Download Common Themes 06.06

NCDD
Common Themes
Note
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The “common themes” were developed from a review of the PowerPoint
presentations and the Research Goals spreadsheet. They are presented in
a highly truncated bullet form and are not in any particular order.
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In searching for commonalities amongst the goals presented by the 12
Working Groups, specifics such as cells, pathways, molecules, and
diseases were eliminated—not because they lacked significance within
individual WGs—but in order to capture ideas that applied to the entire field
of DD research. A few items that did not appear in the presentations have
been added.
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The themes suggest overarching ideas and are offered as a tool—along
with the Research Goals and the Challenges and Steps to Achieve Goals
spreadsheets—to assist you in reviewing the WG presentations in order to
decide on what goals to recommend for the long-range plan for digestive
diseases research. They may also suggest overarching challenges and
steps and identify additional items within the NCDD Charter’s requirements
such as the need for training/education and communication strategies.
Animal models
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Development
Model organisms—novel genes, pathways
Disease Pathogenesis
Pre clinical testing
Needed resource to overcome barriers
Genetics
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Genetic basis of complex diseases
Pathways in pathogenesis
Clues to environmental factors
Diagnostic markers
Pharmacogenomics
Epigenetics—cancer pathogenesis
Microbiology
• Define microbiome of human gut and model
organisms
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Metagenomics
Metabolomics
Host-microbiome-nutrient interactions
Modifiers of development, disease
Prebiotics, Probiotics
• Rapid diagnostics
• Prevention: vaccines
• Therapeutics: novel Rx, multi-drug Rx
Biomarkers
• Refine clinical phenotypes with
biomarkers, surrogate markers
• Diagnosis, stage, predict natural history,
predict and assess response to therapy
• Surrogate markers for clinical trials
Regeneration
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Stem cell biology
Repair factors
Gene, cell therapies, support devices
Innovative surgical approaches
Nutrition, micronutrients, pre/pro biotics
Molecular and cell biology
• Comprehensive analysis of cell biology of
different cell types
• Cell-cell communication
• Tissue and whole organism biology
• “Omics” databases, informatics tools,
linkage of different disciplines
• Alternations in disease states
• Targeted therapeutics, diagnostics
Epidemiology
• Descriptive epidemiology of digestive
diseases
• Natural history
• Identification of risk factors
• Response to therapy
• Resource utilization
• Needed resources: registries, common
nomenclature
Digestive Disease Symptoms
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Defined nomenclature
Tools for assessment
Physiological basis
Brain gut interactions
Modifiers
Novel therapies
QOL
Imaging
• Improved imaging: physical, probes,
functional
• Imaging based novel therapies
Innovative technologies:
Diagnosis, Treatment, and Research
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Endoscopic
Surgical
Non-invasive: capsule
Electrical: stimulation, pacing
Robotics
Tissue ablation
Patient Phenotyping
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Standardized nomenclature
Standardized diagnostic criteria
Biomarkers
Novel physiological tests
Genotyping
Common Research Needs
• Resources: Animals, tissues, libraries,
databases, informatics tools, disease
networks
• Human: Career pathways,
interdisciplinary teams, clinical research
training, financial models
• Lower barriers: HIPAA, IRB, electronic
medical record integration with research
data, public-private partnerships
Education
• Increase public and professional
awareness of medical advances
• Prevention
• Implementation of treatment advances
Immunology and Inflammation
• Protective/harmful mechanisms
– Adaptive immunity
– Innate immunity
– Inflammation
• Contribution of immune mechanisms to
interactions with other cell types, GI
physiology, repair
• Novel therapies: biologics, cells, tolerance
• Prevention: vaccines
Clinical trials
• Innovative clinical trials in digestive diseases:
drugs, biologics, devices, behavioral Rx,
combinations
• Clinical research infrastructure: patients, clinical
investigators, regulatory, industry partnerships,
repositories
• Needs of special populations: women,
minorities, children, health disparities
• Post-marketing: Effectiveness, safety, practice
guidelines