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Save the Date for the 2014 Keystone Symposia meeting on: Tumor Metabolism March 16–21, 2014 Whistler Conference Centre, Whistler, British Columbia, Canada Scientific Organizers: William G. Kaelin, Jr., Benjamin F. Cravatt III and Peter K. Jackson joint with the conference on “Metabolism and Angiogenesis” The conference will: • Investigate the causal roles played by altered metabolism and epigenetics in cancer as well as the resulting potential of metabolic and epigenetic enzymes to serve as a basis for new ways of imaging and treating cancer; • Bring together experts from the fields of both cancer metabolism and epigenetics; • Facilitate additional cross-pollination across fields through the joint pairing with the meeting on “Metabolism and Angiogenesis.” Discounted Abstract Deadline: November 18, 2013 Student/Postdoc Scholarship Application Deadline: November 18, 2013 Abstract Deadline: December 17, 2013 Discounted Registration Deadline: January 15, 2014 For more information and to view the full program, visit www.keystonesymposia.org/14X6 KEYSTONE SYMPOSIA on Molecular and Cellular Biology Tumor Metabolism (X6) Scientific Organizers: William G. Kaelin, Jr., Benjamin F. Cravatt III and Peter K. Jackson Sponsored by Bayer HealthCare Pharmaceuticals, Pfizer Inc., Takeda Pharmaceutical Company Limited and TESARO, Inc. Supported by an educational donation provided by Amgen. Metabolism and Angiogenesis (X5) Scientific Organizers: Peter F. Carmeliet and Michael Simons March 16-21, 2014 • Whistler Conference Centre • Whistler, British Columbia, Canada Supported by the Directors' Fund Abstract & Scholarship Deadline: November 18, 2013 / Abstract Deadline: December 17, 2013 / Discounted Registration Deadline: January 15, 2014 SUNDAY, MARCH 16 Arrival and Registration MONDAY, MARCH 17 Keynote Session (Joint) M. Celeste Simon, University of Pennsylvania, USA Oxygen, Lipids and Cancer Cell Metabolism Steven L. McKnight, University of Texas Southwestern Medical Center, USA Acetate Consumption as a Potential Vulnerability of Certain Types of Human Tumors Luisa Iruela-Arispe, University of California, Los Angeles, USA Endothelial VEGFR2 Signaling in Diabetes Markus Jabs, German Cancer Research Center, Germany Short Talk: Notch Signaling Regulates Systemic Energy Metabolism Poster Session 1 TUESDAY, MARCH 18 Isocitrate Dehydrogenase (X6) William G. Kaelin, Jr., Dana-Farber Cancer Institute, USA The von Hippel-Lindau Tumor Suppressor Protein: Insights into Oxygen Sensing and Cancer Metabolism Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA Novel Metabolic Pathways in Cancer I (Joint) Epigenetic Control by Mutant IDH Matthew G. Vander Heiden, Massachusetts Institute of Technology, Elizabeth Maher, University of Texas Southwestern Medical Center, USA USA Metabolic Pathways Important for Tumor Growth and Survival Metabolic Imaging of IDH Mutant Brain Tumors David M. Sabatini, Whitehead Institute for Biomedical Research, USA Katharine Yen, Agios Pharmaceuticals, USA Amino Acids, Sugars and Cancer Metabolism AG-221 Offers a Survival Advantage in a Primary Human IDH2 Karen H. Vousden, Crick Institute, UK Mutant AML Xenograft Model p53-Pathway Mediated Metabolic Regulation Christian Metallo, University of California, San Diego, USA Ralph J. DeBerardinis, University of Texas Southwestern Medical Short Talk: Exploiting Oncogenic IDH Mutations to Identify Center, USA Therapeutic Targets and Annotate Compartmentalized Pathway Metabolic Versatility in Cancer Cells Function Douglas R. Green, St. Jude Children's Research