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2008 FOCUS STUDY THE REVEREND ROGER PATRICK DORCY CANCER CENTER FOCUS STUDY ON COLON CANCER USING SMC AND NCDB DATA COLON CANCER ST. MARY-CORWIN REGIONAL MEDICAL CENTER (SMC) NATIONAL CANCER DATA BASE (NCDB) NATIONAL COMPREHENSIVE CANCER NETWORK (NCCN) For the year 2007 there were 112, 340 estimated new cases of colon cancer and 41,420 new cases of rectal cancer. Combined these two sites yielded the fourth most frequent site of cancer behind prostate, lung and breast as well as the third most common cause of cancer death. The Cancer Registry at SMC validates these statistics, registering 32 cases of colon cancer and 27 cases of rectal cancer out of a total of 709 analytic cases in 2007. Advances continued in 2007 with progress noted in screening, surgical pathology and systemic treatment which have improved overall survival nationwide. SMC TOP PRIMARY SITES 2007 St. Mary-Corwin Top 12 Primary Sites 2007 Num ber 0 20 40 60 80 100 120 118 Prostate 76 Lung 43 H&N/Esophagus 32 Colon Primary Site 160 148 Breast 30 Lymphoma 29 Bladder 27 Rectum/Rectosigmoid Thyroid 23 Kidney 23 22 Bone Marrow Pancreas 140 16 Through grants from the Colorado Colorectal Screening Program 256 indigent patients were able to be screened with colonoscopy. Those diagnosed with colorectal cancer were then supported through their surgical management and adjuvant chemoradiation on site at SMC. SMC participated in the NCDB e-QUIP study for colorectal cancer which reviewed Lymph Node Dissection (LND) rates as well as use of adjuvant radiation. The Pathology Department at SMC has taken a leadership role in developing and implementing protocols for lymph node retrieval. Our study was able to document a 65% (28/43) success rate in examining at least 12 regional lymph nodes in each resected specimen. This benchmark has now become a standard in the NCCN practice guidelines. Cancer Program Practice Profile Reports (CP3R): for Colon Cancers Diagnosed 2004 - 2006 St. Mary-Corwin Medical Center, Pueblo, CO FACILITY SELECTION ALL MEASURES EPR At least 12 regional lymph nodes are removed and pathologically examined for resected colon cancer. [12RLN] Performance Rates and Reported Cases 2004 2005 2006 Total 68.8% 63.2% 62.5% 65.1% 11/16 12/19 5/8 28/43 16 19 8 43 Cases not assessable due to incomplete tumor characteristics [I] 0 0 0 0 Cases not applicable for this measure by definition [NA] 0 0 0 0 24 20 14 58 40 39 22 101 Estimated Performance Rates Performance Rate Numerator / Denominator Cases eligible for the measure (Denominator) [Comp] Cases not eligible for consideration for any colon measure [NE] Total number of colon cancer cases reported to NCDB Interpreting this table: The estimated performance rates shown in this table provides your cancer program with an indication of the proportion of patients undergoing colon resection that had an adequate lymph node examination. These rates are computed based on data directly reported from your registry to the NCDB using specifications endorsed by the NQF. The CP3R provides cancer programs with the opportunity to examine data to determine if these performance rates are representative of the care provided at the institution. This application provides the ability to review and modify cases using this application, simply click on the cell of underlined cases of interest to view a detailed case listing. Displayed performance rates are immediately updated once modifications via the CP3R are completed by cancer program staff. Note: Any modifications made online should be reflected at the local cancer registry, and cancer programs are encouraged to resubmit data to the NCDB. This page and all contents are Copyright © 2008 by the NCDB and American College of Surgeons, Chicago, IL 60611-3211 Comparison of SMC and Colorado, percentage of patients having 12 or more lymph nodes removed at time of surgery for Colon Cancer Comparison of SMC and Colorado, percentage of patients having 12 or more lymph nodes removed at time of surgery for colon cancer. 