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Download Breast CanCer Mouse Model Cell line Panel
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The Essentials of Life Science Research Globally Delivered™ Breast Cancer Mouse Model Cell Line Panel Breast Cancer Mouse Model cell line panel (ATCC No. TCP-1005™) The Breast Cancer Mouse Model Cell Line Panel (ATCC® No. TCP-1005™) is composed of eight immortalized mouse mammary epithelial cell lines that stably overexpress MEK1 activated mutant (MEKDD), EGFR2/Neu, Myc or Ha-Ras. This panel of cell lines is useful for studying breast cancer, breast cancer metastasis, mouse models of breast cancer, oncogenes in cell transformation, EGFR-MEK signaling pathways, as well as anti-cancer drug discovery and drug resistance. The table below provides more information for the cell lines included in these panels. ATCC No. Designation Source Cell type Overexpression Significant features CRL-3063™ Eph4Ev mouse mammary gland epithelial cell Empty vector The cells were immortalized from mouse mammary epithelial cell line with an empty vector. They are useful as a control. CRL-3069™ B-MEKDD 116 mouse mammary gland epithelial cell Mutant MEK1 The cells stable overexpression of glu-glu epitope-tagged MEK constant activated mutant: Asp218/Asp222 MEK1 phosphorylation site mutant (MEKDD). CRL-3071™ Eph4 1424 mouse mammary gland epithelial cell Mutant MEK1 The cells were derived from a mouse primary breast tumor. The cells stably overexpress glu-glu epitope-tagged MEK1 constitutively activated mutant (MEKDD). CRL-3209™ Eph4 1424.1 mouse mammary gland epithelial cell Mutant MEK1 The cells were derived from a mouse breast tumor metastasis to kidney. The cells stably overexpress glu-glu epitopetagged MEK1 constitutively activated mutant (MEKDD). CRL-3210™ Eph4 1424.2 mouse mammary gland epithelial cell Mutant MEK1 The cells were derived from a mouse breast tumor metastasis to lung. The cells stably overexpress glu-glu epitope-tagged MEK1 constitutively activated mutant (MEKDD). CRL-3086™ M158 mouse mammary gland epithelial cell MYC The cells are a mouse mammary tumor cell line derived from c-myc-initiated transgenic mice. CRL-3090™ NF639 mouse mammary gland epithelial cell EGFR2/NEU The cells are a mouse mammary tumor cell line derived from neu-initiated transgenic mice. CRL-3092™ Ac 711 mouse mammary gland epithelial cell H-RAS The cells are a mouse mammary tumor cell line derived from Ha-ras-initiated transgenic mice. CB-1015-02 © 2015 American Type Culture Collection. The ATCC trademark and trade name, and any other trademarks listed in this publication are trademarks owned by the American Type Culture Collection unless indicated otherwise. Mouse mammary gland image courtesy of Rumela Chakrabarti, Satrajit Sinha, and Yibin Kang. These products are for laboratory use only. Not for human or diagnostic use. ATCC products may not be resold, modified for resale, used to provide commercial services or to manufacture commercial products without prior ATCC written approval. p 800.638.6597 703.365.2700 e [email protected] www.atcc.org ATCC provides these data in good faith, but makes no warranty, express or implied, nor assumes any legal liability or responsibility for any purpose for which the data are used. atcc® the essentials of life science research. Globally delivered.™ 10801 University Boulevard, Manassas, VA 20110
