Download Philips SPECT/CT Systems

Philips SPECT/CT Systems
Ling Shao, PhD
Director, Imaging Physics & System Analysis
Nuclear Medicine, Philips Healthcare
June 14, 2008
*Presented SNM08 Categorical Seminar - Quantitative SPECT and PET for Molecular Imaging
Philips SPECT/CT Portfolio
Precedence 6 & 16
BrightView XCT
(New)
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Philips SPECT/CT Portfolio
Product
BrightView XCT
(New)
Precedence 6
Precedence 16
General positioning
CT Customer value
NM-based
Low dose – high resolution
localization
Ultra-low dose AC
CoPlanar FP
NM tailored workflow
Small room size
Radiology-based
Diagnostic CT apps
Ca++ scoring
Exceptional CT quality
Radiology-based
Premium
Diagnostic CT apps
Ca++ scoring
*Coronary CTA
Highest coverage/throughput
Short breath hold exams
Exceptional CT quality
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Precedence System
Precedence 6/16 slice
Product Names:
•
Precedence 6 slice (NM and Oncology)
•
Precedence 16 slice (Cardiology and Oncology)
Key Performances:
•
•
•
SPECT (Key advances):
–
Detector intrinsic resolution 3.2 mm
–
> 5 mm SPECT reconstruction resolution (Astonish)
–
Half-time acquisition (Cardiac)
Capable of full cardiac CT:
–
Speed: 0.5 second rotation
–
Slice thickness: 0.67 mm slice (spiral), 0.6 mm slice (anode)
–
Resolution: 24 lp/cm
–
Dose (CTDI): 12.85 mGy/100 mAs (head), 6.5 mGy/100 mAs (body)
Registration error
–
≥ 4mm (one pixel)
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BrightView XCT
Technology:
•
Flat Panel Based Volume CT technology
•
Coplanar with SPECT Imaging (cardiac -14 cm)
Key Performances:
•
•
•
SPECT (Key advances):
–
Detector intrinsic resolution 3.2 mm
–
> 5 mm SPECT reconstruction resolution (Astonish)
–
Half-time acquisition
Localization, CT-AC, Bone Imaging
–
Max. Rotation Speed: 12 sec for 360o (14 cm axial FOV)
–
Slice thickness: 0.33 – 2.0+ mm (isotropic voxel)
–
Resolution: >15 lp/cm
–
Dose (CTDI) - Typical: ~ 6 mGy body localization, ~ 1 mGy Attenuation Correction
Registration error
–
≥ 4mm (one pixel)
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BrightView XCT System Components
•
Volumetric CT components
–
–
–
–
–
•
X-ray tube and
collimator
Rotating anode X-ray tube
120 kVp X-ray generator, pulsed or
continuous
4030CB flat panel detector
•
10, 30, 60 fps, dynamic gain
X-ray flat
panel detector
Patient table
X-ray collimator and beam shaper
CBCT image reconstruction using GPU
Volumetric CT system goals
SPECT FOV
54 x 40 cm
–
–
–
–
Low profile
gamma detector
14 cm axial
coverage
X-ray cone-beam overlaps SPECT FOV
o
360 Gantry rotation within a breath-hold
Low-dose CT acquisition parameters
Integrated hybrid software solution
X-ray flat panel
detector
40 x 30 cm
SPECT/C
T Gantry
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System Geometry to Increase Field-of-View
Gantry center
of rotation
Projection Overlap
~4.5 cm
88 cm
45 cm
Unweighted
Projection
•
•
•
•
Detector effectively doubles in size to increase imaging FOV to 47 cm
– Reduces truncation
Flat panel detector is offset ~17.4 cm relative to its center
o
Half projections from 180 opposite views are weighted and combined
3- XCT spins to cover 40 cm SPECT FOV
Weighted
Projection
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Key SPECT/CT Acquisition Features
-Precedence and BrightView XCT
SPECT (Precedence & BrightView):
True Energy
Independence
16 Energy
Windows
Uniform
Performance at all
Energy Levels for
Multi-Peak Imaging
(<300 keV)
MI Tracer
Batteries &
Advanced
Corrections
Concurrent
Imaging
Simultaneous MI
& Conventional
Acquisition
Protocols
Half-time
Acquisition
(Astonish 3D
Reconstruction)
Optimized
Filtering &
Resolution
Compensation
XCT (BrightView XCT):
•NM-driven acquisition user interface/protocols
•No compromise to SPECT functions
•X-ray CT and SPECT are in coplanar for cardiac imaging
•Reconstruction with GPU for faster processing speed
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New Workstation
-Bringing Simplicity to Nuclear Medicine
Workflow to improve clinical impact and cost of ownership
•
PET, SPECT and CT on the same platform
•
Improved access, connectivity - taking Nuclear
Medicine to enterprise
•
Clinically complete Applications Suite
•
Full QC functionality on the workstation
•
Streamlined and fully configurable workflow
–
User-adaptive protocols (change
parameters, defaults on the fly)
–
Access to applications and tools where
needed when needed
–
Imbedding best in class algorithms into
one workflow (AutoSPECT, Astonish AC)
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New Workstation: NM Application Suite
-Bringing Simplicity to Nuclear Medicine
Comprehensive clinical applications and methods.
