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CURRICULUM VITAE Personal Details Name: Raphael CATANE Date and place of birth: October 27, 1942, Roanne, France Address: (W) Chaim Sheba Medical Center Tel Hashomer 52621, ISRAEL Tel: 972-3-5302064 Fax: 972-3-5352214 E-mail:[email protected] (H) 21 Heller St. Jerusalem 93725 02-6785823 Education M.D. 1961-1967 Hebrew University, Hadassah Medical School Advisor: Prof. Felix Bergman Title of thesis: Effect of Regitine on blood pressure Employment History 2001- Director, Division of Oncology, Chaim Sheba Medical Center Tel Hashomer 1994-2001 Director, Institute of Oncology, Shaare Zedek Medical Center, Jerusalem. 1992-1994 Director, Clinical Cancer Research - Pharmaceutical Research Institute, Bristol-Myers Squibb, Wallingford, CT 06492 1990-1992 Acting Head, Sharett Institute of Oncology, Hadassah University Hospital, Jerusalem, Israel 1979-1989 Senior physician, Sharett Institute of Oncology, Hadassah University Hospital, Jerusalem, Israel 1986-1987 Guest Researcher, Biologics Evaluation Section, Investigational Drug Branch, Cancer Therapy Evaluation Program, National Cancer Institute, NIH, Bethesda, Maryland Clinical Associate in the National Cancer Institute, Radiation 1978-1979 June 2004 Oncology Branch, Bethesda, Maryland 1977-1978 Special Assistant to the Chief Investigational Drug Branch, Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 1976-1977 Clinical Associate in Oncology, Roswell Park Memorial Institute, Buffalo, New York 1975-1976 Fellow in Medical Oncology, Center for Developmental Oncology, Roswell Park Memorial Institute, Buffalo, New York. 1972-1975 Resident, Department of Internal Medicine, Barzilai Medical Center, Ashkelon, Israel 1968 Rotating Internship, Hadassah Hospital, Jerusalem, Israel Professional Activities Position in academic administration 1982-1994 Associate Professor, Oncology, Hebrew University-Hadassah Medical School, Jerusalem, Israel (tenured) 1979-1982 Senior Lecturer, Department of Clinical Oncology, Hadassah University Hospital, Jerusalem, Israel (tenured) 2001- Visiting Associate Professor and Chairman, Division of Oncology, Tel Hashomer Campus, Tel Aviv University, Israel Membership in professional/scientific societies 1977 Member – American Society of Clinical Oncology 1980 Member - Israel Society of Clinical Oncology & Radiotherapy 1980 Member - European Association for Cancer Research (EACR) 1983 Member - European Society of Medical Oncology (ESMO) 1984 Member - Israel Society of Immunology 1988 Member - American Association Cancer Research 2 June 2004 Original Articles 1. Bergman F, Catane R, Korczin AD: Central action of regitine (phentolamine) on blood pressure. Arch. Intern. Pharmacodyn. 168: 278-287, 1967. 2. Catane R, Kaufman J, West C, Merrin C, Tsukada Y and Murphy GP: Brain metastasis from prostatic carcinoma. Cancer 38:2583-2587, 1976. 3. Catane R, Mittelman A, Kaufman J and Murphy G: Oral estramustine phosphate. Prolonged therapy for advanced carcinoma of the prostate. New York State J. of Med. 76:1978-1981, 1976. 4. Catane R, Kaufman J, Mittelman A and Murphy GP: Combined therapy of advanced prostatic carcinoma with estramustine and prednimustine. J. Urol. 117:332-335, 1977. 5. Kaufman JH, Catane R and Douglas HO: Combined adriamycin, vincristine and methotrexate in advanced adult soft tissue sarcoma. New York St. J. Med. 77:742-743, 1977. 6. Catane R, Catane H, Takita H, Kaufman J, Mittleman A and Murphy GP: Preliminary study of prednimustine in lung cancer. J. Med. 8:115-121, 1977. 7. Mittelman A, Catane R and Murphy GP: New steroidal alkylating agents in the treatment of advanced, stage D, carcinoma of the prostate. Cancer Treat. Rep. 61:307-310, 1977. 8. Catane R, Kaufman J, Bakshi S, Parthasarathy KL, Mittelman A and Murphy GP: Bone marrow scanning in advanced prostatic carcinoma. New York St. J. Med. 77:1413-1416, 1977. 9. Catane R, Wajsman Z, Chu TM, Saroff J, Mittelman A and Murphy GP: Simultaneous measurement of acid phosphatase activity in bone marrow and peripheral blood serum. Surgical Forum, 28:128-130, 1977. 10. Didolkar MS, Baffi RR, Catane R, Kaufman J and Holyoke ED: Use of methyhl CCNU and procarbazine in advanced malignant melanoma resistant to DTIC therapy. Cancer Treat. Rep., 61:1738-1739, 1977. 11. Mittelman A, Catane R and Murphy GP: Clinical experience with estramustine phosphate (Estracyt) in hormonally resistant stage D carcinoma of the prostate. Current Chemotherapy 2:1278-1282, 1977. 3 June 2004 12. Catane R, Kaufman J, Madajewicz S, Mittelman A and Murphy GP: Prednimustine therapy for advanced prostatic cancer: Brit. J. Urol. 50:29-32, 1978. 13. Catane R, Bono VH, Jr., Louie AC and Muggia FM: High dose methotrexate not a conventional treatment. Cancer Treat. Rep. 62:178180, 1978. 14. Rozencweig M, Von Hoff DD, Catane R and Muggia FM: Platinum complexes in cancer chemotherapy. Antibiotics and Chemotherapy,23:99-112, 1978. 15. Catane R: Clinical experience with estramustine phosphate and prednimustine: Two steroidal alkylating agents compound. Cancer Treat. Rep. 62:1264-1265, 1978. 16. Catane R, Lev L and Rozencweig M: Cis-Diamminedichloroplatinum (DDP). A new drug for cancer. Harefuah 92: 420-430, 1978 (Hebrew). 17. Catane R, Madajewicz S, Wajsman Z, Chu TM and Mittelman A: Prostatic cancer, immunochemical detection of prostatic acid phosphatase in serum and bone marrow. New York St. J. Med., 78:1060-1061, 1978. 18. Catane R, Kaufman J, Nime F, Evans JT and Mittleman A: Phase I study of N6 Benzyladenosine 5'Monophosphate. Cancer Treat. Rep. 62:1978. 