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Endogenous rat GAD67 is targeted to Golgi membranes and presynaptic clusters and
excluded from dendrites in hippocampal neurons.
Kanaani J et al. J Cell Biol doi:10.1083/jcb.200912101
Importance of GAD isozymes
• GAD-65 knockout mice
– Increased seizure susceptibility
– Impaired experience dependent plasticity
• GAD-67 knockout mice
– Normal brain activity
– Cleft palate
• Reduced GAD-67 in psychiatric
disorders (schizophrenia and bipolar)
GABA-T inhibition in neurons increases GABA
current in receptive neurons in cultures.
Inhibition of GAD reduces response.
Depolarization of cells with Potassium increases
GABA current in receptive neurons and GABA-T
inhibition enhances response.
Inactivation of GABA
transmission
Uptake of GABA by Ce GAT-1
in cell culture
Glycine synthesis
Glycine synthesis, release,
and reuptake
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