Comprehensive Planar Suite
•
•
•
•
•
•
•
•
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Planar Gated Analysis
Whole Body Analysis
Pulmonary Analysis
Renal Analysis
Endocrine Analysis
Hepatobiliary Analysis
Gastric Analysis
Esophageal Analysis
Salivary Analysis
Comprehensive SPECT Suite
•
Integrated SPECT/CT AC, Reconstruction, Review
Comprehensive QA Suite
•
•
Daily QC
NEMA Suite
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Automated Workflow Example:
- CT-AC Reconstruction
Automate your Workflow with Auto-Proceed …or pause at each Workstep.
Set Up
AC Map
Recon
Reorient
Review
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Image Quality & Acquisition Speed
• 3D Astonish Reconstruction
– 3D OSEM with resolution, attenuation and
scatter correction
– Multiple peak isotope
– Better image quality
– Toward to better quantitation
• Half-time Acquisition
– Astonish provide equal or better with half-time
acquisition
FB
P
Astonish
• Typical SPECT/CT acquisition (typical US Protocols.)
– Total body scan
• 15 min SPECT + 2 min CT Æ 7 min SPECT + 2
min CT
– Cardiac scan
• 15 min SPECT + 2 min CT Æ 7 min SPECT + 2
min CT
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Image Quality and Acquisition Speed
Astonish provides constant image quality with wide range of count statistics
5 Observers: A relative image quality (RIQ) score with respect to a standard image (64x64x64 matrix, clinical counts, FBP
reconstruction) was assigned to each image by each observer (3: much better, 2: better, 1: slightly better, 0: equivalent, -1: slightly
worse, -2: worse and -3: much worse).
Relative Image quality Score Comparison
2
IQ Score
1.5
1
Astonish -- 32 projection
ASTONISH
FBP
0.5
0
-0.5
FBP – 64 projection
0.17
0.33
0.67
1
-1
-1.5
-2
-2.5
Count Statistics ( % with respect to reference image)
Reference image (conventional
acquisition time)
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Clinical Images of BrightView XCT
Separate control room is not required
for the CT acquisition
Plan the SPECT/CT off the nuclear
medicine p-scope
Flexible breathing protocols to
minimize mis-registration
Images from Radiological Associates of Sacramento,
Courtesy of Dr. Richard Myers, MD
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Patient 1: Cardiac Attenuation Correction
• 194 lbs (88 kg) , Male, 49 yrs
• Dx: Pre-op clearance, Abnormal EKG
• Single 60-second CT, tidal breathing
• Single 12-second CT, end expiration breath hold
CT parameters:
SPECT parameters:
60 second
12 second
Persantine stress, 2.5 hrs p.i.
120 kVp
120 kVp
35 mCi Tc-99m MIBI
5 mA
2.5 mA
64 x 64
10 msec pulse width
continuous
64 azimuths
1.2 mGy CTDIVOL
0.79 mGy CTDIVOL
20 sec/azimuth
1.46 zoom
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Comparison of breath hold and tidal breathing
12 second
Breath hold CT, 0.8mGy
60 second
BrightView XCT launch to sales
Tidal breathing CT, 1.2mGy
Images courtesy of Radiological Associates of Sacramento
Inferior wall attenuation – 12 sec breath hold
AC
No AC
AC
No AC
AC
No AC
Images courtesy of Radiological Associates of Sacramento
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Inferior wall attenuation–60 sec tidal breathing
AC
No AC
AC
No AC
AC
No AC
Images courtesy of Radiological Associates of Sacramento
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Patient 2: Localization
• 143 lbs (65 kg), Female, 54 yrs
• Dx: Lung CA
• Three 12 second CT (breath hold)
CT parameters:
SPECT parameters:
120 kVp
22.9 mCi Tc-99m MDP, 2.5 hrs p.i.
20 mA
128 x 128
continuous pulse width
128 azimuth
6.8 mGy CTDIVOL
20 sec/azimuth
1.0 zoom
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Lung Cancer – bilateral facet disease
BrightView XCT launch to sales
Images courtesy of Radiological Associates of Sacramento
Patient 3: Bone Localization
• 202 lbs (92 kg), Male, 25 yrs
• Dx: Right knee sarcoma
• One 24 second CT
CT parameters:
SPECT parameters:
120 kVp
25.3 mCi Tc-99m MDP, 3 hrs p.i.
80 mA
128 x 128
10 msec pulse width
128 azimuths
14.9 mGy CTDIVOL
20 sec/azimuth
1.4 zoom
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Osteosarcoma, CT resampled to 0.64 mm voxels
BrightView XCT launch to sales
Images courtesy of Radiological Associates of Sacramento
Thank you
you
Thank
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