19. Catane R and Catane H: High dose methotrexate for the therapy of malignant diseases. Harefuah, 95:225-226, 1978. (Hebrew). 20. Penta JS, Von Hoff DD, Louie A, Catane R, Rozencweig M and MuggiaFM: Drug-related fatalities following methotrexate and citrovorum factor administration. Chemiotherapia Oncologica, 2:170174, 1978. 21. Catane R, Louie A and Penta J: Analysis of protocols with high dose methotrexate sponsored by DCT/NCI. Chemiotherapia Oncologica 2: 209-220, 1978. 22. Catane R, Von Hoff DD, Glaubiger D and Muggia FM: Azaserine, DON and azotomycin, three diazo analogs of L-glutamine with clinical antitumor activity. Cancer Treat. Rep. 63:1033-1138, 1979. 23. Muggia FM, Catane R, Douros J and Cooney D: Amino acid manipulations in cancer treatment. A perspective from the NCI workshop. Cancer. Treat. Rep. 63:1137, 1979. 4 June 2004 24. Ovejera AA, Houchens DP, Catane R, Sheridan MA and Muggia FM: Efficacy of 6-diazo-5-oxo-L-norleucine and N-(N-gamma-Glutamyl 6-diazo5-oxo-L-norleucine)-6-diazo-5-oxo-L-norleucine against experimental tumors in conventional and nude mice. Cancer Res. 39:3220-3224, 1979. 25. Lee YJ, Catane R, Rozencweig M, Bono VH, Jr., Muggia FM, Simon R and Staquet M: Analysis and interpretation of response rate for anticancer drugs. Cancer Treat. Rep. 63:1713-1720, 1979. 26. Lee YJ, Staquet M, Simon R, Catane R and Muggia FM: Two stage plans for patient accrual in Phase II cancer clinical trials. Cancer Treat. Rep. 63: 17211726, 1979. 27. Catane R, Mittelman A, Murphy GP and Sandberg AA: Effects of testosterone on estracyt localization in rat prostate. Oncology 37:357-359, 1980. 28. Karakousis CP, Lopez R, Catane R, Rao V, Moore R and Holyoke ED: Intraarterial adriamycin in the treatment of soft tissue sarcomas. J. of Surg. Oncol. 13:21-27, 1980. 29. Madajewicz S, Catane R, Mittelman A, Wajsman Z and Murphy GP: Chemotherapy of advanced, hormonally resistant, prostatic carcinoma. Oncology 37:53-56, 1980. 30. Kisner DL, Catane R and Muggia FM: The rediscovery of DON (6-diazo-5-oxo-L-Norleucine). Recent Results Cancer Res. 74:258-263, 1980. 31. Clement JJ, Gorman MS, Wodinsky I, Catane R and Johnson RK: Enhancement of antitumor activity of alkylating agents by the radiation sensitizer misonidazole. Cancer Res. 40:4165-4172, 1980. 32. Catane R and Muggia FM: Electron-affinic radiosensitizers: Development and clinical prospects. Applied Radiol. 10:25-32, 1981. 33. Halpern J, Catane R, Biran S and Fuks Z: DTIC and actinomycin D with and without C. parvum immunotherapy in advanced malignant melanoma. Tumori 67:215-217, 1981. 34. Witliff J and Catane R: Screening techniques and clinical studies. In Raus J.: Cytotoxic Estrogens. J. Toxicol Environ Health 7:164-165, 1981. 35. Catane R, Schwade JG, Yaar I, Lichter AS, Tepper JE, Dunnick NR, Brody L, Brereton H, Cohen M and Glatstein E: Follow-up neurological evaluation in patients with small cell lung carcinoma treated with prophylactic cranial 5 June 2004 irradiation and chemotherapy. Int. J. Radiation Oncol. Biol. Phys. 7:105-109, 1981. 36. Sulkes A, Catane R and Fuks Z: Predictive tests for cancer chemotherapy. Harefuah 100:249-250, 1981 (in Hebrew). 37. Muggia FM, Penta JS, Catane R, Jensen-Akula MS and Charles LM: Selected anticancer drugs in Phase I trials in the United States. Recent Results Cancer Res. 76:192-209, 1981. 38. Catane R, Lichter A, Lee YJ, Brereton HD, Schwade JG and Glatstein E: Small cell lung cancer: Analysis of treatment factors contributing to prolonged survival. Cancer 48:1936-1943, 1981. 39. Poster DS, Bruno S, Penta JS, Pina K and Catane R: Current status of chemotherapy in the treatment of advanced carcinoma of the thyroid gland. Cancer Clinical Trials 4:301-307, 1981. 40. Carol J, Fuks Z, Catane R, Fridkin M and Treves AJ: The effect of tuftsin on human monocyte cytotoxicity. J. Immun. Resp. Mod. 1:1982. 41. Siegal T, Pfeffer RM, Catane R, Gomori MJ, Sulkes A and Fuks Z: Successful chemotherapy of recurrent intracranial germinoma with spinal metastases. Neurology 35:631-633, 1983. 42. Halpern J, Catane R, Sacks T and Fuks Z: Treatment of febrile granulocytopenic cancer patients receiving antineoplastic therapy with a combination of carbenicillin, cefazolin and gentamycin. J. Medicine 14: 193-203, 1983. 43. Catane R, Schlanger S, Weiss L, Penchas S, Fuks Z, Treves AJ, Gottlieb P and Fridkin M: Antitumor effect of tuftsin in animals. An. N.Y. Acad. Sci. 419:251-260, 1983. 44. Klin, B., Peretz, T., Catane, R, Olschwang D and Magora F: morphine analgesia. Harefuah 106:70-71, 1984 (in Hebrew). Epidural 45. Brufman G, Halpern J, Sulkes A, Catane R and Biran S: Procarbazine, CCNU, and vincristine (PVC) combination chemotherapy for brain tumors. Oncology 41:239-241, 1984. 46. Catane R, Pfeffer MR, Livni N, Rosenmann E, Treves AJ and Eshhar Z: Monoclonal antibodies to carcinoembryonic antigen (CEA) in primary and metastatic tumors. Immunology and Hematology Research Monograph 2: 358-361, 1984. 47. Yablonski-Peretz T, Halpern J, Sulkes A, Fuks Z and Catane R: Small cell lung cancer. Harefuah 106:450-453, 1984 (in Hebrew). 6 June 2004 48. Halpern J, Catane R and Baerwald H: A call for caution in the use of aminogluthetimide: Negative reactions with dexamethasone and beta blocker treatment. J. Medicine 15:59-63, 1984. 49. Pfeffer R, Sulkes A, Peretz T, Fuks Z and Catane R: Phase I study of the combination of mitomycin-C and oral metronidazole. Cancer Treat. Rep. 68:1191-1192, 1984. 50. Uziely B, Sulkes A, Libson E, Isacson R, Ben-Baruch N, Gez E, Effrati-Warner E, Biran S, Fridkin M and Catane R: A Phase II study of tuftsin for the treatment of non-small cell carcinoma of the lung. Chemioterapia 4:1166-1167, 1985. 