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B Cell Maturation, Activation
& Differentiation
Hugh B. Fackrell
Jan 4 ,1998
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B Cell Maturation, Activation
& Differentiation
Assigned Reading
 Content Outline
 Performance Ojectives

– Key terms
– Key Concepts

Short Answer Questions
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Assigned Reading
Chapter: 8 pp 195-222
 Janis Kuby’s Immunology 3rd Ed

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Content Outline
B Cell Maturation
 B Cell Activation & Proliferation
 In Vivo induction of Humoral Response
 B Cell Differentation
 Regulation of B Cell Development

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B Cell Maturation
Bone marrow
 Ig Gene rearrangements
 Pre B cell receptor
 Selection of Immature Self Reactive B
Cells

– negative selection
– rescue editing of light chain genes
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B Cell Activation & Proliferation
T dependent vs T independent antigens
 Origins of activating signals
 Transduction of Activating signals
 B cell coreceptor complex
 T helper cells

– formation of T-B conjugate
– mediation by CD40
– induction of progression signals

Negative selection
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In Vivo Induction
of Humoral Response
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B Cell Differentation

Affinity maturation
– somatic hypermutation
– antigen selection
Class switching
 Plasma cells
 Memory cells

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Regulation of
B Cell Development
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Performance Objectives
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Key Terms

affinity maturation, apotosis, avidity,
capping, carrier effect, cell mediated
immunity,Cytotoxic T cells, Helper T cells,
TH1 cells, TH2 cells, humoral immunity,
immunologic memory, perforin, plasma cells,
primary antibody, programmed cell death,
secondary antibody, thymus dependent
antigens, thymus independent antigens
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Key Concepts
Describe the sequential development of the
humoral immune response.
 Draw a contemporary model for T cell B cell
macrophage interaction
 Describe antigen processing and
presentation by B cells

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Outline the sequence of helper (T/(TH)
cell involvment in antibody production
 Describe the interplay between TH1
and Th2 cells in the development of
immune responses

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Short Answer Questions
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DONE!!!
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