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Akiko Shimamoto Ph.D.
Affiliation:
Meharry Medical College
Neuroscience and Pharmacology
"Neurological Disorders and Mental Health","Women's Health and
Reproductive Biology","Other"
Title: Dr.
Rank: Assistant Professor
Address:
1005 Dr. D.B. Todd Jr. Blvd.
Nashville, TN 37208-3599
Contact:
Email: [email protected]
Telephone: 615-327-6291
Narrative
I am a junior faculty in the Department of Neuroscience and Pharmacology at Meharry Medical
College since January 2014. I was recruited as a new investigator through a Meharry Research Center
for Minority Institution (RCMI) Program in Women's Health Research sponsored by National Institute
on Minority Health and Health Disparities (NIMHD) (G12 MD007586, 2014-2016). Before appointed
as Assistant Professor at Meharry, I was a post-doctoral fellow at a lab led by Dr. Klaus A. Miczek at
the Department of Psychology at Tufts University, who is specialized in psychopharmacology and
behavioral neuroscience. I am an awardee on NIDA INVEST Drug Abuse Research Fellowship that
initiated my postdoctoral work with Dr. Miczek. Before I came to Tufts, I was an Assistant Professor
in field of forensic toxicology at Yamaguchi University School of Medicine. I received my Ph.D. and
Master’s degrees in forensic science with a specialty in forensic toxicology. My current focus is on
astrocytes, glutamate, and its amidated form glutamine, glutamate transporter-1 (GLT-1), sodiumcoupled neutral amino acid transporters 1/2 (SNAT1/2), and presynaptic mitochondria in brain areas
including the prefrontal cortex (PFC) and the nucleus accumbens (NAc). I have an expertise in in vivo
microdialysis, immunohistochemistry, western blot, and behavioral assays, including locomotor
activity, social defeat behaviors, and operant self-administration and relapsing behavior.
Other Positions
Title
Postdoctoral Associate
Institution
Tufts University
Department Psychology Department
Division
Title
Assistant Professor
Institution
Yamaguchi University
Department Legal Medicine
Division
Graduate School of Medicine
Awards and Honors
2007 2008
- INVEST Drug Abuse Research Fellowship
2011
- Young Investigator Travel Award for 2011 American Psychology Association
2016
- RTRN Research Enhancement Award
Publications
1.
Rappeneau V, Blaker A, Petro JR, Yamamoto BK, Shimamoto A. Disruption of the PubMed
Glutamate-Glutamine Cycle Involving Astrocytes in an Animal Model of Depression
for Males and Females. Front Behav Neurosci. 2016; 10:231.
2.
Hwa LS, Nathanson AJ, Shimamoto A, Tayeh JK, Wilens AR, Holly EN, Newman EL, PubMed
DeBold JF, Miczek KA. Aggression and increased glutamate in the mPFC during
withdrawal from intermittent alcohol in outbred mice. Psychopharmacology (Berl).
2015 Aug; 232(16):2889-902.
3.
Hwa LS, Shimamoto A, Kayyali T, Norman KJ, Valentino RJ, DeBold JF, Miczek KA. PubMed
Dissociation of µ-opioid receptor and CRF-R1 antagonist effects on escalated
ethanol consumption and mPFC serotonin in C57BL/6J mice. Addict Biol. 2014 Sep
28.
4.
Han X, Albrechet-Souza L, Doyle MR, Shimamoto A, DeBold JF, Miczek KA. Social PubMed
stress and escalated drug self-administration in mice II. Cocaine and dopamine in
the nucleus accumbens. Psychopharmacology (Berl). 2015 Mar; 232(6):1003-10.
5.
Shimamoto A, Holly EN, Boyson CO, DeBold JF, Miczek KA. Individual differences in PubMed
anhedonic and accumbal dopamine responses to chronic social stress and their link
to cocaine self-administration in female rats. Psychopharmacology (Berl). 2015 Feb;
232(4):825-34.
6.
Quadros IM, Hwa LS, Shimamoto A, Carlson J, DeBold JF, Miczek KA. Prevention of PubMed
alcohol-heightened aggression by CRF-R1 antagonists in mice: critical role for DRNPFC serotonin pathway. Neuropsychopharmacology. 2014 Nov; 39(12):2874-83.
7.
Boyson CO, Holly EN, Shimamoto A, Albrechet-Souza L, Weiner LA, DeBold JF, Miczek PubMed
KA. Social stress and CRF-dopamine interactions in the VTA: role in long-term
escalation of cocaine self-administration. J Neurosci. 2014 May 7; 34(19):6659-67.
8.
Holly EN, Shimamoto A, Debold JF, Miczek KA. Sex differences in behavioral and PubMed
neural cross-sensitization and escalated cocaine taking as a result of episodic social
defeat stress in rats. Psychopharmacology (Berl). 2012 Nov; 224(1):179-88.
9.
Miczek KA, Nikulina EM, Shimamoto A, Covington HE. Escalated or suppressed PubMed
cocaine reward, tegmental BDNF, and accumbal dopamine caused by episodic
versus continuous social stress in rats. J Neurosci. 2011 Jul 6; 31(27):9848-57.
10. Shimamoto A, Debold JF, Holly EN, Miczek KA. Blunted accumbal dopamine response PubMed
to cocaine following chronic social stress in female rats: exploring a link between
depression and drug abuse. Psychopharmacology (Berl). 2011 Nov; 218(1):271-9.