51. Halpern J and Catane R: Oral estramustine phosphate (Estracyt): A broad phase II study. J. Medicine 15:35-43, 1984. 52. Peretz T, Klin B, Warner E, Olschwang D and Catane R: Continuous epidural narcotic analgesia for intractable pain due to malignancy. J. Surg. Oncol. 29:8-10, 1985. 53. Gez E, Catane R, Pfau L and Biran S: High dose metoclopramide as an antiemetic in patients receiving cis-platinum based combination chemotherapy. Gynecol. Oncol. 21:18-22, 1985. 54. Gez E, Sulkes A, Isacson R, Catane R and Weshler Z.: Radiation pneumonitis: A Complication resulting from combined radiation and chemotherapy for early breast cancer. J. Surg. Oncol. 30:116-119, 1985. 55. Siegal T, Siegal TZ, Fields SI, Mizrachi R and Catane R: A selective route of doxorubicin administration improves outcome in experimental malignant epidural cord compression. Neurosurgery 8:576-580, 1986. 56. Catane R, Sulkes A, Uziely B, Gez E, Isacson R, Treves AJ and Fridkin M: Initial clinical studies with tuftsin. Int. J. Immunother. 2:81-85, 1986. 57. Sulkes A, Gez E, Pfeffer R, Catane R, Isacson R and Biran S: Adriamycin, vinblastine and mitomycin-c (AVM) as second line chemotherapy in advanced breast cancer. Cancer Chemother. Pharmacol. 18:162-167, 1986. 58. Ben-Yoseph R, Catane R, Libson A, Chisin R, Kaplan N and Atlan H: Nuclear magnetic resonance in the diagnosis of spinal malignancy. Harefuah 111:39-42, 1986 (in Hebrew). 59. Warner E, Sulkes A, Gez E, Uziely B, Ben-Baruch N, Ben-Yosef R, Biran S and Catane R: Combined immunotherapy and chemotherapy with tuftsin cyclophosphamide in the treatment of small cell lung cancer. Chemioterapia 7 June 2004 6:706- 708, 1987. 60. Siegal T, Sandbank U, Gabizon A, Siegal TZ, Mizrachi R, Ben-David E and Catane R: Alteration of blood-brain-CSF barrier in experimental meningeal carcinomatosis: A morphologic and adriamycin-penetration study. Journal of Neuro-Oncology, 4:233-242, 1987. 61. Kedar E, Zeira E, Lebendiker Z, Weiss DW, Catane R and Shouval D: Human and mouse "LAK" cells expanded in long-term cultures: In vitro and in vivo studies. In: Truit R.L., Gale, R.P. and Bortin, M.M.: Cellular Immunotherapy of Cancer. Prog. Clin. Biol. Res. 244:59-75, 1987. 62. Siegal T, Siegal TZ, Sandbank U, Shohami R, Shapira J, Gomori IM, Ben-David E and Catane R: Experimental neoplastic spinal cord compression: Evoked potentials, edema, prostaglandins and light and electron microscopy. Spine 12:440-448, 1987. 63. Catane R, Catane H and Robinson E: The National Cancer Institute (U.S.A.)faces controversies. (Editorial). Harefuah 114:308-310, 1988 (in Hebrew). 64. Catane R and Longo DL: Monoclonal antibodies for cancer therapy. Isr. J. Med. Sci. 24:471-476, 1988. 65. Siegal T, Melamed E, Sandbank U and Catane R: Early and delayed neurotoxicity of mitoxantrone and doxorubicin following subarachhnoid injection. J. Neurooncol 6:135-140, 1988. 66. Warner-Efrati E, Sulkes A, Weshler Z, Peretz T, Ben-Yosef R, Catane R and Biran S: Chemotherapy induction, consolidation radiotherapy and maintenance alternating chemotherapy in small cell carcinoma of the lung. Isr. J. Med. Sci. 24:593-8, 1988. 67. Ben-Yosef R, Pfeffer R, Gez E and Catane R: Management of malignant pericardial effusion. Harefuah 115:138-41, 1988 (in Hebrew). 68. Siegal T, Siegal Y, Shapira Y, Sandbank U and Catane R: Indomethacin and dexamethasone treatment in experimental neoplastic spinal cord compression: Part 1. Effect on water content and specific gravity. Neurosurgery 22:328-33, 1988. 69. Gez E, Ben Yosef R, Catane R, Brufman, G and Biran, S: Chlorpromazine and dexamethazone versus high-dose metoclopramide and dexamethazone in patients receiving cancer chemotherapy, particularly cis-platinum: A prospective randomized crossover study. Oncology 46:150-154, 1989. 8 June 2004 70. Gabizon A, Peretz T, Sulkes A, Amselem S, Druckman S, Ben-Yosef R, Ben-Baruch N, Catane R, Biran S and Barenholz Y: Systemic Administration of Doxorubicin-Containing Liposomes in Cancer Patients: A Phase I Study. Europ. J. Cancer Clin. Oncol. 25:1795-1803, 1989 71. Catane R, Ben-Yosef R, Livni N, Rosenmann E and Eshhar Z: Monoclonal antibodies against carcino-embryonic antigen discriminate between CEA Produced by Gastrointestinal Tumors and CEA Produced by Other Tumors. Nat. Immun. Cell Growth Regul. 9:203-208, 1990. 72. Shani A, Tichler T, Catane R, Gurwith M, Rozenszajn LA, Gezin A, Levi E, Schlezinger M, Kalechman Y, Michlin H, Shalit F, Engelsman E, Farbstein H, Farbstein M, Albeck M and Sredni, B: Immunologic effects of AS101 in the treatment of cancer patients. Nat. Immun. Cell Growth Regul. 9:182-190, 1990. 73. Korenberg A, Catane R, Peller S, Kaufman S and Fridkin M: Tuftsin induces thromboplastin-like activity in human mononuclear cells and in monocytic cell lines. Blood. 76:814-819, 1990. 74. Ben-Yosef R, Glaser B and Catane R: A somatostatin analogue (SMS 201-995) for the treatment of gut neuroendocrine tumors. Harefuah 119: 1517-20, 1990 (in Hebrew). 75. Surkis R, Rubinraut S, Dagan S, Tzehoval E, Fridkin M, Ben-Yosef R and Catane R: Polytuftsin, a potent precursor for slow release of the phagocytosis stimulating peptide tuftsin. Int. J. Biochem. 22:193-195, 1990. 76. Nitzan DW, Livni N, Marmari Y, Ben-Baruch N, Sela J and Catane R: The use of monoclonal anti-CEA antibody immunohistochemistry in detecting the origin of oral cavity metastasis. Int. J. Oral Maxillofac. Surg. 19:162-164, 1990. 