Hospital, USA Yoko Ogawara, National Cancer Center Research Institute, Japan Balancing Act: Caspases and RIP Kinases in Cell Death and Short Talk: Critical Roles of the IDH2 Mutation in Development and Development Maintenance of Acute Myeloid Leukemia Succinate Dehydrogenase and Fumarate Hydratase (X6) Metabolism and Vascular Branching (X5) *Matthew G. Vander Heiden, Massachusetts Institute of Technology, *Luisa Iruela-Arispe, University of California, Los Angeles, USA USA Michael Potente, Max Planck Institute for Heart and Lung Research, Patrick J. Pollard, University of Edinburgh, UK Germany Oncometabolites: Linking Altered Metabolism With Cancer? Linking Angiogenesis and Metabolism through FOXO Transcription Eyal Gottlieb, Technion Integrated Cancer Center, Israel Factors Revealing New Metabolic Networks in FH-Deficient Tumors Peter F. Carmeliet, University of Leuven, VIB, Belgium Navdeep S. Chandel, Northwestern University, USA Targeting Endothelial Metabolism: Principles and Strategies Targeting Mitochondrial Metabolism for Cancer Therapy Annika Keller, University Hospital Zürich and Uppsala University, Paul-Joseph P. Aspuria, Cedars-Sinai Medical Center, USA Switzerland Short Talk: Succinate Dehydrogenase Inhibition Leads to Endothelial-Pericyte Signaling and Brain Disease Epithelial-Mesenchymal Transition and Reprogrammed Carbon Kari K. Alitalo, University of Helsinki, Finland Metabolism VEGF-B in Metabolic Reprogramming and Cardiovascular Disease Hilary A. Coller, University of California, Los Angeles, USA Metabolism and Angiogenesis: Bidirectional Cross-Talk (X5) Tumor Stromal Cells *Adrian L. Harris, University of Oxford, Weatherall Institute of Peter D. Westenskow, The Scripps Research Institute, USA Molecular Medicine, UK Short Talk: Cone Photoreceptors Generate the Fatty Acid Amide Zoltan P. Arany, University of Pennsylvania, USA Erucamide for Maintenance of the Ocular Vasculature Endothelial PGC-1alpha Mediates Vascular Dysfunction in Diabetes Pengchun Yu, Yale School of Medicine, USA Massimo Santoro, Vesalius Research Center, Belgium Short Talk: Regulation of Lymphangiogenesis by FGF Signaling Novel Non-Mitochondrial Redox Regulator in Endothelial Cells * Session Chair † Invited but not yet accepted Program current as of May 12, 2017. Program subject to change. Meal formats are based on meeting venue. For the most up-to-date details, visit www.keystonesymposia.org/14X6 and www.keystonesymposia.org/14X5. KEYSTONE SYMPOSIA on Molecular and Cellular Biology Tumor Metabolism (X6) Scientific Organizers: William G. Kaelin, Jr., Benjamin F. Cravatt III and Peter K. Jackson Sponsored by Bayer HealthCare Pharmaceuticals, Pfizer Inc., Takeda Pharmaceutical Company Limited and TESARO, Inc. Supported by an educational donation provided by Amgen. Metabolism and Angiogenesis (X5) Scientific Organizers: Peter F. Carmeliet and Michael Simons March 16-21, 2014 • Whistler Conference Centre • Whistler, British Columbia, Canada Supported by the Directors' Fund Abstract & Scholarship Deadline: November 18, 2013 / Abstract Deadline: December 17, 2013 / Discounted Registration Deadline: January 15, 2014 Lactate and Monocarboxylate Transporters (X6) Ubaldo E. Martinez Outschoorn, Thomas Jefferson University, USA Talk Title to be Announced Jacques Pouysségur, University of Nice, France Targeting Lactate/H+ Symporters for Cancer Therapy John Kurhanewicz, University of California, San Francisco, USA Using in Vivo Hyperpolarized 13C MR Imaging for Measuring Metabolic Fluxes Important to Prostate Cancer Progression and Therapeutic Response Sunghee Park, Duke