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Statistical analysis of hemodynamics and processes maintaining human stability using force plate Jan Kříž Quantum Circle Seminar 16 December 2003 Program of the seminar • • • • • • • What is the force plate? (elementary classical mechanics) Postural control (biomechanics, physiology) Hemodynamics Known results (mathematical models of postural control) Our approach Illustration of data analysis Conclusions What is the force plate? 4 load transducers piezoelectric (Kistler) strain gauge (Bertec) Data are mixed by Wheatstone bridges 6 signals linear cross talks => calibration matrix What is the force plate? Only 5 independent signals Fx , Fy ... shear forces Fz ... vertical force x = - My / Fz ... y = M x / Fz coordinates of COP Postural Requirements • Quiet standing - support head and body against gravity - maintain COM within the base of support • Voluntary movement - stabilize body during movement - anticipate goal-directed responses Postural Control Inputs • Somatosensory systems - cutaneous receptors in soles of the feet - muscle spindle & Golgi tendon organ information - ankle joint receptors - proprioreceptors located at other body segments • Vestibular system - located in the inner ear - static information about orientation - linear accelerations, rotations in the space • Visual system - the slowest system for corrections (200 ms) Motor Strategies - to correct human sway - skeletal and muscle system • Ankle strategy - body = inverted pendulum - latency: 90 – 100 ms - generate vertical corrective forces • Hip strategy - larger and more rapid - in anti-phase to movements of the ankle - shear corrective forces • Stepping strategy Postural Control • • • • - central nervous system Spinal cord - reflex ( 50 ms ) - fastest response - local Brainstem / subcortical - automatic response (100 ms) - coordinated response Cortical - voluntary movement (150 ms) Cerebellum Why to study the postural control? • Somatosensory feedback is an important component of the balance control system. • Older adults, patients with diabetic neuropathy ... deficit in the preception of cutaneous and proprioceptive stimuli • Falls are the most common cause of morbidity and mortality among older people. Hemodynamics - cardiac activity and blood flow - possible internal mechanical disturbance to balance Known results • Measurements • quiet standing (different conditions, COP displacements, Fz – cardiac activity, relations between COP and COM) • perturbations of upright stance ( relations between the perturbation onset and EMG activities) • Results • two components of postural sway (slow 0.1 – 0.4 Hz, fast 8 –13 Hz; slow ~ estimate of dynamics, fast ~ translating the estimates into commands) • corrections in anterio-posterior direction: ankle; in lateral direction: hip Known results • suppressing of some receptors -> greater sway • stochastic resonance: noise can enhance the detection and transmission of weak signals in some nonlinear systems ( vibrating insoles, galvanic vestibular stimulation) • Models of postural sway • Inverted pendulum model • Pinned polymer model Inverted pendulum model Eurich, Milton, Phys. Rev. E 54 (1996), 6681 –6684. If’’ + g f’ – mgR sin f = f(f(t-t)) + x(t) m g I g f ... ... ... upright) f ... x mass gravitational constant moment of inertia ... damping coefficient ... tilt angle (f=0 for delayed restoring force ... stochastic force Pinned polymer model Chow, Collins, Phys. Rev. E 52 (1994), 907 –912. posture control – stochactically driven mechanics driven by phenomenological Langevin equation rt2y + mty = T z2y – K y + F(z,t) z y=y(t,z) r m T K F ... ... ... ... ... ... ... height variable 1D transverse coordinate mass density friction coefficient tension elastic restoring constant stochastic driving force Our approach - signals = information of some dynamical system, we do not need to know their physical meaning - we are searching for processes controlling the dynamical system by studying the relations between different signals - Power spectrum (related to Fourier transform) Pkk(f) = (1/fs) Rkk(t) e-2pi f t/fs , Rkk(t) = xk(t+t) xk(t) ... autocorrelation - Correlation, Covariance Rkl(t) = xk(t+t) xl(t) , Ckl(t) = (xk(t+t)mk)(xl(t)-ml) - Coherence Kkl(f) = | Pkl(f) | / (Pkk(f) Pll(f))1/2, Pkl(f) = (1/fs) Rkl(t) e-2pi f t/fs . Measured signals Power spectrum COP positions Lowpass filtering Lowpass filtering: Power spectrum Lowpass filtering: COP positions Highpass filtering Highpass filtering: Power spectrum Highpass filtering: COP positions Coherences 1 Coherences 2 Coherences 3 Coherences 4 Coherences 5 Conclusions - we have data from an interesting dynamical system - we are searching for the processes controlling the system - results (if any) can help in diagnostic medicine