77. Gez E, Strauss N, Catane R, Roisman I and Barak V: The correlation between tumor response, serum prostatic-specific antigen and prostatic acid phosphatase in prostatic carcinoma patients receiving hormonetherapy. J. Tumor Marker Oncol 6:45-51, 1991. 78. Krausz Y, Uziely B, Lijovetsky G, Isacson R, Levinger E, Catane R, Karger H. and Atlan H: Scintigraphic Evaluation of Patients with Thyroid Carcinoma - Therapeutic Approaches. Isr. J. Med. Sci. 28:206-211, 1992. 79. Drakos PE, Gez E, and Catane R: Hepatitis Due to Cyproterone Acetate. Eur. J. Cancer 28a:1931-2, 1992. 9 June 2004 80. Vlodavsky I, Ishai-Michaeli R, Mohsen M, Bar-Shavit R, Catane R, Ekre H-PT and Svahn CM: Modulation of neovascularization and metastasis by species of heparin. Advances Exp. Biol. 313:317-327, 1992. 81. Krausz Y, Uziely B, Karger H, Isacson R, Catane R and Glaser B: Recurrence associated mortality in patients with differentiated thyroid carcinoma. J Surg Oncol 52:164-168, 1993. 82. Haim N, Oman SD, Galai N, Burde B, Nathan S and Catane R: Estimation of creatinine clearance without 24-hour urine collection: A useful guide during cisplatin therapy. Acta Oncologica 32:409-412, 1993. 83. Gorodetsky R, Mou X, Vexler A, Kaufman B, Catane R and Loewenthal E: Noninvasive follow-up of platinum pharmacokinetics in the skin of patients on cisplatin chemotherapy. Cancer, 72:446-454, 1993. 84. Onetto N, Canetta R, Winograd B, Catane R, Dougan M, Grechko J, Burroughs J and Rozencweig M: Overview of Taxol safety. JNCI, 15:131-140, 1993. 85. Gabizon A, Catane R, Uziely B, Kaufman B, Safra T, Cohen R, Martin F, Huang A and Barenholz Y: Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes. Cancer Res, 54:987-992, 1994. 86. Gabizon A, Isacson R, Libson E, Kaufman B, Uziely B, Catane R, BenDor CG, Cass Y, Peretz T, Sulkes A, Chisin R and Barenholz Y: Clinical studies of liposome-encapsulated anthracyclines. Acta Oncologica, 33:779-786, 1994. 87. Sredni B, Albeck M, Tichler T, Shani A, Shapira J, Bruderman I, Catane R, Kaufman B and Kalechman Y: Bone marrow - sparing and prevention of alopecia by AS101 in non-small-cell lung cancer patients treated with carboplatin and etoposide. J Clin Oncol, 13:2342-2353, 1995 88. Cherny NJ and Catane R: (Editorial), Professional negligence in the management of cancer pain. A case for urgent reforms. Cancer, 76:21812185,1995. 89. Marin O, Lernau O and Catane R: Axillary lymph node dissection in breast cancer. Harefuah 130:260-262, 1996 (in Hebrew). 90. Cherny N and Catane R: Palliative medicine and the medical oncologist, defining the purview of care. Hematol/Oncol Clinics N Am, 10:1-20, 1996. 10 June 2004 91. Sredni B, Xu R-H, Albeck M, Gafter U, Gal R, Shani A, Tichler T, Shapira Bruderman I, Catane R, Kaufman B, Whisnant JK. The protective role of the immunomodulatory AS101 against chemotherapy-induced alopecia studies on Human and animal models. Int J Cancer 65:97-103, 1996. 92. Sredni B, Tichler T, Shani A, Catane R, Kaufman B, Strassmann G, Albeck M, and Kalechman Y. Predominance of TH1 Response in tumor-bearing mice and cancer patients treated with AS101. JNCI 88:1276-1284, 1996. 93. Levy-Lahad E, Catane R, Eisenberg S, Kaufman B, Hornreich G, Lishinsky E, Shohat M, Weber BL, Beller U, Lahad A, Halle D: Founder BRCA1 and BRCA2 mutations in Ashkenazi Jews in Israel: Frequency and differential penetrance in ovarian cancer and in breast-ovarian cancer families. Am J Hum Genet 60:1059-67, 1997. 94. Beller U, Halle D, Catane R, Kaufman B, Hornreich G, Levy-Lahad E: High frequency of BRCA1 and BRCA2 germline mutations in Ashkenazi Jewish ovarian cancer patients, regardless of family history. Gynecol Oncol 67:123126, 1997. 95. Sapir R, Catane R, Strauss-Liviatan N, Cherny NI: Cancer pain: Knowledge and attitude of physicians in Israel. J Pain Sympt Manag 17:266-276, 1999. 96. Chertin B, Spitz IM, Lindenberg T, Kuzman P, Algur N, MooYoung AJ, Catane R, Farcas A: An implant releasing the GNRH agonist Histerelin maintains medical castration for up to 30 months in metastatic prostate cancer. J Urol 163:838-844, 2000. 97.Levy-Lahad E, Krieger M, Gottfeld T, Renbaum P, Klein G, Eisenberg S, Lahad A, Kaufman B, Catane R: BRCA1 and BRCA2 mutation carriers as potential candidates for chemoprevention trials. J Cell Biochem 77:13-18, 2000. 98. Sapir R, Catane R, Kaufman B, Isacson R, Segal A, Wein S, Cherny N: Cancer patient expectations of and communication with oncologists and oncology nurses: The experience in an integrated oncology and palliative care service. Support Care Cancer; 8:458-463, 2000. 99. Kalechman Y, Longo DL, Catane R, Shani A, Albeck M, Sredni B: Synergistic Antitumor Effect of Paclitaxel (Taxol) + AS101 in murine model of B16 melanoma: association with RAS-dependent signal transduction pathways. Int J Cancer 86:281-8 , 2000. 100.Sredni B, Longo DL, Catane R, Shani A, Albeck M, Kalechman Y: Synergistic antitumoral effect of the immunomodulator AS101 + 11 June 2004 paclitaxel (Taxol). Association with ras-dependent signal transduction pathways. Exp Hematol 28: 1694 , 2000 101. Levy-Lahad E, Lahad A, Eisenberg S, Dagan E, Paperna T, Kasinetz L, Catane R, Kaufman B, Beller U, Renbaum P, Gershoni-Baruch R:A single nucleotide polymorphism in the RAD51 gene modifies cancer risk in BRCA2 but not BRCA1 carriers. Proc Natl Acad Sci 98: 3232-3236 , 2001 102. Ron IG, Wigler N, Borovik R, Brufman G, Rizel S, Shani A, Brenner J, Farbstein H, Dale A, Inbar MJ, Brenner HJ , Chaitchik S, Catane R : CMF (cyclophosphamide, mitoxantrone, 5-fluorouracil) as adjuvant chemotherapy for stage II lymph-node positive breast cancer: a phase III randomized multicenter study. Am J Clin Oncol 24: 323-327 , 2001. 