11. Miczek KA, Nikulina EM, Takahashi A, Covington HE, Yap JJ, Boyson CO, Shimamoto PubMed
A, de Almeida RM. Gene expression in aminergic and peptidergic cells during
aggression and defeat: relevance to violence, depression and drug abuse. Behav
Genet. 2011 Nov; 41(6):787-802.
12. Takahashi A, Shimamoto A, Boyson CO, DeBold JF, Miczek KA. GABA(B) receptor PubMed
modulation of serotonin neurons in the dorsal raphé nucleus and escalation of
aggression in mice. J Neurosci. 2010 Sep 1; 30(35):11771-80.
13. Shimamoto A, Liu JY, Fujimiya T. SIAM-Like phenomenon caused by low doses of PubMed
alcohol. Alcohol Clin Exp Res. 2010 Feb; 34 Suppl 1:S2-6.
14. Liu J, Yano M, Shimamoto A, Noma T, Matsuzaki M, Fujimiya T. Chronic effects of PubMed
ethanol on pharmacokinetics and left ventricular systolic function in rats. Alcohol
Clin Exp Res. 2007 Mar; 31(3):493-9.
15. Kozawa S, Yukawa N, Liu J, Shimamoto A, Kakizaki E, Fujimiya T. Effect of chronic PubMed
ethanol administration on disposition of ethanol and its metabolites in rat. Alcohol.
2007 Mar; 41(2):87-93.
16. Shimamoto A, Liu J, Kozawa S, Fujimiya T. Determination of endogenous PubMed
testosterone in rat tissues following fetal alcohol exposure using HPLC with UV
detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 May 19; 836(12):69-73.
17. Kiyoshima A, Kudo K, Goto Y, Tobimatsu S, Ikeda N. Cerebral concentrations of myo- PubMed
inositol in rats with induced brain death. Leg Med (Tokyo). 2005 Mar; 7(2):110-2.
18. Ishida T, Kudo K, Kiyoshima A, Inoue H, Tsuji A, Ikeda N. Sensitive determination of PubMed
alpha-methyltryptamine (AMT) and 5-methoxy-N,N-diisopropyltryptamine (5MeODIPT) in whole blood and urine using gas chromatography-mass spectrometry. J
Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 25; 823(1):47-52.
19. Kudo K, Nishida N, Kiyoshima A, Ikeda N. A fatal case of poisoning by lidocaine PubMed
overdosage--analysis of lidocaine in formalin-fixed tissues: a case report. Med Sci
Law. 2004 Jul; 44(3):266-71.
20. Kiyoshima A, Kudo K, Goto Y, Tobimatsu S, Ikeda N. Changes of the cerebral PubMed
mannitol concentrations in the course of brain death of a rodent model. Leg Med
(Tokyo). 2004 Apr; 6(2):117-24.
21. Kudo K, Kiyoshima A, Ohtsuka Y, Ikeda N. Simultaneous determination of PubMed
bromvalerylurea and allylisopropylacetylurea in human blood and urine by gas
chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life
Sci. 2003 Jul 5; 791(1-2):171-7.
22. Nishida N, Ikeda N, Kudo K, Tsuji A, Kiyoshima A. Forensic significance of conduction PubMed
system abnormalities as a precise cause of accidental death. Int J Legal Med. 2002
Dec; 116(6):344-9.
23. Hino Y, Kudo K, Kiyoshima A, Ikeda N. A sudden death following tetracaine-induced PubMed
spinal anesthesia. Leg Med (Tokyo). 2002 Mar; 4(1):55-9.
24. Kudo K, Ikeda N, Kiyoshima A, Hino Y, Nishida N, Inoue N. Toxicological analysis of PubMed
chlorhexidine in human serum using HPLC on a polymer-coated ODS column. J Anal
Toxicol. 2002 Mar; 26(2):119-22.
25. Kiyoshima A, Kudo K, Nishida N, Ikeda N. HPLC simultaneous determination of PubMed
glycerol and mannitol in human tissues for forensic analysis. Forensic Sci Int. 2002
Feb 18; 125(2-3):127-33.
26. Kiyoshima A, Kudo K, Hino Y, Ikeda N. Sensitive and simple determination of PubMed
mannitol in human brain tissues by gas chromatography-mass spectrometry. J
Chromatogr B Biomed Sci Appl. 2001 Jul 5; 758(1):103-8.
27. Tanaka E, Shimamoto A, Nakamura T, Terao K, Misawa S. Differences in PubMed
chlorzoxazone metabolism in full mature male and female Sprague-Dawley rat,
Beagle dog and Cynomolgus monkey liver. Hum Exp Toxicol. 2000 Feb; 19(2):122-5.
28. Takenouchi T, Fujimoto M, Shimamoto A, Munekata E. Isolation and PubMed
characterization of Cox17p from porcine heart by determining its survival-promoting
activity in NIH3T3 cells. Biochim Biophys Acta. 1999 Nov 16; 1472(3):498-508.
29. Shimamoto A, Tanaka E, Mizuno D, Misawa S. Age- and sex-related changes in PubMed
toluene metabolism by rat hepatic microsomes in vitro. Res Commun Mol Pathol
Pharmacol. 1999; 104(3):265-76.
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