease follows an autosomal-dominant inheritance pattern. Since no one gender is more affected than the other, it does not appear to follow a sex-linked pattern. The occurrence of the genotype does not skip generations, so it is most likely not recessive. b. The cross of the two parents in generation IV can result in two genotypes and phenotypes. It is important to remember that since this allele appears to be dominant, the affected male can have either of the genotypes EE (homozygous dominant) or Ee (heterozygous dominant). The female parent is most likely heterozygous for the trait. If the male is homozygous, then all offspring will be EE or Ee and all will show symptoms of the disorder. If the male is heterozygous, then all offspring will be EE, Ee, or ee. The percentage probability of the offspring having the disorder is 75%, and the percentage probability of the offspring either not showing the symptoms or not being carriers of the affected allele is 25%. Science 30: Unit A 14 Chapter and Unit Review Suggested Answers 1. a. c. e. g. 2. 3. b. d. f. h. atrium septum vena cava pulmonary vein ventricle heart valves pulmonary artery aorta Artery Vein Capillary Sketch: should show a thick-walled vessel A red/pink colour can be used to illustrate the oxygenated blood flowing through the vessel. Sketch: should show a thin-walled vessel that should include valves A blue/purple colour can be used to illustrate deoxygenated blood flowing through the vessel. Sketch: should show a tiny thin-walled vessel only one cell thick Role: to carry oxygen-rich blood away from the heart; (exception: pulmonary artery) Role: to carry oxygen-poor blood toward the heart; (exception: pulmonary vein) Role: thin enough to allow gas exchange between cells and bloodstream a. b. c. d. white blood cell sample of plasma red blood cell platelet 4. Similarities and differences between anginas, heart attacks, and strokes are shown in this table. Similarities Differences • The chances of developing all three disorders can be increased by stress, smoking, a lack of exercise, and a diet high in cholesterol and saturated fats. • A heart attack results in damage to the muscle cells of the heart. It is caused by a blockage in an artery that delivers oxygenated blood to the heart. • Heredity can play a role in developing any one of these conditions. •A stroke is caused by a blockage in the arteries that supply blood to the brain. • A buildup of plaque in arteries can play a factor in developing these conditions. •A constriction of the coronary vessels of the heart causes angina, while a complete blockage of these vessels causes a heart attack. • Anginas and heart attacks affect the coronary vessels of the heart. • Both a heart attack and a stroke can be caused by a blood clot (thrombosis). Science 30: Unit A 15 • Angina is a pain caused by oxygen-starved heart muscles but both strokes and heart attacks cause cells to die. Chapter and Unit Review Suggested Answers Science 30 © 2007 Alberta Education (www.education.gov.ab.ca). Third-party copyright credits are listed on the attached copyright credit page. Unit A Review Questions Science 30 © 2007 Alberta Education (www.education.gov.ab.ca). Third-party copyright credits are listed on the attached copyright credit page. 5. The following table matches each type of white blood cell to a person or an object from a hockey game. Person or Object and Role 6. Type of White Blood Cell Coach—co-ordinates and directs team’s moves and analyzes other team’s plays d. helper T-cells Offensive players—try to keep opposing team’s players and puck on opposition side a. macrophage Coach’s playbook—keeps records of strategies used to win games b. memory B- and T-cells Referee—calls an end to game e. suppressor T-cells Jersey—makes a distinction between players f. antigen Defensive players—respond to opposing players who have broken through their defensive line c. B-cells a. b. c. d. e. f. g. h. karyotype gamete DNA gene amino acid chromosome protein DNA base triplet 7. a. WW or Ww c. W or w b. ww d. vestigial wings 8. Alternating deoxyribose sugars and phosphate groups form the spine or each side of the DNA ladder. Attached to each of the sugar groups is one of four nitrogen bases—adenine, cytosine, guanine, or thymine. The adenine bases pair with the thymine bases, and the cytosine bases pair with the guanine bases. These pairings join together the two complementary halves or strands of the DNA molecule. Students may use a diagram to explain the structure of DNA. 9. a. Autosomal genetic diseases are caused by non-functioning genes found on one of the 22 pairs of autosomal chromosomes. Both males and females have two copies of the gene that causes the genetic disease. If the disease is autosomal dominant, offspring need only one copy of the improperly functioning gene to develop the genetic disease. b. If the disease is autosomal recessive, then offspring lacking a dominant functioning gene will develop the disease. c. Sex-linked genetic diseases are caused by non-functioning genes found on X or Y chromosomes. Sex-linked diseases affect the two genders in different proportions. For example, genetic diseases caused by genes on the X chromosome affect males more frequently than females because males have only one copy of this gene. Science 30: Unit A 16 Chapter and Unit Review Suggested Answers step 1: Extract strands of DNA from cells in biological evidence. step 2: Use enzymes to cut the DNA into smaller fragments. step 3: Put the DNA fragments in a special gel placed within an electric field. step 4: DNA fragments become separated as they are pulled through the gel by the electric field. step 5: Observe and photograph the pattern of bands that form. step 6: Perform the same procedure on DNA from the cells of suspects. step 7: Compare the DNA fingerprint from the crime scene evidence to fingerprints from suspects. step 8: A matching fingerprint will link the suspect to the biological evidence. 11. Oxygenated blood appears bright red while deoxygenated blood appears more bluish. Since less of the baby’s blood is getting oxygenated, the blood in its vessels—including those capillaries near the skin’s surface— would be bluer. This lack of oxygenated blood gives the baby’s skin a bluer appearance than usual. 