103. Ron IG, Wigler N, Borovik R, Peretz T, Rizel S, Shani A, Brenner J, Farbstein H, Brenner HJ , Chaitchik S, Catane R, Inbar MJ: CMF (cyclophosphamide, mitoxantrone, 5-fluorouracil) as adjuvant chemotherapy for stage II lymph-node positive breast cancer: results by demographic and clinic subgroups. Am J Clin Oncol 25: 520-2, 2002. 104. Cherny NI, Catane R; European Socity of Medical Oncology Taskforce on Palliative and Supportive Care: Attitudes of medical oncologists toward palliative care for patients with advanced and incurable cancer. Cancer 98(11): 2502-10, 2003. 105. Kohne CH, CataneR, Klein B, Ducreux M, Thuss-Patience P, Niederle N, Gips M, Preusser P, Knuth A, Clemens M, Bugat R, Figer I, Shani A, Fages B, Di Betta D, Jacques C, Wilke HJ: Irinotecan is active in chemonaive patients with metastatic gastric cancer: a phase II multicentric trail. Br J Cancer 89(6):997-1001, 2003. 106. Cherny NI, Catane R, Kosmidis P; ESMO Taskforce on Supportive and Palliative Care: ESMO takes a stand on supportive and palliative care. Ann Oncology 14(9):1335-7, 2003. 107. Yakobson E, Eisenberg S, Isacson R, Halle D, Levy-Lahad E, Catane R, Safro M, Sobolev V, Huot T, Peters G, Ruiz A, Malvehy J, Puig S, Chompret A, Avril MF, Shafir R, Peretz H, Bressac-de Paillerets B: A single Mediterranean, possibly Jewish, origin for the Va159Gly CDKN2A mutation in four melanoma-prone families: Eur J Hum Genet 11(4):288-96, 2003. 108. O'Brien ME, Wigler N, Inbar M, Rosso R, Grischke E, Santoro A, Catane R, Kieback DG, Tomczak P, Ackland SP, Orlandi F, Mellars L, Alland L, Tendler C; CAELYX Breast Cancer Study Group: Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX/Doxil) versus conventional 12 June 2004 doxorubicin for first-line treatment of metastatic breast cancer. Ann Oncol. 15(3):440-9, 2004. 109. Katz D, Segal A, Alberton Y, Jurim O, Reissman P, Catane R, Cherny NI: Neoadjuvant imatinib for unresectable gastrointestinal stromal tumor. Anticancer Drugs. 15(6):599-602, 2004. 110. Kundel Y, Pfeffer R, Lauffer M, Ramon J, Catane R, Symon Z: Salvage prostatic fossa radiation therapy for biochemical failure after radical prostatectomy: the Sheba experience. Isr Med Assoc J. 6(6):329-31, 2004. Case Reports 1. Catane R, and Davidson JT: A hazard of cuffed flexometallic endotracheal tubes. Brit. J. Anesthesiol. 41:1086, 1969. 2.Catane R, and Vago T: Puerperal sepsis caused by osteomyelitis of the pubic bone. Harefuah. 85:370-371, 1973 (in Hebrew). 3.Catane R, and Wisclicki L: Retinal vein thrombosis following intranasal injection of prednisone. Harefuah. 87:511-512, 1974 (in Hebrew). 4.Catane R, Kaufman JH, Douglas HO, Kim U and Mittelman A: Nephrotic syndrome associated with gastric cancer. J. Surg. Oncol. 9:207-211, 1977. 5.Catane R, Kaufman J, Mittelman A, and Murphy GP: Disappearance of osteoblastic metastases in prostatic carcinoma following estramustine therapy. J.A.M.A. 237:2471, 1977 (letter). 6.Catane R, Kaufman J, Mittelman A, and Murphy GP: Attenuation of myelosuppression with lithium. New Eng. J. Med. 297:452, 1977 (Letter). 7. Litvin Y, Hage S, Catane R and Horne T: Reversibility of glucocorticoid-induced osteopenia, a case report. Clinical Nuclear Medicine 7:268-271, 1982. 8.Halpern J, Koplovic J and Catane R: Malignant fibrous histiocytoma developing in irradiated sacral chordoma. Cancer 53:2661-2662, 1984. 9.Yablonsky-Peretz T, Sulkes A, Polliack A, Weshler Z, Okon E and Catane R: Secondary myelofibrosis with metastatic breast cancer simulating agnogenic myeloid metaplasia. Report of a case and review of the literature. Med. Pediatr. Oncol. 13:92-96, 1985. 13 June 2004 10. Ben-Yosef R, Warner E, Gez E and Catane R: Malignant pericardial effusion associated with metastatic rectal cancer: Case Report, J. Chemother. 1:342-5, 1989. 11. Ben-Yosef R, Gez E and Catane R: Acute pericarditis following bleomycin: a case report and literature analysis. J. Chemother. 2:70-71, 1990. 12. Drakos P, Bar-Ziv J and Catane R: Tumor lysis syndrome in non-hematologic malignancies: Report of a case and review of the literature. Am. J. Clin. Oncol, 17:502-505, 1994. Review Articles 1. Abell, C., Catane R, Elmer G, Holcenberg J, Roberts J and Wellner D (eds): Proceedings of the workshop on amino-acid imbalance in the treatment of cancer. Cancer Treat. Rep. 63:1009-1138, 1979. 2.Catane R, Schwade JG, Turisi AT, Webber BL and Muggia FM: Pulmonary toxicity after radiation and bleomycin. A review. Int. J. Radiation Oncology Biol. Phys. 5:1513-1518, 1979. 3.Catane R, Catane H and Robinson E: Small cell lung cancer: Prospects for cure. Harefuah 27:309-210 1979, (in Hebrew). 4.Catane R, Catane H and Rozencweig M: Economical aspects of cancer therapy. Harefuah, 128:182-185, 1995 (in Hebrew). 5.Ronson A., Cherny N., Catane R: The Treatment of Pain in Oncology. Med Hyg. 58:1181-1185 , 2000. Chapters in Books 1. Muggia FM, Catane R, Lee YJ and Rozencweig, M: Factors Responsible for Therapeutic Success in Osteosarcoma: A Critical Analysis of Adjuvant Trial Result. In Adj. Therapy of Cancer. Edited by S.E. Jones and S.E. Salmon. Grune and Stratton, Inc. 1979 pp 383390. 2. Catane R, Bruno S, and Muggia FM: Prospects for Compounds Utilizing Estrogens as Carriers of Cytotoxic Molecules in Cancer Treatment. In: Raus J, Martens, H. and Leclerq, C.K.: Cytotoxic 14 June 2004 Estrogens in Hormone Receptive Tumors. Press, London, 1980. pp 263-270, Academic 3. Siegal T, Gabizon A, Sandbank U, Mizrachi R, Siegal TZ, Catane R: Intravenous Adriamycin in Experimental Meningeal Carcinomatosis: Tissue Concentrations and Therapeutic Efficacy. In: Biology of Brain Tumors. Walker M.D., and Thomas D.G. (Eds.), Martinus Nihoff, Boston, 1986 pp. 445-452. 