120% 7 pts 100% 100% 15 pts 80% 15 pts 18 pts 80% Percentage 72% 12 pts 67% 70% 63% SMC 60% 51% 54% 51% 49% 42% 41% 40% 20% 0% 2003 2004 2005 2006 Years and Total 2007 TOTAL COLORADO Percentage of Patients with 12 or more Lymph Nodes Removed During Surgery for Colon Cancer using all NCDB Data PERCENTAGE OF PATIENTS WITH 12 OR MORE LYMPH NODES REMOVED DURING SURGERY FOR COLON CANCER, USING ALL NCDB DATA 80.00% 16 PTS 19 PTS 70.00% 8 PTS PERCENTAGE 60.00% 50.00% SMC 40.00% COLORADO NCDB NCDB 30.00% 20.00% 10.00% 0.00% 2004 2005 YEAR 2006 The average colorectal patient at SMC is diagnosed in their eighth decade (age 70-79) which is approximately 3-5% older than state and national trends. There is a higher prevalence in Colorado State registries for female diagnoses over male with a smaller trend at SMC. Whether this reflects a reluctance on the part of males to undergo screening or a true gender difference may be a subject for future study AGE OF COLON CANCER PATIENTS DIAGNOSED 2000-2005 SMC, NCDB, COLORADO Age of Colon Cancer Diagnosed 2000-2005 SMC, NCDB, COLO 35% 30% Percentage 25% 20% SMC NCDB COLO 15% 10% 5% 0% <40 40-49 50-59 60-69 Age 70-79 80-89 90> GENDER OF COLON CANCER DIAGNOSED 20002005 SMC, NCDB, COLORADO Gender of Colon Cancer Diagnosed 2000-2005 SMC, NCDB, COLO 53% 52% 51% Percentage 50% 49% SMC NCDB COLO 48% 47% 46% 45% 44% MALE FEMALE Gender Nearly 65% of all patients undergo surgical resection for colorectal cancer with about 20% receiving chemotherapy according to registry data. These numbers correlate closely with state and national registries. At SMC a variation was seen in stage distribution with a migration from Stage III to later Stage IV. TREATMENT OF COLON CANCER DIAGNOSED 2000-2005 SMC, NCDB, COLORADO Treatment of Colon Cancer Diagnosed 2000- 2005 SMC, NCDB, COLORADO 80% 70% 60% Percentage 50% SMC 40% NCDB COLO 30% 20% 10% 0% Surg only Surg/Chemo Other Treatment None STAGE OF COLON CANCER DIAGNOSED 2000-2005 SMC, NCDB, COLORADO Stage of Colon Cancer diagnosed 2000-2005 SMC, NCDB, COLO 30% 25% Percentage 20% SMC 15% NCDB COLO 10% 5% 0% 0 I II III Stage IV UNK This delay in diagnosis along with higher age and comorbidity factors yielded lower survival seen mostly in Stage II. These trends will be subject to closer review. OBSERVED SURVIVAL FOR STAGE I COLON CANCER 1998-2000 FOR NCDB AND COLORADO, 1995-2000 FOR SMC OBSERVED SURVIVAL FOR STAGE I COLON CANCER 1998-2000 FOR NCDB AND COLORADO, 1995-2000 FOR SMC 120% CUMULATIVE SURVIVAL RATE 100% 80% SMC N=40 NCDB 60% COLO SMC 40% 20% 0% AT DX 1 2 3 YEARS AFTER DIAGNOSIS 4 5 OBSERVED SURVIVAL FOR STAGE II COLON CANCER 1998-2000 FOR NCDB AND COLORADO, 1995-2000 FOR SMC OBSERVED SURVIVAL FOR STAGE II COLON CANCER 1998-2000 FOR NCDB AND COLORADO, 1995-2000 FOR SMC 120% CUMULATIVE SURVIVAL RATE 100% 80% SMC N=102 NCDB 60% COLO SMC 40% 20% 0% AT DX 1 2 3 YEARS AFTER DIAGNOSIS 4 5 OBSERVED SURVIVAL FOR STAGE III COLON CANCER 1998-2000 FOR NCDB AND COLORADO, 1995-2000 FOR SMC OBSERVED SURVIVAL FOR STAGE III COLON CANCER 1998-2000 FOR NCDB AND COLORADO, 1995-2000 FOR SMC 120% CUMULATIVE SURVIVAL RATE 100% 80% NCDB COLO 60% SMC SMC N=58 40% 20% 0% AT DX 1 2 3 YEARS AFTER DIAGNOSIS 4 5 OBSERVED SURVIVAL FOR STAGE IV COLON CANCER 1998-2000 FOR NCDB AND COLORADO, 1995-2000 FOR SMC OBSERVED SURVIVAL FOR STAGE IV COLON CANCER 1998-2000 FOR NCDB AND COLORADO, 1995-2000 FOR SMC 120% CUMULATIVE SURVIVAL RATE 100% 80% NCDB 60% COLO SMC 40% 20% SMC N=45 0% AT DX 1 2 3 YEARS AFTER DIAGNOSIS 4 5 Also seen was lower use of chemotherapy in Stage III which may reflect the rural nature of our region with some added barriers to treatment. TREATMENT OF STAGE III COLON CANCER 20002005 SMC, NCDB, COLORADO TREATMENT OF STAGE III COLON CANCER 2000-2005, SMC, NCDB, COLORADO 60% 50% PERCENT 40% SMC 30% NCDB COLORADO 20% 10% 0% SURG ONLY SURG/CHEMO TREATMENT OTHER SMC remains committed to excellence in the management of cancer diagnoses and treatment. Under the guidance of it’s multispecialty cancer committee. These and other trends will be reviewed and targeted for scrutiny and improvement. Vaughan R. Cipperly, MD Cancer Committee Chairman