University Medical Center, USA Short Talk: PGC-1alpha/ERRalpha Regulates Lactate-Fueled Mitochondrial Oxidative Metabolism in Breast Cancer Metabolism and Anti-Angiogenic Therapy (X5) Dai Fukumura, Massachusetts General Hospital, USA Vascular Normalization and Metabolic Microenvironment Patrizia Agostinis, KU Leuven, Belgium Tumor Vessel Normalization by Chloroquine Independent on Autophagy Blockage Olivier Feron, Université Catholique de Louvain, Belgium Targeting Lactate and Glutamine Metabolism in Endothelial Cells Adrian L. Harris, University of Oxford, Weatherall Institute of Molecular Medicine, UK Metabolic Response to Anti-Angiogenic Therapy Guy Eelen, Vesalius Research Center, KU Leuven, Belgium Short Talk: Deletion of Glutamine Synthetase in Endothelial Cells Novel Metabolic Pathways in Cancer II (X5) Leads to Vessel Branching Defects *M. Celeste Simon, University of Pennsylvania, USA Stephanie M. Cossette, Medical College of Wisconsin, USA James M. Phang, NCI at Frederick, National Institutes of Health, USA Short Talk: Sucrose Non-Fermenting Related Kinase (SNRK) Is an The Proline Regulatory Axis: Metabolic Reprogramming in Cancer AMPK Family Member that Is Essential for Cardiac Metabolism in vivo Yury I. Miller, University of California, San Diego, USA Poster Session 3 Cholesterol Efflux and Angiogenesis † Natalie Sheng Jie Lim , National University Singapore, Singapore Workshop: Monitoring Metabolism (X6) Short Talk: Strategy to Enhance Angiogenesis: A Prolyl Hydroxylase Hilary A. Coller, University of California, Los Angeles, USA Inhibitor and Lysophospholipid Approach Metabolism of Quiescent Cells Hwee Ying Lim, National University of Singapore, Singapore Linda C. Hsieh-Wilson, California Institute of Technology, USA Role of Lymphatic Vessels in Cholesterol Clearance and the The Interplay of Protein Glycosylation and Cancer Metabolism Involvement of High-Density Lipoproteins in Regulating Lymphatic Alan Saghatelian, The Salk Institute for Biological Studies, USA Function Protein-Metabolite Interactions Brian W. Wong, Vesalius Research Center, Belgium Sakino Toue, Ajinomoto Co., Inc, Japan Short Talk: Investigating the Metabolism of Venous and Lymphatic Short Talk: MALDI-Imaging Mass Spectrometry Assisted by On-Tissue Endothelial Cells Chemical Derivatization for Visualizing Multiple Amino Acids in Human Colon Cancer Xenografts Poster Session 2 WEDNESDAY, MARCH 19 Metabolism and Epigenetic Enzymes (X6) Lucy A. Godley, University of Chicago, USA Regulation of Hematopoiesis by 5-Hydroxymethylcytosine Chuan He, University of Chicago, USA Epigenetic DNA and RNA Demethylation in Mammalian Regulation Anne Brunet, Stanford University, USA Metabolic and Epigenetic Regulation of Aging Paul Guilhamon, University College London Cancer Institute, UK Short Talk: Meta-Analysis of IDH-Mutant Cancers Identifies a New Interaction Partner for TET2 Hong-Wu Chen, University of California, Davis, USA Short Talk: Reprogramming Metabolism for Cancer Therapeutic Resistance by Histone Methylases Lipid Metabolism (X6) Daniel K. Nomura, University of California, Berkeley, USA Mapping Dyregulated Metabolic Pathways in Cancer Using Functional Proteomic and Metabolomic Platforms Gerald Hoefler, Medical University of Graz, Austria Adipose Triglyceride Lipase (ATGL) is a Metabolic Tumor Suppressor Gene Ernst R. Lengyel, University of Chicago, USA Crosstalk between Cancer Cells and Adipocytes Jurre J. Kamphorst, CR-UK Beatson Institute and University of Glasgow, UK Short Talk: Hypoxic and Ras-Transformed Cells Support Growth by Scavenging Fatty Acids from