4. Epstein N, Warner-Efrati E and Catane R: Monoclonal Antibodies in Cancer Diagnosis and Therapy. In: Mizrachi, A. (ed). Monoclonal Antibodies Production and Application. Alan R. Liss Inc. 1988, New York pp. 305-333. 5. Sredni B, Catane R, Shani A, Gezin A, Levi E, Schlezinger M, Kalechman Y, Michlin H, Shalit F, Rosenzajn LA Farbstein H, and Albeck M: Phase I study of AS101 (an organotellurium compound) in patients with advanced malignancies. In: Recent Advances in Chemotherapy. (Eds.), E. Ruvinstein and D. Adam, Jerusalem, E. Lewin-Epstein, 1990, pp. 851.1-851.4. 6. Catane R: Cancer of an Unknown Primary Site (CUPS). In: Everyone's Guide to Cancer Therapy. Edited by M. Dollinger and E.H. Rosenbaum, Somerville House, Toronto, Andrews and McMeel, Kansas City & N.Y., 1991, pp. 265-270. 7. Catane R and Mitchell MS: What happens in Biological Therapy. In: Everyone's Guide to Cancer Therapy. Edited by M. Dollinger and E.H. Rosenbaum, Sommerville House, Toronto, Andrews and McMeel, Kansas City & N.Y., 1991, pp. 62-69. 8. Vlodavsky I, Ishai-Michaeli R, Mohsen M, Korner G and Catane R: Involvement of heparanase and extracellular matrix-bound fibroblast growth factor in tumor progression. In: Breast Cancer: biological and clinical progress (ed. L. Dogliotti, A. Sapino and G. Bussolati) Kluwer Adacemic Publishers 1992 pp. 135-150. 9. Vlodavsky I, Eldor A, Ishai-Michaeli R, Korner G, Benezra M, Catane R and Bar-Shavit R: Extracellular matrix-bound growth factors, enzymes and plasma proteins: Possible involvement in atherosclerosis. Atherosclerosis IX (ed. O. Stein, S. Eisenberg, and Y. Stein) R&L creative communications Ltd. pp. 351-358, 1993. 10. Vlodavsky I, Benezra M, Ishai-Michaeli R, Catane R and Ben-Sasson S: Control of tumor-metastasis and angiogenesis by the extracellular matrix: Involvement of heparan sulfate and heparin-like molecules. In: Frontiers in Cancer Research, Edited by A. Frensdorff, Tel Aviv University Edition pp. 188-197, 1993. 15 June 2004 11. Gabizon A, Uziely B, Kaufman B, Safra T, Catane R and Barenholz Y: A new generation of doxorubicin-loaded liposomes with improved localization in tumors: preclinical and clinical studies. In: Cancer Treatment An Update. Edited by P. Banzet, J.F. Holland, D. Khayat and M. Weil. Springer-Verlag, France 1993, pp. 820-822. 12. Kaufman B, Wagschal-Drori L, Gotfeld O, Eisenberg S, Beller U, Lahad A, Levy-Lahad E, Catane R: Differential clinical and endocrine features in Ashkenazi ovarian cancer patients with BRCA1 and BRCA2 mutations. In: New Technologies for Gynecologic and Obstetric Investigation. Edited by A.R. Genozzari and P.G. Artini. CIC International Edition, Rome, 1999, pp. 55-59. 13. Cherny N.I., Catane R, “Psycho-oncology and Communication,” In: Cavalli F., Hansen H.H. and Kaye S.B., Textbook of Medical Oncology, 2nd Ed., London: Martin Dunitz Publishers, 2004 (in press). Abstracts (since 1992) 1. Kaufman B, Gez E, Feigin E, Wygoda M, Uziely B, Isacson R, Shnider B, Catane R: Reduction of M-VAC toxicity by Leucovorin. Proc. Am. Assoc. Cancer Res. 33:219, 1992. 2. Uziely B, Dorembus D, Brufman G, Lewin A, Catane R, Mor-Yosef S: The effect of tamoxifen on the endometrium. Proc. Am. Assoc. Cancer Res. 33: 281, 1992. 3. Peretz, T, Kaplan A, Barak V, Baider L, Sulkes A, Rentschler F, Stephanos S, Catane R: Interferon (IFN) as a modulator of hormonal therapy in breast cancer. Preliminary results of a randomized study. Proc. Am. Assoc. Cancer Res. 33:335, 1992. 4. Vexler A, Mou X, Loewental E, Kaufman B, Catane R and Gorodetsky R: Non-invasive follow-up of platinum level in the skin of patients during cisplatin therapy. Proc. Am. Assoc. Cancer Res. 33:535, 1992. 5. Gabizon A, Catane R, Uziely B, Kaufman B, Safra T, Barenholz Y, Huang A: Pharmacokinetics of Doxorubicin encapsulated in stealth liposomes in cancer patients. Annals. Oncol. 3(S1):140, 1992. 6. Sredni B, Albeck M, Bruderman M, Shapiro Y, Tichler T, Shani A, Catane R, Farbstein M, Kalechman Y: A randomized trial of chemotherapy versus AS101 plus chemotherapy in patients with nonsmall cell lung cancer Experimental Hematol. 20:778, 1992. 16 June 2004 7. Brufman G, Uziely B, Gera-Ben-Dor C and Catane, R: Adjuvant chemotherapy for breast cancer patients with four or more positive axillary lymph nodes: A preliminary report of a randomized trial comparing C.M.F. (cyclophosphamide methotrexate and 5-fluorouracil) versus C.X.F. (cyclophosphamide, mitoxantrone and 5-fluorouracil). Proc. ASCO 11: 67, 1992. 8. Gabizon A, Catane R, Uziely B, Kaufman B, Safra T, Barenholz Y, Huang A: A pilot study of doxorubicin encapsulated in longcirculating (stealth) liposomes (S-Dox) in cancer patients. Proc. ASCO 11:124, 1992. 9. Peylan-Ramu N, Deutsch V. Heshing Y, Catane R and Eldor A: The effect of carboplatin (CP) on megakaryocyte (MK) progenitors and platelet production. Proc. ASCO 11:124, 1992. 10. Tichler T, Bruderman Y, Shani A, Catane R, Brenner H, Kalichman Y, Farbstein M, Albeck M, Sredni B: Chemotherapy in non-small cell carcinoma of lung with and without a new immunomodulator - AS101. Proc. ASCO 11:08, 1992. 11. Onetto N, Rozencweig M, Canetta, R Winograd B, Catane R, Dougan M, Grechko J, and Burroughs J: An Integrated Analysis of the Safety of Single Agent Taxol. Proc. 2nd NCI Workshop on Taxol and Taxus, 1992. 