12. a. The following Punnett square illustrates a cross between a male with the genotype Rh+/Rh- and a female with the genotype Rh-/Rh-. Rh– Rh– Rh+ Rh+/Rh– Rh+/Rh– Rh– Rh–/Rh– Rh–/Rh– b. The percentage probability that the offspring will have the Rh positive blood type is 50%. c. The percentage probability that the offspring will have the Rh negative blood type is 50%. d. The percentage probability that the offspring will have the Rh positive blood type but carry the Rh negative blood type allele is 50%. e. The Rh positive antigens on the surface of the red blood cells would not be recognized by the transfusion recipient’s immune system. These donated blood cells would be treated as an invading pathogen. The body would produce antibodies against these antigens to cause clumping of the blood. This response could result in the death of the recipient who has received this non-compatible blood. Science 30: Unit A 17 Chapter and Unit Review Suggested Answers Science 30 © 2007 Alberta Education (www.education.gov.ab.ca). Third-party copyright credits are listed on the attached copyright credit page. 10. The basic steps involved in producing and using a DNA fingerprint to positively identify biological evidence left at a crime scene are as follows. Science 30 © 2007 Alberta Education (www.education.gov.ab.ca). Third-party copyright credits are listed on the attached copyright credit page. 13. A patient will likely experience the symptoms noted given each of the following blood results. Blood Test Results Possible Symptoms a low red blood cell count The patient will most likely experience difficulty getting sufficient oxygen and may feel short of breath. a high white blood cell count The patient is most likely battling an infection against a disease-causing pathogen. The patient may feel the symptoms of a cold or flu such as tiredness, fever, and swollen lymph glands. a very low T-cell count The patient will have trouble fighting off infections and may be sick with a rare disease or illness. The patient may have contracted HIV, which destroys T-cells. a low platelet count The patient will have difficulty clotting blood when blood vessels are ruptured, which results in excessive bleeding. This may be a result of hemophilia. 14. a. The gene that produces these antigens in humans will be isolated and inserted into the DNA of a pig embryo by the use of a modified virus or a bacterial plasmid. b. Risk Benefit Diseases that previously couldn’t be passed are now passed from pigs to humans. People would have a much shorter wait for organs. 15. a. A negative effect from taking an immune-suppressant drug—such as cyclosporin—is the suppression of the patient’s immune system, which makes the patient more susceptible to infectious diseases. b. Identical twins have identical genetics so they have the same antigens on their organs. The organ recipient’s immune system will not treat the new organ as an invading organism. 16. A karyotype can be used to determine what species the genetic sample was taken from (different species have different numbers of chromosomes). This aspect of karyotyping can be used in wildlife forensics. A karyotype can also determine the gender of an individual. This data can be used in forensic investigations. And a karyotype can determine if an individual has missing chromosomes or extra chromosomes. This information can be used in prenatal tests to determine if a baby has a genetic disorder such as Down syndrome. Science 30: Unit A 18 Chapter and Unit Review Suggested Answers b. The offspring will be heterozygotes and possess both a dominant allele and a recessive allele. c. His results are producing the same results as Mendel’s investigation of pea plants. Both of the parent plants must be heterozygotic. If a Punnett square cross between two heterozygotic parents (Rr ¥ Rr) is performed, the results illustrate a distinctive 3:1 ratio of the dominant trait over the recessive trait. R r R RR Rr r Rr r r 18. The point mutation in mutated sequence #2 changed a DNA triplet code that produced leucine to a “stop” or “terminate” instruction. The amino acid chain would be incomplete and the protein would most likely not function properly. 19. a. The following Punnett square illustrates the cross of alleles of Tsar Nicholas II and Tsarina Alexandra. XH Xh XH XH XH XH Xh Y XH Y Xh Y b. The percentage probability of a male offspring from this cross developing hemophilia is 50%. c. The percentage probability that a female will develop hemophilia from a cross between parents with those genotypes is 0%. Alexei’s sisters could only have been carriers. d. The non-functioning gene that caused Alexei’s hemophilia was present in every one of his cells. This genetic defect made him unable to efficiently clot his blood, and there is no cure for this condition. Alexei could have been treated only by repeated transfusions of blood or with a blood-clotting factor from a suitable donor. e. Each person has a unique sequence of bases in his or her DNA. A DNA fingerprint can be done to create a pattern of bands unique to each individual. These DNA fingerprints can be used to positively identify someone. More closely related individuals have more similar DNA. 20. a. The egg cell is haploid (1n) with one-half of the number of chromosomes as an autosomal body cell. b. The autosomal cell would be diploid (2n) with two copies of each chromosome. c. The clone zygote would be diploid (2n) like the body cell. d. If the chromosomes weren’t removed, the fused zygote would have more chromosomes than needed. The zygote would not develop properly. Science 30: Unit A 19 Chapter and Unit Review Suggested Answers Science 30 © 2007 Alberta Education (www.education.gov.ab.ca). Third-party copyright credits are listed on the attached copyright credit page. 17. a. Red is the dominant colour phenotype. Science 30 © 2007 Alberta Education (www.education.gov.ab.ca). Third-party copyright credits are listed on the attached copyright credit page. e. The processes of cloning and fertilization are compared and contrasted in this table. Similarities Differences • With a clone, all the genetic information comes from one individual. • Both result in a diploid zygote. • Both require implantation in a uterus to develop completely. Development is the same for both processes once the zygote is implanted. • The offspring produced by fertilization are genetically unique. Clones are genetically identical to their donors. • Both result in a baby being produced— cloning does not produce adults or organisms with the memories of their genetic donors. • Two gametes are required for fertilization, but only one egg cell and one body cell are needed for cloning. • Developing a clone zygote requires a process carried out in artificial lab conditions. f. Acquired characteristics shape an individual. Differences in experiences could create a different personality or mannerism in the sheep. Differences in physical environmental factors, such as diet or accidents, could cause physical differences between the clone and the original sheep. Science 30: Unit A 20 Chapter and Unit Review Suggested Answers