Lysophospholipids * Session Chair † Invited but not yet accepted Program current as of May 12, 2017. Program subject to change. Meal formats are based on meeting venue. For the most up-to-date details, visit www.keystonesymposia.org/14X6 and www.keystonesymposia.org/14X5. KEYSTONE SYMPOSIA on Molecular and Cellular Biology Tumor Metabolism (X6) Scientific Organizers: William G. Kaelin, Jr., Benjamin F. Cravatt III and Peter K. Jackson Sponsored by Bayer HealthCare Pharmaceuticals, Pfizer Inc., Takeda Pharmaceutical Company Limited and TESARO, Inc. Supported by an educational donation provided by Amgen. Metabolism and Angiogenesis (X5) Scientific Organizers: Peter F. Carmeliet and Michael Simons March 16-21, 2014 • Whistler Conference Centre • Whistler, British Columbia, Canada Supported by the Directors' Fund Abstract & Scholarship Deadline: November 18, 2013 / Abstract Deadline: December 17, 2013 / Discounted Registration Deadline: January 15, 2014 Metabolism and Pathological Angiogenesis (X5) Yoshiaki Kubota, Keio University, Japan Oxidative Stress as a Target for Anti-Angiogenic Therapy *Michael Simons, Yale University, USA Vascular Fate Determination Massimiliano Mazzone, KULeuven - VIB, Belgium Influence of Macrophage Metabolism on Vessel Shape: Implications for Cancer Tony Walshe, Novartis, USA Short Talk: Mitochondrial Oxidative Phosphorylation and Redox Signaling Govern Endothelial Cell Fate Decisions Sara Zanivan, CRUK Beatson Institute, UK Elucidating Endothelial Metabolism Using Quantitative Proteomics Ulrike Harjes, University of Oxford, UK Dll4-Notch and Foxo1 Co-Regulate Endothelial Fatty Acid Binding Protein 4 Miguel Quintela-Fandino, Spanish National Cancer Research Centre, Spain Short Talk: Metabolic Synthetic Lethality: Antiangiogenic Treatment Plus Phenformin in Breast Cancer Anuradha Doddaballapur, Institute of Cardiovascular Regeneration, Germany Short Talk: Shear Stress and Krüppel-Like Factor 2 Regulate Endothelial Metabolism by Repressing PFKFB3 THURSDAY, MARCH 20 Novel Cancer Metabolic Targets (Joint) Almut Schulze, University of Würzburg/Theodor-Boveri Institute, Germany The Role of Glucose and Lipid Metabolism in Growth and Survival of Cancer Cells Jonathan Hurov, Agios Pharmaceuticals, USA Investigation of Glutaminase (GLS1) Dependency in Cancer Cells Tom O'Brien, Genentech, Inc., USA and Peter K. Jackson, Stanford University, USA Inhibiting Glycolysis with a New LDHA Inhibitor Brooke M. Emerling, Sanford Burnham Prebys Medical Discovery Institute, USA Short Talk: Deletion of Phosphatidylinositol-5-Phosphate 4-Kinases Results in Impaired Growth of p53 Deficient Tumors by Mediating Changes in Metabolism Kristen E.N. Scott, H. Lee Moffitt Cancer Center & Research Institute, USA Short Talk: De Novo Fatty Acid Synthesis Is Regulated by Myc and Is Required for B-Lymphoma Survival FRIDAY, MARCH 21 Departure Novel Cancer Metabolic Targets II (X6) Benjamin F. Cravatt III, The Scripps Research Institute, USA Crosstalk between Metabolic and Signaling Pathways in Cancer Sandaruwan Geeganage, Eli Lilly and Company, USA Targeting Metabolic Reprogramming for Cancer – A Pharma Perspective Nissim Hay, University of Illinois at Chicago, USA Targeting Glucose Metabolism for Cancer Therapy Metabolism and Angiogenesis: Therapeutic Implications (X5) *Massimiliano Mazzone, KULeuven - VIB, Belgium * Session Chair † Invited but not yet accepted Program current as of May 12, 2017. Program subject to change. Meal formats are based on meeting venue. For the most up-to-date details, visit www.keystonesymposia.org/14X6 and www.keystonesymposia.org/14X5.