12. Shani A Tichler T, Bruderman I, Shapiro Y, Guber A, Catane, R, Kalichman, Y, Farbstein M., Albek M, and Sredni B: Granulocytes and platelets CSF effect of a new immunomodulator. AS101 Annals Oncol 3 (supp 5):8, 1992. 13. Deutsch V, Nagler A, Catane R, Barak V, Slavin S, Olson T and Eldor A: Megakaryocyte growth factors in sera of thrombocytopenic patients undergoing chemotherapy, radiotherapy or allogeneic bone marrow transplantation. Proc. XIVth Congress Internat Soc Thrombosis Hemostasis, New York, 1993. 14. Lotan C, Peretz T, Lebensart P, Lyass O and Catane R: Tamoxifen may induce fatty changes in the liver of breast cancer patients. Proc Am Assoc Cancer Res 34: 200, 1993. 15. Gabizon A, Uziely B, Isacson R, Kaufman B, Safra T, Catane R, and Barenholz Y: A pilot clinical study of Doxil, a new doxorubicin liposome preparation. Proc. IVth Internat. Cong. Anti-Cancer Chemotherapy, Paris, 1993. 16. Fields S, Catane R, Gomori JM, Kaufman B, Tuchner Z, Peretz T, Libove A and Degani H: Contrast enhanced breast cancer MRI 17 June 2004 evaluation of chemotherapy response. Breast Cancer Res. & Treat. 27:147, 1993. 17. Tichler T, Shani A, Catane R, Farbstein H, Kalechman Y, Albeck M and Sredni B: What is MTD? Eur. J. Cancer 29A (Supp 6):535, 1993. 18. Shani A, Tichler T, Pavlozky F, Shapiro Y, Bruderman I, Guber A, Catane R, Kaufman B, Kalechman Y, Farbstein M, Albeck M and Sredni B: Platelets, granulocytes and hair growth factor effect of the new immunomodulator AS101 in chemotherapy treated lung cancer patients. Eur. J. Cancer 27A (supp 6):552, 1993. 19. Peretz T, Baider L, Catane R, Barak V, Isacson R, Hubert A and Kaplan A: Interferon and tamoxifen for patients with advanced breast cancer and negative estrogen receptors. Eur. J. Cancer 27A (supp 6):587, 1993. 20. Pfeffer MR, Sulkes A and Catane R: CADOM (cyclophosphamide, adriamycin, dacarbazine, vincristine and methotrexate) protocol for advanced soft tissue sarcomas. Eur. J. Cancer 27 (supp 6):5184, 1993. 21. Catane R, Winograd B, Canetta R, Holcenberg JS, Caron D and Garrison L: PIXY321: Overview of clinical activity. Proc 2nd internat. Symposium: Cytokines and Growth Factors in Cancer, Munich, 1993. 22. Fields S, Degani H, Gomori JM, Libove A, Zajicek G, Peretz T and Catane R: Magnetic Resonance Imaging of breast cancer allows for early determination of response to chemotherapy. Proc. Am. Assoc. Cancer Research 35, 1994. 23. Degani H, Furman E, Margalit R, Horowitz A, Goldberg I, Fields S, Catane R, Gomori JM, Libove A, Zajicek G and Peretz T: Assessment of breast cancer response to therapy by contrast enhanced MRI at high spatial and temporal resolution. Cellular Biochemistry. y-506: 252, 1994. 24. Degani H, Fields S, Catane R, Gomori JM, Peretz T and Libove A: Evaluation of breast cancer therapy with contrast enhanced MRI at high spatial resolution. JMRI 4:116,1994. 25. Peretz T, Shani A, Borovick R, Steiner M, Catane R, Farbstein A, Sulkes A and Figer A: A randomized study of 5FU and levamizole vs. 5FU and leucovorin as adjuvant therapy of colon cancer. Proc ASCO, 14:214, 1995. 18 June 2004 26. Beller U, Ashkenazi J, Hornreich G, Hiller N, Lavie O, Neuman M, and Catane R: Phase II trial of Paclitaxel in refractory ovarian cancer. Br J Obst Gynecol 102:342, 1995. 27. Sredni B, Xu R, Tichler T, Shani A, Catane R, Kaufman B, Albeck M, and Kalechman Y: The protective role of the immuno-modulator AS 101 against chemotherapy-induced alopecia. Proc Am Assoc Cancer Res 37:A3291, 1996. 28. Rivenzon D, Polak-Charcon S, Catane R and Degani H: The effect of retinoic acid on the energetics and glucose metabolism of T47D human breast cancer cells; NMR studies. Proc Am Assoc Cancer Res 37:A3431, 1996. 29. Sapir R, Catane R and Cherny NI. Cancer pain: Knowledge and attitudes of physicians in Israel. Proc. ASCO, 16:42, 1997. 30. Kaufman B, Halle D, Catane R, Cherny NI, Isaacson R, Hornreich G, Beller U and Levy-Lahad E. BRCA Mutation analysis in breast cancer patients may help prevent subsequent ovarian cancer. Proc. ASCO, 16:537, 1997. 31. Peretz T, Figer A, Borovik R, Steiner M, Catane R, Sulkes A, and Shani A. 5FU+Leucovorin (LV) as active and less toxic regimen than 5FU+Levamisole (LM) in the adjuvant therapy of colorectal cancer Israel cooperative Oncology group. Proc. ASCO, 16:265, 1997. 32. Catane R, Lahad A, Kaufman B, Isaacson R, Hornreich G, Beller U, Renbaum P, Halle D, and Levy-Lahad E: BRCA mutations as a potential tumor diagnostic marker. J Tu Mark Oncol 12:27, 1997. 33. Catane R, Halle D, Kaufman B, Eisenberg S, Isaacson R, Cherny N, Lahad A, Hornreich G, Beller U, and Levy-Lahad E: Breast and ovarian cancer risk in BRCA mutation carriers: Implications for prevention. Eur J Cancer 33:512-513, 1997. 34. Kaufman B, Drori-Wagschall L, Beller U, Lahad A, Isacson R, Hornreich G, Cherny N, Segal A, Eisenberg S, Halle D, Catane R and Levy-Lahad E: Differential prognosis and reproductive histories in Ashkenazi ovarian cancer patients with BRCA1 vs. BRCA2 mutations. Proc Am Soc Clinical Oncol 17:556A, 1998. 35. Halle D, Catane R, Kaufman B, Isacson R, Cherny N, Beller U, Hornreich G and Levy-Lahad E: A new BRCA2 mutation in Ashkenazi and non-Ashkenazi Jewish patients: Another founder mutation? Proc Am Assoc Cancer Res 39:30, 1998. 19 June 2004 36. Chertin B, Lindenberg T, Zilberman M, Catane R, Abu-Arafeh W, Algur N, Kuzma P, Spitz IM and Farkas A: Prolonged testosterone suppression in prostate cancer with an implant releasing the GnRH agonist histrelin. Br J Urol 81(S4):69, 1998. 37. Sapir R, Catane R, Kaufman B, Isacson R, Segal A, Wein S, Cherny N: Cancer patient expectations of, and comunication with oncologists and oncology nurses: The experience of an integrated oncology and palliative care service. Proc Am Soc Clin Oncol 18:606a, 1999. 38. Cherny NI, Sapir R, Catane R, Kaufman B, Isacson R, Segal A, Wein S: Symptom prevalence and severity among ambulatory cancer patients attending an integrated oncology-palliative care day hospital. Proc Am Soc Clin Oncol 18:582a, 1999. 39. Fornasiero A, Wormann B, Weh H, Nowacki M, Merimski O, Catane R, Boussard B, Oulid-Aissa D, Di Costanzi F: Extensive clinical experience with Campto® within 3 large randomized studies: Data reported on more than 800 patients (Pts) with metastatic colorectal cancer (MCRC). Proc Am Soc Clin Oncol 18:284a,1999. 40. Halle D, Renbaum P, Orkin B, Farkash A, Segal A, Cherny N, CataneR: Substantially improved sensitivity of urine screening for bladder cancer using genetic markers over routine cytology: Preliminary data from a prospective study. Proc Am Assoc Ca Res 40:691, 1999. 41. Kohne CH, Thuss-Patience P, Catane R, Klein H, Peretz T, Preusser P, Niederle N, Ducreux M, Wilke H, Jacques C: Final results of a Phase II Trial of CPT-11 in patients with advanced gastric cancer. Proc Am Soc Clin Oncol 18:258a, 1999. 42. Levi-Lahad E, Kaufman B, Eisenberg S, Gottfeld O, Beller U, Renbaum P, Lahad A, Catane R: Differentiation ovarian cancer survival in Ashkenazi BRCA1/BRCA2 carriers. Am J Hu Gen 65: A135, 1999. 43. Kaufman B, Segal A, Levi-Lahad E, Eisenberg S, Isacson R, Cherny N, Beller U, Lahad A, Catane R: Different biological effect of BRCA1 and BRCA2 mutations in Ashkenazi breast and ovarian cancer patients. Ann Oncol (Supp 4) 11:21, 2000. 44. Levi-Lahad E, Eisenberg S, Dagan E, , Catane R, Kaufman B, Center P: The RAD51 –135C SNP modifies breast and ovarian cancer risk in BRCA2 carriers, but not in BRCA1 carriers. Proc Am Soc Hum Genet , 2000. 45. Cherny NI, Iliam M, Al-Hijawi B, Catane R, Sapir R: Israel, Jordan and Palestinian Collaborative Cancer Pain Survey. Proc. ASCO 20:300b, 2001. 20 June 2004 46. Goldenberg-Furmanov M, Stein I, Pikarsky E, Catane R, Vigoda M, Laster M,Corn BW, Ben-Sasson SA: A designer inhibitor of novel protein-kinase causes regression of human hormone refractory prostate cance xenografts in nude mice. Europ. J Cancer 37:S218,2001. 47. Yakobson EA, Eisenberg S, Isakson R, Halle D, Levy-Lahad E, Catane R, Sobolev V, Safro M, Huot T, Peters G, Chompret A, Avril M-F, Shafir R, Peretz H, Bressac-dePaillerets B: Val 59 Gly CDKN2A (p16) germline mutation may be of Mediterranean (Jewish?) origin. Melanoma Research 11:S69-S70, 2001 48. Catane R. Defining alternative medicine. Isr Med Assoc J. 4: 314, 2002 49.Catane R, Cherny N, Kaufman B, Portnoy O, Pfeffer R, Sapir R, livneh J, HadasI, Apter S.: Calcification instead of shrinkage following successful imatinib therapy Of GIST.Annals of Oncology. 13 (Supp 5): 30-31, 2002. 50. Cherny N, Catane R, Attitudes of ESMO membership to the role of medical oncologyisis in the palliative care of patients with advanced cancer and dying patients. Annals of Oncology. 13 (Supp 5): 183, 2002 51. Weitzen R, Zach L, Kaufman B, Tichler T, Rath P, Pfeffer R, Baram J, Ben-David M, Rizel S, Catane R,: High incidence of brain metastasis (BM) in patients on trastuzumab for advanced breast cancer: Proc ASCO 21:31b, 2000. 52. Baram J, Goldhammer Y, Ram Z, Tichler T, Nass D, Catane R, Pfeffer R, Blatt I : Any role for brain irradiation in the treatment of primary central nervous system lymphoma ( PCNSL). Proc ASCO 21: 67b 2002. 53. Pfeffer MR, Rath P, Kundel Y, Zehavi M, Koller M, Papa M, Shabtai M, Livne J, Catane R,. A phase I-II study of preoperative radiotherapy and escalating doses of oral UFT for rectal cancer. Proc ASTRO 2002. 54. Safra T, Simchoni S, Kaufman B, Beller U, Eisenberg-Barzilai S, Renbaum P, Catane R, Levy-Lahad E,: Moderate breast cancer penetrance in molecularly proven BRCA 1 / 2 carriers. Proc ASCO 21:427a, 2002. 55. Kundel Y, Catane R, Levitt M, and Pfeffer R: Adjuvant chemotherapy and whole abdominal irradiation for node positive gastric carcinoma is tolerable but apparently ineffective: Results of a retrospective analysis. Gastrointestinal Cancers Symposium, Abstr No. 21, 2004. 56. Wolf I, Sadetzki S, Gluck I, Oberman B, Ben David M, Papa MZ, Catane R, Kaufman B: The effects of diabetes mellitus on the diagnosis, stage and treatment of breast cancer: Proc. ASCO 22:39, (abstr 156), 2003. 21 June 2004 57. Tichler TE, Wolf I, Brenner H, Catane R:Lack of efficacy of a continuous infusion, dose intense 5-fluorouracil based combination chemotherapy for the treatment of carcinoma of unknown primary site. Proc. ASCO 22:785, (abstr 3155), 2003. 58. Goldfarb AJ, Bianconi MI, Otero S, Storino C, Abranson D, Soto E, Catane R, Koliren L: Multidisciplinary management of gestational trophoblastic disease (GTD). Proc Asco 22:473 (abstr 1899), 2003. 59. Gluck I, Wolf I, Sadetzki S, Oberman B, Papa MZ, Gluck N, Catane R, Kaufman B: Prognostic characteristics in very young premenopausal breast cancer patients compared to older premenopausal patients. Proc ASCO 22:896 (abstr 3604), 2003. 60. Gips M, Catane R, Heching I, Levitt l, Segal A, Beb-Shachar M, Perez T.: The Israeli experience with Gefetinib (`Iressa`, ZD 1839) as single agent treatment of advanced non-small-cell lung cancer. Proc ASCO 2004. 61. Weber D, Mor K, Catane R, Zymon Z.: Consequences of death on group process during a long term moderated web based support group. Proceedings Am Soc Llin Oncol 2004. 62. Weitzen R, Harari G, Catane R, Mandel M.: Melanoma risk in women with previous breast cancer. Proc ASCO 2004. 22 June 2004